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[{"key": "dc.contributor.advisor", "value": "F\u00f6hr, Tiina", "language": "", "element": "contributor", "qualifier": "advisor", "schema": "dc"}, {"key": "dc.contributor.author", "value": "Blomqvist, Jenny", "language": "", "element": "contributor", "qualifier": "author", "schema": "dc"}, {"key": "dc.date.accessioned", "value": "2023-12-04T07:20:25Z", "language": null, "element": "date", "qualifier": "accessioned", "schema": "dc"}, {"key": "dc.date.available", "value": "2023-12-04T07:20:25Z", "language": null, "element": "date", "qualifier": "available", "schema": "dc"}, {"key": "dc.date.issued", "value": "2023", "language": "", "element": "date", "qualifier": "issued", "schema": "dc"}, {"key": "dc.identifier.uri", "value": "https://jyx.jyu.fi/handle/123456789/92174", "language": null, "element": "identifier", "qualifier": "uri", "schema": "dc"}, {"key": "dc.description.abstract", "value": "Useita biomarkkereita ja niiden yhdistelmi\u00e4 on kehitetty mittaamaan ik\u00e4\u00e4ntymist\u00e4, jotta saavutettaisiin syvempi ymm\u00e4rrys ik\u00e4\u00e4ntymisest\u00e4 ilmi\u00f6n\u00e4 kuin mihin kronologisen i\u00e4n avulla pystyt\u00e4\u00e4n. Osalla biomarkkereista ker\u00e4t\u00e4\u00e4n tietoa ik\u00e4\u00e4ntymisest\u00e4 erilaisten toiminnallisten mittausten avulla. Fyysisen aktiivisuuden on osoitettu edesauttavan ik\u00e4\u00e4ntyneiden toimintakyky\u00e4 monin tavoin. Ik\u00e4\u00e4ntymiseen liittyv\u00e4t toimintakyvyn muutokset voivat kuitenkin rajoittaa fyysist\u00e4 aktiivisuutta ja ik\u00e4\u00e4ntymisen on havaittu olevan yhteydess\u00e4 fyysisen aktiivisuuden tason laskuun. T\u00e4m\u00e4n opinn\u00e4ytety\u00f6n tavoitteena on tutkia toiminnallisen biologisen i\u00e4n summamuuttujan (fBioAge) yhteytt\u00e4 fyysiseen aktiivisuuteen kotona asuvilla i\u00e4kk\u00e4ill\u00e4 henkil\u00f6ill\u00e4.\n\nT\u00e4m\u00e4n poikkileikkaustutkimuksen aineisto koostui v\u00e4est\u00f6pohjaisen tutkimuksen osallistujista, jotka k\u00e4yttiv\u00e4t kiihtyvyysanturia v\u00e4hint\u00e4\u00e4n kolme p\u00e4iv\u00e4\u00e4 ja joilla oli tulos kaikkien summamuuttuja fBioAge:n osatekij\u00f6iden mittauksista: itseraportoitu kuulo ja n\u00e4k\u00f6, maksimaalinen puristusvoima, k\u00e4velyaika (3 m) ja hengityselimist\u00f6n toiminta (uloshengityksen sekuntikapasiteetti, FEV1) (n=407, 61.7 % naisia). Toiminnalliset mittaustulokset muutettiin standardipisteiksi, joista muodostettiin summamuuttuja fBioAge. Heikommat tulokset toiminnallisista mittauksista viittaavat korkeampaan toiminnalliseen ik\u00e4\u00e4n. Osallistujat edustivat ik\u00e4ryhmi\u00e4 75-, 80- ja 85-vuotiaat. FBioAge:n yhteytt\u00e4 fyysiseen aktiivisuuden kokonaism\u00e4\u00e4r\u00e4\u00e4n sek\u00e4 keskiraskaan-raskaan fyysisen aktiivisuuden m\u00e4\u00e4r\u00e4\u00e4n tarkasteltiin lineaarisella regressioanalyysilla. Regressiomallit vakioitiin i\u00e4ll\u00e4, sukupuolella, elintapatekij\u00f6ill\u00e4 (tupakointi ja alkoholin k\u00e4ytt\u00f6), kroonisten sairauksien lukum\u00e4\u00e4r\u00e4ll\u00e4, painoindeksill\u00e4 (BMI) sek\u00e4 apuv\u00e4lineiden k\u00e4yt\u00f6ll\u00e4.\n\nFBioAge vaihteli 24.2 ja 98.7 v\u00e4lill\u00e4 ja oli keskim\u00e4\u00e4rin 49.4 (keskihajonta 9.8). Naisten fBioAge oli keskim\u00e4\u00e4rin korkeampi kuin miesten (naiset 50.6 ja miehet 47.4, p=0.001). Korkeampi fBioAge oli yhteydess\u00e4 v\u00e4h\u00e4isemp\u00e4\u00e4n fyysisen aktiivisuuden kokonaism\u00e4\u00e4r\u00e4\u00e4n (i\u00e4ll\u00e4 ja sukupuolella vakioitu standardoitu regressiokerroin = -0.205, p<0.001) ja keskiraskaan-raskaan fyysisen aktiivisuuden m\u00e4\u00e4r\u00e4\u00e4n (-0.183, p<0.001). Perusmalleissa ei ollut interaktiota i\u00e4n ja sukupuolen v\u00e4lill\u00e4. Vakiointi elintapatekij\u00f6ill\u00e4 ei vaikuttanut tuloksiin. FBioAgen yhteys fyysisen aktiivisuuden kokonaism\u00e4\u00e4r\u00e4\u00e4n (-0.125, p=0.008) ja keskiraskaan-raskaan fyysisen aktiivisuuden m\u00e4\u00e4r\u00e4\u00e4n (-0.105, p=0.027) s\u00e4ilytti tilastollisen merkitsevyytens\u00e4 t\u00e4ysin vakioiduissa malleissa. \n\nFBioAge on yhteydess\u00e4 objektiivisesti mitattuun fyysisen aktiivisuuden kokonaism\u00e4\u00e4r\u00e4\u00e4n sek\u00e4 keskiraskaan-raskaan fyysisen aktiivisuuden m\u00e4\u00e4r\u00e4\u00e4n i\u00e4st\u00e4 ja sukupuolesta riippumatta. Yhteys n\u00e4ytt\u00e4isi olevan hieman vahvempi miehill\u00e4 kuin naisilla sek\u00e4 85-vuotiaiden ik\u00e4ryhm\u00e4ss\u00e4. Vaikuttaisi silt\u00e4, ett\u00e4 mit\u00e4 korkeampi toiminnallinen ik\u00e4 on, sit\u00e4 v\u00e4hemm\u00e4n on fyysist\u00e4 aktiivisuutta. Tulevaisuudessa tarvitaan pitkitt\u00e4istutkimuksia toiminnallisen i\u00e4n ja fyysisen aktiivisuuden yhteyden syy-seuraus-suhteen selvitt\u00e4miseksi tutkimusjoukossa, jossa on laajempaa vaihtelua toimintakyvyss\u00e4.", "language": "fi", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.abstract", "value": "Several individual biomarkers and sets of biomarkers, for example epigenetic clocks, have been developed to measure and gain a deeper understanding of ageing than we can achieve through chronological age. Some biomarkers focus on obtaining information about ageing trough different functional measurement. Physical activity (PA) has been shown to be beneficial for older adults\u2019 functional ability in many ways. However, age-related changes in functional capacity can hinder engagement in physical activity and ageing is associated with a decline in PA levels. The aim of this thesis is to investigate the association of a sum variable of functional biological age (fBioAge) with PA in older people living at home. \n\nThis cross-sectional study included participants from a population-based study who had worn an accelerometer for at least three whole days and who had participated in measurements of all the elements of sum variable fBioAge: self-reported hearing and vision, maximal isometric hand-grip strength, walking time (3m) and respiratory function (Forced Expiratory Volume in the first second, FEV1) (n=407, 61.7% women). Five functional measurement results were transformed to standard scores and summed up together to create the sum variable fBioAge. Weaker results from the five functional measurements indicate higher functional age. Participants represented age cohorts of 75-, 80- and 85-years. Linear regression analyses were used to investigate the associations of fBioAge with total PA and absolute moderate to vigorous PA (MVPA). Regression models were adjusted for age, sex, lifestyle factors (smoking and alcohol consumption), a number of chronic diseases, Body Mass Index (BMI) and use of assistive devices. \n\nFBioAge ranged between 24.2 and 98.7 with the mean of 49.4 (SD 9.8) in all participants. Women\u2019s fBioAge scores were higher on average compared to men (women 50.6 and men 47.4, p=0.001). Higher fBioAge was associated with lower amount of total PA (age and sex adjusted standardized coefficient = -0.205, p<0.001) and absolute MVPA (-0.183, p<0.001). There was no interaction for age and sex in the basic models. Further adjustment for lifestyle factors did not affect the results. The association of fBioAge with total PA (-0.125, p=0.008) and absolute MVPA (-0.105, p=0.027) remained statistically significant in the fully adjusted models. \n\nFBioAge is associated with objectively measured total PA and absolute MVPA independent of sex and chronological age. However, the association appears to be slightly stronger in men than in women and in the age group of 85 years. It seems that the higher functional age is, the less physically active older people are. Future research is needed to examine the causal relationship between functional age and physical activity in longitudinal study designs with a population that has greater variance in functional ability.", "language": "en", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Submitted by Paivi Vuorio (paelvuor@jyu.fi) on 2023-12-04T07:20:25Z\nNo. of