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[{"key": "dc.contributor.advisor", "value": "Pekkala, Satu", "language": "", "element": "contributor", "qualifier": "advisor", "schema": "dc"}, {"key": "dc.contributor.advisor", "value": "Ketola, Tarmo", "language": "", "element": "contributor", "qualifier": "advisor", "schema": "dc"}, {"key": "dc.contributor.author", "value": "Kunnas, Kari", "language": "", "element": "contributor", "qualifier": "author", "schema": "dc"}, {"key": "dc.date.accessioned", "value": "2021-08-03T06:47:53Z", "language": null, "element": "date", "qualifier": "accessioned", "schema": "dc"}, {"key": "dc.date.available", "value": "2021-08-03T06:47:53Z", "language": null, "element": "date", "qualifier": "available", "schema": "dc"}, {"key": "dc.date.issued", "value": "2021", "language": "", "element": "date", "qualifier": "issued", "schema": "dc"}, {"key": "dc.identifier.uri", "value": "https://jyx.jyu.fi/handle/123456789/77262", "language": null, "element": "identifier", "qualifier": "uri", "schema": "dc"}, {"key": "dc.description.abstract", "value": "Paljon energiaa sis\u00e4lt\u00e4v\u00e4n ravinnon lis\u00e4\u00e4ntyminen osana tavallista ruokavaliota on viimeisten vuosikymmenien aikana todettu johtavan ylipainosta aiheutuviin terveyshaittoihin ja muuttavan suolistomikrobiston rakennetta. Viime vuosien aikana on tullut lis\u00e4\u00e4 n\u00e4ytt\u00f6\u00e4, joka viittaa suoliston ja aivojen v\u00e4liseen yhteyteen, jota kutsutaan suoli-aivo-akseliksi. Suolistobakteeri Faecalibacterium prausnitziin m\u00e4\u00e4r\u00e4n on todettu olevan yhteydess\u00e4 niin suoliston h\u00e4iri\u00f6iden, kuin masennuksen ja ahdistuksen kaltaisten h\u00e4iri\u00f6iden lieventymiseen, mik\u00e4 viittaa sen vaikuttavan sek\u00e4 suoliston ett\u00e4 aivojen terveyteen. F. prausnitzii on eritt\u00e4in anaerobinen, mik\u00e4 tekee sen k\u00e4yt\u00f6st\u00e4 probioottina vaikeaa. T\u00e4ss\u00e4 tutkimuksessa sen m\u00e4\u00e4r\u00e4\u00e4n pyrittiin vaikuttamaan prebioottisen xylo-oligosakkaridin (XOS) avulla sellaisten rottien suolistossa, joille sy\u00f6tettiin v\u00e4h\u00e4- tai korkearasvaista ruokaa, joko XOS:n kanssa tai ilman. Pyrin selvitt\u00e4m\u00e4\u00e4n korkearasvaisen ruokavalion ja XOS:n vaikutusta F. prausnitziin m\u00e4\u00e4r\u00e4\u00e4n sek\u00e4 aikuisi\u00e4n neurogeneesiin ja inflammaatioon aivotursossa. Kahdentoista viikon ravitsemusintervetion j\u00e4lkeen rotat lopetettiin, niiden aivot viipaloitiin leikkeiksi ja v\u00e4rj\u00e4ttiin immunohistologisin menetelmin. Korkearasvaisen ruokavalion todettiin johtavan suurempaan painonnousuun ja v\u00e4h\u00e4rasvaisen ruokavalion havaittiin XOS:n kanssa johtavan korkeampaan F. prausnitziin m\u00e4\u00e4r\u00e4\u00e4n. Ryhmien v\u00e4liset erot mikrogliojen aktiivisuuden merkkiaineissa olivat yll\u00e4tt\u00e4vi\u00e4: v\u00e4h\u00e4rasvainen ruoka vaikutti olevan yhteydess\u00e4 korkeampaan aktiivisuustasoon. Uusien hermosolujen m\u00e4\u00e4r\u00e4t olivat ryhmiss\u00e4 samalla tasolla, viitaten siihen, ettei ruokavalio vaikuttanut neurogeneesiin.", "language": "fi", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.abstract", "value": "The increase in high energy food as a part of regular nutrition in the last decades has been shown to cause negative health effects related to obesity and to alter the gut microbiota composition. In the past years, the amount of evidence pointing towards a connection between the gut microbiota and the brain, the gut-brain axis (GBA), has increased. Previous studies have shown a link between the abundance of a specific gut microbe, Faecalibacterium prausnitzii, and improvements in intestinal disorders as well as depression-like and anxiety-like behavior, suggesting that it influences both gut and brain health. F. prausnitzii is extremely oxygen sensitive, making its use as a probiotic difficult. Thus, its abundance was attempted to be manipulated by using a prebiotic fiber, xylo-oligosaccharide (XOS), in rats fed with high or low-fat feed. XOS has been shown to affect the abundance of F. prausnitzii in the gut. In this study the effects of a high-fat diet and/or dietary XOS on F. prausnitzii, and hippocampal inflammation and adult neurogenesis were examined. After a twelve-week dietary intervention, the rats were euthanized, and their hippocampi were sectioned and stained with immunohistological methods. The high-fat diet was found to increase weight gain and a low-fat diet with XOS was observed to have a positive influence on the abundance of F. prausnitzii. There were unexpected differences in the markers of activated microglia between the groups, as the low-fat diet seemed to associate with higher levels of markers. The number of newborn neurons did not differ between the groups, suggesting that the different diets did not affect adult