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[{"key": "dc.contributor.advisor", "value": "Nissinen, Maija", "language": "", "element": "contributor", "qualifier": "advisor", "schema": "dc"}, {"key": "dc.contributor.author", "value": "Liljedahl, Ia-Beate", "language": "", "element": "contributor", "qualifier": "author", "schema": "dc"}, {"key": "dc.date.accessioned", "value": "2021-08-02T07:33:24Z", "language": null, "element": "date", "qualifier": "accessioned", "schema": "dc"}, {"key": "dc.date.available", "value": "2021-08-02T07:33:24Z", "language": null, "element": "date", "qualifier": "available", "schema": "dc"}, {"key": "dc.date.issued", "value": "2021", "language": "", "element": "date", "qualifier": "issued", "schema": "dc"}, {"key": "dc.identifier.uri", "value": "https://jyx.jyu.fi/handle/123456789/77253", "language": null, "element": "identifier", "qualifier": "uri", "schema": "dc"}, {"key": "dc.description.abstract", "value": "T\u00e4m\u00e4n pro gradu -tutkielman kirjallisuuskatsaus k\u00e4sittelee grafeenipohjaisia l\u00e4\u00e4kekuljettimia. Tutkielmassa perehdyt\u00e4\u00e4n grafeenin ja sen johdannaisten, grafeenioksidin ja pelkistetyn grafeenioksidin, kemiallisiin ominaisuuksiin ja funktionalisointiin sek\u00e4 grafeeniin pohjautuvien materiaalien biologiseen k\u00e4ytt\u00e4ytymiseen, mukaan lukien k\u00e4ytt\u00e4ytyminen biologisissa nesteiss\u00e4, biokertyminen, annostelureitit, immuunivasteet ja tulehdukselliset vasteet, solutargetointi, solumyrkyllisyys ja k\u00e4ytt\u00e4ytyminen veren komponenttien kanssa. Lis\u00e4ksi esitell\u00e4\u00e4n sy\u00f6p\u00e4l\u00e4\u00e4keaineiden liitt\u00e4minen grafeenipohjaisiin l\u00e4\u00e4keainekuljettimiin ja l\u00e4\u00e4keaineiden vapauttaminen alustoista. \nKokeellista osiota alustavassa miniprojektissa valmistettiin grafeenioksidiin ja pelkistettyyn grafeenioksidiin pohjautuvat yhdisteet, GO-PheOtBu ja rGO-PheOtBu Jyv\u00e4skyl\u00e4n yliopistossa. Tutkielman kokeellinen osio suoritettiin Orionilla, ja ty\u00f6n tavoite oli valmistaa grafeenioksidiin pohjautuvia konjugaatteja, joihin liitettyj\u00e4 linkkereit\u00e4 voidaan hy\u00f6dynt\u00e4\u00e4 SPAAC-reaktioissa. SPAAC-reaktioissa tavoite oli muodostaa 1,2,3-triatsoli bisyklononyynin sis\u00e4lt\u00e4m\u00e4n konjugaatin ja syntetisoidun pienmolekyylin atsidiryhm\u00e4n avulla. Projektissa valmistettiin rGO-amiini-BCN-PEG konjugaatti, jonka rakenne vahvistettiin FT-IR karakterisoinnilla.", "language": "fi", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.abstract", "value": "The literature part of this Master's thesis will focus on graphene-based nanomaterials as drug delivery platforms. The chemical properties and functionalization of pristine graphene and its oxygen-containing derivatives, graphene oxide and reduced graphene oxide, will be discussed. The biological behaviour of the graphene-based nanomaterials is introduced, including behaviour in biological fluids, bioaccumulation, administration routes, immune and inflammatory reply, cell targeting, cellular toxicity and behaviour with the blood components. The attachment of multiple anticancer drugs to the graphene-based platforms and the release of the drugs from them is described.\nThe miniproject was an introductory project for the experimental part. Graphene oxide and reduced graphene oxide-based constructs with phenylalanine tert-butyl ester were synthesized and characterized at the University of Jyv\u00e4skyl\u00e4. In the experimental part, conducted at Orion Corporation, the aim was to synthesize graphene oxide-based conjugates having covalently bound linker for strain promoted alkyne-azide cycloaddition (SPAAC). In the SPAAC reactions, bicyclononyne (BCN) containing conjugate and an azide group of the synthesized small molecule were used to form 1,2,3-triazole. The rGO-amine-BCN-PEG conjugate was successfully synthesized and characterized with FT-IR.", "language": "en", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Submitted by Paivi Vuorio (paelvuor@jyu.fi) on 2021-08-02T07:33:24Z\nNo. of bitstreams: 0", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Made available in DSpace on 2021-08-02T07:33:24Z (GMT). No. of bitstreams: 0\n Previous issue date: 2021", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.format.extent", "value": "106", "language": "", "element": "format", "qualifier": "extent", "schema": "dc"}, {"key": "dc.format.mimetype", "value": "application/pdf", "language": null, "element": "format", "qualifier": "mimetype", "schema": "dc"}, {"key": "dc.language.iso", "value": "eng", "language": null, "element": "language", "qualifier": "iso", "schema": "dc"}, {"key": "dc.rights", "value": "In Copyright", "language": "en", "element": "rights", "qualifier": null, "schema": "dc"}, {"key": "dc.title", "value": "Graphene-based drug delivery platforms", "language": "", "element": "title", "qualifier": null, "schema": "dc"}, {"key": "dc.type", "value": "master thesis", "language": null, "element": "type", "qualifier": null, "schema": "dc"}, {"key": "dc.identifier.urn", "value": "URN:NBN:fi:jyu-202108024421", "language": "", "element": "identifier", "qualifier": "urn", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Pro gradu -tutkielma", "language": "fi", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Master\u2019s thesis", "language": "en", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Matemaattis-luonnontieteellinen tiedekunta", "language": "fi", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Faculty of Sciences", "language": "en", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Kemian laitos", "language": "fi", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Department of Chemistry", "language": "en", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "Jyv\u00e4skyl\u00e4n yliopisto", "language": "fi", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "University of Jyv\u00e4skyl\u00e4", "language": "en", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Orgaaninen kemia", "language": "fi", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Organic Chemistry", "language": "en", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "yvv.contractresearch.funding", "value": "0", "language": "", "element": "contractresearch", "qualifier": "funding", "schema": "yvv"}, {"key": "dc.type.coar", "value": "http://purl.org/coar/resource_type/c_bdcc", "language": null, "element": "type", "qualifier": "coar", "schema": "dc"}, {"key": "dc.rights.accesslevel", "value": "openAccess", "language": null, "element": "rights", "qualifier": "accesslevel", "schema": "dc"}, {"key": "dc.type.publication", "value": "masterThesis", "language": null, "element": "type", "qualifier": "publication", "schema": "dc"}, {"key": "dc.subject.oppiainekoodi", "value": "4035", "language": "", "element": "subject", "qualifier": "oppiainekoodi", "schema": "dc"}, {"key": "dc.subject.yso", "value": "grafeeni", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "grafeenioksidi", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "graphene", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "graphene oxide", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.format.content", "value": "fulltext", "language": null, "element": "format", "qualifier": "content", "schema": "dc"}, {"key": "dc.rights.url", "value": "https://rightsstatements.org/page/InC/1.0/", "language": null, "element": "rights", "qualifier": "url", "schema": "dc"}, {"key": "dc.type.okm", "value": "G2", "language": null, "element": "type", "qualifier": "okm", "schema": "dc"}]
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