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[{"key": "dc.contributor.advisor", "value": "K\u00e4rkk\u00e4inen, Salme", "language": "", "element": "contributor", "qualifier": "advisor", "schema": "dc"}, {"key": "dc.contributor.advisor", "value": "Haapala, Eero", "language": "", "element": "contributor", "qualifier": "advisor", "schema": "dc"}, {"key": "dc.contributor.author", "value": "Heinonen, Saara", "language": "", "element": "contributor", "qualifier": "author", "schema": "dc"}, {"key": "dc.date.accessioned", "value": "2022-06-06T11:15:39Z", "language": null, "element": "date", "qualifier": "accessioned", "schema": "dc"}, {"key": "dc.date.available", "value": "2022-06-06T11:15:39Z", "language": null, "element": "date", "qualifier": "available", "schema": "dc"}, {"key": "dc.date.issued", "value": "2022", "language": "", "element": "date", "qualifier": "issued", "schema": "dc"}, {"key": "dc.identifier.uri", "value": "https://jyx.jyu.fi/handle/123456789/81511", "language": null, "element": "identifier", "qualifier": "uri", "schema": "dc"}, {"key": "dc.description.abstract", "value": "T\u00e4ss\u00e4 tutkielmassa tavoitteena on tutkia Alzheimerin taudin (AD) geneettisen riskin yhteytt\u00e4 seerumista m\u00e4\u00e4ritettyyn insuliinipitoisuuteen. AD on aivoja rappeuttava tauti, jonka perinn\u00e4ist\u00e4 syyt\u00e4 ei t\u00e4ysin tiedet\u00e4. Suurimmassa osassa tapauksista AD ei ole perinn\u00f6llinen, mutta taudin geneettisi\u00e4 riskitekij\u00f6it\u00e4 tunnetaan, ja niist\u00e4 tunnetuin geeni on APOE. Diabetes on yksi AD:n riskitekij\u00f6ist\u00e4. Diabetesta on olemassa eri tyyppej\u00e4, joille kaikille ominaista on h\u00e4iri\u00f6 haiman insuliinin tuotannossa. Insuliini on ainoa verensokeria laskeva hormoni.\n\nTutkielman aineiston analyysiosiossa k\u00e4ytet\u00e4\u00e4n syd\u00e4n- ja verisuonitautisairastuvuuden ehk\u00e4isyprojektin (STRIP) aineistoa. Perheit\u00e4 rekrytoitiin lapsen viiden kuukauden neuvolatarkastuksen yhteydess\u00e4 helmikuun 1990 ja kes\u00e4kuun 1992 v\u00e4lisen\u00e4 aikana. Tutkimukseen osallistui yhteens\u00e4 1\\:062 lasta, jotka jaettiin interventio- ja kontrolliryhmiin seitsem\u00e4n kuukauden i\u00e4ss\u00e4. Interventioryhm\u00e4n perheille annettiin lapseen kohdistuvaa ravitsemus- ja el\u00e4m\u00e4ntapaneuvontaa tutkimusk\u00e4ynnin yhteydess\u00e4. Tutkimuksen interventiovaihe jatkui, kunnes henkil\u00f6t t\u00e4yttiv\u00e4t 20 vuotta. Tutkimusk\u00e4ynnill\u00e4 otettiin verin\u00e4yte, mitattiin paino, pituus ja verenpaine. Lis\u00e4ksi ravitsemusta seurattiin ruokap\u00e4iv\u00e4kirjan avulla. AD:n geneettist\u00e4 riski\u00e4 kuvaavat kaksi muuttujaa, joista toisessa APOE on laskettu mukaan.\n\nKoska aineiston perusteella seerumin insuliipitoisuudet eiv\u00e4t muutu lineaarisesti ajan suhteen, k\u00e4ytet\u00e4\u00e4n semiparametrista additiivista sekamallia. K\u00e4yt\u00e4nn\u00f6ss\u00e4 additiivisessa mallissa vasteen ja selitt\u00e4v\u00e4n muuttujan v\u00e4lille sallitaan ep\u00e4lineaarinen yhteys. T\u00e4ss\u00e4 tutkielmassa k\u00e4ytet\u00e4\u00e4n sit\u00e4 kuvaavana funktiona kuutiosplini\u00e4. T\u00e4ll\u00f6in malliin saadaan k\u00e4yr\u00e4muoto. Mallinnus tehd\u00e4\u00e4n riskisummille erikseen. N\u00e4iden lis\u00e4ksi selitt\u00e4viksi muuttujiksi on valittu painoindeksi, ruokavalion terveellisyytt\u00e4 kuvaava indeksi, sukupuoli, interventio- ja kontrolliryhm\u00e4\u00e4n kuuluminen sek\u00e4 ik\u00e4 tutkimusk\u00e4ynnill\u00e4. Osassa malleista on riskisumman ja sukupuolen v\u00e4linen interaktiotermi.\n\nToteutetuissa mallinnuksissa ilman riskisumman ja sukupuolen v\u00e4list\u00e4 interaktiotermi\u00e4 AD:n geneettisell\u00e4 riskill\u00e4 ei ollut merkitsev\u00e4\u00e4 vaikutusta seerumin insuliinipitoisuuksiin. Osassa malleista kyseinen interaktiotermi nousi merkitsev\u00e4ksi. Muita merkitsevi\u00e4 muuttujia malleissa olivat interventio- ja kontrolliryhm\u00e4\u00e4n kuuluminen sek\u00e4 painoindeksi.", "language": "fi", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Submitted by Miia Hakanen (mihakane@jyu.fi) on 2022-06-06T11:15:39Z\nNo. of bitstreams: 0", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Made available in DSpace on 2022-06-06T11:15:39Z (GMT). No. of bitstreams: 0\n Previous issue date: 