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[{"key": "dc.contributor.advisor", "value": "Pihko, Petri", "language": "", "element": "contributor", "qualifier": "advisor", "schema": "dc"}, {"key": "dc.contributor.advisor", "value": "Verma, Prachi", "language": "", "element": "contributor", "qualifier": "advisor", "schema": "dc"}, {"key": "dc.contributor.author", "value": "Bruce, Veera", "language": "", "element": "contributor", "qualifier": "author", "schema": "dc"}, {"key": "dc.date.accessioned", "value": "2022-06-15T07:40:38Z", "language": null, "element": "date", "qualifier": "accessioned", "schema": "dc"}, {"key": "dc.date.available", "value": "2022-06-15T07:40:38Z", "language": null, "element": "date", "qualifier": "available", "schema": "dc"}, {"key": "dc.date.issued", "value": "2022", "language": "", "element": "date", "qualifier": "issued", "schema": "dc"}, {"key": "dc.identifier.uri", "value": "https://jyx.jyu.fi/handle/123456789/81721", "language": null, "element": "identifier", "qualifier": "uri", "schema": "dc"}, {"key": "dc.description.abstract", "value": "T\u00e4m\u00e4n pro gradu -tutkielman kirjallinen osa k\u00e4sittelee dikinaaniluonnonaineita ja niiden synteesej\u00e4. Jotta kokeellinen osa tukisi parhaiten kirjallista osaa, keskityt\u00e4\u00e4n siin\u00e4 kehitt\u00e4m\u00e4\u00e4n synteesireitti dikinaanirugolle, jota voidaan mahdollisesti tulevaisuudessa k\u00e4ytt\u00e4\u00e4 osana humilisiini E luonnonaineen totaalisynteesi\u00e4. \n\nKahdesta fuusioituneesta syklopentaanista koostuvien dikinaanien laaja esiintyvyys luonnonaineissa on kasvattanut niiden kiinnostusta kemistien parissa. Vaikka dikinaaneille on l\u00f6ydetty useita synteesikeinoja, tutkimusta uusien ja tehokkaampien metodien l\u00f6yt\u00e4miseksi tehd\u00e4\u00e4n yh\u00e4. Ty\u00f6n kirjallisen osan alkupuolella k\u00e4sitell\u00e4\u00e4n dikinaanirakenteeseen liittyv\u00e4\u00e4 teoriaa sek\u00e4 niiden yleisimpi\u00e4 synteesistrategioita, mik\u00e4 toimii johdantona kirjallisen osan loppuosaan. Koska suuri osa dikinaaniluonnonaineista kuuluu terpeeneihin ja terpenoideihin, halutaan tutkielman kirjallisessa osassa my\u00f6s perehty\u00e4 niihin liittyv\u00e4\u00e4n teoriaan. Kirjallisen osan lopussa perehdyt\u00e4\u00e4n yksinkertaisten sek\u00e4 monimutkaisempien dikinaaniluonnonaineiden synteeseihin keskittyen erityisesti stereokemian muodostumiseen. \n\nTy\u00f6n kokeellisessa osassa pyrit\u00e4\u00e4n suunnittelemaan ja toteuttamaan mahdollisimman tehokas synteesireitti funktionalisoidulle dikinaanirungolle. Syntetisoitava rakenne valikoitiin toimivaksi humilisiini E:n totaalisynteesin yhten\u00e4 v\u00e4lituotteena. Dikinaanin synteesi esitet\u00e4\u00e4n ty\u00f6ss\u00e4 reaktio kerrallaan. Synteesin ideana oli valmistaa alifaattinen ketju, joka syklisoitaisiin Pauson\u2013Khand-reaktiolla. Erityinen onnistuminen koettiin Claisen-toisiintumisen toimiessa suhteellisen miedoissa olosuhteissa, jolloin suunniteltu synteesi pystyttiin toteuttamaan pienemm\u00e4ll\u00e4 m\u00e4\u00e4r\u00e4ll\u00e4 v\u00e4livaiheita. Useista yrityksist\u00e4 huolimatta synteesin viimeinen vaihe, Pauson\u2013Khand-reaktio ei toiminut eik\u00e4 syklisaatiota pystytty optioimaan aikataulullisista syist\u00e4 johtuen.", "language": "fi", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Submitted by Miia Hakanen (mihakane@jyu.fi) on 2022-06-15T07:40:38Z\nNo. of bitstreams: 0", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Made available in DSpace on 2022-06-15T07:40:38Z (GMT). No. of bitstreams: 0\n Previous issue date: 2022", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.format.extent", "value": "113", "language": "", "element": "format", "qualifier": "extent", "schema": "dc"}, {"key": "dc.format.mimetype", "value": "application/pdf", "language": null, "element": "format", "qualifier": "mimetype", "schema": "dc"}, {"key": "dc.language.iso", "value": "fin", "language": null, "element": "language", "qualifier": "iso", "schema": "dc"}, {"key": "dc.rights", "value": "In Copyright", "language": "en", "element": "rights", "qualifier": null, "schema": "dc"}, {"key": "dc.subject.other", "value": "polykinaanit", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "dikinaanit", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.title", "value": "Dikinaanirunkoisten luonnonaineiden synteesi", "language": "", "element": "title", "qualifier": null, "schema": "dc"}, {"key": "dc.type", "value": "master thesis", "language": null, "element": "type", "qualifier": null, "schema": "dc"}, {"key": "dc.identifier.urn", "value": "URN:NBN:fi:jyu-202206153331", "language": "", "element": "identifier", "qualifier": "urn", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Pro gradu -tutkielma", "language": "fi", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Master\u2019s thesis", "language": "en", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Matemaattis-luonnontieteellinen tiedekunta", "language": "fi", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Faculty of Sciences", "language": "en", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Kemian laitos", "language": "fi", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Department of Chemistry", "language": "en", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "Jyv\u00e4skyl\u00e4n yliopisto", "language": "fi", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "University of Jyv\u00e4skyl\u00e4", "language": "en", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Orgaaninen kemia", "language": "fi", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Organic Chemistry", "language": "en", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "yvv.contractresearch.funding", "value": "0", "language": "", "element": "contractresearch", "qualifier": "funding", "schema": "yvv"}, {"key": "dc.type.coar", "value": "http://purl.org/coar/resource_type/c_bdcc", "language": null, "element": "type", "qualifier": "coar", "schema": "dc"}, {"key": "dc.rights.accesslevel", "value": "openAccess", "language": null, "element": "rights", "qualifier": "accesslevel", "schema": "dc"}, {"key": "dc.type.publication", "value": "masterThesis", "language": null, "element": "type", "qualifier": "publication", "schema": "dc"}, {"key": "dc.subject.oppiainekoodi", "value": "4035", "language": "", "element": "subject", "qualifier": "oppiainekoodi", "schema": "dc"}, {"key": "dc.subject.yso", "value": "kemia", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "opinn\u00e4ytteet", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "synteesi", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "orgaaninen kemia", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "luonnonaineet", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.format.content", "value": "fulltext", "language": null, "element": "format", "qualifier": "content", "schema": "dc"}, {"key": "dc.rights.url", "value": "https://rightsstatements.org/page/InC/1.0/", "language": null, "element": "rights", "qualifier": "url", "schema": "dc"}, {"key": "dc.type.okm", "value": "G2", "language": null, "element": "type", "qualifier": "okm", "schema": "dc"}]
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