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[{"key": "dc.contributor.advisor", "value": "Multanen, Juhani", "language": "", "element": "contributor", "qualifier": "advisor", "schema": "dc"}, {"key": "dc.contributor.advisor", "value": "Parviainen, Tiina", "language": "", "element": "contributor", "qualifier": "advisor", "schema": "dc"}, {"key": "dc.contributor.advisor", "value": "Karjalainen, Teemu", "language": "", "element": "contributor", "qualifier": "advisor", "schema": "dc"}, {"key": "dc.contributor.author", "value": "Raatikainen, Saara", "language": "", "element": "contributor", "qualifier": "author", "schema": "dc"}, {"key": "dc.date.accessioned", "value": "2021-12-07T07:23:02Z", "language": null, "element": "date", "qualifier": "accessioned", "schema": "dc"}, {"key": "dc.date.available", "value": "2021-12-07T07:23:02Z", "language": null, "element": "date", "qualifier": "available", "schema": "dc"}, {"key": "dc.date.issued", "value": "2021", "language": "", "element": "date", "qualifier": "issued", "schema": "dc"}, {"key": "dc.identifier.uri", "value": "https://jyx.jyu.fi/handle/123456789/78889", "language": null, "element": "identifier", "qualifier": "uri", "schema": "dc"}, {"key": "dc.description.abstract", "value": "T\u00e4m\u00e4n pro gradu -tutkielman tavoitteena oli tarkastella tuntoaivokuoren toimintaa murtumapotilailla varhaisessa toipumisvaiheessa. Aiemmissa aivokuvantamis- ja kliinisiss\u00e4 tutkimuksissa on tarkasteltu somatosensorisen j\u00e4rjestelm\u00e4n plastisia muutoksia vammojen kroonisessa toipumisvaiheessa ja komplisoituneissa tapauksissa tai kokeellisin menetelmin terveill\u00e4 koehenkil\u00f6ill\u00e4. Ei-komplisoituneisiin ja ei hermovammaa sis\u00e4lt\u00e4viin raajavammoihin liittyv\u00e4\u00e4 tuntoaivokuoren toimintaa ei ole juurikaan tutkittu tai raportoitu kirjallisuudessa, etenk\u00e4\u00e4n varhaisen toipumisvaiheen osalta. Raajavammojen j\u00e4lkeiseen heikkoon toipumiseen mahdollisesti altistavien neuraalisten mekanismien tunnistamiseksi erilaisia hermostollisia mekanismeja tulisi tarkastella ja ymm\u00e4rt\u00e4\u00e4 tarkemmin yleisess\u00e4 raajavammajoukossa. T\u00e4m\u00e4 tutkielma pyrki hakemaan vastauksia kahteen kysymykseen: 1. Eroavatko tuntoaivokuoren her\u00e4tevasteet toisistaan murtumapotilaiden ja terveiden verrokkien v\u00e4lill\u00e4? 2. Eroavatko tuntoaivokuoren her\u00e4tevasteet toistaan vammautuneen ja terveen puolen v\u00e4lill\u00e4?\n\nT\u00e4h\u00e4n tutkimukseen rekrytoitiin 10 tervett\u00e4 henkil\u00f6\u00e4 ja 9 rannemurtumapotilasta. Murtumasta oli tutkimushetkell\u00e4 kulunut keskim\u00e4\u00e4rin 9 viikkoa, immobilisaation kesto oli keskim\u00e4\u00e4rin 5 viikkoa ja potilaat olivat p\u00e4\u00e4osin oireettomia. Tunto\u00e4rsykkeen\u00e4 k\u00e4ytettiin s\u00e4hk\u00f6ist\u00e4, kivutonta stimulusta, joka annettiin eriaikaisesti molempiin k\u00e4siin, ja somatosensoriset aivokuoren her\u00e4tevasteet mitattiin MEG:lla (magnetoenkefalografialla). Lis\u00e4ksi tutkittavien k\u00e4sien tuntoa arvioitiin kliinisien testien avulla, jolla saatiin tutkimusjoukkoa kuvaavaa tietoa. P\u00e4\u00e4tulosmuuttujana oli tuntoaivokuorelta mitattujen her\u00e4tevasteiden huippuamplitudit.\n\nAivokuorelta mitatut vasteet paikannettiin molemmissa ryhmiss\u00e4 temporoparietaalisille alueille, kahdessa aikaikkunassa (39-69 ms ja 90-110 ms \u00e4rsykkeen j\u00e4lkeen). Huippuvasteiden oletettiin kuvastavan S1 ja S2 (primaarinen ja sekundaarinen tuntoaivokuori) toimintaa. Yhdess\u00e4k\u00e4\u00e4n ryhmien tai puolien (oikea vs. vasen, vamma vs. terve) v\u00e4lisiss\u00e4 vertailuissa ei havaittu tilastollisesti merkitsevi\u00e4 eroja mitatuissa huippuamplitudeissa, kummallakaan aivoalueella. Parietaalialueella havaittiin suuntaus voimakkaampiin kontralateraalisiin vasteisiin murtuneen k\u00e4den osalta verrokkeihin (35 %) ja terveeseen k\u00e4teen (26 %) verrattuna. Aivopuoliskojen v\u00e4linen (kontra- vs. ipsilateraalinen vaste) suhde korostui niill\u00e4 potilailla (n=3), joilla ilmeni eniten oireita kliinisess\u00e4 tutkimuksessa.", "language": "fi", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.abstract", "value": "The aim of this master\u2019s thesis was to explore cortical somatosensory function in a general fracture patient population during a subacute recovery phase. Previous brain imaging and clinical studies have explored plastic changes in the somatosensory system in chronic and complicated limb injury cases or in experimental studies on healthy subjects. There is very limited evidence and literature available that would describe cortical somatosensory nervous system responses to non-neural and non-complicated limb injuries, particularly in the early-to-mid phases of recovery. In order to gain perspective of neural mechanisms that may act as predisposing factors for poor recovery after a limb injury, different neural mechanisms and changes in a general limb injury population need to be explored and understood better. This study aimed at answering two questions: 1. Do cortical somatosensory evoked responses differ between fracture patients and healthy controls? 2. Do cortical somatosensory evoked responses differ between the affected and non-affected sides?\n\nTen healthy subjects and 9 distal radius fracture patients were recruited for this study. The mean time from the fracture was 9 weeks at the time of assessment, mean duration of immobilization was 5 weeks and patients were mainly asymptomatic. Somatosensory evoked responses were triggered using an electronic, non-painful stimulus to both hands separately and cortical responses were recorded using MEG (magnetoencephalography). Clinical assessment focusing on sensory function of the hands was carried out in all participants to provide descriptive data of the study population. Main outcomes were the peak amplitudes of stimulus evoked somatosensory cortical responses.\n\nCortical responses were retrieved to temporoparietal areas in two time windows (39-69 ms and 90-110 ms post stimulus) in both groups. The peak responses were assumed to reflect S1 and S2 (primary and secondary somatosensory cortex) activity. There were no statistically significant differences in any of the analyzed peak amplitudes between groups or between sides (right vs left, affected vs non-affected) in either cortical area. A tendency for stronger contralateral parietal cortex activity was noted for the fractured hand stimuli when compared to healthy controls (35 %) or to the healthy side (26 %). Within person interhemispheric relationship (contra vs ipsilateral response) was further enhanced in those patients (n=3) that presented with several symptoms or sensory signs in the clinical assessment.", "language": "en", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Submitted by Paivi Vuorio (paelvuor@jyu.fi) on 2021-12-07T07:23:02Z\nNo. of bitstreams: 0", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Made available in DSpace on 2021-12-07T07:23:02Z (GMT). No. of bitstreams: 0\n Previous issue date: 2021", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.format.extent", "value": "82", "language": "", "element": "format", "qualifier": "extent", "schema": "dc"}, {"key": "dc.format.mimetype", "value": "application/pdf", "language": null, "element": "format", "qualifier": "mimetype", "schema": "dc"}, {"key": "dc.language.iso", "value": "eng", "language": null, "element": "language", "qualifier": "iso", "schema": "dc"}, {"key": "dc.rights", "value": "In Copyright", "language": "en", "element": "rights", "qualifier": null, "schema": "dc"}, {"key": "dc.subject.other", "value": "somatosensorinen her\u00e4tevaste", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "tuntoaivokuori", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.title", "value": "Cortical somatosensory evoked responses in a subacute phase after a limb injury : an explorative MEG study.", "language": "", "element": "title", "qualifier": null, "schema": "dc"}, {"key": "dc.type", "value": "master