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[{"key": "dc.contributor.advisor", "value": "Karvanen, Juha", "language": "", "element": "contributor", "qualifier": "advisor", "schema": "dc"}, {"key": "dc.contributor.advisor", "value": "Laakkonen, Eija", "language": "", "element": "contributor", "qualifier": "advisor", "schema": "dc"}, {"key": "dc.contributor.author", "value": "Laaksovuori, Katariina", "language": "", "element": "contributor", "qualifier": "author", "schema": "dc"}, {"key": "dc.date.accessioned", "value": "2023-05-22T10:23:59Z", "language": null, "element": "date", "qualifier": "accessioned", "schema": "dc"}, {"key": "dc.date.available", "value": "2023-05-22T10:23:59Z", "language": null, "element": "date", "qualifier": "available", "schema": "dc"}, {"key": "dc.date.issued", "value": "2023", "language": "", "element": "date", "qualifier": "issued", "schema": "dc"}, {"key": "dc.identifier.uri", "value": "https://jyx.jyu.fi/handle/123456789/87054", "language": null, "element": "identifier", "qualifier": "uri", "schema": "dc"}, {"key": "dc.description.abstract", "value": "T\u00e4m\u00e4n pro gradu -tutkielman tavoitteena on selvitt\u00e4\u00e4, onko lapsiluvun vaikutus sepelvaltimotautiriskiin yleistett\u00e4viss\u00e4 yhdysvaltalaisesta populaatiosta jyv\u00e4skyl\u00e4l\u00e4iseen keski-ik\u00e4isill\u00e4 naisilla hy\u00f6dynt\u00e4en kausaalivaikutuksen siirtoa. Tutkielmassa selvitet\u00e4\u00e4n, millaisin oletuksin kausaalivaikutuksen siirto on mahdollista, ja mit\u00e4 tietoa kummastakin populaatiosta tarvitaan kausaalivaikutuksen estimoimiseksi kohdepopulaatiossa. Lopulta halutaan tiet\u00e4\u00e4, kuinka hyvin kausaalivaikutuksen estimoimiseksi valittu malli ennustaa sepelvaltimotautitapaukset kohdepopulaatiossa.\n\nTutkielmassa hy\u00f6dynnet\u00e4\u00e4n l\u00e4hdepopulaationa yhdysvaltalaista SWAN-tutkimuksen osa-aineistoa ja kohdepopulaationa jyv\u00e4skyl\u00e4l\u00e4ist\u00e4 ERMA-tutkimuksen osa-aineistoa. Aineistojen tutkimushenkil\u00f6t ovat keski-ik\u00e4isi\u00e4 naisia.\n\nTutkielmassa m\u00e4\u00e4ritell\u00e4\u00e4n kausaalimalli lapsiluvun vaikutukselle sepelvaltimotautiriskiin. Mallin graafilla kuvattu kausaalirakenne on samanlainen kummallekin populaatiolle, ja sen avulla kuvataan ilmi\u00f6\u00f6n liittyvi\u00e4 kausaalisuhteita. Kun erot graafin muuttujissa populaatioiden v\u00e4lill\u00e4 ovat tiedossa, voidaan laskea siirtokaava, jolla kausaalivaikutus kohdepopulaatiossa estimoidaan. Siirtokaavasta n\u00e4hd\u00e4\u00e4n, mit\u00e4 muuttujia l\u00e4hdepopulaatiosta tarvitaan mallin sovittamiseksi, ja mit\u00e4 tietoa kohdepopulaatiosta tarvitaan sepelvaltimotautitapausten lukum\u00e4\u00e4r\u00e4n estimoimiseksi.\n\nSWAN-aineistoon sovitetaan Coxin malli, jossa sepelvaltimotautia selitet\u00e4\u00e4n siirtokaavan mukaan lapsiluvulla, tupakoinnilla, etnisella taustalla, koulutusasteella, siviilis\u00e4\u00e4dyll\u00e4, i\u00e4ll\u00e4 ja lis\u00e4ksi painoindeksill\u00e4 (body mass index, BMI), jos BMI oletetaan havaituksi. Mallilla ennustetaan sepelvaltimotautitapausten lukum\u00e4\u00e4r\u00e4 ERMA-aineistossa. Ennusteeseen tarvitaan siirtokaavan mukaan ERMA-aineistosta tupakointi, etninen tausta, koulutusaste, siviilis\u00e4\u00e4ty, ik\u00e4 sek\u00e4 lis\u00e4ksi BMI, jos BMI oletetaan havaituksi. Mallin sovituksessa on huomioitu i\u00e4n p\u00e4ivittyminen ajan kuluessa, mutta ennusteessa k\u00e4ytet\u00e4\u00e4n ERMA-aineiston seurannan alun ik\u00e4\u00e4. Muut muuttujat ovat sek\u00e4 mallinnuksessa ett\u00e4 ennusteessa seurannan alun arvoja.