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[{"key": "dc.contributor.advisor", "value": "Siev\u00e4nen, Elina", "language": "", "element": "contributor", "qualifier": "advisor", "schema": "dc"}, {"key": "dc.contributor.advisor", "value": "Escuder, Beatriu", "language": "", "element": "contributor", "qualifier": "advisor", "schema": "dc"}, {"key": "dc.contributor.author", "value": "Poimala, Milka", "language": "", "element": "contributor", "qualifier": "author", "schema": "dc"}, {"key": "dc.date.accessioned", "value": "2022-12-15T11:51:43Z", "language": null, "element": "date", "qualifier": "accessioned", "schema": "dc"}, {"key": "dc.date.available", "value": "2022-12-15T11:51:43Z", "language": null, "element": "date", "qualifier": "available", "schema": "dc"}, {"key": "dc.date.issued", "value": "2022", "language": "", "element": "date", "qualifier": "issued", "schema": "dc"}, {"key": "dc.identifier.uri", "value": "https://jyx.jyu.fi/handle/123456789/84415", "language": null, "element": "identifier", "qualifier": "uri", "schema": "dc"}, {"key": "dc.description.abstract", "value": "T\u00e4m\u00e4n pro gradu -tutkielman teoriaosa esittelee lyhyesti supramolekulaarisen kemian, supramolekulaaristen geelien, aminohappojen sek\u00e4 peptidien konseptit. Kolmea aminohappoa - fenyylialaniinia, lysiini\u00e4 ja arginiinia - tarkastellaan l\u00e4hemmin, koska niit\u00e4 k\u00e4ytet\u00e4\u00e4n t\u00e4m\u00e4n tutkielman kokeellisessa osassa. Lis\u00e4ksi tarkastellaan 3D-tulostusta teorian perusteista l\u00e4htien aina aminohappopohjaisten supramolekulaaristen geelien eri tulostustekniikoihin. Lis\u00e4ksi k\u00e4yd\u00e4\u00e4n l\u00e4pi niiden k\u00e4ytt\u00f6mahdollisuuksia l\u00e4\u00e4ketieteess\u00e4. Lopuksi sivutaan joitakin kiinteit\u00e4 \n3D-tulosteita sek\u00e4 3D-tulostettuja sy\u00f6t\u00e4vi\u00e4 geelej\u00e4. \n\nTutkielman kokeellinen osa suoritettiin Jaume I -yliopistossa, Castello\u0301n de La Planassa, Espanjassa. Ty\u00f6n tavoitteena oli l\u00f6yt\u00e4\u00e4 sopiva guanylointireaktio dipeptidipohjaiselle hydrogelaattorille. Lis\u00e4ksi aloitusreagenssina k\u00e4ytetty\u00e4 dipeptidipohjaista hydrogelaattoria valmistettiin lis\u00e4\u00e4 nelivaiheisen synteesin kautta. Tuotteet karakterisoitiin k\u00e4ytt\u00e4m\u00e4ll\u00e4 NMR-spektroskopiaa ja massaspektrometriaa. Guanyloidulla gelaattorimolekyylill\u00e4 suoritettiin geeliytymiskokeita ja valmistetulle hydrogeelille tehtiin 3D-tulostuskoe. Lis\u00e4ksi geeli\u00e4 tutkittiin reologisin menetelmin. Guanylointireaktio onnistui, mutta gelaattorimolekyyli ei muodostanut vahvaa geeli\u00e4, eik\u00e4 se siten ollut sopiva k\u00e4ytett\u00e4v\u00e4ksi tulostamisessa.", "language": "fi", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.abstract", "value": "The theory part of this Master\u2019s thesis introduces shortly the concepts of supramolecular chemistry, supramolecular gels, amino acids, and peptides. The emphasis is on three amino acids; phenylalanine, lysine, and arginine, which are used in the experimental part of this thesis. Furthermore, 3D printing is viewed from the general basics to amino acid based supramolecular gel printing techniques with their applications in the medical field. Also, some solid prints and 3D printed edible gels in food science are introduced.\n\nThe experimental part was conducted in the University of Jaume I in Castello\u0301n de la Plana, Spain. The aim of the experimental part was to find a suitable guanylation reaction for a dipeptide based hydrogelator. Also, more of the starting reagent, dipeptide based hydrogelator, was synthesized through four step synthesis. The products were characterized by NMR spectroscopy and mass spectrometry. Gelation tests were conducted with the guanylated gelator, in addition to which a 3D printing experiment was performed and rheological studies executed. The guanylation reaction was successful, but the gelator molecule did not form a strong gel. Thus, it unfortunately was not suitable for printing.", "language": "en", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Submitted by Paivi Vuorio (paelvuor@jyu.fi) on 2022-12-15T11:51:43Z\nNo. of bitstreams: 0", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Made