thesis", "language": null, "element": "type", "qualifier": null, "schema": "dc"}, {"key": "dc.identifier.urn", "value": "URN:NBN:fi:jyu-202112075881", "language": "", "element": "identifier", "qualifier": "urn", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Pro gradu -tutkielma", "language": "fi", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Master\u2019s thesis", "language": "en", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Liikuntatieteellinen tiedekunta", "language": "fi", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Faculty of Sport and Health Sciences", "language": "en", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Liikunta- ja terveystieteet", "language": "fi", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Sport and Health Sciences", "language": "en", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "Jyv\u00e4skyl\u00e4n yliopisto", "language": "fi", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "University of Jyv\u00e4skyl\u00e4", "language": "en", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Fysioterapia", "language": "fi", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Physiotherapy", "language": "en", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "yvv.contractresearch.collaborator", "value": "public", "language": "", "element": "contractresearch", "qualifier": "collaborator", "schema": "yvv"}, {"key": "yvv.contractresearch.funding", "value": "0", "language": "", "element": "contractresearch", "qualifier": "funding", "schema": "yvv"}, {"key": "yvv.contractresearch.initiative", "value": "university", "language": "", "element": "contractresearch", "qualifier": "initiative", "schema": "yvv"}, {"key": "dc.type.coar", "value": "http://purl.org/coar/resource_type/c_bdcc", "language": null, "element": "type", "qualifier": "coar", "schema": "dc"}, {"key": "dc.rights.accesslevel", "value": "restrictedAccess", "language": null, "element": "rights", "qualifier": "accesslevel", "schema": "dc"}, {"key": "dc.type.publication", "value": "masterThesis", "language": null, "element": "type", "qualifier": "publication", "schema": "dc"}, {"key": "dc.subject.oppiainekoodi", "value": "50422", "language": "", "element": "subject", "qualifier": "oppiainekoodi", "schema": "dc"}, {"key": "dc.subject.yso", "value": "MEG", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "murtumat", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "aivokuori", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "tuntoaisti", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "MEG", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "fractures", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "cerebral cortex", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "sense of feeling", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.format.content", "value": "fulltext", "language": null, "element": "format", "qualifier": "content", "schema": "dc"}, {"key": "dc.rights.url", "value": "https://rightsstatements.org/page/InC/1.0/", "language": null, "element": "rights", "qualifier": "url", "schema": "dc"}, {"key": "dc.rights.accessrights", "value": "The author has not given permission to make the work publicly available electronically. Therefore the material can be read only at the archival workstation at Jyv\u00e4skyl\u00e4 University Library (https://kirjasto.jyu.fi/collections/archival-workstation).", "language": "en", "element": "rights", "qualifier": "accessrights", "schema": "dc"}, {"key": "dc.rights.accessrights", "value": "Tekij\u00e4 ei ole antanut lupaa avoimeen julkaisuun, joten aineisto on luettavissa vain Jyv\u00e4skyl\u00e4n yliopiston kirjaston arkistoty\u00f6semalta. Ks. https://kirjasto.jyu.fi/kokoelmat/arkistotyoasema..", "language": "fi", "element": "rights", "qualifier": "accessrights", "schema": "dc"}, {"key": "dc.type.okm", "value": "G2", "language": null, "element": "type", "qualifier": "okm", "schema": "dc"}]
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