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[{"key": "dc.contributor.advisor", "value": "Nissinen, Maija", "language": "", "element": "contributor", "qualifier": "advisor", "schema": "dc"}, {"key": "dc.contributor.author", "value": "Nikkola, Veera", "language": "", "element": "contributor", "qualifier": "author", "schema": "dc"}, {"key": "dc.date.accessioned", "value": "2023-11-20T12:04:01Z", "language": null, "element": "date", "qualifier": "accessioned", "schema": "dc"}, {"key": "dc.date.available", "value": "2023-11-20T12:04:01Z", "language": null, "element": "date", "qualifier": "available", "schema": "dc"}, {"key": "dc.date.issued", "value": "2023", "language": "", "element": "date", "qualifier": "issued", "schema": "dc"}, {"key": "dc.identifier.uri", "value": "https://jyx.jyu.fi/handle/123456789/91966", "language": null, "element": "identifier", "qualifier": "uri", "schema": "dc"}, {"key": "dc.description.abstract", "value": "T\u00e4m\u00e4 opinn\u00e4ytety\u00f6n kirjallisuuskatsaus k\u00e4sittelee erilaisten liuottimien vaikutusta orgaanisten peptidipohjaisten geelien valmistukseen, morfologiaan ja ominaisuuksiin. Tutkielmassa perehdyt\u00e4\u00e4n erityisesti liuottimien polaarisuuden, erilaisten liuotinseosten ja liuottimen pH:n vaikutuksiin geeliytymisprosessissa. Tutkielman lopuksi k\u00e4sitell\u00e4\u00e4n erilaisia sovelluksia, joissa organogeelej\u00e4 monipuolisine ominaisuuksineen on k\u00e4ytetty hy\u00f6dyksi l\u00e4\u00e4ketieteellisten sovelluksien alustoina. \n\nOpinn\u00e4ytety\u00f6n kokeellisessa osuudessa syntetisoitiin aminohappopohjainen alhaisen molekyylipainon gelaattori Boc-Leu-Phe-OtBu ja valmistettiin peptidipohjaisia geelej\u00e4 k\u00e4ytt\u00e4en geeliytymisprosessissa liuottimina kemiallisesti aktiivisia tert-butyyliestereit\u00e4 ja -eettereit\u00e4. Tutkimuksen hypoteesina oli aikaisempi tutkimus kemiallisesti aktiivisista liuottimista. Geeliytymisprosessissa muodostuneiden geelien aikasidonnaista, dynaamista reaktiotasapainon muutosta seurattiin infrapunaspektroskopialla (FT-IR), ydinmagneettisella resonanssispektroskopialla (NMR) ja pyyhk\u00e4isyelektronimikroskoopilla (SEM). Lis\u00e4ksi geelien termodynaamista palautumista ja kyky\u00e4 sitoa liuotinta seurattiin geeliytymisl\u00e4mp\u00f6tilan Tgel-sol avulla ja geelien turpoamistestill\u00e4 (swelling-test).", "language": "fi", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.abstract", "value": "This literature review goes through how different solvents affect the gelation process, morphology, and properties of peptide-based gels. The goal of the study was to find generalization about the effects of solvent properties, polarity, different solvent mixtures, and pH on the gelation process. By studying solvent conditions and control over self-assembly processes, new gel properties can be achieved, offering extensive prospects for developing novel peptide-based gel applications. \n\nThe focus of the thesis is mainly on low molecule weight gelators (LMWGs) and self-assembly, but a few interesting examples of polymer hydrogels and copolymerization were also included. The literature part introduces the gelation process and mechanical properties of gels, followed by a discussion of solvents used in gelation processes and ending it with a few interesting gel applications.\n\nThe experimental part aimed to form new gels with chemically active tert-butyl esters and ethers with a low molecular weight gelator, Fmoc-Leu-Phe-OtBu. The gelation process, gel morphology, and time-dependent nature were studied and reported.", "language": "en", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Submitted by Paivi Vuorio (paelvuor@jyu.fi) on 2023-11-20T12:04:01Z\nNo. of bitstreams: 0", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Made available in DSpace on 2023-11-20T12:04:01Z (GMT). No. of bitstreams: 0\n Previous issue date: 2023", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.format.extent", "value": "107", "language": "", "element": "format", "qualifier": "extent", "schema": "dc"}, {"key": "dc.language.iso", "value": "eng", "language": null, "element": "language", "qualifier": "iso", "schema": "dc"}, {"key": "dc.rights", "value": "In Copyright", "language": null, "element": "rights", "qualifier": null, "schema": "dc"}, {"key": "dc.title", "value": "Solvent effect on gel formation and properties of peptide-based gels", "language": "", "element": "title", "qualifier": null, "schema": "dc"}, {"key": "dc.type", "value": "master thesis", "language": null, "element": "type", "qualifier": null, "schema": "dc"}, {"key": "dc.identifier.urn", "value": "URN:NBN:fi:jyu-202311207985", "language": "", "element": "identifier", "qualifier": "urn", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Master\u2019s thesis", "language": "en", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Pro gradu -tutkielma", "language": "fi", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Matemaattis-luonnontieteellinen tiedekunta", "language": "fi", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Faculty of Sciences", "language": "en", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Kemian laitos", "language": "fi", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Department of Chemistry", "language": "en", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "Jyv\u00e4skyl\u00e4n yliopisto", "language": "fi", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "University of Jyv\u00e4skyl\u00e4", "language": "en", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Kemia", "language": "fi", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Chemistry", "language": "en", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "yvv.contractresearch.funding", "value": "0", "language": "", "element": "contractresearch", "qualifier": "funding", "schema": "yvv"}, {"key": "dc.type.coar", "value": "http://purl.org/coar/resource_type/c_bdcc", "language": null, "element": "type", "qualifier": "coar", "schema": "dc"}, {"key": "dc.rights.copyright", "value": "\u00a9 The Author(s)", "language": null, "element": "rights", "qualifier": "copyright", "schema": "dc"}, {"key": "dc.rights.accesslevel", "value": "openAccess", "language": null, "element": "rights", "qualifier": "accesslevel", "schema": "dc"}, {"key": "dc.type.publication", "value": "masterThesis", "language": null, "element": "type", "qualifier": "publication", "schema": "dc"}, {"key": "dc.subject.oppiainekoodi", "value": "4038", "language": "", "element": "subject", "qualifier": "oppiainekoodi", "schema": "dc"}, {"key": "dc.subject.yso", "value": "geelit", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "liuottimet", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "gels", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "solvents", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.rights.url", "value": "https://rightsstatements.org/page/InC/1.0/", "language": null, "element": "rights", "qualifier": "url", "schema": "dc"}]
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