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[{"key": "dc.contributor.advisor", "value": "Jalasvuori, Matti", "language": "", "element": "contributor", "qualifier": "advisor", "schema": "dc"}, {"key": "dc.contributor.advisor", "value": "Per\u00e4kyl\u00e4, Juuli", "language": "", "element": "contributor", "qualifier": "advisor", "schema": "dc"}, {"key": "dc.contributor.advisor", "value": "Given, Cindy", "language": "", "element": "contributor", "qualifier": "advisor", "schema": "dc"}, {"key": "dc.contributor.author", "value": "Gynther, Veera", "language": "", "element": "contributor", "qualifier": "author", "schema": "dc"}, {"key": "dc.contributor.author", "value": "Loula, Tuomo", "language": "", "element": "contributor", "qualifier": "author", "schema": "dc"}, {"key": "dc.contributor.author", "value": "Moisio, Vilma", "language": "", "element": "contributor", "qualifier": "author", "schema": "dc"}, {"key": "dc.date.accessioned", "value": "2022-01-31T06:53:43Z", "language": null, "element": "date", "qualifier": "accessioned", "schema": "dc"}, {"key": "dc.date.available", "value": "2022-01-31T06:53:43Z", "language": null, "element": "date", "qualifier": "available", "schema": "dc"}, {"key": "dc.date.issued", "value": "2021", "language": "", "element": "date", "qualifier": "issued", "schema": "dc"}, {"key": "dc.identifier.uri", "value": "https://jyx.jyu.fi/handle/123456789/79563", "language": null, "element": "identifier", "qualifier": "uri", "schema": "dc"}, {"key": "dc.description.abstract", "value": "Antibioottiresistenssi on kasvava ongelma bakteerien aiheuttamien infektiotautien hoidossa, ja sit\u00e4 on pyritty ratkaisemaan k\u00e4ytt\u00e4m\u00e4ll\u00e4 hoitomuotona bakteereita infektoivia faageja. Bakteerien on havaittu kehitt\u00e4v\u00e4n my\u00f6s faageja vastaan resistenssin, mik\u00e4 vaikuttaa bakteerin kelpoisuuteen usein heikent\u00e4v\u00e4sti. Acinetobacter baumannii on Maailman terveysj\u00e4rjest\u00f6n prioriteettipatogeeni. Se on herk\u00e4sti antibiooteille resistentiksi tuleva bakteeri, joka aiheuttaa vakavia opportunistisia infektioita. T\u00e4ss\u00e4 kandidaatintutkielmassa selvitettiin faagiresistenssin muodostumisen vaikutuksia Acinetobacter baumannii -sairaalabakteerin kasvuominaisuuksiin. Potilasn\u00e4ytteist\u00e4 eristetyt Acinetobacter baumannii -kannat altistettiin niit\u00e4 infektoiville faageille. Resistenssin kehitt\u00e4neiden ja altistamattomien kantojen kasvuominaisuuksia vertailtiin spektrofotometrisesti Bioscreen C -mittauksella. Resistenssin kehittymisen havaittiin p\u00e4\u00e4osin heikent\u00e4v\u00e4n bakteerien kasvuominaisuuksia. Suurin saavutettu bakteerim\u00e4\u00e4r\u00e4 pieneni jokaisella resistentill\u00e4 kannalla ja suurin kasvunopeus heikentyi l\u00e4hes jokaisella resistentill\u00e4 kannalla verrattuna altistamattomiin kantoihin. Kasvun heikentyminen on yhteydess\u00e4 muun muassa bakteerin virulenssin alenemiseen ja antibioottiherkkyyden kasvuun. Tutkimuksesta saatuja tuloksia voidaan n\u00e4in ollen hy\u00f6dynt\u00e4\u00e4 faagiterapian ja antibioottien yhdistelm\u00e4hoitojen kehitt\u00e4misess\u00e4.", "language": "fi", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.abstract", "value": "Antibiotic resistance is a growing concern among treatment of infections caused by bacteria. Phages have been proposed as an alternative treatment method. Bacteria can develop a resistance for phages, often having a negative effect on bacterial fitness. Acinetobacter baumannii is a priority pathogen of World Health Organization, developing antibiotic resistance easily and causing serious opportunistic infections in hospitals. In this bachelor's thesis, the effects of phage resistance on growth characteristics of Acinetobacter baumannii were studied. Bacterial strains from patients were exposed to phages capable of infecting them. The strains with developed phage resistance and strains not exposed to phages were then compared spectrophotometrically by Bioscreen C measurements. The development of phage resistance was detected to mainly weaken bacterial growth. Maximum bacterial population was reduced with every phage resistant strain and maximum growth rate was reduced with almost every phage resistant