\n\nMallin antaman ennusteen mukaan ERMA-aineistossa sepelvaltimotautitapauksia ilmenee 1.50\u20136.58 (95 %:n luottamusv\u00e4lit v\u00e4lill\u00e4 [1.41, 6.87]) riippuen lapsiluvusta ja siit\u00e4 oletetaanko BMI havaituksi vai ei. Todellinen tapausten lukum\u00e4\u00e4r\u00e4 ERMA-aineistossa on kaksi. Mallin mukaan lapsiluvun kasvaessa riski sairastua sepelvaltimotautiin kasvaa, mik\u00e4 tukee aikaisempaa tutkimusta aiheesta.", "language": "fi", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Submitted by Paivi Vuorio (paelvuor@jyu.fi) on 2023-05-22T10:23:59Z\nNo. of bitstreams: 0", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Made available in DSpace on 2023-05-22T10:23:59Z (GMT). No. of bitstreams: 0\n Previous issue date: 2023", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.format.extent", "value": "51", "language": "", "element": "format", "qualifier": "extent", "schema": "dc"}, {"key": "dc.language.iso", "value": "fin", "language": null, "element": "language", "qualifier": "iso", "schema": "dc"}, {"key": "dc.rights", "value": "In Copyright", "language": null, "element": "rights", "qualifier": null, "schema": "dc"}, {"key": "dc.subject.other", "value": "kausaalivakutuksen siirto", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "kausaalivaikutuksen yleist\u00e4minen", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "kausaalimalli", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "lapsiluvun vaikutus sepelvaltimotautiin", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.title", "value": "Lapsiluvun ja sepelvaltimotaudin kausaalisuhteen yleistys yhdysvaltalaisesta populaatiosta jyv\u00e4skyl\u00e4l\u00e4iseen keski-ik\u00e4isill\u00e4 naisilla", "language": "", "element": "title", "qualifier": null, "schema": "dc"}, {"key": "dc.type", "value": "master thesis", "language": null, "element": "type", "qualifier": null, "schema": "dc"}, {"key": "dc.identifier.urn", "value": "URN:NBN:fi:jyu-202305223127", "language": "", "element": "identifier", "qualifier": "urn", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Master\u2019s thesis", "language": "en", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Pro gradu -tutkielma", "language": "fi", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Matemaattis-luonnontieteellinen tiedekunta", "language": "fi", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Faculty of Sciences", "language": "en", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Matematiikan ja tilastotieteen laitos", "language": "fi", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Department of Mathematics and Statistics", "language": "en", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "Jyv\u00e4skyl\u00e4n yliopisto", "language": "fi", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "University of Jyv\u00e4skyl\u00e4", "language": "en", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Tilastotiede", "language": "fi", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Statistics", "language": "en", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "yvv.contractresearch.funding", "value": "0", "language": "", "element": "contractresearch", "qualifier": "funding", "schema": "yvv"}, {"key": "dc.type.coar", "value": "http://purl.org/coar/resource_type/c_bdcc", "language": null, "element": "type", "qualifier": "coar", "schema": "dc"}, {"key": "dc.rights.copyright", "value": "\u00a9 The Author(s)", "language": null, "element": "rights", "qualifier": "copyright", "schema": "dc"}, {"key": "dc.rights.accesslevel", "value": "openAccess", "language": null, "element": "rights", "qualifier": "accesslevel", "schema": "dc"}, {"key": "dc.type.publication", "value": "masterThesis", "language": null, "element": "type", "qualifier": "publication", "schema": "dc"}, {"key": "dc.subject.oppiainekoodi", "value": "4043", "language": "", "element": "subject", "qualifier": "oppiainekoodi", "schema": "dc"}, {"key": "dc.subject.yso", "value": "lapsiluku", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "sepelvaltimotauti", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "naiset", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "tilastomenetelm\u00e4t", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "mallintaminen", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.rights.url", "value": "https://rightsstatements.org/page/InC/1.0/", "language": null, "element": "rights", "qualifier": "url", "schema": "dc"}]
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