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[{"key": "dc.contributor.author", "value": "Heiskanen, Noora", "language": "", "element": "contributor", "qualifier": "author", "schema": "dc"}, {"key": "dc.date.accessioned", "value": "2024-01-22T06:42:23Z", "language": null, "element": "date", "qualifier": "accessioned", "schema": "dc"}, {"key": "dc.date.available", "value": "2024-01-22T06:42:23Z", "language": null, "element": "date", "qualifier": "available", "schema": "dc"}, {"key": "dc.date.issued", "value": "2023", "language": null, "element": "date", "qualifier": "issued", "schema": "dc"}, {"key": "dc.identifier.uri", "value": "https://jyx.jyu.fi/handle/123456789/92955", "language": null, "element": "identifier", "qualifier": "uri", "schema": "dc"}, {"key": "dc.description.abstract", "value": "The literature part of this master\u2019s thesis discusses the usage of hydrogels in cell culture. It goes through the microenvironmental aspects that need to be considered when choosing a hydrogel for cell culture. The differences between natural, synthetic and hybrid hydrogels are \nexplained, and examples of hydrogels used in biomedical applications are described. The aim of the experimental part was to synthesise 9-fluorenylmethyloxycarbonyl-protected diphenylalanine dipeptide (FmocFFCOOH) and cinnamoyl-protected diphenylalanine dipeptide (CinFFCOOH) to compare their gelation properties. The nuclear magnetic resonance (NMR) spectroscopic, high-resolution mass spectrometric (HR-MS) and Fourier-transform infrared (FT-IR) spectroscopic analyses were performed to identify the products and prove their purities. For FmocFFCOOH, the conducted gelation trials showed promising results. Unfortunately, for CinFFCOOH, there was not enough clean product or time to do gelation analysis", "language": "en", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.abstract", "value": "T\u00e4m\u00e4n tutkielman kirjallisuuskatsaus k\u00e4sittelee soluviljelyss\u00e4 k\u00e4ytettyj\u00e4 hydrogeelej\u00e4. \nTutkielmassa k\u00e4yd\u00e4\u00e4n l\u00e4pi soluviljelyn asettamia vaatimuksia hydrogeeleille sek\u00e4 esitet\u00e4\u00e4n jo \ntunnettuja hydrogeelej\u00e4, niiden eri luokkia, ominaisuuksia ja eroja. Lopuksi tutustutaan \nhydrogeelien erilaisiin sovellusmahdollisuuksiin biol\u00e4\u00e4ketieteess\u00e4. Kokeellisen osan tavoitteena oli syntetisoida kaksi suojattua dipeptidi\u00e4 ja vertailla niiden \ngeeliytymisominaisuuksia. Syntetisoidut dipeptidit olivat 9-fluorenyylimetyylioksikarbonyyli- suojattu difenyylialaniinidipeptidi (FmocFFCOOH) ja kinnamoyyli- suojattu difenyylialaniinidipeptidi (CinFFCOOH). Synteesituotteiden tunnistamiseen ja puhtauden \nm\u00e4\u00e4ritt\u00e4miseen k\u00e4ytettiin ydinmagneettista resonanssispektroskopiaa (NMR), infrapunaspektroskopiaa (FTIR) ja korkean resoluution massaspektrometri\u00e4. FmocFFCOOH:lle tehdyiss\u00e4 gelaatiokokeissa saatiin lupaavia tuloksia. Valitettavasti CinFFCOOH:lle ei saatu tehty\u00e4 haluttuja gelaatiokokeita ja analyysej\u00e4, sill\u00e4 puhdasta reaktiotuotetta ei ollut k\u00e4ytett\u00e4viss\u00e4 riitt\u00e4v\u00e4sti.", "language": "fi", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Submitted by Paivi Vuorio (paelvuor@jyu.fi) on 2024-01-22T06:42:23Z\nNo. of bitstreams: 0", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Made available in DSpace on 2024-01-22T06:42:23Z (GMT). No. of bitstreams: 0\n Previous issue date: 2023", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.format.extent", "value": "88", "language": "", "element": "format", "qualifier": "extent", "schema": "dc"}, {"key": "dc.language.iso", "value": "eng", "language": null, "element": "language", "qualifier": "iso", "schema": "dc"}, {"key": "dc.rights", "value": "In Copyright", "language": "en", "element": "rights", "qualifier": null, "schema": "dc"}, {"key": "dc.title", "value": "Synthesis and gelation assessment of functionalized diphenylalanine dipeptides : towards cell culture applications", "language": "", "element": "title", "qualifier": null, "schema": "dc"}, {"key": "dc.type", "value": "master thesis", "language": null, "element": "type", "qualifier": null, "schema": "dc"}, {"key": "dc.identifier.urn", "value": "URN:NBN:fi:jyu-202401221448", "language": null, "element": "identifier", "qualifier": "urn", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Master\u2019s thesis", "language": "en", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Pro gradu -tutkielma", "language": "fi", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Faculty of Sciences", "language": "en", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Matemaattis-luonnontieteellinen tiedekunta", "language": "fi", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Kemian laitos", "language": "fi", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Department of Chemistry", "language": "en", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "University of Jyv\u00e4skyl\u00e4", "language": "en", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "Jyv\u00e4skyl\u00e4n yliopisto", "language": "fi", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Orgaaninen kemia", "language": "fi", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Organic Chemistry", "language": "en", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "yvv.contractresearch.funding", "value": "0", "language": "", "element": "contractresearch", "qualifier": "funding", "schema": "yvv"}, {"key": "dc.type.coar", "value": "http://purl.org/coar/resource_type/c_bdcc", "language": null, "element": "type", "qualifier": "coar", "schema": "dc"}, {"key": "dc.rights.copyright", "value": "\u00a9 The Author(s)", "language": null, "element": "rights", "qualifier": "copyright", "schema": "dc"}, {"key": "dc.rights.accesslevel", "value": "openAccess", "language": null, "element": "rights", "qualifier": "accesslevel", "schema": "dc"}, {"key": "dc.type.publication", "value": "masterThesis", "language": null, "element": "type", "qualifier": "publication", "schema": "dc"}, {"key": "dc.subject.oppiainekoodi", "value": "4035", "language": null, "element": "subject", "qualifier": "oppiainekoodi", "schema": "dc"}, {"key": "dc.subject.yso", "value": "hydrogeelit", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "soluviljely", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "kudosteknologia", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "geelit", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "hydrogels", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "cell culture", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "tissue engineering", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "gels", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.rights.url", "value": "https://rightsstatements.org/page/InC/1.0/", "language": null, "element": "rights", "qualifier": "url", "schema": "dc"}]
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