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[{"key": "dc.contributor.advisor", "value": "Hulmi, Juha", "language": null, "element": "contributor", "qualifier": "advisor", "schema": "dc"}, {"key": "dc.contributor.author", "value": "Kaasinen, Sasu", "language": null, "element": "contributor", "qualifier": "author", "schema": "dc"}, {"key": "dc.date.accessioned", "value": "2024-04-18T06:01:00Z", "language": null, "element": "date", "qualifier": "accessioned", "schema": "dc"}, {"key": "dc.date.available", "value": "2024-04-18T06:01:00Z", "language": null, "element": "date", "qualifier": "available", "schema": "dc"}, {"key": "dc.date.issued", "value": "2024", "language": null, "element": "date", "qualifier": "issued", "schema": "dc"}, {"key": "dc.identifier.uri", "value": "https://jyx.jyu.fi/handle/123456789/94368", "language": null, "element": "identifier", "qualifier": "uri", "schema": "dc"}, {"key": "dc.description.abstract", "value": "T\u00e4m\u00e4n pro gradu -tutkielman tarkoituksena on selvitt\u00e4\u00e4 voimaharjoittelun, voimaharjoittelutauon ja uudelleenharjoittelun vaikutusta ribosomien biogeneesiin. T\u00e4ss\u00e4 tutkielmassa tarkastellaan my\u00f6s jatkuvan ja tauon sis\u00e4lt\u00e4v\u00e4n voimaharjoittelun vaikutusta ribosomien biogeneesiin. Lis\u00e4ksi tarkastellaan ribosomien biogeneesin ja lihaskasvun v\u00e4list\u00e4 korrelaatiota voimaharjoittelun my\u00f6t\u00e4.\n\nRibosomien biogeneesi viittaa ribosomien m\u00e4\u00e4r\u00e4\u00e4n kasvun. Ribosomit ovat solujen proteiinisynteesikoneita. Niiden m\u00e4\u00e4r\u00e4n kasvun on havaittu olevan linkittynyt lihaskasvuun. On kuitenkin ep\u00e4selv\u00e4\u00e4, mill\u00e4 aikajanalla ribosomien biogeneesi\u00e4 tapahtuu voimaharjoittelun my\u00f6t\u00e4. On my\u00f6s ep\u00e4selv\u00e4\u00e4, miten voimaharjoittelutauko ja voimaharjoittelun jatko uudelleen tauon j\u00e4lkeen vaikuttaa ribosomien biogeneesiin. Lis\u00e4ksi ribosomien biogeneesin merkityksest\u00e4 lihaskasvussa on ristiriitaista tietoa. T\u00e4ss\u00e4 tutkielmassa tutkittavat (n = 24) tekiv\u00e4t voimaharjoittelua 20 viikkoa. Jatkuva ryhm\u00e4 (n = 13), aloitti 10 viikon kontrollijaksolla ja suoritti t\u00e4m\u00e4n j\u00e4lkeen 20 viikon voimaharjoittelujakson. Uudelleenharjoitteluryhm\u00e4 (n = 11) aloitti 10 viikon voimaharjoittelujaksolla, jota seurasi 10 viikon voimaharjoittelutauko ja lopuksi jatkoivat voimaharjoittelua uudelleen 10 viikon ajan. Uloimman reisilihaksen poikkipinta-alan muutosta mitattiin ultra\u00e4\u00e4nell\u00e4 10 viikon v\u00e4lein. Lihasbiopsiat otettiin uloimmasta reisilihaksesta 10 viikon v\u00e4lein. Lihasn\u00e4ytteist\u00e4 eristettiin RNA, jonka pitoisuus m\u00e4\u00e4ritettiin spektrofotometrialla. RNA:n pitoisuutta ja RNA:n m\u00e4\u00e4r\u00e4\u00e4 suhteessa uloimman reisilihaksen kokoon k\u00e4ytettiin markkerina ribosomien m\u00e4\u00e4r\u00e4lle ja biogeneesille. Tilastollisen merkitsevyyden rajaksi asetettiin p < 0.05.\n\nVoimaharjoittelu kasvatti lihasten poikkipinta-alaa ilman eroa ryhmien v\u00e4lill\u00e4 jakson lopussa. RNA:n pitoisuus kasvoi l\u00e4ht\u00f6tasoon verrattuna 20 viikon voimaharjoittelun, mutta ei 10 viikon j\u00e4lkeen. RNA:n kokonaism\u00e4\u00e4r\u00e4 (RNA:n pitoisuuden ja lihaskoon muutoksen tulo) oli kasvanut jo kymmenen viikon kohdalla, mutta muutosta 10 ja 20 viikon voimaharjoittelun v\u00e4lill\u00e4 ei ollut. Ryhmien v\u00e4lill\u00e4 ei ollut merkitt\u00e4vi\u00e4 eroja ribosomien biogeneesin markkereissa. Voimaharjoittelutauon aikana RNA:n pitoisuudessa tai m\u00e4\u00e4r\u00e4ss\u00e4 ei tapahtunut muutoksia, vaikka lihaskoko pieneni. Lihaskoon kasvun ja RNA:n m\u00e4\u00e4r\u00e4n kasvun v\u00e4lill\u00e4 oli positiivinen korrelaatio 10 viikon, mutta ei 20 viikon voimaharjoittelun j\u00e4lkeen.