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[{"key": "dc.contributor.advisor", "value": "Kujala, Jan", "language": "", "element": "contributor", "qualifier": "advisor", "schema": "dc"}, {"key": "dc.contributor.author", "value": "Ik\u00e4l\u00e4inen, Juhani", "language": "", "element": "contributor", "qualifier": "author", "schema": "dc"}, {"key": "dc.date.accessioned", "value": "2025-01-29T05:58:36Z", "language": null, "element": "date", "qualifier": "accessioned", "schema": "dc"}, {"key": "dc.date.available", "value": "2025-01-29T05:58:36Z", "language": null, "element": "date", "qualifier": "available", "schema": "dc"}, {"key": "dc.date.issued", "value": "2024", "language": "", "element": "date", "qualifier": "issued", "schema": "dc"}, {"key": "dc.identifier.uri", "value": "https://jyx.jyu.fi/handle/123456789/99808", "language": null, "element": "identifier", "qualifier": "uri", "schema": "dc"}, {"key": "dc.description.abstract", "value": "Aivojen rytminen eli oskillatorinen aktiivisuus liittyy olennaisesti ty\u00f6muistin sujuvaan toimintaan. Toisaalta oskillatorisen aivotoiminnan poikkeavuuksia muistiteht\u00e4viss\u00e4 on havaittu eteneviss\u00e4 neurorappeumasairauksissa, mik\u00e4 on synnytt\u00e4nyt kiinnostusta tutkia oskillaatioita n\u00e4iden sairauksien\nbiomarkkerina. Tulevat potilastutkimukset edellytt\u00e4v\u00e4t kuitenkin mahdollisimman lyhyit\u00e4 ja tehokkaita mittausasetelmia, jollaisia ei ole aiemmin testattu muistiteht\u00e4viin perustuvissa MEG-\ntutkimuksissa. \n\nT\u00e4ss\u00e4 tutkielmassa tarkastellaan lyhytkestoisen magnetoenkefalografiamittauksen (MEG) k\u00e4ytt\u00f6kelpoisuutta ty\u00f6muistiin liittyvien oskillaatioiden tutkimuksessa. Tutkittavat (n = 11) suorittivat Sternbergin muistiteht\u00e4v\u00e4n, jonka aikana mitattiin magnetoenkefalografialla aivojen oskillatorista aktiivisuutta. Tutkittavien teht\u00e4v\u00e4n\u00e4 oli painaa mieleen 2-4 numeron pituisia sarjoja. Theeta-, alfa- ja gamma -taajuisen aktiivisuuden muutoksia suhteessa muistikuormaan (lyhyt vs. pitk\u00e4 numerosarja) tarkasteltiin teht\u00e4v\u00e4n yll\u00e4pitovaiheen aikana. MEG-mittauksen lyhent\u00e4mist\u00e4 edelleen\nsimuloitiin osittaisotannalla ja sen vaikutuksia aineiston luotettavuuteen sis\u00e4korrelaatiokertoimen kautta.\n\nLyhytkestoisella mittauksella havaittiin viitteit\u00e4 muutoksista aivojen oskillatorisessa toiminnassa kokeen yll\u00e4pitovaiheen aikana muistikuorman vaihdellessa. Havaittiin, ett\u00e4 mittausaineiston v\u00e4hent\u00e4misest\u00e4 huolimatta, n\u00e4ist\u00e4 muutoksista saatiin luotettavia arvioita. Tulokset puoltavat lyhyiden MEG-mittausten hy\u00f6dynt\u00e4mist\u00e4 ty\u00f6muistiin liittyv\u00e4n oskillatorisen aivotoiminnan jatkotutkimuksissa.", "language": "fi", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.abstract", "value": "The rhythmic, or oscillatory, activity of the brain is closely related to the smooth functioning of working memory. On the other hand, abnormalities in oscillatory brain activity have been observed in memory tasks in the context of progressive neurodegenerative diseases, which has sparked interest in investigating oscillations as biomarkers for these diseases. However, future patient studies will require measurement setups that are as short and efficient as possible, which have not been previously piloted in memory task-based MEG studies.\n\nThis thesis examines the feasibility of short-duration magnetoencephalography (MEG) measurements in studying working memory. The participants (n = 11) performed the Sternberg memory task, during which oscillatory brain activity was measured with MEG. The participants' task was to memorize sequences of 2\u20134 digits. Changes in theta, alpha, and gamma frequency activity\nrelative to memory load (short vs. long digit sequence) were analyzed during the maintenance phase of the task. The effect of shortening the measurement time was simulated using partial sampling, and its impact on the reliability of MEG data was assessed through the intra-correlation coefficient.