Comparing individual muscle size and strength responses in younger and older adults after prolonged resistance training

Several weeks of systematic resistance exercise, termed resistance training (RT), increases muscle size and strength in both younger and older adults and is recognized as a key measure towards combatting age-related neuromuscular decline. Considerable inter-individual variation exists, however, in t...

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Main Author: Vandeweerd, Joshua
Other Authors: Liikuntatieteellinen tiedekunta, Faculty of Sport and Health Sciences, Liikunta- ja terveystieteet, Sport and Health Sciences, Jyväskylän yliopisto, University of Jyväskylä
Format: Master's thesis
Language:eng
Published: 2021
Subjects:
Online Access: https://jyx.jyu.fi/handle/123456789/76328
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author Vandeweerd, Joshua
author2 Liikuntatieteellinen tiedekunta Faculty of Sport and Health Sciences Liikunta- ja terveystieteet Sport and Health Sciences Jyväskylän yliopisto University of Jyväskylä
author_facet Vandeweerd, Joshua Liikuntatieteellinen tiedekunta Faculty of Sport and Health Sciences Liikunta- ja terveystieteet Sport and Health Sciences Jyväskylän yliopisto University of Jyväskylä Vandeweerd, Joshua Liikuntatieteellinen tiedekunta Faculty of Sport and Health Sciences Liikunta- ja terveystieteet Sport and Health Sciences Jyväskylän yliopisto University of Jyväskylä
author_sort Vandeweerd, Joshua
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description Several weeks of systematic resistance exercise, termed resistance training (RT), increases muscle size and strength in both younger and older adults and is recognized as a key measure towards combatting age-related neuromuscular decline. Considerable inter-individual variation exists, however, in the adaptations to RT. Whether this inter-individual variation differs between younger and older adults has not been extensively studied. Further, whether baseline characteristics such as pre-training muscle size and strength can predict individual responses to RT is not definitively known. The purpose of this study was to determine the magnitude of inter-individual variability in responses to prolonged RT, whether it differs between younger and older adults, and whether pre-training characteristics are related to an individual’s response to RT. Data from three previous studies in untrained younger men and/or older men and women who performed 6-12 months of supervised, progressive, whole-body RT were pooled for this retrospective analysis. Participants (n = 156) were divided into a younger group (YOUNG, n = 65, 31.6 ± 7.0 years) and an older group (OLD, n = 91, 69.2 ± 2.7 years). Measurements of muscle size – vastus lateralis cross-sectional area (VLCSA) via ultrasound – and strength – quadriceps maximal voluntary contraction (QMVC) by isometric dynamometer – were completed pre- and post-intervention. Relative changes in VLCSA (ΔVLCSA) were greater in YOUNG (12.8 ± 9.3 %, range: -6.0 to +40.7 %) compared to OLD (5.3 ± 13.0 %, range: -19.5 to +49.9 %) (p < 0.001). Ten YOUNG participants (15 %) were classified as muscle size non-responders (post-testing score below the smallest worthwhile change of the measurement) compared to 58 OLD participants (64 %). There was a significant difference in the variability of muscle size changes between YOUNG and OLD (p = 0.014). Relative change in QMVC (ΔQMVC) did not differ between YOUNG (6.4 ± 17.3 %, range: -22.8 to +57.2 %) and OLD (9.2 ± 17.2 %, range: -43.0 to +67.8 %) (p = 0.321). Twenty-seven YOUNG participants (42 %) were classified as muscle strength non- responders compared to 26 OLD participants (29 %). The variability in muscle strength changes did not differ between YOUNG and OLD (p = 0.802). Smaller pre-training VLCSA was related to greater ΔVLCSA in YOUNG (r = -0.308, p = 0.012) but not OLD (r = -0.044, p = 0.679). Lower pre-training QMVC was related to greater ΔQMVC in both YOUNG (r = -0.353, p = 0.004) and OLD (r = -0.283, p = 0.007). This investigation shows the considerable heterogeneity that exists in the muscle size and strength adaptations to RT. Older adults appear to exhibit diminished and more variable muscle size but not strength responses to RT compared to younger adults. This indicates that RT prescriptions aimed at maximizing muscle growth may need to be differentiated for older populations. Additionally, pre-training values are only weakly correlated to the RT-induced changes in muscle size and strength indicating that many other factors contribute to the inter- individual variability in muscle size and strength responses to RT.
