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[{"key": "dc.contributor.advisor", "value": "Karvanen, Juha", "language": null, "element": "contributor", "qualifier": "advisor", "schema": "dc"}, {"key": "dc.contributor.advisor", "value": "Sarapohja, Toni", "language": null, "element": "contributor", "qualifier": "advisor", "schema": "dc"}, {"key": "dc.contributor.author", "value": "Tabell, Otto", "language": "", "element": "contributor", "qualifier": "author", "schema": "dc"}, {"key": "dc.date.accessioned", "value": "2024-06-03T10:26:20Z", "language": null, "element": "date", "qualifier": "accessioned", "schema": "dc"}, {"key": "dc.date.available", "value": "2024-06-03T10:26:20Z", "language": null, "element": "date", "qualifier": "available", "schema": "dc"}, {"key": "dc.date.issued", "value": "2024", "language": null, "element": "date", "qualifier": "issued", "schema": "dc"}, {"key": "dc.identifier.uri", "value": "https://jyx.jyu.fi/handle/123456789/95441", "language": null, "element": "identifier", "qualifier": "uri", "schema": "dc"}, {"key": "dc.description.abstract", "value": "Dexmedetomidine is a sedative drug which is especially used to sedate patients in intensive care. In 2019, SPICE III researchers reported of a worrying safety signal related to the drug. According to the study, under 65-year-old patients who belonged to the dexmedetomidine group had a higher mortality risk in comparison to the control group. In 2023, an additional study showed that an increase of dexmedetomidine dose was linked to increased mortality in the case of younger patients.\n\nThe aim of this master's thesis is to reanalyse the SPICE III dataset with the intention to use causal inference to estimate the effect of a dose change on mortality. In addition to using causal inference, this thesis uses an alternative approach to patient selection, as well as statistical modeling. \n\nThe model addresses certain issues that appeared during the previous analyses. The results of the thesis regarding dexmedetomidine were partially different compared to the results of previous studies. The increase of average dose didn't appear to increase the mortality. Instead, the increase of average midazolam dose was linked to an increase in mortality.", "language": "en", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.abstract", "value": "Deksmedetomidiini on l\u00e4\u00e4keaine, jota k\u00e4ytet\u00e4\u00e4n erityisesti tehohoitopotilaiden rauhoittamiseen. Vuonna 2019 SPICE III -tutkimuksen yhteydess\u00e4 valmisteeseen liittyen havaittiin turvallisuushuoli. Tutkimuksen mukaan deksmedetomidiiniryhm\u00e4\u00e4n kuuluneilla alle 65-vuotiailla tehohoitopotilailla oli suurempi riski kuolla verrokkiryhm\u00e4n potilaisiin n\u00e4hden. Lis\u00e4ksi vuonna 2023 julkaistussa artikkelissa deksmedetomidiiniannoksen kasvun havaittiin olevan yhteydess\u00e4 kasvavaan kuolleisuuteen nuoremmilla potilailla.\n\nT\u00e4ss\u00e4 tutkielmassa tarkastellaan SPICE III -tutkimuksen aineistoa uudelleen toisenlaisin menetelmin. Tavoitteena on luoda kausaalimalli keskim\u00e4\u00e4r\u00e4isen l\u00e4\u00e4keannostuksen vaikutukselle potilaiden kuolleisuuteen. Kausaalip\u00e4\u00e4ttelyn soveltamisen lis\u00e4ksi tutkielman tapa rajata aineisto sek\u00e4 mallintaa kuolleisuutta on aiempiin tutkimuksiin n\u00e4hden poikkeava. \n\nMallin avulla pystyttiin vastaamaan tiettyihin ongelmakohtiin, joita aiempien tutkimusten analyysien kohdalla havaittiin. Tutkielman tulokset deksmedetomidiiniin liittyen eroavat joissain m\u00e4\u00e4rin aiempien tutkimusten tuloksista, sill\u00e4 mallin mukaan keskim\u00e4\u00e4r\u00e4isen annoksen nostaminen ei vaikuta kasvattavan kuolleisuutta. Sen sijaan keskim\u00e4\u00e4r\u00e4isen midatsolaamiannoksen kasvun todettiin olevan yhteydess\u00e4 kasvavaan kuolleisuuteen.", "language": "fi", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Submitted by Paivi Vuorio (paelvuor@jyu.fi) on 2024-06-03T10:26:20Z\nNo. of bitstreams: 0", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Made available in DSpace on 2024-06-03T10:26:20Z (GMT). No. of bitstreams: 0\n Previous issue date: 2024", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.format.extent", "value": "39", "language": "", "element": "format", "qualifier": "extent", "schema": "dc"}, {"key": "dc.language.iso", "value": "fin", "language": null, "element": "language", "qualifier": "iso", "schema": "dc"}, {"key": "dc.rights", "value": "In Copyright", "language": "en", "element": "rights", "qualifier": null, "schema": "dc"}, {"key": "dc.subject.other", "value": "Bayes-tilastotiede", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "kausaalip\u00e4\u00e4ttely", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "logistinen regressio", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "l\u00e4\u00e4ketutkimus", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.title", "value": "Kausaalimalli l\u00e4\u00e4keannostuksen aiheuttamalle kuolleisuudelle tehohoitopotilailla", "language": "", "element": "title", "qualifier": null, "schema": "dc"}, {"key": "dc.type", "value": "master thesis", "language": null, "element": "type", "qualifier": null, "schema": "dc"}, {"key": "dc.identifier.urn", "value": "URN:NBN:fi:jyu-202406034205", "language": null, "element": "identifier", "qualifier": "urn", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Master\u2019s thesis", "language": "en", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Pro gradu -tutkielma", "language": "fi", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Faculty of Sciences", "language": "en", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Matemaattis-luonnontieteellinen tiedekunta", "language": "fi", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Department of Mathematics and Statistics", "language": "en", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Matematiikan ja tilastotieteen laitos", "language": "fi", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "University of Jyv\u00e4skyl\u00e4", "language": "en", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "Jyv\u00e4skyl\u00e4n yliopisto", "language": "fi", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Statistics", "language": "en", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Tilastotiede", "language": "fi", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "yvv.contractresearch.collaborator", "value": "business", "language": "", "element": "contractresearch", "qualifier": "collaborator", "schema": "yvv"}, {"key": "yvv.contractresearch.funding", "value": "Ei erillist\u00e4 rahoitusta, gradu tehty ty\u00f6suhteen aikana", "language": "", "element": "contractresearch", "qualifier": "funding", "schema": "yvv"}, {"key": "yvv.contractresearch.initiative", "value": "business", "language": "", "element": "contractresearch", "qualifier": "initiative", "schema": "yvv"}, {"key": "dc.type.coar", "value": "http://purl.org/coar/resource_type/c_bdcc", "language": null, "element": "type", "qualifier": "coar", "schema": "dc"}, {"key": "dc.rights.accesslevel", "value": "openAccess", "language": null, "element": "rights", "qualifier": "accesslevel", "schema": "dc"}, {"key": "dc.type.publication", "value": "masterThesis", "language": null, "element": "type", "qualifier": "publication", "schema": "dc"}, {"key": "dc.subject.oppiainekoodi", "value": "4043", "language": null, "element": "subject", "qualifier": "oppiainekoodi", "schema": "dc"}, {"key": "dc.subject.yso", "value": "bayesilainen menetelm\u00e4", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "deksmedetomidiini", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "tehohoito", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.rights.url", "value": "https://rightsstatements.org/page/InC/1.0/", "language": null, "element": "rights", "qualifier": "url", "schema": "dc"}]
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