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[{"key": "dc.contributor.advisor", "value": "Heikkil\u00e4, Tero", "language": "", "element": "contributor", "qualifier": "advisor", "schema": "dc"}, {"key": "dc.contributor.author", "value": "Sinisalo, Sanni", "language": "", "element": "contributor", "qualifier": "author", "schema": "dc"}, {"key": "dc.date.accessioned", "value": "2024-05-21T05:36:30Z", "language": null, "element": "date", "qualifier": "accessioned", "schema": "dc"}, {"key": "dc.date.available", "value": "2024-05-21T05:36:30Z", "language": null, "element": "date", "qualifier": "available", "schema": "dc"}, {"key": "dc.date.issued", "value": "2024", "language": "", "element": "date", "qualifier": "issued", "schema": "dc"}, {"key": "dc.identifier.uri", "value": "https://jyx.jyu.fi/handle/123456789/94998", "language": null, "element": "identifier", "qualifier": "uri", "schema": "dc"}, {"key": "dc.description.abstract", "value": "Boorineutronikaappaushoito on s\u00e4dehoidon muoto, joka perustuu kasvainkudokseen keskittyneen boorin isotoopin herkk\u00e4\u00e4n reagointikykyyn neutronis\u00e4teilyn kanssa. Reaktiosta syntyneet hiukkaset menett\u00e4v\u00e4t suurimman osan energiastaan kasvaimen alueelle, jolloin kasvain tuhoutuu. Boorineutronikaappaushoitoa pidet\u00e4\u00e4n hyv\u00e4n\u00e4 s\u00e4dehoitona, koska siin\u00e4 s\u00e4teilyannos muodostuu vasta kasvaimessa j\u00e4tt\u00e4en samalla normaalin, terveen kudoksen s\u00e4teilyannoksen hyvin pieneksi. Hoitoon liittyy my\u00f6s huonoja puolia. Suurin ongelma liittyy seoksiin, joilla boori saadaan kasvaimeen. Booriseoksen tulee t\u00e4ytt\u00e4\u00e4 tiettyj\u00e4 vaatimuksia, mutta viel\u00e4 ei ole l\u00f6ydetty t\u00e4ydellisesti niit\u00e4 kaikkia samanaikaisesti t\u00e4ytt\u00e4vi\u00e4 seoksia. Lis\u00e4ksi ongelmana on hoitoon liittyv\u00e4t dosimetrian laskut, koska ne ovat monen s\u00e4teilyl\u00e4hteen takia monimutkaisia ja aikaa vievi\u00e4. Muun muassa n\u00e4iden ongelmien takia hoito on viel\u00e4 kehitysvaiheessa eik\u00e4 se ole yleistynyt k\u00e4ytetyimm\u00e4ksi s\u00e4dehoidoksi.\n\nT\u00e4m\u00e4 tutkielma k\u00e4y l\u00e4pi kiihdytinpohjaisen boorineutronikaappaushoidon toimintaperiaatetta, hoitoon liittyv\u00e4\u00e4 dosimetriaa sek\u00e4 hoidon hyvi\u00e4 ja huonoja puolia. Tutkielman alussa k\u00e4sitell\u00e4\u00e4n my\u00f6s nopeasti s\u00e4teilyn biologisia vaikutuksia. Lis\u00e4ksi perehdyt\u00e4\u00e4n eri maissa toteutettujen tutkimuksien perusteella hoidossa saataviin s\u00e4teilyannoksiin sek\u00e4 mahdollisiin hoidon sivuvaikutuksiin", "language": "fi", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.abstract", "value": "Boron neutron capture therapy is a form of radiation therapy based on the reactivity of a boron isotope concentrated in tumor tissue to neutron radiation. The particles generated from the reaction lose most of their energy in the tumor area, causing the tumor to be destroyed. Boron neutron capture therapy is considered a good form of radiation therapy, because in it the radiation dose is mostly formed in the tumor and at the same time the dose of the normal, healthy tissue remains very low. There are also downsides to the treatment. The biggest problem is related to the compounds used to get boron into the tumor. The boron compound must meet certain requirements, but no compound has yet been found that would perfectly meet all of them simultaneously. In addition, there is a problem with the treatment-related dosimetry calculations, because they are very complicated and time-consuming due to the many radiation sources. Among other things, due to these problems, the treatment is still in the development phase and it has not become the most widely used radiation therapy. \n\nThis thesis reviews the operating principle of accelerator-based boron neutron capture therapy, the dosimetry related to the treatment and the pros and cons of the treatment. At the beginning of the thesis, the biological effects of radiation are also discussed shortly. In addition, based on studies carried out in different countries, radiation doses received during the treatment and possible side effects of the treatment are discussed.", "language": "en", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Submitted by Paivi Vuorio (paelvuor@jyu.fi) on 2024-05-21T05:36:30Z\nNo. of bitstreams: 0", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Made available in DSpace on 2024-05-21T05:36:30Z (GMT). No. of bitstreams: 0\n Previous issue date: 2024", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.format.extent", "value": "28", "language": "", "element": "format", "qualifier": "extent", "schema": "dc"}, {"key": "dc.language.iso", "value": "fin", "language": null, "element": "language", "qualifier": "iso", "schema": "dc"}, {"key": "dc.rights", "value": "In Copyright", "language": "en", "element": "rights", "qualifier": null, "schema": "dc"}, {"key": "dc.subject.other", "value": "boorineutronikaappaushoito", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "BNCT", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.title", "value": "Sy\u00f6p\u00e4kasvainten tuhoaminen boorineutronikaappaushoidolla", "language": "", "element": "title", "qualifier": null, "schema": "dc"}, {"key": "dc.type", "value": "bachelor thesis", "language": null, "element": "type", "qualifier": null, "schema": "dc"}, {"key": "dc.identifier.urn", "value": "URN:NBN:fi:jyu-202405213760", "language": "", "element": "identifier", "qualifier": "urn", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Bachelor's thesis", "language": "en", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Kandidaatinty\u00f6", "language": "fi", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Matemaattis-luonnontieteellinen tiedekunta", "language": "fi", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Faculty of Sciences", "language": "en", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Fysiikan laitos", "language": "fi", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Department of Physics", "language": "en", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "Jyv\u00e4skyl\u00e4n yliopisto", "language": "fi", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "University of Jyv\u00e4skyl\u00e4", "language": "en", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Fysiikka", "language": "fi", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Physics", "language": "en", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "yvv.contractresearch.funding", "value": "0", "language": "", "element": "contractresearch", "qualifier": "funding", "schema": "yvv"}, {"key": "dc.type.coar", "value": "http://purl.org/coar/resource_type/c_7a1f", "language": null, "element": "type", "qualifier": "coar", "schema": "dc"}, {"key": "dc.rights.accesslevel", "value": "openAccess", "language": null, "element": "rights", "qualifier": "accesslevel", "schema": "dc"}, {"key": "dc.type.publication", "value": "bachelorThesis", "language": null, "element": "type", "qualifier": "publication", "schema": "dc"}, {"key": "dc.subject.oppiainekoodi", "value": "4021", "language": "", "element": "subject", "qualifier": "oppiainekoodi", "schema": "dc"}, {"key": "dc.subject.yso", "value": "s\u00e4teilyannokset", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "hoitomenetelm\u00e4t", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "s\u00e4teilytys", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "s\u00e4teily", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "boori", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.rights.url", "value": "https://rightsstatements.org/page/InC/1.0/", "language": null, "element": "rights", "qualifier": "url", "schema": "dc"}]
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