strain compared to its respective unexposed strain. The inhibition in growth is connected to, for example, decline in virulence and increased antibiotic sensitivity. As such, the results of this study bring promise towards phage therapy and antibiotic combination treatment development.", "language": "en", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Submitted by Paivi Vuorio (paelvuor@jyu.fi) on 2022-01-31T06:53:43Z\nNo. of bitstreams: 0", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Made available in DSpace on 2022-01-31T06:53:43Z (GMT). No. of bitstreams: 0\n Previous issue date: 2021", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.format.extent", "value": "30", "language": "", "element": "format", "qualifier": "extent", "schema": "dc"}, {"key": "dc.language.iso", "value": "fin", "language": null, "element": "language", "qualifier": "iso", "schema": "dc"}, {"key": "dc.rights", "value": "In Copyright", "language": "en", "element": "rights", "qualifier": null, "schema": "dc"}, {"key": "dc.subject.other", "value": "suurin bakteerim\u00e4\u00e4r\u00e4", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "suurin kasvunopeus", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.title", "value": "Faagiresistenssin vaikutus Acinetobacter baumannii -sairaalabakteerin kasvuominaisuuksiin", "language": "", "element": "title", "qualifier": null, "schema": "dc"}, {"key": "dc.type", "value": "bachelor thesis", "language": null, "element": "type", "qualifier": null, "schema": "dc"}, {"key": "dc.identifier.urn", "value": "URN:NBN:fi:jyu-202201311330", "language": "", "element": "identifier", "qualifier": "urn", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Bachelor's thesis", "language": "en", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Kandidaatinty\u00f6", "language": "fi", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Matemaattis-luonnontieteellinen tiedekunta", "language": "fi", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Faculty of Sciences", "language": "en", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Bio- ja ymp\u00e4rist\u00f6tieteiden laitos", "language": "fi", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Department of Biological and Environmental Science", "language": "en", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "Jyv\u00e4skyl\u00e4n yliopisto", "language": "fi", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "University of Jyv\u00e4skyl\u00e4", "language": "en", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Solu- ja molekyylibiologia", "language": "fi", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Cell and molecular biology", "language": "en", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "yvv.contractresearch.funding", "value": "0", "language": "", "element": "contractresearch", "qualifier": "funding", "schema": "yvv"}, {"key": "dc.type.coar", "value": "http://purl.org/coar/resource_type/c_7a1f", "language": null, "element": "type", "qualifier": "coar", "schema": "dc"}, {"key": "dc.rights.accesslevel", "value": "openAccess", "language": null, "element": "rights", "qualifier": "accesslevel", "schema": "dc"}, {"key": "dc.type.publication", "value": "bachelorThesis", "language": null, "element": "type", "qualifier": "publication", "schema": "dc"}, {"key": "dc.subject.oppiainekoodi", "value": "4013", "language": "", "element": "subject", "qualifier": "oppiainekoodi", "schema": "dc"}, {"key": "dc.subject.yso", "value": "fagiterapia", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "bakteerit", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "resistenssi", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "mikrobiologia", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "infektiot", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "Acinetobacter baumannii", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "sairaalainfektiot", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "mikrobil\u00e4\u00e4kkeet", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.rights.url", "value": "https://rightsstatements.org/page/InC/1.0/", "language": null, "element": "rights", "qualifier": "url", "schema": "dc"}]
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