| fullrecord |
[{"key": "dc.contributor.advisor", "value": "Haapala, Eero", "language": "", "element": "contributor", "qualifier": "advisor", "schema": "dc"}, {"key": "dc.contributor.author", "value": "Laurikainen, Marika", "language": "", "element": "contributor", "qualifier": "author", "schema": "dc"}, {"key": "dc.date.accessioned", "value": "2023-06-09T05:13:52Z", "language": null, "element": "date", "qualifier": "accessioned", "schema": "dc"}, {"key": "dc.date.available", "value": "2023-06-09T05:13:52Z", "language": null, "element": "date", "qualifier": "available", "schema": "dc"}, {"key": "dc.date.issued", "value": "2023", "language": "", "element": "date", "qualifier": "issued", "schema": "dc"}, {"key": "dc.identifier.uri", "value": "https://jyx.jyu.fi/handle/123456789/87584", "language": null, "element": "identifier", "qualifier": "uri", "schema": "dc"}, {"key": "dc.description.abstract", "value": "Aivoverenkierron h\u00e4iri\u00f6 (avh) on merkitt\u00e4v\u00e4 tautitaakkaa, kuolleisuutta ja terveydenhuollon kustannuksia kasvattava sairaus. Arvioiden mukaan jopa 90 % avh:n tautitaakasta liittyy riskitekij\u00f6ihin, joihin voidaan vaikuttaa aktiivisella toiminnalla. Objektiivisesti mitattua maksimaalista hapenottokyky\u00e4 (VO2max) pidet\u00e4\u00e4n parhaana kardiorespiratorisen kuntotason mittarina. Seurantatutkimuksissa on havaittu k\u00e4\u00e4nt\u00e4en verrannollinen yhteys VO2max:n ja avh-riskin v\u00e4lill\u00e4. Aikaisemmissa tutkimuksissa on useimmiten k\u00e4ytetty kehonpainoon suhteutettua VO2max:a. T\u00e4t\u00e4 on kuitenkin arvosteltu, sill\u00e4 kehonpainoon suhteutettu VO2max usein v\u00e4\u00e4rist\u00e4\u00e4 VO2max:n todellista merkityst\u00e4 terveydelle. T\u00e4m\u00e4n pro gradu -tutkielman tarkoituksena oli selvitt\u00e4\u00e4 VO2max:n ja avh:n yhteytt\u00e4 kehonkoostumus huomioiden. VO2max:a tarkasteltiin laajemmin absoluuttisen arvon lis\u00e4ksi kehonpainoon, rasvattomaan kehonpainoon sek\u00e4 matemaattisesti mallinnettuun kehonpainoon suhteutettuna.\nT\u00e4m\u00e4n tutkielman aineisto oli osa Kuopio Ischaemic Heart Disease Risk Factor -seurantatutkimusta. Aineiston tutkimusjoukkoon kuului yhteens\u00e4 573 it\u00e4suomalaista miest\u00e4, joiden i\u00e4n mediaani oli 59,9 vuotta seurannan alkaessa. Tutkittavien VO2max mitattiin suoralla oirerajoitteisella polkupy\u00f6r\u00e4ergometritestill\u00e4. Selitett\u00e4v\u00e4 muuttuja oli avh, jota koskeva informaatio saatiin sairaalarekistereist\u00e4. Aineiston analysointiin k\u00e4ytettiin riippumattomien otosten t-testi\u00e4, Mann-Whitneyn U-testi\u00e4, graafisia Kaplan-Meier-kuvaajia sek\u00e4 Coxin regressiomallia.\nYhteens\u00e4 93 henkil\u00f6ll\u00e4 havaittiin avh seurannan aikana. Graafisissa malleissa matalimpaan VO2max-kolmannekseen sijoittuneilla havaittiin suurin avh-riski verrattuna keskimm\u00e4iseen ja ylimp\u00e4\u00e4n kolmannekseen sijoittuviin. Kaikkien jatkuvien VO2max-muuttujien osalta Coxin regressiomalleissa havaittiin tilastollisesti merkitsev\u00e4 suojaava yhteys avh-riskiin (adj. HR 0,954\u20130,999, p<0,05). Yhteys oli vahvin kehonpainoon suhteutetulla VO2max:lla ja l\u00e4hes yht\u00e4 vahva rasvattomaan kehonpainoon suhteutetulla VO2max:lla. VO2max-kolmannesten mukaan tehdyss\u00e4 Coxin regressiomallissa havaittiin tilastollisesti merkitsev\u00e4sti pienempi avh-riski kehonpainoon, rasvattomaan kehonpainoon ja matemaattisesti mallinnettuun kehonpainoon suhteutetun VO2max:n keskimm\u00e4iseen (adj. HR 0,406\u20130,490) ja ylimp\u00e4\u00e4n (adj. HR 0,484\u20130,528) kolmannekseen sijoittuvilla verrattuna matalimpaan VO2max-kolmannekseen. Keskimm\u00e4iseen VO2max-kolmannekseen sijoittuvilla havaittiin pienin avh-riski. Kaikissa malleissa toinen tilastollisesti merkitsev\u00e4 muuttuja oli systolinen verenpaine, joka lis\u00e4si avh-riski\u00e4 (adj. HR 1,017\u20131,018).