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[{"key": "dc.contributor.advisor", "value": "Vehni\u00e4inen, Eeva-Riikka", "language": "", "element": "contributor", "qualifier": "advisor", "schema": "dc"}, {"key": "dc.contributor.advisor", "value": "Rigaud, Cyril", "language": "", "element": "contributor", "qualifier": "advisor", "schema": "dc"}, {"key": "dc.contributor.advisor", "value": "Eriksson, Andreas", "language": "", "element": "contributor", "qualifier": "advisor", "schema": "dc"}, {"key": "dc.contributor.author", "value": "J\u00e4rvenp\u00e4\u00e4, Kaisa", "language": "", "element": "contributor", "qualifier": "author", "schema": "dc"}, {"key": "dc.date.accessioned", "value": "2021-04-27T09:29:23Z", "language": null, "element": "date", "qualifier": "accessioned", "schema": "dc"}, {"key": "dc.date.available", "value": "2021-04-27T09:29:23Z", "language": null, "element": "date", "qualifier": "available", "schema": "dc"}, {"key": "dc.date.issued", "value": "2021", "language": "", "element": "date", "qualifier": "issued", "schema": "dc"}, {"key": "dc.identifier.uri", "value": "https://jyx.jyu.fi/handle/123456789/75217", "language": null, "element": "identifier", "qualifier": "uri", "schema": "dc"}, {"key": "dc.description.abstract", "value": "Polyaromaattiset hiilivedyt (PAH) ovat ymp\u00e4rist\u00f6ss\u00e4 esiintyvi\u00e4 orgaanisia haitta-aineita, joiden l\u00e4hteit\u00e4 ovat fossiilisten polttoaineiden ep\u00e4t\u00e4ydellinen palaminen ja mets\u00e4palot mutta my\u00f6s esimerkiksi j\u00e4tevedet. Reteeni\u00e4 (7-isopropyyli-1-metyylifenantreeni) havaitaan erityisesti paperi- ja sellutehtaiden alapuolisten vesist\u00f6jen sedimenteiss\u00e4. T\u00e4ss\u00e4 pro gradu -tutkielmassa tutkittiin altistuksen ajankohdan ja keston merkityst\u00e4 reteenin kehitystoksisuuteen kirjolohen (Oncorhynchus mykiss) poikasissa. Kalanpoikasia altistettiin reteenille eri pituisia ajanjaksoja kahdessa eri kehitysvaiheessa ruskuaispussivaiheen aikana. Tutkittavia vasteita olivat Cyp1a-induktio, ruskuaispussitaudin oireiden ilmentyminen ja vakavuus (BSD-indeksi), poikasten pituus ja ruskuaisen pinta-ala sek\u00e4 syd\u00e4men syke. Cyp1a-induktio oli selv\u00e4sti koholla positiivisissa kontrolleissa, mutta merkitsev\u00e4 ero havaittiin vain aikaisemmassa altistuksessa. BSD-indeksi kasvoi l\u00e4hes j\u00e4rjestelm\u00e4llisesti altistuksen keston my\u00f6t\u00e4 ja korreloi merkitsev\u00e4sti Cyp1a-induktion kanssa. Merkitsevi\u00e4 eroja k\u00e4sittelyjen v\u00e4lill\u00e4 havaittiin enemm\u00e4n aikaisemmassa altistuksessa. Tulosten perusteella altistuksen keston piteneminen ja aikaisempi kehitysvaihe lis\u00e4\u00e4v\u00e4t reteenin toksisuutta kirjolohenpoikasissa. T\u00e4m\u00e4 on t\u00e4rke\u00e4 huomioida, kun arvioidaan reteenialtistuksen vaikutuksia vesist\u00f6iss\u00e4.", "language": "fi", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.abstract", "value": "Polycyclic aromatic hydrocarbons (PAH) are ubiquitous environmental pollutants sourcing from incomplete combustion of fossil fuels and forest fires but also e.g., industrial effluents. Retene (7-Isopropyl-1-methylphenanthrene) is found especially in the sediments downstream of paper- and pulp mills. In this master\u2019s thesis, the effect of timing and duration of the exposure on the developmental toxicity of retene in rainbow trout (Oncorhynchus mykiss) larvae was studied. Rainbow trout larvae were exposed to retene for periods of different lengths at two time points during the yolk sac stage. The effects of the exposures were evaluated through assessing Cyp1a-induction, appearance and severity of blue sac disease (BSD) symptoms, length and yolk area of the larvae and heartbeat. Cyp1a-induction was clearly increased in the positive controls but significant difference was found solely in the early exposure. BSD-index increased almost systematically with the duration of the exposure and correlated significantly with the Cyp1a-induction. Generally, more significant differences between the treatments were found in the early exposure in comparison to the late exposure. According to the results, retene toxicity seems to increase with the length of the exposure and earlier developmental stage of the rainbow trout larvae. This is worth considering in the risk assessment of retene in the aquatic environment.", "language": "en", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Submitted by Miia Hakanen (mihakane@jyu.fi) on 2021-04-27T09:29:23Z\nNo. of bitstreams: 0", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Made available in DSpace on 2021-04-27T09:29:23Z (GMT). No. of bitstreams: 0\n Previous issue date: 