In vitro glycoengineering of a monoclonal antibody produced in insect cells

In vitro glycoengineering of a monoclonal antibody produced in insect cells

Sugar modifications, in particular, N-glycans, largely determine protein quality, functionality, and, in case of therapeutic biomolecules, safety. Therapeutic monoclonal antibodies (mAbs) generate immune response through effector functions, for which they require complex N-glycans with high levels o...

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Bibliographic Details
Main Author: Zhurina, Anastasiia
Other Authors: Matemaattis-luonnontieteellinen tiedekunta, Faculty of Sciences, Bio- ja ympäristötieteiden laitos, Department of Biological and Environmental Science, Jyväskylän yliopisto, University of Jyväskylä
Format: Master's thesis
Language:eng
Published: 2024
Subjects:
effector functions
glycoengineering
homogenous glycoprofile
Lepidopteran insect cells
monoclonal antibody
Solu- ja molekyylibiologia
Cell and molecular biology
4013
Online Access: https://jyx.jyu.fi/handle/123456789/96162

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