bitstreams: 0", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Made available in DSpace on 2023-12-04T07:20:25Z (GMT). No. of bitstreams: 0\n Previous issue date: 2023", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.format.extent", "value": "70", "language": "", "element": "format", "qualifier": "extent", "schema": "dc"}, {"key": "dc.language.iso", "value": "eng", "language": null, "element": "language", "qualifier": "iso", "schema": "dc"}, {"key": "dc.rights", "value": "In Copyright", "language": null, "element": "rights", "qualifier": null, "schema": "dc"}, {"key": "dc.subject.other", "value": "biomarker of aging", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "functional ability", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "functional biological age", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.title", "value": "Association of functional age with physical activity in older people living at home", "language": "", "element": "title", "qualifier": null, "schema": "dc"}, {"key": "dc.type", "value": "master thesis", "language": null, "element": "type", "qualifier": null, "schema": "dc"}, {"key": "dc.identifier.urn", "value": "URN:NBN:fi:jyu-202312048172", "language": "", "element": "identifier", "qualifier": "urn", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Master\u2019s thesis", "language": "en", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Pro gradu -tutkielma", "language": "fi", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Liikuntatieteellinen tiedekunta", "language": "fi", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Faculty of Sport and Health Sciences", "language": "en", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Liikunta- ja terveystieteet", "language": "fi", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Sport and Health Sciences", "language": "en", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "Jyv\u00e4skyl\u00e4n yliopisto", "language": "fi", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "University of Jyv\u00e4skyl\u00e4", "language": "en", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Gerontologia ja kansanterveys", "language": "fi", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Gerontology and Public Health", "language": "en", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "yvv.contractresearch.funding", "value": "0", "language": "", "element": "contractresearch", "qualifier": "funding", "schema": "yvv"}, {"key": "dc.type.coar", "value": "http://purl.org/coar/resource_type/c_bdcc", "language": null, "element": "type", "qualifier": "coar", "schema": "dc"}, {"key": "dc.rights.copyright", "value": "\u00a9 The Author(s)", "language": null, "element": "rights", "qualifier": "copyright", "schema": "dc"}, {"key": "dc.rights.accesslevel", "value": "openAccess", "language": null, "element": "rights", "qualifier": "accesslevel", "schema": "dc"}, {"key": "dc.type.publication", "value": "masterThesis", "language": null, "element": "type", "qualifier": "publication", "schema": "dc"}, {"key": "dc.subject.oppiainekoodi", "value": "50423", "language": "", "element": "subject", "qualifier": "oppiainekoodi", "schema": "dc"}, {"key": "dc.subject.yso", "value": "ik\u00e4\u00e4ntyminen", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "ik\u00e4\u00e4ntyneet", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "fyysinen aktiivisuus", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "kotona asuminen", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "ageing", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "older people", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "physical activeness", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "living at home", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.rights.url", "value": "https://rightsstatements.org/page/InC/1.0/", "language": null, "element": "rights", "qualifier": "url", "schema": "dc"}]
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