2022", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.format.extent", "value": "58", "language": "", "element": "format", "qualifier": "extent", "schema": "dc"}, {"key": "dc.format.mimetype", "value": "application/pdf", "language": null, "element": "format", "qualifier": "mimetype", "schema": "dc"}, {"key": "dc.language.iso", "value": "fin", "language": null, "element": "language", "qualifier": "iso", "schema": "dc"}, {"key": "dc.rights", "value": "In Copyright", "language": "en", "element": "rights", "qualifier": null, "schema": "dc"}, {"key": "dc.subject.other", "value": "additiivinen sekamalli", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "kuutiosplini", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "geneettinen riski", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "STRIP-tutkimus", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.title", "value": "Additiivinen sekamalli : sovelluksena Alzheimerin taudin geneettisen riskin vaikutus insuliinin arvoihin", "language": "", "element": "title", "qualifier": null, "schema": "dc"}, {"key": "dc.type", "value": "master thesis", "language": null, "element": "type", "qualifier": null, "schema": "dc"}, {"key": "dc.identifier.urn", "value": "URN:NBN:fi:jyu-202206063128", "language": "", "element": "identifier", "qualifier": "urn", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Pro gradu -tutkielma", "language": "fi", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Master\u2019s thesis", "language": "en", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Matemaattis-luonnontieteellinen tiedekunta", "language": "fi", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Faculty of Sciences", "language": "en", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Matematiikan ja tilastotieteen laitos", "language": "fi", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Department of Mathematics and Statistics", "language": "en", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "Jyv\u00e4skyl\u00e4n yliopisto", "language": "fi", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "University of Jyv\u00e4skyl\u00e4", "language": "en", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Tilastotiede", "language": "fi", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Statistics", "language": "en", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "yvv.contractresearch.funding", "value": "0", "language": "", "element": "contractresearch", "qualifier": "funding", "schema": "yvv"}, {"key": "dc.type.coar", "value": "http://purl.org/coar/resource_type/c_bdcc", "language": null, "element": "type", "qualifier": "coar", "schema": "dc"}, {"key": "dc.rights.accesslevel", "value": "restrictedAccess", "language": null, "element": "rights", "qualifier": "accesslevel", "schema": "dc"}, {"key": "dc.type.publication", "value": "masterThesis", "language": null, "element": "type", "qualifier": "publication", "schema": "dc"}, {"key": "dc.subject.oppiainekoodi", "value": "4043", "language": "", "element": "subject", "qualifier": "oppiainekoodi", "schema": "dc"}, {"key": "dc.subject.yso", "value": "Alzheimerin tauti", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "insuliini", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "tilastotiede", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.format.content", "value": "fulltext", "language": null, "element": "format", "qualifier": "content", "schema": "dc"}, {"key": "dc.rights.url", "value": "https://rightsstatements.org/page/InC/1.0/", "language": null, "element": "rights", "qualifier": "url", "schema": "dc"}, {"key": "dc.rights.accessrights", "value": "The author has not given permission to make the work publicly available electronically. Therefore the material can be read only at the archival workstation at Jyv\u00e4skyl\u00e4 University Library (https://kirjasto.jyu.fi/collections/archival-workstation).", "language": "en", "element": "rights", "qualifier": "accessrights", "schema": "dc"}, {"key": "dc.rights.accessrights", "value": "Tekij\u00e4 ei ole antanut lupaa avoimeen julkaisuun, joten aineisto on luettavissa vain Jyv\u00e4skyl\u00e4n yliopiston kirjaston arkistoty\u00f6semalta. Ks. https://kirjasto.jyu.fi/kokoelmat/arkistotyoasema..", "language": "fi", "element": "rights", "qualifier": "accessrights", "schema": "dc"}, {"key": "dc.type.okm", "value": "G2", "language": null, "element": "type", "qualifier": "okm", "schema": "dc"}]
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