\nTulosten mukaan miehill\u00e4 korkeampi VO2max vaikuttaisi suojaavan avh:hon sairastumiselta riippumatta kehonkoostumuksesta. Alimpaan VO2max-kolmannekseen sijoittuvilla avh-riski oli suurin. Jatkossa tarvitaan erityisesti RCT-tutkimuksia aiheesta, sill\u00e4 l\u00e4hes kaikki tutkimukset perustuvat seuranta- tai poikkileikkausasetelmiin.", "language": "fi", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.abstract", "value": "Stroke is a major cause of disability-adjusted life years, mortality and health-care costs. It is estimated that as much as 90 % of the burden of stroke is associated with potentially modifiable risk factors. Objectively measured maximal oxygen uptake, VO2max, is known to be the most accurate variable to measure cardiorespiratory fitness. Previous cohort studies have reported inverse associations between cardiorespiratory fitness and stroke. However, majority of these studies have used the typical scaling of VO2max to body mass. Scaling to body mass has been criticized because of its potentially distorted associations with health. Therefore, the aim of this master\u2019s thesis was to study the relationship between VO2max and stroke also taking body composition into account. VO2max was examined both as an absolute number and scaled to body mass, fat free mass and allometrically modeled body mass.\nThe data of this master\u2019s thesis was a part of the Kuopio Ischaemic Heart Disease Risk Factor -study. The study population consisted of 573 men living in Kuopio and its nearby areas. The median age of the study population was 59,9 years at the baseline. Cardiorespiratory fitness was measured by an incremental maximal exercise test to volitional fatigue on cycle ergometer. VO2max was directly measured by respiratory gas analysis during the test. Stroke was the dependent variable of this thesis. Information of strokes was derived from national hospital registers. The data was analyzed using the independent samples t-test, Mann-Whitney\u2019s U-test, Kaplan-Meier graphs and Cox regression models.\nIn total, 93 people had a stroke during mean follow-up of 16 years. According to non-adjusted graphic models, stroke risk was highest in the lowest third of VO2max. Various Cox regression models were adjusted by different well-known stroke risk factors. Cox regression models revealed that all VO2max-variables had a statistically significant (p<0,05) protective association with stroke. This association was strongest between stroke and VO2max scaled to body mass. However, the association between stroke and VO2max scaled to fat free mass was almost as strong as compared to VO2max scaled to body mass. Adjusted Cox regression models for VO2max-thirds revealed a statistically significant lower risk of stroke in the middle third (adj. HR 0,406-0,490) and in the upper third of VO2max (adj. HR 0,484-0,528) compared to the lowest third of VO2max scaled to body mass, fat free body mass and allometrically modelled body mass. Stroke risk was lowest in the middle third of VO2max. In addition, systolic blood pressure was another statistically significant risk factor for stroke in every model (adj. HR 1,017\u20131,018).\nThe results of this master\u2019s thesis suggest that for men, higher VO2max has a protective association with stroke, regardless of body composition. Risk of stroke was highest in the lowest third of VO2max. Majority of studies investigating associations between cardiorespiratory fitness and stroke are cohort studies and cross-sectional studies. There is a clear need for randomized controlled trials investigating these themes further.", "language": "en", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Submitted by Miia Hakanen (mihakane@jyu.fi) on 2023-06-09T05:13:52Z\nNo. of bitstreams: 0", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Made available in DSpace on 2023-06-09T05:13:52Z (GMT). No. of bitstreams: 0\n Previous issue date: 2023", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.format.extent", "value": "73", "language": "", "element": "format", "qualifier": "extent", "schema": "dc"}, {"key": "dc.language.iso", "value": "fin", "language": null, "element": "language", "qualifier": "iso", "schema": "dc"}, {"key": "dc.rights", "value": "In