Depression-related alterations in deviance detection ERPs in the auditory and somatosensory modality

Automaattisilla sähköfysiologisilla aivovasteilla mitatut kuulo- ja tuntoärsykemuutokset ovat potentiaalisia työkaluja masennuksen hermostollisten merkkien tunnistamiseksi. Kyseiset vasteet ovat kuitenkin saaneet osakseen vain vähän huomiota tutkimuskirjallisuudessa. Tässä tutkimuksessa käytimme odd...

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Päätekijät: Topal, Volkan, Louhisto, Kasper
Muut tekijät: Kasvatustieteiden ja psykologian tiedekunta, Faculty of Education and Psychology, Psykologian laitos, Department of Psychology, Jyväskylän yliopisto, University of Jyväskylä
Aineistotyyppi: Pro gradu
Kieli:eng
Julkaistu: 2022
Aiheet:
Linkit: https://jyx.jyu.fi/handle/123456789/83201
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author Topal, Volkan Louhisto, Kasper
author2 Kasvatustieteiden ja psykologian tiedekunta Faculty of Education and Psychology Psykologian laitos Department of Psychology Jyväskylän yliopisto University of Jyväskylä
author_facet Topal, Volkan Louhisto, Kasper Kasvatustieteiden ja psykologian tiedekunta Faculty of Education and Psychology Psykologian laitos Department of Psychology Jyväskylän yliopisto University of Jyväskylä Topal, Volkan Louhisto, Kasper Kasvatustieteiden ja psykologian tiedekunta Faculty of Education and Psychology Psykologian laitos Department of Psychology Jyväskylän yliopisto University of Jyväskylä
author_sort Topal, Volkan
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description Automaattisilla sähköfysiologisilla aivovasteilla mitatut kuulo- ja tuntoärsykemuutokset ovat potentiaalisia työkaluja masennuksen hermostollisten merkkien tunnistamiseksi. Kyseiset vasteet ovat kuitenkin saaneet osakseen vain vähän huomiota tutkimuskirjallisuudessa. Tässä tutkimuksessa käytimme oddball -paradigmaa (jossa harvinainen ‘poikkeava ärsyke’ annettiin ‘toistettujen ärsykkeiden’ sarjassa), mittaamaan auditiivisen intensiteettimuutoksen ja somatosensorisen lokaatiomuutoksen aiheuttamia tapahtumasidonnaisia herätevasteita (ERP), tarkemmin ottaen poikkeavuusnegatiivisuus- (MMN/MMR) ja P3a -vasteita. Tarkastelimme näiden herätevasteiden kykyä erotella masentuneet potilaat ei-masentuneista verrokeista. Lisäksi tutkimme korreloiko BDI-II-kyselyllä mitattu masennuksen vakavuusaste (kokonaisvakavuus, somaattisen oireilun vakavuus, tai kognitiivisaffektiivisen oireilun vakavuus) herätevasteiden kanssa. Kaiken kaikkiaan 57 tutkittavaa, iältään 18–62 vuotta (18 masentunutta, 39 ei-masentunutta), osallistui tutkimukseen. Tämän tutkimuksen tulokset osoittivat, että yksikään herätevasteista ei erotellut masentuneita potilaita ei-masentuneista verrokeista. Lisäksi yksikään masennuksen vakavuusasteindekseistä ei korreloinut tapahtumasidonnaisten herätevasteiden kanssa. Tulokset viittaavat siihen, että muutoksen havaitseminen auditiivisessa ja somatosensorisessa ärsykeympäristössä on normaalilla tasolla masentuneilla potilailla, ja näin ollen kyseisistä tapahtumasidonnaisista herätevasteista ei löydetty potentiaalia masennuksen hermostollisten merkkien tunnistamiseksi. Pienestä otoskoosta johtuen tutkimuksen tuloksia tulisi kuitenkin pitää suuntaa antavina. Lisätutkimusta tarvitaan, jotta voitaisiin muodostaa luotettavia johtopäätöksiä tapahtumasidonnaisten herätevasteiden potentiaalista tunnistaa masennuksen hermostollisia merkkejä. The brain's automatic electrophysiological responses to changes in the auditory and somatosensory environment represent potential tools for identifying depression-related neural markers. However, they have received scarce research attention to date. In this study, we used an oddball stimulus condition, in which a rare ‘deviant stimulus’ was interspersed with a frequent ‘standard stimulus’, to measure mismatch responses (MMN/MMR) and P3a component of event-related potentials (ERPs) to auditory intensity- and somatosensory location changes. We investigated whether these responses differentiate depressed patients from non-depressed controls. In addition, we investigated whether depression severity (overall depression severity, cognitive-affective symptom severity, or somatic symptom severity), as measured by the BDI-II, correlates with the ERPs. A total of 57 participants aged between 18 and 62 years (18 depressed, 39 non-depressed), participated in the study. We found that none of the ERPs differentiated depressed patients from non-depressed controls. Furthermore, none of the depression severity indices correlated with the ERPs. The results indicate normal levels of automatic auditory- and somatosensory change detection among depressed patients, and therefore no biomarker potential was recognized in these ERPs. However, the results from this study should be considered preliminary due to the small sample size. More research is needed to assess the potential utility of ERPs as biomarkers of depression.