\n\nTulokset viittaavat siihen, ett\u00e4 voimaharjoittelun my\u00f6t\u00e4 tapahtuu ribosomien biogeneesi\u00e4, joka tasaantuu voimaharjoittelujakson aikana. Voimaharjoittelutauon tai ilman voimaharjoittelutaukoa sis\u00e4lt\u00e4v\u00e4ll\u00e4 harjoittelulla adaptaatiot ovat samankaltaiset, kun voimaharjoittelujakson kokonaiskesto on sama. Voimaharjoittelutauolla ei ollut vaikutusta ribosomien m\u00e4\u00e4r\u00e4\u00e4n. Tulokset my\u00f6s tukevat aiempia l\u00f6yd\u00f6ksi\u00e4, joiden mukaan ribosomien biogeneesi on yhteydess\u00e4 lihaskasvuun. Lopuksi, ribosomien biogeneesin merkitys lihaskasvussa vaikuttaisi pienenentyv\u00e4n voimaharjoittelun edetess\u00e4.", "language": "fi", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.abstract", "value": "The aim of this thesis is to study the effect of resistance training, detraining, and retraining on ribosome biogenesis. This thesis also studies the effect of continuous and intermittent (containing detraining and retraining) resistance training on ribosome biogenesis. Finally, associations between ribosome biogenesis and skeletal muscle hypertrophy with resistance training is also one aim of this thesis.\n\nRibosome biogenesis refers to an increase in ribosomal content. Ribosomes are the protein synthesis machines of the cells. The increase in ribosomal content has been shown to be associated with skeletal muscle hypertrophy. However, the timeline of ribosome biogenesis with resistance training is still unclear. It is also unclear how continuous resistance training and intermittent training effect ribosome biogenesis. Also, there is conflicting evidence regarding the importance of ribosome biogenesis on skeletal muscle hypertrophy. In this thesis participants (n = 24) performed 20 weeks of resistance training. Continuous training group (n = 13) started with 10 weeks of non-training, after which they did 20 weeks of resistance training. The Tradere group (n = 11) started with 10 weeks of resistance training, did a 10-week detraining period and finished with 10 weeks of retraining. Change in vastus lateralis (VL) cross-sectional area (CSA) was measured with ultrasound every 10 weeks. Muscle biopsies were taken every 10 weeks from VL. RNA was extracted from muscle tissue samples. RNA concentration was determined with a spectrophotometer. Total RNA concentration and estimated absolute RNA by VL CSA were used as a marker for ribosome biogenesis and content.\n\nTotal RNA concentration was elevated after 20 weeks of resistance training but not after 10 weeks. Estimated absolute RNA by VL CSA increased after 10 weeks of resistance training but there was no further increase from 10 to 20 weeks of resistance training. There were no significant differences between groups in markers of ribosome biogenesis or skeletal muscle hypertrophy during the resistance training periods. During detraining RNA concentration and estimated absolute RNA by VL CSA did not change, whereas skeletal muscle size decreased. There was a positive correlation between skeletal muscle hypertrophy and estimated absolute RNA by VL CSA after 10 weeks but not after 20 weeks of resistance training.\n\nResults suggest that resistance training induces ribosome biogenesis that stabilizes as resistance training continues. Continuous and intermittent resistance training provide similar training adaptations if the length of the resistance training period is equal. Detraining did not affect ribosomal content. Mechanism and significance are unclear. Results also support earlier findings that ribosome biogenesis may influence skeletal muscle hypertrophy. However, the influence of ribosome biogenesis on skeletal muscle hypertrophy appears to decrease with resistance training over time.", "language": "en", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Submitted by Paivi Vuorio (paelvuor@jyu.fi) on 2024-04-18T06:01:00Z\nNo. of bitstreams: 0", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Made available in DSpace on 2024-04-18T06:01:00Z (GMT). No. of bitstreams: 0\n Previous issue date: 2024", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.format.extent", "value": "96", "language": "", "element": "format", "qualifier": "extent", "schema": "dc"}, {"key": "dc.format.mimetype", "value": "application/pdf", "language": null, "element": "format", "qualifier": "mimetype", "schema": "dc"}, {"key": "dc.language.iso", "value": "eng", "language": null, "element": "language", "qualifier": "iso", "schema": "dc"}, {"key": "dc.rights", "value": "In