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[{"key": "dc.contributor.advisor", "value": "Laakkonen, Eija", "language": null, "element": "contributor", "qualifier": "advisor", "schema": "dc"}, {"key": "dc.contributor.author", "value": "Virkki, Anni Irene Elina", "language": "", "element": "contributor", "qualifier": "author", "schema": "dc"}, {"key": "dc.date.accessioned", "value": "2024-06-14T09:33:45Z", "language": null, "element": "date", "qualifier": "accessioned", "schema": "dc"}, {"key": "dc.date.available", "value": "2024-06-14T09:33:45Z", "language": null, "element": "date", "qualifier": "available", "schema": "dc"}, {"key": "dc.date.issued", "value": "2024", "language": null, "element": "date", "qualifier": "issued", "schema": "dc"}, {"key": "dc.identifier.uri", "value": "https://jyx.jyu.fi/handle/123456789/95882", "language": null, "element": "identifier", "qualifier": "uri", "schema": "dc"}, {"key": "dc.description.abstract", "value": "Cardiovascular diseases and type 2 diabetes are major contributors to the decline in health and functional capacity of older people. They are also a major public health cost. Metabolic syndrome is a risk factor for these diseases. Both lifestyle and aging affect metabolic health.\n\nDuring menopause, estrogen production from the ovaries ceases, and the risk of metabolic syndrome increases. Menopausal symptoms are treated with hormone therapy (HT), which can also affect metabolic health. The aim of this study was to determine whether the changes in metabolic syndrome components that occur during natural menopause (NM) differ from the changes occurring during HT-treated menopause. The variables included in the study were total cholesterol, HDL cholesterol, LDL cholesterol, triglycerides, glucose, waist circumference, systolic blood pressure and diastolic blood pressure.\n\nThe University of Jyv\u00e4skyl\u00e4's ERMA and EsmiRs data were used as material. The subjects were women aged 47\u201355 years from Jyv\u00e4skyl\u00e4, who had not reached menopause at baseline and who transitioned from one menopausal phase to another during follow-up. The subjects were divided into a HT group (n = 33) and NM group (n = 115). Repeated measures analysis of variance was used as the main method of analysis. The model was controlled for baseline visceral fat and menopausal stage.\n\nWhitin the groups changes promoting metabolic health were an increase in HDL cholesterol and a decrease in diastolic blood pressure in both groups, as well as a decrease in glucose and systolic blood pressure in the HT group. Systolic blood pressure and glucose increased in the NM group.\n \nBetween the groups in uncontrolled main analyses the main effect of time on the variables was statistically significant (p < 0.001) except for systolic blood pressure (p = 0.486) and glucose (p = 0.578). A statistically significant (p = 0.012) group and time interaction explained 8.9% of the variation in diastolic blood pressure.\n\nIn controlled analyses, time was associated with HDL-cholesterol variation (p = 0.007). In both groups the change was similar and minor. Except for diastolic blood pressure (p = 0.006) group-level changes did not differ from each other. The group and time interaction explained 5.1% of the variation in diastolic blood pressure. In the HT group diastolic blood pressure decreased by 5.5% and in the NM group by 0.9%.