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[{"key": "dc.contributor.advisor", "value": "Tikkanen, Heikki", "language": "", "element": "contributor", "qualifier": "advisor", "schema": "dc"}, {"key": "dc.contributor.advisor", "value": "Kainulainen, Heikki", "language": "", "element": "contributor", "qualifier": "advisor", "schema": "dc"}, {"key": "dc.contributor.author", "value": "Alho, Iisa", "language": null, "element": "contributor", "qualifier": "author", "schema": "dc"}, {"key": "dc.date.accessioned", "value": "2017-11-16T13:15:57Z", "language": "", "element": "date", "qualifier": "accessioned", "schema": "dc"}, {"key": "dc.date.available", "value": "2017-11-16T13:15:57Z", "language": "", "element": "date", "qualifier": "available", "schema": "dc"}, {"key": "dc.date.issued", "value": "2017", "language": null, "element": "date", "qualifier": "issued", "schema": "dc"}, {"key": "dc.identifier.other", "value": "oai:jykdok.linneanet.fi:1794030", "language": null, "element": "identifier", "qualifier": "other", "schema": "dc"}, {"key": "dc.identifier.uri", "value": "https://jyx.jyu.fi/handle/123456789/55907", "language": "", "element": "identifier", "qualifier": "uri", "schema": "dc"}, {"key": "dc.description.abstract", "value": "Nilkka-olkavarsipainesuhteen ja verisuonten j\u00e4ykkyyden yhteys hengitys- ja verenkiertoelimist\u00f6n kuntoon sek\u00e4 vapaa-ajan fyysiseen aktiivisuuteen tyypin 1 diabetesta sairastavilla miehill\u00e4.\r\n\r\nJohdanto. Tyypin 1 diabetesta sairastavilla valtimosairauksien riski on huomattavasti kohonnut verrattuna henkil\u00f6ihin, joilla ei ole diabetesta. Fyysisen aktiivisuuden on osoitettu olevan yhteydess\u00e4 matalampaan syd\u00e4n- ja verisuonisairauksien riskiin, mink\u00e4 takia fyysisen aktiivisuuden lis\u00e4\u00e4minen voisi auttaa tyypin 1 diabeetikkojen sairastumisriskin hallitsemisessa. Tutkimuksen tarkoitus oli vertailla nilkka-olkavarsipainesuhdetta (ABI) ja valtimoiden j\u00e4ykkyytt\u00e4 CAVI-indeksill\u00e4 mitattuna tyypin 1 diabetesta sairastavien ja terveiden nuorien miehien v\u00e4lill\u00e4 ja tarkastella ABI:n ja CAVI:n yhteytt\u00e4 hengitys- ja verenkiertoelimist\u00f6n kuntoon sek\u00e4 vapaa-ajan fyysiseen aktiivisuuteen (LTPA).\r\nMenetelm\u00e4t. T\u00e4ss\u00e4 tutkimuksessa k\u00e4ytetty aineisto on osa \u201dExercise, Diet and Genes in T1D\u201d (EDGE) Helsinki -projektia. 12 tyypin 1 diabetesta sairastavaa miest\u00e4 (T1D) ja 17 tervett\u00e4 verrokkia (kontrolliryhm\u00e4) osallistuivat tutkimukseen. Kaikki tutkittavat suorittivat polkupy\u00f6r\u00e4ergometritestin nousevalla kuormituksella uupumukseen asti maksimaalisen hapenottokyvyn (VO2max) m\u00e4\u00e4ritt\u00e4miseksi. Vapaa-ajan fyysist\u00e4 aktiivisuutta kartoitettiin kyselylomakkeella. ABI, CAVI ja verenpaine mitattiin VaSera VS-1500 -laitteella.\r\nTulokset. VO2max oli merkitsev\u00e4sti matalampi T1D-ryhm\u00e4ss\u00e4 kuin kontrolliryhm\u00e4ss\u00e4 (p<0.05). Ryhmien v\u00e4lill\u00e4 ei havaittu ero vapaa-ajan fyysisess\u00e4 aktiivisuudessa. CAVI oli korkeampi T1D-ryhm\u00e4ss\u00e4 (p<0.01), mutta ABI:ssa ei havaittu eroa ryhmien v\u00e4lill\u00e4. LTPA korreloi negatiivisesti CAVI:n kanssa T1D-ryhm\u00e4ss\u00e4 (r=-0.72 oikea ja r=-0.68 vasen CAVI, p<0.05), mutta ei kontrolliryhm\u00e4ss\u00e4. VO2max ei korreloinut ABI:n tai CAVI:n kanssa kummassakaan ryhm\u00e4ss\u00e4. \r\nJohtop\u00e4\u00e4t\u00f6kset. Nuorilla tyypin 1 diabetesta sairastavilla miehill\u00e4 on jo havaittavissa subkliinist\u00e4 valtimoiden kovettumista, joka voisi viitata kohonneeseen ennenaikaisen valtimoiden kovettumisen ja valtimotautien riskiin. Hengitys- ja verenkiertoelimist\u00f6n kunto ei n\u00e4ytt\u00e4isi olevan yhteydess\u00e4 valtimoiden j\u00e4ykkyyteen, mutta vapaa-ajan fyysisen aktiivisuuden lis\u00e4\u00e4minen saattaisi olla