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[{"key": "dc.contributor.advisor", "value": "Astikainen, Piia", "language": "", "element": "contributor", "qualifier": "advisor", "schema": "dc"}, {"key": "dc.contributor.advisor", "value": "Aitta-Aho, Teemu", "language": "", "element": "contributor", "qualifier": "advisor", "schema": "dc"}, {"key": "dc.contributor.author", "value": "Takalo, Hanna", "language": "", "element": "contributor", "qualifier": "author", "schema": "dc"}, {"key": "dc.date.accessioned", "value": "2024-09-10T09:00:21Z", "language": null, "element": "date", "qualifier": "accessioned", "schema": "dc"}, {"key": "dc.date.available", "value": "2024-09-10T09:00:21Z", "language": null, "element": "date", "qualifier": "available", "schema": "dc"}, {"key": "dc.date.issued", "value": "2024", "language": "", "element": "date", "qualifier": "issued", "schema": "dc"}, {"key": "dc.identifier.uri", "value": "https://jyx.jyu.fi/handle/123456789/96982", "language": null, "element": "identifier", "qualifier": "uri", "schema": "dc"}, {"key": "dc.description.abstract", "value": "Muutokset modernissa ruokateknologiassa ovat helpottaneet ep\u00e4terveellisten valintojen tekemist\u00e4, mik\u00e4 on johtanut somaattisiin ja psykologisiin ongelmiin. T\u00e4h\u00e4n perustuen uudeksi psykiatriseksi h\u00e4iri\u00f6ksi on lis\u00e4tty ahmintah\u00e4iri\u00f6. Tutkimus 5-HT2A agonististen psykedeelien tutkimus on nouseva trendi. Alustavien kliinisten kokeiden tulosten perusteella niist\u00e4 voi olla apua monissa psykiatrisissa sek\u00e4 tunne-el\u00e4m\u00e4n h\u00e4iri\u00f6iss\u00e4. Psykedeelien vaikutusta ahmintah\u00e4iri\u00f6\u00f6n ei kuitenkaan ole juurikaan tutkittu.\nT\u00e4m\u00e4n pro gradu -tutkielman tavoitteena oli tarkastella vaikuttaako klassinen psykedeeli lysergihapon dietyyliamidi (LSD) hiirten normaaliin sek\u00e4 herkkuruuan kulutukseen. Ahmiminen operationalisoitiin kahdella eri koeasetelmalla. Sukroosin eskalaatiokokeessa hiiret saivat sek\u00e4 tavallista ruokaa ett\u00e4 sukroositabletteja ruokinta-automaatista. Toisessa korkeakalorisessa rasva-ahmintamallissa hiiret jaettiin kolmeen ryhm\u00e4\u00e4n, jotka saivat tavallista jyrsij\u00e4pelletti\u00e4 ja rasvaruokaa jatkuvasti tai 24 tunnin ajan. Kun sy\u00f6mist\u00e4 oli testattu, tutkittiin eri LSD-annosten vaikutuksia sy\u00f6misk\u00e4ytt\u00e4ytymiseen.\nSukroosieskalaation tuloksista ei ollut havaittavissa hiirten mieltymyst\u00e4 sukroosipelletteihin, vaan sukroosiryhm\u00e4n hiiret s\u00f6iv\u00e4t ylip\u00e4\u00e4t\u00e4\u00e4n sek\u00e4 tavallista ruokatyyppi\u00e4 ett\u00e4 sukroosia kontrolliryhm\u00e4\u00e4 enemm\u00e4n. LSD ei vaikuttanut hiirten sy\u00f6misk\u00e4ytt\u00e4ytymiseen. Runsaskalorisessa rasva-ahmintakokeessa rajoitetun ajan rasvaa saaneet hiiret ahmivat perustasolla rasvaa merkitsev\u00e4sti muihin ryhmiin verrattuna, mutta psykedeelivaikutusta ei ilmennyt kolmella eri LSD-annoksella miss\u00e4\u00e4n ryhm\u00e4ss\u00e4.\nTulokset her\u00e4tt\u00e4v\u00e4t kysymyksi\u00e4 LSD:n soveltuvuudesta ahmintah\u00e4iri\u00f6n hoidossa ja yleisesti siit\u00e4, mallintavatko el\u00e4inmallit tarpeeksi psykiatristen sairauksien psykologista ja emotionaalista kompleksisuutta. T\u00e4m\u00e4 pro gradu -tutkielma ja sen tulokset luovat pohjaa tuleville tutkimuksille psykedeelien vaikutuksista ahmintah\u00e4iri\u00f6\u00f6n ja ruokariippuvuuteen.", "language": "fi", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.abstract", "value": "The advancements in modern food technology have made palatable foods more accessible resulting in somatic and psychological problems. Based on this, a new classification in eating disorders has been proposed: binge eating disorder (BED). \nResearch on 5-HT2A agonist psychedelic compounds is a popular topic and preliminary clinical trials show promising results in the treatment of many psychiatric conditions and emotional problems. However, research specifically addressing psychedelics and BED is limited.\nThis master\u2019s thesis aimed to observe whether the classical psychedelic lysergic acid diethylamide (LSD) influences the consumption of normal and palatable foods in mice. Binge eating was operationalized in two different experimental designs. The first one was sucrose escalation where the mice received ordinary and sucrose tablets from a feeding device. The second experiment, the high-calorie fat bingeing, divided the mice into three groups that would get standard rodent chow and high-calorie fat pellets either continuously or intermittently for 24 hours. After testing the levels of eating, the effects of different doses of LSD on eating behaviors were investigated.