\n\nThe results support the previous understanding of the deterioration of metabolic health during menopause. Diastolic blood pressure decreased more in the HT group, which may indicate better heart health. The study strengthened the understanding of the complexity of the effects of HT, the diversity of the challenges related to its research, and underlined the necessity of further research. It is important to study the subject further because HT is common, and its connections with the components of the metabolic syndrome are still contradictory.", "language": "en", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.abstract", "value": "Syd\u00e4n- ja verisuonisairaudet ja tyypin 2 diabetes ovat ik\u00e4\u00e4ntyvien hyvinvointia ja terveytt\u00e4 heikent\u00e4vi\u00e4 tekij\u00f6it\u00e4. Lis\u00e4ksi ne ovat mittavia terveydenhuollon kulueri\u00e4. Metabolinen oireyhtym\u00e4 on n\u00e4iden sairauksien riskitekij\u00e4. Sek\u00e4 elintavat ett\u00e4 ik\u00e4\u00e4ntyminen vaikuttavat aineenvaihduntaterveyteen.\nVaihdevuosien aikana estrogeenin tuotanto munasarjoista loppuu, ja metabolisen oireyhtym\u00e4n riski kasvaa. Vaihdevuosioireita hoidetaan hormonihoidon avulla, mik\u00e4 voi vaikuttaa my\u00f6s aineenvaihduntaterveyteen. T\u00e4m\u00e4n tutkimuksen tavoitteena oli selvitt\u00e4\u00e4 eroavatko luonnollisten vaihdevuosien (LV) aikana tapahtuvat metabolisen oireyhtym\u00e4n osatekij\u00f6iden muutokset hormonihoidettujen (HH) vaihdevuosien aikana tapahtuvista muutoksista. Muuttujina tutkimuksessa olivat kokonaiskolesteroli, HDL-kolesteroli, LDL-kolesteroli, triglyseridit, verensokeri, vy\u00f6t\u00e4r\u00f6nymp\u00e4rys sek\u00e4 systolinen ja diastolinen verenpaine.\nMateriaalina k\u00e4ytettiin Jyv\u00e4skyl\u00e4n yliopiston ERMA- ja EsmiRs-aineistoja. Tutkittavat olivat 47\u201355-vuotiaita jyv\u00e4skyl\u00e4l\u00e4isi\u00e4 naisia, jotka tutkimuksen alussa eiv\u00e4t olleet saavuttaneet menopaussia, ja jotka seurannan aikana siirtyiv\u00e4t vaihdevuosivaiheesta toiseen. Tutkittavat jaettiin HH-ryhm\u00e4\u00e4n (n = 33) sek\u00e4 LV-ryhm\u00e4\u00e4n (n = 115). P\u00e4\u00e4analyysimenetelm\u00e4n\u00e4 k\u00e4ytettiin toistomittauksien varianssianalyysi\u00e4. Malli kontrolloitiin alkumittauksen viskeraalisen rasvan m\u00e4\u00e4r\u00e4ll\u00e4 ja vaihdevuosivaiheella.\nRyhmien sis\u00e4ll\u00e4 systolinen verenpaine ja glukoosi laskivat HH-ryhm\u00e4ss\u00e4 ja nousivat LV- ryhm\u00e4ss\u00e4. Aineenvaihduntaterveytt\u00e4 edist\u00e4v\u00e4t muutokset olivat HDL-kolesterolin nousu ja diastolisen verenpaineen lasku molemmissa ryhmiss\u00e4, sek\u00e4 glukoosin ja systolisen verenpaineen lasku HH-ryhm\u00e4ss\u00e4. \nRyhmien v\u00e4lill\u00e4 kontrolloimattomissa p\u00e4\u00e4analyyseiss\u00e4 ajan p\u00e4\u00e4vaikutus muuttujiin oli systolista verenpainetta (p = 0,486) ja glukoosia (p = 0,578) lukuun ottamatta tilastollisesti merkitsev\u00e4 (p < 0,001). Tilastollisesti merkitsev\u00e4 (p = 0,012) ryhm\u00e4n ja ajan yhdysvaikutus selitti 8,9 % diastolisen verenpaineen vaihtelusta.\nKontrolloidussa analyyseiss\u00e4 aika oli yhteydess\u00e4 HDL-kolesterolin vaihteluun (p = 0,007). Molemmissa ryhmiss\u00e4 muutos oli samansuuntainen ja v\u00e4h\u00e4inen. Ryhm\u00e4tason muutokset eiv\u00e4t diastolista verenpainetta lukuun ottamatta (p = 0,006) eronneet toisistaan. Ryhm\u00e4n ja ajan yhdysvaikutus selitti diastolisen verenpaineen vaihtelusta 5,1 %. HH-ryhm\u00e4ss\u00e4 diastolinen verenpaine laski 5,5 %, ja LV-ryhm\u00e4ss\u00e4 0,9 %.