erityisen hy\u00f6dyllist\u00e4 tyypin 1 diabeetikolle valtimoiden kovettumisen ehk\u00e4isemiseksi.", "language": "fi", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.abstract", "value": "Introduction. In individuals with type 1 diabetes the risk of arterial diseases is considerably increased compared to nondiabetic individuals. Since physical activity has been shown to be associated with decreased cardiovascular disease risk it could help in the management of the disease risk. The aim of this study was to compare ankle-brachial index (ABI) and cardio-ankle vascular index (CAVI) in young men with and without type 1 diabetes and to analyze the associations of ABI and CAVI with cardiorespiratory fitness and leisure-time physical activity (LTPA).\r\nMethods. The data are a part of an \u201cExercise, Diet and Genes in T1D\u201d (EDGE) Helsinki project. Twelve men with type 1 diabetes (T1D) and 17 healthy age- and anthropometry-matched men (control) volunteered in the study. All subjects performed incremental cycling exercise test until volitional fatigue to determine maximal oxygen uptake (VO2max). Leisure-time physical activity was assessed through a questionnaire. ABI, CAVI, and blood pressure were measured with VaSera VS-1500. \r\nResults. VO2max was significantly lower in T1D compared to control group (p<0.05). No differences were found in LTPA. CAVI was significantly higher in T1D (p<0.01) but no difference in ABI was found. LTPA correlated negatively with CAVI in T1D (r=-0.72 for right and r=-0.68 for left CAVI, p<0.05) but not in control group. VO2max was not found to be correlated with ABI and CAVI in T1D or control group. \r\nConclusions. Young men with type 1 diabetes seem to already have subclinically increased arterial stiffness possibly implicating increased risk of premature arterial stiffening and arterial complications. Cardiorespiratory fitness does not seem to be associated with arterial stiffness but increasing LTPA might be especially beneficial for individuals with type 1 diabetes to combat arterial stiffening.", "language": "en", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Submitted using Plone Publishing form by Iisa Alho (iikaalho) on 2017-11-16 13:15:57.164114. Form: Pro gradu -lomake (https://kirjasto.jyu.fi/julkaisut/julkaisulomakkeet/pro-gradu-lomake). JyX data: [jyx_publishing-allowed (fi) =True]", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Submitted by jyx lomake-julkaisija (jyx-julkaisija.group@korppi.jyu.fi) on 2017-11-16T13:15:57Z\r\nNo. of bitstreams: 2\r\nURN:NBN:fi:jyu-201711164269.pdf: 1112626 bytes, checksum: 90b03eacfee80f2e015a344219d4fe00 (MD5)\r\nlicense.html: 4917 bytes, checksum: 8cd7e456cce3474044055d1dc7904a7e (MD5)", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Made available in DSpace on 2017-11-16T13:15:57Z (GMT). No. of bitstreams: 2\r\nURN:NBN:fi:jyu-201711164269.pdf: 1112626 bytes, checksum: 90b03eacfee80f2e015a344219d4fe00 (MD5)\r\nlicense.html: 4917 bytes, checksum: 8cd7e456cce3474044055d1dc7904a7e (MD5)\r\n Previous issue date: 2017", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.format.extent", "value": "1 verkkoaineisto (110 sivua)", "language": null, "element": "format", "qualifier": "extent", "schema": "dc"}, {"key": "dc.format.mimetype", "value": "application/pdf", "language": null, "element": "format", "qualifier": "mimetype", "schema": "dc"}, {"key": "dc.language.iso", "value": "eng", "language": null, "element": "language", "qualifier": "iso", "schema": "dc"}, {"key": "dc.rights", "value": "In Copyright", "language": "en", "element": "rights", "qualifier": null, "schema": "dc"}, {"key": "dc.subject.other", "value": "tyypin 1 diabetes", "language": null, "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": 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