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[{"key": "dc.contributor.advisor", "value": "Sillanp\u00e4\u00e4, Elina", "language": "", "element": "contributor", "qualifier": "advisor", "schema": "dc"}, {"key": "dc.contributor.author", "value": "Hokkala, Sara", "language": "", "element": "contributor", "qualifier": "author", "schema": "dc"}, {"key": "dc.date.accessioned", "value": "2021-05-31T17:56:38Z", "language": null, "element": "date", "qualifier": "accessioned", "schema": "dc"}, {"key": "dc.date.available", "value": "2021-05-31T17:56:38Z", "language": null, "element": "date", "qualifier": "available", "schema": "dc"}, {"key": "dc.date.issued", "value": "2021", "language": "", "element": "date", "qualifier": "issued", "schema": "dc"}, {"key": "dc.identifier.uri", "value": "https://jyx.jyu.fi/handle/123456789/76114", "language": null, "element": "identifier", "qualifier": "uri", "schema": "dc"}, {"key": "dc.description.abstract", "value": "Sepelvaltimotauti on monitekij\u00e4inen sairaus, jonka kehittymiseen vaikuttavat perinn\u00f6llinen alttius, ymp\u00e4rist\u00f6 ja elintavat. Sepelvaltimotautiin sairastumisessa, kuolleisuudessa sek\u00e4 riskitekij\u00f6iss\u00e4 on sukupuolten v\u00e4lisi\u00e4 eroja. Estrogeeni suojaa naisia menopaussiin saakka, mink\u00e4 j\u00e4lkeen naisten riskitekij\u00e4t usein nousevat ja sepelvaltimotaudin riski kasvaa. Mit\u00e4 nuorempana menopaussi koetaan, sit\u00e4 korkeampi on sepelvaltimotaudin riski. Sepelvaltimotaudin ja menopaussin ajankohdan on aiemmissa tutkimuksissa spekuloitu selittyv\u00e4n yhteisill\u00e4 geneettisill\u00e4 tekij\u00f6ill\u00e4. T\u00e4ss\u00e4 pro gradu -tutkielmassa tarkasteltiin sepelvaltimotaudin perinteisten riskitekij\u00f6iden, sepelvaltimotaudin geneettisen riskisumman ja menopaussin ajankohdan yhteytt\u00e4 naisten sepelvaltimotautiin. Lis\u00e4ksi tutkittiin ensimm\u00e4ist\u00e4 kertaa, onko sepelvaltimotaudin geneettinen riskisumma yhteydess\u00e4 menopaussin ajankohtaan.\nKoehenkil\u00f6t osallistuivat Finnish Twin Study on Aging (FITSA) -tutkimukseen, jonka alkumittaukset ja kyselyt toteutettiin vuonna 2000\u20132001. Otokseen kuului 434 tutkimushetkell\u00e4 63\u201376-vuotiasta kaksosnaista, joita k\u00e4sitell\u00e4\u00e4n t\u00e4ss\u00e4 tutkielmassa yksil\u00f6in\u00e4. Tutkittavat ovat antaneet suostumuksensa DNA-n\u00e4ytteeseen, josta tehtiin genomin kartoitus k\u00e4ytt\u00e4en Illumina HumanHap610- ja Illumina CoreExome genotyypin muodostusta ja 1000 Genomes -projektin Impute2 v2.3.09 vertailutietoja. Genomianalyysin tietoja k\u00e4ytettiin sepelvaltimotaudin yksil\u00f6llisen geneettisen riskin laskemiseen, perustuen 49 310:een geenivarianttia sis\u00e4lt\u00e4v\u00e4\u00e4n sepelvaltimotaudin riskisummaan ja niiden painokertoimiin. Perinteisten riskitekij\u00f6iden (LDL-kolesteroli, tupakointi, systolinen verenpaine, vy\u00f6t\u00e4r\u00f6n ymp\u00e4rys ja tyypin 2 diabetes) lis\u00e4ksi malleihin sis\u00e4llytettiin menopaussin ajankohta, hormonikorvaushoidon k\u00e4ytt\u00f6 sek\u00e4 koulutuksen kesto ja vapaa-ajan liikunnan m\u00e4\u00e4r\u00e4. Riskitekij\u00f6iden yhteytt\u00e4 sepelvaltimotaudin sairastavuuteen tarkasteltiin bin\u00e4\u00e4risell\u00e4 logistisella regressiolla, muodostaen nelj\u00e4 erilaista mallia. Sepelvaltimotaudin geneettisen riskisumman yhteytt\u00e4 menopaussin ajankohtaan tarkasteltiin kovarianssianalyysilla. \nOtoksen naisista 12 % (n=53) sairasti sepelvaltimotautia tutkimushetkell\u00e4. Pelk\u00e4st\u00e4\u00e4n perinteiset riskitekij\u00e4t selittiv\u00e4t heikosti sepelvaltimotaudin sairastavuutta, mutta sepelvaltimotaudin geneettinen riskisumma ja menopaussin ajankohta lis\u00e4siv\u00e4t selitysastetta merkitt\u00e4v\u00e4sti (11,8 % \u2192 21,1 %). Hormonikorvaushoidon k\u00e4ytt\u00f6, koulutuksen kesto ja liikunnan lis\u00e4\u00e4minen paransivat selitysastetta edelleen (25,9 %). Lopullisessa mallissa tilastollisesti merkitseviksi muuttujiksi osoittautuivat LDL-kolesteroli, systolinen verenpaine, geneettinen riskisumma, hormonikorvaushoito sek\u00e4 koulutuksen kesto. Sepelvaltimotaudin geneettinen riskisumma ei ollut merkitsev\u00e4ss\u00e4 yhteydess\u00e4 menopaussin ajankohdan kanssa (p=0.280), mutta menopaussin ajankohdan keskiarvo vaihteli lineaarisesti ennakko-oletusten mukaisesti, ollen matalin sepelvaltimotaudin korkean geneettisen riskin ryhm\u00e4ss\u00e4. \nT\u00e4m\u00e4 tutkielma osoitti, ett\u00e4 v\u00e4h\u00e4isesti perinteisi\u00e4 riskitekij\u00f6it\u00e4 omaavien ja tavanomaista sepelvaltimotaudin sairastumisik\u00e4\u00e4 nuorempien naisten sepelvaltimotaudin riski\u00e4 arvioitaessa on tarpeen huomioida sek\u00e4 geneettiset tekij\u00e4t ett\u00e4 menopaussi ja