\nThe results indicated that the mice in the sucrose escalation experiment did not show a preference for the hedonic sucrose pellets although the sucrose group consumed more food overall compared to the control. LSD did not affect their eating patterns. In the high-calorie fat bingeing experiment, the intermittent group showed significant fat bingeing at baseline, but the psychedelic effect did not manifest after administering three different doses of LSD.\nThe results raise questions about the suitability of LSD in treating BED and in general if animal models shed light on the emotional and psychological complexity of psychiatric diseases. This master\u2019s thesis and its findings pave the way for future applications for psychedelic research for binge eating disorder and food addiction.", "language": "en", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Submitted by Paivi Vuorio (paelvuor@jyu.fi) on 2024-09-10T09:00:21Z\nNo. of bitstreams: 0", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Made available in DSpace on 2024-09-10T09:00:21Z (GMT). No. of bitstreams: 0\n Previous issue date: 2024", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.format.extent", "value": "37", "language": "", "element": "format", "qualifier": "extent", "schema": "dc"}, {"key": "dc.language.iso", "value": "eng", "language": null, "element": "language", "qualifier": "iso", "schema": "dc"}, {"key": "dc.rights", "value": "In Copyright", "language": "en", "element": "rights", "qualifier": null, "schema": "dc"}, {"key": "dc.subject.other", "value": "psychedelics", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "mouse models", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.title", "value": "The potential of LSD in treating binge eating : findings from two different experimental designs in mice", "language": "", "element": "title", "qualifier": null, "schema": "dc"}, {"key": "dc.type", "value": "master thesis", "language": null, "element": "type", "qualifier": null, "schema": "dc"}, {"key": "dc.identifier.urn", "value": "URN:NBN:fi:jyu-202409105863", "language": null, "element": "identifier", "qualifier": "urn", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Master\u2019s thesis", "language": "en", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Pro gradu -tutkielma", "language": "fi", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Kasvatustieteiden ja psykologian tiedekunta", "language": "fi", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Faculty of Education and Psychology", "language": "en", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Psykologian laitos", "language": "fi", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Department of Psychology", "language": "en", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "Jyv\u00e4skyl\u00e4n yliopisto", "language": "fi", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "University of Jyv\u00e4skyl\u00e4", "language": "en", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Psykologia", "language": "fi", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Psychology", "language": "en", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "yvv.contractresearch.funding", "value": "0", "language": "", "element": "contractresearch", "qualifier": "funding", "schema": "yvv"}, {"key": "dc.type.coar", "value": "http://purl.org/coar/resource_type/c_bdcc", "language": null, "element": "type", "qualifier": "coar", "schema": "dc"}, {"key": "dc.rights.accesslevel", "value": "openAccess", "language": null, "element": "rights", "qualifier": "accesslevel", "schema": "dc"}, {"key": "dc.type.publication", "value": "masterThesis", "language": null, "element": "type", "qualifier": "publication", "schema": "dc"}, {"key": "dc.subject.oppiainekoodi", "value": "202", "language": "", "element": "subject", "qualifier": "oppiainekoodi", "schema": "dc"}, {"key": "dc.subject.yso", "value": "serotoniini", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "sy\u00f6mish\u00e4iri\u00f6t", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "LSD", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "kohtauksittainen ahmimish\u00e4iri\u00f6", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "serotonin", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "eating disorders", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "LSD", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "binge eating disorder", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.rights.url", "value": "https://rightsstatements.org/page/InC/1.0/", "language": null, "element": "rights", "qualifier": "url", "schema": "dc"}]
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