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[{"key": "dc.contributor.advisor", "value": "Pihko, Petri", "language": "", "element": "contributor", "qualifier": "advisor", "schema": "dc"}, {"key": "dc.contributor.advisor", "value": "Leino, Teppo", "language": "", "element": "contributor", "qualifier": "advisor", "schema": "dc"}, {"key": "dc.contributor.author", "value": "Rintamaa, Mikael", "language": "", "element": "contributor", "qualifier": "author", "schema": "dc"}, {"key": "dc.date.accessioned", "value": "2020-12-11T08:02:06Z", "language": null, "element": "date", "qualifier": "accessioned", "schema": "dc"}, {"key": "dc.date.available", "value": "2020-12-11T08:02:06Z", "language": null, "element": "date", "qualifier": "available", "schema": "dc"}, {"key": "dc.date.issued", "value": "2020", "language": "", "element": "date", "qualifier": "issued", "schema": "dc"}, {"key": "dc.identifier.uri", "value": "https://jyx.jyu.fi/handle/123456789/73123", "language": null, "element": "identifier", "qualifier": "uri", "schema": "dc"}, {"key": "dc.description.abstract", "value": "T\u00e4m\u00e4 tutkielma on jaettu kahteen osaan, joista ensimm\u00e4isess\u00e4 kirjallisessa osassa tarkastellaan kemiallista reaktiota, joka tunnetaan Passerini-reaktiona. Tutkielmassa k\u00e4yd\u00e4\u00e4n l\u00e4pi reaktion komponenttien, eli isonitriilin, karbonyylin ja Br\u00f8nsted-Lowry- tai Lewis-happokomponentin vaihtelumahdollisuuksia, sek\u00e4 erilaisia katalyyttisi\u00e4 ja enantio- ja diastereoselektiivisi\u00e4 variantteja. Lis\u00e4ksi pohditaan Passerini-reaktion ja sen muunnelmien mekanismeja, toteutuksia ja liuottimen vaikutusta. Erityist\u00e4 huomiota kiinnitet\u00e4\u00e4n katalysoituihin versioihin ja niiden kehitysmahdollisuuksiin. Kirjallisuuskatsauksessa tarkastellaan my\u00f6s luonnonainesynteesej\u00e4, joissa katalysoituja Passerini-reaktioita on hy\u00f6dynnetty.\n\nTutkielman toinen osio koostuu laboratoriossa tehdyn kokeellisen osuuden raportoinnista. Kokeellisen osuuden ensisijainen tarkoitus oli toteuttaa totaalisynteesit luonnonaineisiin nostosiini A ja nostosiini B, k\u00e4ytt\u00e4en apuna uuden kiraalisen hiilen muodostavaa Passerini-reaktiota. Kyseisi\u00e4 suunnitelmia ja toteutuksia on osittain tehty Saara Riuttam\u00e4en opinn\u00e4ytety\u00f6ss\u00e4, joka toimii oman tutkimukseni l\u00e4ht\u00f6kohtana. Synteesipolut suunniteltiin siten, ett\u00e4 viimeisten vaiheiden tulosten annettiin ratkaista saadaanko tuotteeksi joko nostosiini A tai nostosiini B. Toissijainen tarkoitus ty\u00f6ss\u00e4 oli kehitt\u00e4\u00e4 stereoselektiivinen variantti Passerini-reaktioon. Kirjallisuuskatsauksen perusteella kehitettiin uusia boorihaposta johdettuja kiraalisia borinihappoja stereoselektiiviseen Passerini-reaktioon. N\u00e4iden Lewis-happojen synteesit j\u00e4tettiin kuitenkin kehitysasteille, sill\u00e4 varmuutta niiden synteesien onnistumisista ei saatu. Totaalisynteesipolun viimeisi\u00e4 vaiheita nostosiini B:hen ei ehditty saattaa loppuun kokonaisuudessaan, mutta reaktiosarjan viimeisess\u00e4 vaiheessa saatiin kuitenkin ep\u00e4puhdasta nostosiini B:t\u00e4 tuotteena. Nostosiini A:n synteesi j\u00e4i suunnitteluasteelle.", "language": "fi", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Submitted by Paivi Vuorio (paelvuor@jyu.fi) on 2020-12-11T08:02:06Z\nNo. of bitstreams: 0", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Made available in DSpace on 2020-12-11T08:02:06Z (GMT). No. of bitstreams: 0\n Previous issue date: 2020", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.format.extent", "value": "190", "language": "", "element": "format", "qualifier": "extent", "schema": "dc"}, {"key": "dc.format.mimetype", "value": "application/pdf", "language": null, "element": "format", "qualifier": "mimetype", "schema": "dc"}, {"key": "dc.language.iso", "value": "fin", "language": null, "element": "language", "qualifier": "iso", "schema": "dc"}, {"key": "dc.rights", "value": "In Copyright", "language": "en", "element": "rights", "qualifier": null, "schema": "dc"}, {"key": "dc.title", "value": "Katalysoidut Passerini-reaktiot luonnonainesynteesiss\u00e4", "language": "", "element": "title", "qualifier": null, "schema": "dc"}, {"key": "dc.type", "value": "master thesis", "language": null, "element": "type", "qualifier": null, "schema": "dc"}, {"key": "dc.identifier.urn", "value": "URN:NBN:fi:jyu-202012117069", "language": "", "element": "identifier", "qualifier": "urn", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Pro gradu -tutkielma", "language": "fi", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Master\u2019s thesis", "language": "en", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Matemaattis-luonnontieteellinen tiedekunta", "language": "fi", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Faculty of Sciences", "language": "en", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Kemian laitos", "language": "fi", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Department of Chemistry", "language": "en", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "Jyv\u00e4skyl\u00e4n yliopisto", "language": "fi", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "University of Jyv\u00e4skyl\u00e4", "language": "en", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Orgaaninen kemia", "language": "fi", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Organic Chemistry", "language": "en", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "yvv.contractresearch.funding", "value": "0", "language": "", "element": "contractresearch", "qualifier": "funding", "schema": "yvv"}, {"key": "dc.type.coar", "value": "http://purl.org/coar/resource_type/c_bdcc", "language": null, "element": "type", "qualifier": "coar", "schema": "dc"}, {"key": "dc.rights.accesslevel", "value": "openAccess", "language": null, "element": "rights", "qualifier": "accesslevel", "schema": "dc"}, {"key": "dc.type.publication", "value": "masterThesis", "language": null, "element": "type", "qualifier": "publication", "schema": "dc"}, {"key": "dc.subject.oppiainekoodi", "value": "4035", "language": "", "element": "subject", "qualifier": "oppiainekoodi", "schema": "dc"}, {"key": "dc.subject.yso", "value": "orgaaninen kemia", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "katalyytit", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "kemia", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "luonnonaineet", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.format.content", "value": "fulltext", "language": null, "element": "format", "qualifier": "content", "schema": "dc"}, {"key": "dc.rights.url", "value": "https://rightsstatements.org/page/InC/1.0/", "language": null, "element": "rights", "qualifier": "url", "schema": "dc"}, {"key": "dc.type.okm", "value": "G2", "language": null, "element": "type", "qualifier": "okm", "schema": "dc"}]
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