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spellingShingle Topal, Volkan Louhisto, Kasper Depression-related alterations in deviance detection ERPs in the auditory and somatosensory modality depression severity auditory mismatch negativity (aMMN) somatosensory mismatch response (sMMR) auditory P3a (aP3a) somatosensory P3a (sP3a) event-related potential (ERP) oddball paradigm intensity change location change masennuksen vakavuusaste poikkeavuusnegatiivisuusvaste kuuloärsykkeissä (aMMN) poikkeavuusvaste tuntoärsykkeissä (sMMR) P3a kuuloärsykkeissä (aP3a) P3a tuntoärsykkeissä (sP3a) tapahtumasidonnainen herätevaste (ERP) oddball-paradigma intensiteetinmuutos lokaationmuutos Psykologia Psychology 202 masennus depression (mental disorders)
title Depression-related alterations in deviance detection ERPs in the auditory and somatosensory modality
title_full Depression-related alterations in deviance detection ERPs in the auditory and somatosensory modality
title_fullStr Depression-related alterations in deviance detection ERPs in the auditory and somatosensory modality Depression-related alterations in deviance detection ERPs in the auditory and somatosensory modality
title_full_unstemmed Depression-related alterations in deviance detection ERPs in the auditory and somatosensory modality Depression-related alterations in deviance detection ERPs in the auditory and somatosensory modality
title_short Depression-related alterations in deviance detection ERPs in the auditory and somatosensory modality
title_sort depression related alterations in deviance detection erps in the auditory and somatosensory modality
title_txtP Depression-related alterations in deviance detection ERPs in the auditory and somatosensory modality
topic depression severity auditory mismatch negativity (aMMN) somatosensory mismatch response (sMMR) auditory P3a (aP3a) somatosensory P3a (sP3a) event-related potential (ERP) oddball paradigm intensity change location change masennuksen vakavuusaste poikkeavuusnegatiivisuusvaste kuuloärsykkeissä (aMMN) poikkeavuusvaste tuntoärsykkeissä (sMMR) P3a kuuloärsykkeissä (aP3a) P3a tuntoärsykkeissä (sP3a) tapahtumasidonnainen herätevaste (ERP) oddball-paradigma intensiteetinmuutos lokaationmuutos Psykologia Psychology 202 masennus depression (mental disorders)
topic_facet 202 P3a kuuloärsykkeissä (aP3a) P3a tuntoärsykkeissä (sP3a) Psychology Psykologia auditory P3a (aP3a) auditory mismatch negativity (aMMN) depression (mental disorders) depression severity event-related potential (ERP) intensiteetinmuutos intensity change location change lokaationmuutos masennuksen vakavuusaste masennus oddball paradigm oddball-paradigma poikkeavuusnegatiivisuusvaste kuuloärsykkeissä (aMMN) poikkeavuusvaste tuntoärsykkeissä (sMMR) somatosensory P3a (sP3a) somatosensory mismatch response (sMMR) tapahtumasidonnainen herätevaste (ERP)
url https://jyx.jyu.fi/handle/123456789/83201 http://www.urn.fi/URN:NBN:fi:jyu-202209124547
work_keys_str_mv AT topalvolkan depressionrelatedalterationsindeviancedetectionerpsintheauditoryandsomatosensorymoda