available in DSpace on 2022-12-15T11:51:43Z (GMT). No. of bitstreams: 0\n Previous issue date: 2022", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.format.extent", "value": "88", "language": "", "element": "format", "qualifier": "extent", "schema": "dc"}, {"key": "dc.format.mimetype", "value": "application/pdf", "language": null, "element": "format", "qualifier": "mimetype", "schema": "dc"}, {"key": "dc.language.iso", "value": "eng", "language": null, "element": "language", "qualifier": "iso", "schema": "dc"}, {"key": "dc.rights", "value": "In Copyright", "language": "en", "element": "rights", "qualifier": null, "schema": "dc"}, {"key": "dc.title", "value": "Dipeptide-based hydrogelators and 3D printed gels", "language": "", "element": "title", "qualifier": null, "schema": "dc"}, {"key": "dc.type", "value": "master thesis", "language": null, "element": "type", "qualifier": null, "schema": "dc"}, {"key": "dc.identifier.urn", "value": "URN:NBN:fi:jyu-202212155670", "language": "", "element": "identifier", "qualifier": "urn", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Pro gradu -tutkielma", "language": "fi", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Master\u2019s thesis", "language": "en", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Matemaattis-luonnontieteellinen tiedekunta", "language": "fi", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Faculty of Sciences", "language": "en", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Kemian laitos", "language": "fi", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Department of Chemistry", "language": "en", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "Jyv\u00e4skyl\u00e4n yliopisto", "language": "fi", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "University of Jyv\u00e4skyl\u00e4", "language": "en", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Kemia", "language": "fi", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Chemistry", "language": "en", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "yvv.contractresearch.funding", "value": "0", "language": "", "element": "contractresearch", "qualifier": "funding", "schema": "yvv"}, {"key": "dc.type.coar", "value": "http://purl.org/coar/resource_type/c_bdcc", "language": null, "element": "type", "qualifier": "coar", "schema": "dc"}, {"key": "dc.rights.accesslevel", "value": "openAccess", "language": null, "element": "rights", "qualifier": "accesslevel", "schema": "dc"}, {"key": "dc.type.publication", "value": "masterThesis", "language": null, "element": "type", "qualifier": "publication", "schema": "dc"}, {"key": "dc.subject.oppiainekoodi", "value": "4038", "language": "", "element": "subject", "qualifier": "oppiainekoodi", "schema": "dc"}, {"key": "dc.subject.yso", "value": "supramolekulaarinen kemia", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "3D-tulostus", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "geelit", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "hydrogeelit", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "aminohapot", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "kudosteknologia", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "painotekniikka", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "supramolecular chemistry", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "3D printing", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "gels", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "hydrogels", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "amino acids", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "tissue engineering", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "printing technology", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.format.content", "value": "fulltext", "language": null, "element": "format", "qualifier": "content", "schema": "dc"}, {"key": "dc.rights.url", "value": "https://rightsstatements.org/page/InC/1.0/", "language": null, "element": "rights", "qualifier": "url", "schema": "dc"}, {"key": "dc.type.okm", "value": "G2", "language": null, "element": "type", "qualifier": "okm", "schema": "dc"}]
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