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[{"key": "dc.contributor.advisor", "value": "Hulmi, Juha", "language": "", "element": "contributor", "qualifier": "advisor", "schema": "dc"}, {"key": "dc.contributor.advisor", "value": "Pekkala, Satu", "language": "", "element": "contributor", "qualifier": "advisor", "schema": "dc"}, {"key": "dc.contributor.author", "value": "Hellsten, Ella", "language": "", "element": "contributor", "qualifier": "author", "schema": "dc"}, {"key": "dc.date.accessioned", "value": "2022-12-22T07:17:23Z", "language": null, "element": "date", "qualifier": "accessioned", "schema": "dc"}, {"key": "dc.date.available", "value": "2022-12-22T07:17:23Z", "language": null, "element": "date", "qualifier": "available", "schema": "dc"}, {"key": "dc.date.issued", "value": "2022", "language": "", "element": "date", "qualifier": "issued", "schema": "dc"}, {"key": "dc.identifier.uri", "value": "https://jyx.jyu.fi/handle/123456789/84548", "language": null, "element": "identifier", "qualifier": "uri", "schema": "dc"}, {"key": "dc.description.abstract", "value": "T\u00e4ss\u00e4 pro gradu -tutkielmassa selvitettiin suolistomikrobiston koostumuksen yhteyksi\u00e4\nkardiometabolisten sairauksien riskitekij\u00f6ihin ylipainoisilla naisilla. My\u00f6s kuuden viikon\nkest\u00e4vyysharjoittelun vaikutuksia tarkasteltiin tutkittavien suolistomikrobiston koostumukseen\nja kardiometabolisiin riskitekij\u00f6ihin. Lopuksi tarkasteltiin viel\u00e4 muuttujien muutosten v\u00e4lisi\u00e4\nyhteyksi\u00e4. T\u00e4ss\u00e4 ty\u00f6ss\u00e4 on k\u00e4ytetty Munukan ym. (2018) tutkimuksen aineistoa. Tutkimukseen\nosallistui 15 ylipainoista keskim\u00e4\u00e4rin 36,8-vuotiasta naista, jotka olivat sedentaarisia ja BMI\noli yli 27,5 (kg/m\u00b2).\nMittaukset suoritettiin perustasolla sek\u00e4 kontrollijakson ja harjoitusjakson j\u00e4lkeen. Mittaukset\nsis\u00e4lsiv\u00e4t laboratoriotestej\u00e4 sek\u00e4 submaksimaalisen polkupy\u00f6r\u00e4ergometritestin. N\u00e4iden lis\u00e4ksi\ntutkittavat t\u00e4yttiv\u00e4t ruoka- ja liikuntap\u00e4iv\u00e4kirjaa ja heid\u00e4n tuli yll\u00e4pit\u00e4\u00e4 normaalia sy\u00f6mis- ja\nliikuntak\u00e4ytt\u00e4ytymist\u00e4\u00e4n koko tutkimuksen ajan. Kehonkoostumusta arvioitiin DXA-laitteella\nja verin\u00e4ytteist\u00e4 analysoitiin eri rasva-arvoja, insuliini- ja glukoosiarvoja sek\u00e4 tulehdustekij\u00f6it\u00e4.\nTutkittavat ker\u00e4siv\u00e4t itselt\u00e4\u00e4n ulosten\u00e4ytteet ohjeiden mukaisesti. N\u00e4ytteist\u00e4 eristettiin DNA ja\nsuolistomikrobien koostumus analysoitiin 16S rRNA-geenin amplikonisekvensoinnin avulla.\nLiikunnan vaikutuksia suolistomikrobistoon tarkasteltiin tarkemmin metagenomianalyysill\u00e4.\nTutkimuksen tilastollisia analyysej\u00e4 tehtiin IBM SPSS Statistics 28-ohjelmalla (IBM, USA).\nYhteyksi\u00e4 tarkasteltiin Spearmanin korrelaatiotesteill\u00e4 ja kardiometabolisten muuttujien\nkeskiarvoeroja ennen ja j\u00e4lkeen harjoitusjakson m\u00e4\u00e4ritettiin kahden riippuvan otoksen t-testin\navulla.\nTutkittavien suolistomikrobien ja kehonkoostumuksen, rasva- ja kolesteroliarvojen,\ninsuliiniresistenssin tason sek\u00e4 elimist\u00f6n tulehdusstatuksen v\u00e4lill\u00e4 havaittiin monia yhteyksi\u00e4.\nKest\u00e4vyysharjoittelu laski tutkittavien painoa, keskivartalon rasvamassaa sek\u00e4 LDLkolesterolia. Kest\u00e4vyysharjoittelulla oli my\u00f6s suolistomikrobiston koostumukseen vaikutuksia\nja harjoittelun havaittiin lis\u00e4\u00e4v\u00e4n Verrucomicrobia-p\u00e4\u00e4jakson, Verrucomicrobiaceae- ja\nAkkermansia-suvun sek\u00e4 laskevan Proteobacteria-suvun suolistomikrobien m\u00e4\u00e4r\u00e4\u00e4 (Munukka\nym. 2018). Muuttujien muutosten v\u00e4lill\u00e4 havaittiin my\u00f6s muutamia merkitsevi\u00e4 yhteyksi\u00e4.