Copyright", "language": "en", "element": "rights", "qualifier": null, "schema": "dc"}, {"key": "dc.subject.other", "value": "resistance training", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "ribosome biogenesis", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "skeletal muscle hypertrophy", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "retraining", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "detraining", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.title", "value": "Effect of resistance training, detraining, and retraining on ribosome biogenesis", "language": null, "element": "title", "qualifier": null, "schema": "dc"}, {"key": "dc.type", "value": "master thesis", "language": null, "element": "type", "qualifier": null, "schema": "dc"}, {"key": "dc.identifier.urn", "value": "URN:NBN:fi:jyu-202404182985", "language": null, "element": "identifier", "qualifier": "urn", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Master\u2019s thesis", "language": "en", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Pro gradu -tutkielma", "language": "fi", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Faculty of Sport and Health Sciences", "language": "en", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Liikuntatieteellinen tiedekunta", "language": "fi", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Sport and Health Sciences", "language": "en", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Liikunta- ja terveystieteet", "language": "fi", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "University of Jyv\u00e4skyl\u00e4", "language": "en", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "Jyv\u00e4skyl\u00e4n yliopisto", "language": "fi", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Exercise Physiology", "language": "en", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Liikuntafysiologia", "language": "fi", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "yvv.contractresearch.funding", "value": "0", "language": "", "element": "contractresearch", "qualifier": "funding", "schema": "yvv"}, {"key": "dc.type.coar", "value": "http://purl.org/coar/resource_type/c_bdcc", "language": null, "element": "type", "qualifier": "coar", "schema": "dc"}, {"key": "dc.rights.copyright", "value": "\u00a9 The Author(s)", "language": null, "element": "rights", "qualifier": "copyright", "schema": "dc"}, {"key": "dc.rights.accesslevel", "value": "restrictedAccess", "language": null, "element": "rights", "qualifier": "accesslevel", "schema": "dc"}, {"key": "dc.type.publication", "value": "masterThesis", "language": null, "element": "type", "qualifier": "publication", "schema": "dc"}, {"key": "dc.subject.oppiainekoodi", "value": "5011", "language": null, "element": "subject", "qualifier": "oppiainekoodi", "schema": "dc"}, {"key": "dc.subject.yso", "value": "voimaharjoittelu", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "ribosomit", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "strength training", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "ribosomes", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.format.content", "value": "fulltext", "language": null, "element": "format", "qualifier": "content", "schema": "dc"}, {"key": "dc.rights.url", "value": "https://rightsstatements.org/page/InC/1.0/", "language": null, "element": "rights", "qualifier": "url", "schema": "dc"}, {"key": "dc.rights.accessrights", "value": "The author has not given permission to make the work publicly available electronically. Therefore the material can be read only at the archival workstation at Jyv\u00e4skyl\u00e4 University Library (https://kirjasto.jyu.fi/en/workspaces/facilities/facilities#autotoc-item-autotoc-2).", "language": "en", "element": "rights", "qualifier": "accessrights", "schema": "dc"}, {"key": "dc.rights.accessrights", "value": "Tekij\u00e4 ei ole antanut lupaa avoimeen julkaisuun, joten aineisto on luettavissa vain Jyv\u00e4skyl\u00e4n yliopiston kirjaston arkistoty\u00f6semalta. Ks. https://kirjasto.jyu.fi/fi/tyoskentelytilat/laitteet-ja-tilat#autotoc-item-autotoc-2.", "language": "fi", "element": "rights", "qualifier": "accessrights", "schema": "dc"}]
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