hormonikorvaushoidon k\u00e4ytt\u00f6. Tulosten perusteella on todenn\u00e4k\u00f6ist\u00e4, ett\u00e4 sepelvaltimotautia ja menopaussia selitt\u00e4v\u00e4t osittain jaetut geneettiset tekij\u00e4t, ja sepelvaltimotaudin geneettisen riskisumman yhteys menopaussin ajankohtaan tulisikin tarkastaa suuremmalla otoskoolla. Naisten sepelvaltimotaudin biologisten erityispiirteiden tutkimus voi auttaa l\u00f6yt\u00e4m\u00e4\u00e4n ja kohdentamaan entist\u00e4 yksil\u00f6llisempi\u00e4 sepelvaltimotaudin ehk\u00e4isy- ja hoitokeinoja.", "language": "fi", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Submitted by Paivi Vuorio (paelvuor@jyu.fi) on 2021-05-31T17:56:38Z\nNo. of bitstreams: 0", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Made available in DSpace on 2021-05-31T17:56:38Z (GMT). No. of bitstreams: 0\n Previous issue date: 2021", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.format.extent", "value": "92", "language": "", "element": "format", "qualifier": "extent", "schema": "dc"}, {"key": "dc.format.mimetype", "value": "application/pdf", "language": null, "element": "format", "qualifier": "mimetype", "schema": "dc"}, {"key": "dc.language.iso", "value": "fin", "language": null, "element": "language", "qualifier": "iso", "schema": "dc"}, {"key": "dc.rights", "value": "In Copyright", "language": "en", "element": "rights", "qualifier": null, "schema": "dc"}, {"key": "dc.subject.other", "value": "geneettinen riskisumma", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.title", "value": "Perinteisten riskitekij\u00f6iden, geneettisen riskisumman ja menopaussin yhteys naisten sepelvaltimotautiin", "language": "", "element": "title", "qualifier": null, "schema": "dc"}, {"key": "dc.type", "value": "master thesis", "language": null, "element": "type", "qualifier": null, "schema": "dc"}, {"key": "dc.identifier.urn", "value": "URN:NBN:fi:jyu-202105313356", "language": "", "element": "identifier", "qualifier": "urn", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Pro gradu -tutkielma", "language": "fi", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Master\u2019s thesis", "language": "en", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Liikuntatieteellinen tiedekunta", "language": "fi", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Faculty of Sport and Health Sciences", "language": "en", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Liikunta- ja terveystieteet", "language": "fi", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Sport and Health Sciences", "language": "en", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "Jyv\u00e4skyl\u00e4n yliopisto", "language": "fi", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "University of Jyv\u00e4skyl\u00e4", "language": "en", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Gerontologia ja kansanterveys", "language": "fi", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Gerontology and Public Health", "language": "en", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "yvv.contractresearch.funding", "value": "0", "language": "", "element": "contractresearch", "qualifier": "funding", "schema": "yvv"}, {"key": "dc.type.coar", "value": "http://purl.org/coar/resource_type/c_bdcc", "language": null, "element": "type", "qualifier": "coar", "schema": "dc"}, {"key": "dc.rights.accesslevel", "value": "openAccess", "language": null, "element": "rights", "qualifier": "accesslevel", "schema": "dc"}, {"key": "dc.type.publication", "value": "masterThesis", "language": null, "element": "type", "qualifier": "publication", "schema": "dc"}, {"key": "dc.subject.oppiainekoodi", "value": "50423", "language": "", "element": "subject", "qualifier": "oppiainekoodi", "schema": "dc"}, {"key": "dc.subject.yso", "value": "sepelvaltimotauti", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "naiset", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "vaihdevuodet", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "riskitekij\u00e4t", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "syd\u00e4n- ja verisuonitaudit", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "hormonihoito", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "perinn\u00f6llinen alttius", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.format.content", "value": "fulltext", "language": null, "element": "format", "qualifier": "content", "schema": "dc"}, {"key": "dc.rights.url", "value": "https://rightsstatements.org/page/InC/1.0/", "language": null, "element": "rights", "qualifier": "url", "schema": "dc"}, {"key": "dc.type.okm", "value": "G2", "language": null, "element": "type", "qualifier": "okm", "schema": "dc"}]
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