Copyright", "language": null, "element": "rights", "qualifier": null, "schema": "dc"}, {"key": "dc.subject.other", "value": "kardiorespiratorinen kunto", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "VO2max", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "VO2max:n suhteutus", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "stroke", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "cardiorespiratory fitness", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "maximal oxygen uptake", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "VO2max scaling", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.title", "value": "Kardiorespiratorisen kunnon yhteys aivoverenkierron h\u00e4iri\u00f6\u00f6n sairastumiseen", "language": "", "element": "title", "qualifier": null, "schema": "dc"}, {"key": "dc.type", "value": "master thesis", "language": null, "element": "type", "qualifier": null, "schema": "dc"}, {"key": "dc.identifier.urn", "value": "URN:NBN:fi:jyu-202306093653", "language": "", "element": "identifier", "qualifier": "urn", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Master\u2019s thesis", "language": "en", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Pro gradu -tutkielma", "language": "fi", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Liikuntatieteellinen tiedekunta", "language": "fi", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Faculty of Sport and Health Sciences", "language": "en", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Liikunta- ja terveystieteet", "language": "fi", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Sport and Health Sciences", "language": "en", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "Jyv\u00e4skyl\u00e4n yliopisto", "language": "fi", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "University of Jyv\u00e4skyl\u00e4", "language": "en", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Liikuntal\u00e4\u00e4ketiede", "language": "fi", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Sport Medicine", "language": "en", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "yvv.contractresearch.funding", "value": "0", "language": "", "element": "contractresearch", "qualifier": "funding", "schema": "yvv"}, {"key": "dc.type.coar", "value": "http://purl.org/coar/resource_type/c_bdcc", "language": null, "element": "type", "qualifier": "coar", "schema": "dc"}, {"key": "dc.rights.copyright", "value": "\u00a9 The Author(s)", "language": null, "element": "rights", "qualifier": "copyright", "schema": "dc"}, {"key": "dc.rights.accesslevel", "value": "restrictedAccess", "language": null, "element": "rights", "qualifier": "accesslevel", "schema": "dc"}, {"key": "dc.type.publication", "value": "masterThesis", "language": null, "element": "type", "qualifier": "publication", "schema": "dc"}, {"key": "dc.subject.oppiainekoodi", "value": "5042", "language": "", "element": "subject", "qualifier": "oppiainekoodi", "schema": "dc"}, {"key": "dc.subject.yso", "value": "maksimaalinen hapenotto", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "aivoverenkiertoh\u00e4iri\u00f6t", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "riskitekij\u00e4t", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.rights.url", "value": "https://rightsstatements.org/page/InC/1.0/", "language": null, "element": "rights", "qualifier": "url", "schema": "dc"}, {"key": "dc.rights.accessrights", "value": "The author has not given permission to make the work publicly available electronically. Therefore the material can be read only at the archival workstation at Jyv\u00e4skyl\u00e4 University Library (https://kirjasto.jyu.fi/collections/archival-workstation).", "language": "en", "element": "rights", "qualifier": "accessrights", "schema": "dc"}, {"key": "dc.rights.accessrights", "value": "Tekij\u00e4 ei ole antanut lupaa avoimeen julkaisuun, joten aineisto on luettavissa vain Jyv\u00e4skyl\u00e4n yliopiston kirjaston arkistoty\u00f6semalta. Ks. https://kirjasto.jyu.fi/kokoelmat/arkistotyoasema..", "language": "fi", "element": "rights", "qualifier": "accessrights", "schema": "dc"}]
|