neurogenesis.", "language": "en", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Submitted by Paivi Vuorio (paelvuor@jyu.fi) on 2021-08-03T06:47:53Z\nNo. of bitstreams: 0", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Made available in DSpace on 2021-08-03T06:47:53Z (GMT). No. of bitstreams: 0\n Previous issue date: 2021", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.format.extent", "value": "58", "language": "", "element": "format", "qualifier": "extent", "schema": "dc"}, {"key": "dc.format.mimetype", "value": "application/pdf", "language": null, "element": "format", "qualifier": "mimetype", "schema": "dc"}, {"key": "dc.language.iso", "value": "eng", "language": null, "element": "language", "qualifier": "iso", "schema": "dc"}, {"key": "dc.rights", "value": "In Copyright", "language": "en", "element": "rights", "qualifier": null, "schema": "dc"}, {"key": "dc.subject.other", "value": "F. prausnitzii", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "gut-brain axis", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.title", "value": "Effects of high-fat diet and prebiotic fiber supplementation on hippocampal inflammation and adult neurogenesis", "language": "", "element": "title", "qualifier": null, "schema": "dc"}, {"key": "dc.type", "value": "master thesis", "language": null, "element": "type", "qualifier": null, "schema": "dc"}, {"key": "dc.identifier.urn", "value": "URN:NBN:fi:jyu-202108034430", "language": "", "element": "identifier", "qualifier": "urn", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Pro gradu -tutkielma", "language": "fi", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Master\u2019s thesis", "language": "en", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Matemaattis-luonnontieteellinen tiedekunta", "language": "fi", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Faculty of Sciences", "language": "en", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Bio- ja ymp\u00e4rist\u00f6tieteiden laitos", "language": "fi", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Department of Biological and Environmental Science", "language": "en", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "Jyv\u00e4skyl\u00e4n yliopisto", "language": "fi", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "University of Jyv\u00e4skyl\u00e4", "language": "en", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Solu- ja molekyylibiologia", "language": "fi", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Cell and molecular biology", "language": "en", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "yvv.contractresearch.funding", "value": "0", "language": "", "element": "contractresearch", "qualifier": "funding", "schema": "yvv"}, {"key": "dc.type.coar", "value": "http://purl.org/coar/resource_type/c_bdcc", "language": null, "element": "type", "qualifier": "coar", "schema": "dc"}, {"key": "dc.rights.accesslevel", "value": "openAccess", "language": null, "element": "rights", "qualifier": "accesslevel", "schema": "dc"}, {"key": "dc.type.publication", "value": "masterThesis", "language": null, "element": "type", "qualifier": "publication", "schema": "dc"}, {"key": "dc.subject.oppiainekoodi", "value": "4013", "language": "", "element": "subject", "qualifier": "oppiainekoodi", "schema": "dc"}, {"key": "dc.subject.yso", "value": "ksylo-oligosakkaridit", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "aivot", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "ruokavaliot", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "suolistomikrobisto", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "probiootit", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "prebiootit", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "hermosto", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "hippokampus", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "xylooligosaccharides", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "brain", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "diets", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "gastrointestinal microbiota", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "probiotics", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "prebiotics", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "nervous system", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "hippocampus", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.format.content", "value": "fulltext", "language": null, "element": "format", "qualifier": "content", "schema": "dc"}, {"key": "dc.rights.url", "value": "https://rightsstatements.org/page/InC/1.0/", "language": null, "element": "rights", "qualifier": "url", "schema": "dc"}, {"key": "dc.type.okm", "value": "G2", "language": null, "element": "type", "qualifier": "okm", "schema": "dc"}]
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