\nTulokset tukevat aiempaa k\u00e4sityst\u00e4 aineenvaihduntaterveyden heikkenemisest\u00e4 vaihdevuosien edetess\u00e4. HH-ryhm\u00e4ss\u00e4 diastolinen verenpaine laski enemm\u00e4n, mik\u00e4 voi indikoida parempaa syd\u00e4nterveytt\u00e4. Tutkimus vahvisti k\u00e4sityst\u00e4 hormonihoidon vaikutusten kompleksisuudesta, sen tutkimiseen liittyvien haasteiden monimuotoisuudesta ja alleviivasi jatkotutkimuksen tarpeellisuutta. Aihetta on t\u00e4rke\u00e4 tutkia lis\u00e4\u00e4, koska hoito on yleist\u00e4, ja sen yhteydet metabolisen oireyhtym\u00e4n osatekij\u00f6ihin ovat viel\u00e4 ristiriitaisia.", "language": "fi", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Submitted by Miia Hakanen (mihakane@jyu.fi) on 2024-06-14T09:33:45Z\nNo. of bitstreams: 0", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Made available in DSpace on 2024-06-14T09:33:45Z (GMT). No. of bitstreams: 0\n Previous issue date: 2024", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.format.extent", "value": "61", "language": "", "element": "format", "qualifier": "extent", "schema": "dc"}, {"key": "dc.language.iso", "value": "fin", "language": null, "element": "language", "qualifier": "iso", "schema": "dc"}, {"key": "dc.rights", "value": "In Copyright", "language": "en", "element": "rights", "qualifier": null, "schema": "dc"}, {"key": "dc.title", "value": "Vaihdevuosien aikaisen hormonihoidon yhteys metaboliseen terveyteen", "language": "", "element": "title", "qualifier": null, "schema": "dc"}, {"key": "dc.type", "value": "master thesis", "language": null, "element": "type", "qualifier": null, "schema": "dc"}, {"key": "dc.identifier.urn", "value": "URN:NBN:fi:jyu-202406144648", "language": null, "element": "identifier", "qualifier": "urn", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Master\u2019s thesis", "language": "en", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Pro gradu -tutkielma", "language": "fi", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Faculty of Sport and Health Sciences", "language": "en", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Liikuntatieteellinen tiedekunta", "language": "fi", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Sport and Health Sciences", "language": "en", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Liikunta- ja terveystieteet", "language": "fi", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "University of Jyv\u00e4skyl\u00e4", "language": "en", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "Jyv\u00e4skyl\u00e4n yliopisto", "language": "fi", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Gerontology and Public Health", "language": "en", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Gerontologia ja kansanterveys", "language": "fi", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "yvv.contractresearch.funding", "value": "0", "language": "", "element": "contractresearch", "qualifier": "funding", "schema": "yvv"}, {"key": "dc.type.coar", "value": "http://purl.org/coar/resource_type/c_bdcc", "language": null, "element": "type", "qualifier": "coar", "schema": "dc"}, {"key": "dc.rights.accesslevel", "value": "openAccess", "language": null, "element": "rights", "qualifier": "accesslevel", "schema": "dc"}, {"key": "dc.type.publication", "value": "masterThesis", "language": null, "element": "type", "qualifier": "publication", "schema": "dc"}, {"key": "dc.subject.oppiainekoodi", "value": "50423", "language": null, "element": "subject", "qualifier": "oppiainekoodi", "schema": "dc"}, {"key": "dc.subject.yso", "value": "vaihdevuodet", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "hormonihoito", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "metabolinen oireyhtym\u00e4", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.rights.url", "value": "https://rightsstatements.org/page/InC/1.0/", "language": null, "element": "rights", "qualifier": "url", "schema": "dc"}]
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