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[{"key": "dc.contributor.advisor", "value": "Kangas, Elina", "language": "", "element": "contributor", "qualifier": "advisor", "schema": "dc"}, {"key": "dc.contributor.advisor", "value": "Astikainen, Piia", "language": "", "element": "contributor", "qualifier": "advisor", "schema": "dc"}, {"key": "dc.contributor.author", "value": "Topal, Volkan", "language": "", "element": "contributor", "qualifier": "author", "schema": "dc"}, {"key": "dc.contributor.author", "value": "Louhisto, Kasper", "language": "", "element": "contributor", "qualifier": "author", "schema": "dc"}, {"key": "dc.date.accessioned", "value": "2022-09-12T06:50:20Z", "language": null, "element": "date", "qualifier": "accessioned", "schema": "dc"}, {"key": "dc.date.available", "value": "2022-09-12T06:50:20Z", "language": null, "element": "date", "qualifier": "available", "schema": "dc"}, {"key": "dc.date.issued", "value": "2022", "language": "", "element": "date", "qualifier": "issued", "schema": "dc"}, {"key": "dc.identifier.uri", "value": "https://jyx.jyu.fi/handle/123456789/83201", "language": null, "element": "identifier", "qualifier": "uri", "schema": "dc"}, {"key": "dc.description.abstract", "value": "Automaattisilla s\u00e4hk\u00f6fysiologisilla aivovasteilla mitatut kuulo- ja tunto\u00e4rsykemuutokset ovat potentiaalisia ty\u00f6kaluja masennuksen hermostollisten merkkien tunnistamiseksi. Kyseiset vasteet ovat kuitenkin saaneet osakseen vain v\u00e4h\u00e4n huomiota tutkimuskirjallisuudessa. T\u00e4ss\u00e4 tutkimuksessa k\u00e4ytimme oddball -paradigmaa (jossa harvinainen \u2018poikkeava \u00e4rsyke\u2019 annettiin \u2018toistettujen \u00e4rsykkeiden\u2019 sarjassa), mittaamaan auditiivisen intensiteettimuutoksen ja somatosensorisen lokaatiomuutoksen aiheuttamia tapahtumasidonnaisia her\u00e4tevasteita (ERP), tarkemmin ottaen poikkeavuusnegatiivisuus- (MMN/MMR) ja P3a -vasteita. Tarkastelimme n\u00e4iden her\u00e4tevasteiden kyky\u00e4 erotella masentuneet potilaat ei-masentuneista verrokeista. Lis\u00e4ksi tutkimme korreloiko BDI-II-kyselyll\u00e4 mitattu masennuksen vakavuusaste (kokonaisvakavuus, somaattisen oireilun vakavuus, tai kognitiivisaffektiivisen oireilun vakavuus) her\u00e4tevasteiden kanssa.\nKaiken kaikkiaan 57 tutkittavaa, i\u00e4lt\u00e4\u00e4n 18\u201362 vuotta (18 masentunutta, 39 ei-masentunutta), osallistui tutkimukseen. T\u00e4m\u00e4n tutkimuksen tulokset osoittivat, ett\u00e4 yksik\u00e4\u00e4n her\u00e4tevasteista ei erotellut masentuneita potilaita ei-masentuneista verrokeista. Lis\u00e4ksi yksik\u00e4\u00e4n masennuksen vakavuusasteindekseist\u00e4 ei korreloinut tapahtumasidonnaisten her\u00e4tevasteiden kanssa. Tulokset viittaavat siihen, ett\u00e4 muutoksen havaitseminen auditiivisessa ja somatosensorisessa \u00e4rsykeymp\u00e4rist\u00f6ss\u00e4 on normaalilla tasolla masentuneilla potilailla, ja n\u00e4in ollen kyseisist\u00e4 tapahtumasidonnaisista her\u00e4tevasteista ei l\u00f6ydetty potentiaalia masennuksen hermostollisten merkkien tunnistamiseksi. Pienest\u00e4 otoskoosta johtuen tutkimuksen tuloksia tulisi kuitenkin pit\u00e4\u00e4 suuntaa antavina. Lis\u00e4tutkimusta tarvitaan, jotta voitaisiin muodostaa luotettavia johtop\u00e4\u00e4t\u00f6ksi\u00e4 tapahtumasidonnaisten her\u00e4tevasteiden potentiaalista tunnistaa masennuksen hermostollisia merkkej\u00e4.", "language": "fi", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.abstract", "value": "The brain's automatic electrophysiological responses to changes in the auditory and somatosensory environment represent potential tools for identifying depression-related neural markers. However, they have received scarce research attention to date. In this study, we used an oddball stimulus condition, in which a rare \u2018deviant stimulus\u2019 was interspersed with a frequent \u2018standard stimulus\u2019, to measure mismatch responses (MMN/MMR) and P3a component of event-related potentials (ERPs) to auditory intensity- and somatosensory location changes. We investigated whether these responses differentiate depressed patients from non-depressed controls. In addition, we investigated whether depression severity (overall depression severity, cognitive-affective symptom severity, or somatic symptom severity), as measured by the BDI-II, correlates with the ERPs.\nA total of 57 participants aged between 18 and 62 years (18 depressed, 39 non-depressed), participated in the study. We found that none of the ERPs differentiated depressed patients from non-depressed controls. Furthermore, none of the depression severity indices correlated with the ERPs. The results indicate normal levels of automatic auditory- and somatosensory change detection among depressed patients, and therefore no biomarker potential was recognized in these ERPs. However, the results from this study should be considered preliminary due to the small sample size. More research is needed to assess the potential utility of ERPs as biomarkers of depression.", "language": "en", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Submitted by Paivi Vuorio (paelvuor@jyu.fi) on 2022-09-12T06:50:20Z\nNo. of bitstreams: 0", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Made available in DSpace on 2022-09-12T06:50:20Z (GMT). No. of bitstreams: 0\n Previous issue date: 2022", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.format.extent", "value": "55", "language": "", "element": "format", "qualifier": "extent", "schema": "dc"}, {"key": "dc.format.mimetype", "value": "application/pdf", "language": null, "element": "format", "qualifier": "mimetype", "schema": "dc"}, {"key": "dc.language.iso", "value": "eng", "language": null, "element": "language", "qualifier": "iso", "schema": "dc"}, {"key": "dc.rights", "value": "In Copyright", "language": "en", "element": "rights", "qualifier": null, "schema": "dc"}, {"key": "dc.subject.other", "value": "depression severity", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "auditory mismatch negativity (aMMN)", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "somatosensory mismatch response (sMMR)", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "auditory P3a (aP3a)", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "somatosensory P3a (sP3a)", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "event-related potential (ERP)", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "oddball paradigm", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "intensity change", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "location change", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "masennuksen vakavuusaste", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "poikkeavuusnegatiivisuusvaste kuulo\u00e4rsykkeiss\u00e4 (aMMN)", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "poikkeavuusvaste tunto\u00e4rsykkeiss\u00e4 (sMMR)", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "P3a kuulo\u00e4rsykkeiss\u00e4 (aP3a)", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "P3a tunto\u00e4rsykkeiss\u00e4 (sP3a)", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "tapahtumasidonnainen her\u00e4tevaste (ERP)", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "oddball-paradigma", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "intensiteetinmuutos", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "lokaationmuutos", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.title", "value": "Depression-related alterations in deviance detection ERPs in the auditory and somatosensory modality", "language": "", "element": "title", "qualifier": null, "schema": "dc"}, {"key": "dc.type", "value": "master thesis", "language": null, "element": "type", "qualifier": null, "schema": "dc"}, {"key": "dc.identifier.urn", "value": "URN:NBN:fi:jyu-202209124547", "language": "", "element": "identifier", "qualifier": "urn", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Pro gradu -tutkielma", "language": "fi", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Master\u2019s thesis", "language": "en", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Kasvatustieteiden ja psykologian tiedekunta", "language": "fi", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Faculty of Education and Psychology", "language": "en", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Psykologian laitos", "language": "fi", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Department of Psychology", "language": "en", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "Jyv\u00e4skyl\u00e4n yliopisto", "language": "fi", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "University of Jyv\u00e4skyl\u00e4", "language": "en", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Psykologia", "language": "fi", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Psychology", "language": "en", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "yvv.contractresearch.funding", "value": "0", "language": "", "element": "contractresearch", "qualifier": "funding", "schema": "yvv"}, {"key": "dc.type.coar", "value": "http://purl.org/coar/resource_type/c_bdcc", "language": null, "element": "type", "qualifier": "coar", "schema": "dc"}, {"key": "dc.rights.accesslevel", "value": "openAccess", "language": null, "element": "rights", "qualifier": "accesslevel", "schema": "dc"}, {"key": "dc.type.publication", "value": "masterThesis", "language": null, "element": "type", "qualifier": "publication", "schema": "dc"}, {"key": "dc.subject.oppiainekoodi", "value": "202", "language": "", "element": "subject", "qualifier": "oppiainekoodi", "schema": "dc"}, {"key": "dc.subject.yso", "value": "masennus", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "depression (mental disorders)", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.format.content", "value": "fulltext", "language": null, "element": "format", "qualifier": "content", "schema": "dc"}, {"key": "dc.rights.url", "value": "https://rightsstatements.org/page/InC/1.0/", "language": null, "element": "rights", "qualifier": "url", "schema": "dc"}, {"key": "dc.type.okm", "value": "G2", "language": null, "element": "type", "qualifier": "okm", "schema": "dc"}]
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