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Considerable inter-individual variation exists, however, in the adaptations to RT. Whether this inter-individual variation differs between younger and older adults has not been extensively studied. Further, whether baseline characteristics such as pre-training muscle size and strength can predict individual responses to RT is not definitively known. The purpose of this study was to determine the magnitude of inter-individual variability in responses to prolonged RT, whether it differs between younger and older adults, and whether pre-training characteristics are related to an individual\u2019s response to RT.\r\n\r\nData from three previous studies in untrained younger men and/or older men and women who performed 6-12 months of supervised, progressive, whole-body RT were pooled for this retrospective analysis. Participants (n = 156) were divided into a younger group (YOUNG, n = 65, 31.6 \u00b1 7.0 years) and an older group (OLD, n = 91, 69.2 \u00b1 2.7 years). Measurements of muscle size \u2013 vastus lateralis cross-sectional area (VLCSA) via ultrasound \u2013 and strength \u2013 quadriceps maximal voluntary contraction (QMVC) by isometric dynamometer \u2013 were completed pre- and post-intervention.\r\n\r\nRelative changes in VLCSA (\u0394VLCSA) were greater in YOUNG (12.8 \u00b1 9.3 %, range: -6.0 to +40.7 %) compared to OLD (5.3 \u00b1 13.0 %, range: -19.5 to +49.9 %) (p < 0.001). Ten YOUNG participants (15 %) were classified as muscle size non-responders (post-testing score below the smallest worthwhile change of the measurement) compared to 58 OLD participants (64 %). There was a significant difference in the variability of muscle size changes between YOUNG and OLD (p = 0.014). Relative change in QMVC (\u0394QMVC) did not differ between YOUNG (6.4 \u00b1 17.3 %, range: -22.8 to +57.2 %) and OLD (9.2 \u00b1 17.2 %, range: -43.0 to +67.8 %) (p = 0.321). Twenty-seven YOUNG participants (42 %) were classified as muscle strength non- responders compared to 26 OLD participants (29 %). The variability in muscle strength changes did not differ between YOUNG and OLD (p = 0.802). Smaller pre-training VLCSA was related to greater \u0394VLCSA in YOUNG (r = -0.308, p = 0.012) but not OLD (r = -0.044, p = 0.679). Lower pre-training QMVC was related to greater \u0394QMVC in both YOUNG (r = -0.353, p = 0.004) and OLD (r = -0.283, p = 0.007).\r\n\r\nThis investigation shows the considerable heterogeneity that exists in the muscle size and strength adaptations to RT. Older adults appear to exhibit diminished and more variable muscle size but not strength responses to RT compared to younger adults. This indicates that RT prescriptions aimed at maximizing muscle growth may need to be differentiated for older populations. 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spellingShingle Vandeweerd, Joshua Comparing individual muscle size and strength responses in younger and older adults after prolonged resistance training inter-individual variability hypertrophy non-responders cross-sectional area maximal voluntary contraction Valmennus- ja testausoppi Science in Sport Coaching and Fitness Testing 5013 ikääntyminen voimaharjoittelu lihasvoima ageing strength training muscle strength
title Comparing individual muscle size and strength responses in younger and older adults after prolonged resistance training
title_full Comparing individual muscle size and strength responses in younger and older adults after prolonged resistance training
title_fullStr Comparing individual muscle size and strength responses in younger and older adults after prolonged resistance training Comparing individual muscle size and strength responses in younger and older adults after prolonged resistance training
title_full_unstemmed Comparing individual muscle size and strength responses in younger and older adults after prolonged resistance training Comparing individual muscle size and strength responses in younger and older adults after prolonged resistance training
title_short Comparing individual muscle size and strength responses in younger and older adults after prolonged resistance training
title_sort comparing individual muscle size and strength responses in younger and older adults after prolonged resistance training
title_txtP Comparing individual muscle size and strength responses in younger and older adults after prolonged resistance training
topic inter-individual variability hypertrophy non-responders cross-sectional area maximal voluntary contraction Valmennus- ja testausoppi Science in Sport Coaching and Fitness Testing 5013 ikääntyminen voimaharjoittelu lihasvoima ageing strength training muscle strength
topic_facet 5013 Science in Sport Coaching and Fitness Testing Valmennus- ja testausoppi ageing cross-sectional area hypertrophy ikääntyminen inter-individual variability lihasvoima maximal voluntary contraction muscle strength non-responders strength training voimaharjoittelu
url https://jyx.jyu.fi/handle/123456789/76328 http://www.urn.fi/URN:NBN:fi:jyu-202106083542
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