2021", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.format.extent", "value": "78", "language": "", "element": "format", "qualifier": "extent", "schema": "dc"}, {"key": "dc.format.mimetype", "value": "application/pdf", "language": null, "element": "format", "qualifier": "mimetype", "schema": "dc"}, {"key": "dc.language.iso", "value": "fin", "language": null, "element": "language", "qualifier": "iso", "schema": "dc"}, {"key": "dc.rights", "value": "In Copyright", "language": "en", "element": "rights", "qualifier": null, "schema": "dc"}, {"key": "dc.subject.other", "value": "AhR", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "BSD", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "Cyp1a", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "ELS", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "kalanpoikanen", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "kehitysvaihe", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "ruskuaispussitauti", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "toksikologia", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.title", "value": "Altistuksen ajankohdan ja keston vaikutus reteenin kehitystoksisuuteen kirjolohen (Oncorhynchus mykiss) poikasissa", "language": "", "element": "title", "qualifier": null, "schema": "dc"}, {"key": "dc.type", "value": "master thesis", "language": null, "element": "type", "qualifier": null, "schema": "dc"}, {"key": "dc.identifier.urn", "value": "URN:NBN:fi:jyu-202104272527", "language": "", "element": "identifier", "qualifier": "urn", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Pro gradu -tutkielma", "language": "fi", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Master\u2019s thesis", "language": "en", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Matemaattis-luonnontieteellinen tiedekunta", "language": "fi", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Faculty of Sciences", "language": "en", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Bio- ja ymp\u00e4rist\u00f6tieteiden laitos", "language": "fi", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Department of Biological and Environmental Science", "language": "en", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "Jyv\u00e4skyl\u00e4n yliopisto", "language": "fi", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "University of Jyv\u00e4skyl\u00e4", "language": "en", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Ymp\u00e4rist\u00f6tiede", "language": "fi", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Environmental science", "language": "en", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "yvv.contractresearch.funding", "value": "0", "language": "", "element": "contractresearch", "qualifier": "funding", "schema": "yvv"}, {"key": "dc.type.coar", "value": "http://purl.org/coar/resource_type/c_bdcc", "language": null, "element": "type", "qualifier": "coar", "schema": "dc"}, {"key": "dc.rights.accesslevel", "value": "restrictedAccess", "language": null, "element": "rights", "qualifier": "accesslevel", "schema": "dc"}, {"key": "dc.type.publication", "value": "masterThesis", "language": null, "element": "type", "qualifier": "publication", "schema": "dc"}, {"key": "dc.subject.oppiainekoodi", "value": "40151", "language": "", "element": "subject", "qualifier": "oppiainekoodi", "schema": "dc"}, {"key": "dc.subject.yso", "value": "j\u00e4tevesi", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "PAH-yhdisteet", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "vesist\u00f6t", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "\u00f6ljyonnettomuudet", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "kirjolohi", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.format.content", "value": "fulltext", "language": null, "element": "format", "qualifier": "content", "schema": "dc"}, {"key": "dc.rights.url", "value": "https://rightsstatements.org/page/InC/1.0/", "language": null, "element": "rights", "qualifier": "url", "schema": "dc"}, {"key": "dc.rights.accessrights", "value": "The author has not given permission to make the work publicly available electronically. Therefore the material can be read only at the archival workstation at Jyv\u00e4skyl\u00e4 University Library (https://kirjasto.jyu.fi/collections/archival-workstation).", "language": "en", "element": "rights", "qualifier": "accessrights", "schema": "dc"}, {"key": "dc.rights.accessrights", "value": "Tekij\u00e4 ei ole antanut lupaa avoimeen julkaisuun, joten aineisto on luettavissa vain Jyv\u00e4skyl\u00e4n yliopiston kirjaston arkistoty\u00f6semalta. Ks. https://kirjasto.jyu.fi/kokoelmat/arkistotyoasema..", "language": "fi", "element": "rights", "qualifier": "accessrights", "schema": "dc"}, {"key": "dc.type.okm", "value": "G2", "language": null, "element": "type", "qualifier": "okm", "schema": "dc"}]
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