\nJohtop\u00e4\u00e4t\u00f6ksen\u00e4 voidaan todeta, ett\u00e4 suolistomikrobisto on yhteydess\u00e4 kardiometabolisiin\nriskitekij\u00f6ihin ylipainoisilla naisilla ja liikunnalla voidaan vaikuttaa my\u00f6nteisesti\nkardiometabolisiin riskitekij\u00f6ihin sek\u00e4 suolistomikrobiston koostumukseen. Lis\u00e4\u00e4 tutkimusta\nkuitenkin tarvitaan suuremmalla aineistolla, jotta tuloksia voidaan yleist\u00e4\u00e4 ja pit\u00e4\u00e4 luotettavina.", "language": "fi", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Submitted by Miia Hakanen (mihakane@jyu.fi) on 2022-12-22T07:17:22Z\nNo. of bitstreams: 0", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Made available in DSpace on 2022-12-22T07:17:23Z (GMT). No. of bitstreams: 0\n Previous issue date: 2022", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.format.extent", "value": "107", "language": "", "element": "format", "qualifier": "extent", "schema": "dc"}, {"key": "dc.format.mimetype", "value": "application/pdf", "language": null, "element": "format", "qualifier": "mimetype", "schema": "dc"}, {"key": "dc.language.iso", "value": "fin", "language": null, "element": "language", "qualifier": "iso", "schema": "dc"}, {"key": "dc.rights", "value": "In Copyright", "language": "en", "element": "rights", "qualifier": null, "schema": "dc"}, {"key": "dc.subject.other", "value": "kardiometaboliset riskitekij\u00e4t", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.title", "value": "Suolistomikrobiston yhteys kardiometabolisten sairauksien riskitekij\u00f6ihin ylipainoisilla tutkittavilla", "language": "", "element": "title", "qualifier": null, "schema": "dc"}, {"key": "dc.type", "value": "master thesis", "language": null, "element": "type", "qualifier": null, "schema": "dc"}, {"key": "dc.identifier.urn", "value": "URN:NBN:fi:jyu-202212225793", "language": "", "element": "identifier", "qualifier": "urn", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Pro gradu -tutkielma", "language": "fi", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Master\u2019s thesis", "language": "en", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Liikuntatieteellinen tiedekunta", "language": "fi", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Faculty of Sport and Health Sciences", "language": "en", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Liikunta- ja terveystieteet", "language": "fi", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Sport and Health Sciences", "language": "en", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "Jyv\u00e4skyl\u00e4n yliopisto", "language": "fi", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "University of Jyv\u00e4skyl\u00e4", "language": "en", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Liikuntafysiologia", "language": "fi", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Exercise Physiology", "language": "en", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "yvv.contractresearch.funding", "value": "0", "language": "", "element": "contractresearch", "qualifier": "funding", "schema": "yvv"}, {"key": "dc.type.coar", "value": "http://purl.org/coar/resource_type/c_bdcc", "language": null, "element": "type", "qualifier": "coar", "schema": "dc"}, {"key": "dc.rights.accesslevel", "value": "openAccess", "language": null, "element": "rights", "qualifier": "accesslevel", "schema": "dc"}, {"key": "dc.type.publication", "value": "masterThesis", "language": null, "element": "type", "qualifier": "publication", "schema": "dc"}, {"key": "dc.subject.oppiainekoodi", "value": "5011", "language": "", "element": "subject", "qualifier": "oppiainekoodi", "schema": "dc"}, {"key": "dc.subject.yso", "value": "ylipaino", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "suolistomikrobisto", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "suolisto", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "lihavuus", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.format.content", "value": "fulltext", "language": null, "element": "format", "qualifier": "content", "schema": "dc"}, {"key": "dc.rights.url", "value": "https://rightsstatements.org/page/InC/1.0/", "language": null, "element": "rights", "qualifier": "url", "schema": "dc"}, {"key": "dc.rights.accessrights", "value": "", "language": null, "element": "rights", "qualifier": "accessrights", "schema": "dc"}, {"key": "dc.type.okm", "value": "G2", "language": null, "element": "type", "qualifier": "okm", "schema": "dc"}]
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