\n\nShort-duration measurements revealed signs of changes in the brain's rhythmic activity during the maintenance phase of the task, as memory load varied. Despite reducing the amount of data collected, reliable estimates of these changes were obtained, supporting the use of short MEG\nmeasurements in further research on the oscillatory function of working memory.", "language": "en", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Submitted by Paivi Vuorio (paelvuor@jyu.fi) on 2025-01-29T05:58:36Z\nNo. of bitstreams: 0", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Made available in DSpace on 2025-01-29T05:58:36Z (GMT). No. of bitstreams: 0\n Previous issue date: 2024", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.format.extent", "value": "34", "language": "", "element": "format", "qualifier": "extent", "schema": "dc"}, {"key": "dc.language.iso", "value": "fin", "language": null, "element": "language", "qualifier": "iso", "schema": "dc"}, {"key": "dc.rights", "value": "In Copyright", "language": "en", "element": "rights", "qualifier": null, "schema": "dc"}, {"key": "dc.subject.other", "value": "oskillatorinen aivotoiminta", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "lyhytkestoinen mittaus", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "oscillatory brain activity", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "short-term measurement", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.title", "value": "Ty\u00f6muistin yll\u00e4pitovaiheen tutkiminen lyhytkestoisella magnetoenkefalografiamittauksella : pilottitutkimus neurodegeneratiivisten sairauksien varhaisen diagnoosimenetelm\u00e4n kehitt\u00e4miseen", "language": "", "element": "title", "qualifier": null, "schema": "dc"}, {"key": "dc.type", "value": "master thesis", "language": null, "element": "type", "qualifier": null, "schema": "dc"}, {"key": "dc.identifier.urn", "value": "URN:NBN:fi:jyu-202501291571", "language": null, "element": "identifier", "qualifier": "urn", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Master\u2019s thesis", "language": "en", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Pro gradu -tutkielma", "language": "fi", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Kasvatustieteiden ja psykologian tiedekunta", "language": "fi", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Faculty of Education and Psychology", "language": "en", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Psykologian laitos", "language": "fi", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Department of Psychology", "language": "en", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "Jyv\u00e4skyl\u00e4n yliopisto", "language": "fi", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "University of Jyv\u00e4skyl\u00e4", "language": "en", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Psykologia", "language": "fi", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Psychology", "language": "en", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "yvv.contractresearch.funding", "value": "0", "language": "", "element": "contractresearch", "qualifier": "funding", "schema": "yvv"}, {"key": "dc.type.coar", "value": "http://purl.org/coar/resource_type/c_bdcc", "language": null, "element": "type", "qualifier": "coar", "schema": "dc"}, {"key": "dc.rights.accesslevel", "value": "openAccess", "language": null, "element": "rights", "qualifier": "accesslevel", "schema": "dc"}, {"key": "dc.type.publication", "value": "masterThesis", "language": null, "element": "type", "qualifier": "publication", "schema": "dc"}, {"key": "dc.subject.oppiainekoodi", "value": "202", "language": "", "element": "subject", "qualifier": "oppiainekoodi", "schema": "dc"}, {"key": "dc.subject.yso", "value": "muistisairaudet", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "muisti (kognitio)", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "aivot", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "ty\u00f6muisti", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "tutkimus", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "neurofysiologia", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "toiminta", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "neuropsykologia", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "kognitiiviset prosessit", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "MEG", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "h\u00e4iri\u00f6t", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.rights.url", "value": "https://rightsstatements.org/page/InC/1.0/", "language": null, "element": "rights", "qualifier": "url", "schema": "dc"}]
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