| fullrecord |
[{"key": "dc.contributor.author", "value": "Mattila, Milla", "language": "", "element": "contributor", "qualifier": "author", "schema": "dc"}, {"key": "dc.date.accessioned", "value": "2020-11-16T07:26:52Z", "language": null, "element": "date", "qualifier": "accessioned", "schema": "dc"}, {"key": "dc.date.available", "value": "2020-11-16T07:26:52Z", "language": null, "element": "date", "qualifier": "available", "schema": "dc"}, {"key": "dc.date.issued", "value": "2020", "language": "", "element": "date", "qualifier": "issued", "schema": "dc"}, {"key": "dc.identifier.uri", "value": "https://jyx.jyu.fi/handle/123456789/72621", "language": null, "element": "identifier", "qualifier": "uri", "schema": "dc"}, {"key": "dc.description.abstract", "value": "Amidit ovat yleisi\u00e4 ja t\u00e4rkeit\u00e4 yhdisteit\u00e4 biologisissa systeemeiss\u00e4. Erityisesti aryyli- ja heteroaryyliamideilla on havaittu monenlaisia bioaktiivisia ominaisuuksia, joita voidaan hy\u00f6dynt\u00e4\u00e4 esimerkiksi kipul\u00e4\u00e4kkeen\u00e4, kasvitieteess\u00e4 ja sy\u00f6p\u00e4hoidoissa. Ne ovatkin t\u00e4rkeit\u00e4 synteettisi\u00e4 ja luonnossa esiintyvi\u00e4 l\u00e4\u00e4keaineita, ja siksi kiinnostavia l\u00e4\u00e4ketieteellisess\u00e4 ja orgaanisessa synteesitutkimuksessa.\nAryyliamideilla on useita sy\u00f6p\u00e4\u00e4 torjuvia ominaisuuksia, joista merkitt\u00e4vin on erilaisten proteiinien ja entsyymien inhibointi. Useat aryyliamidit toimivat tyrosiinikinaasi tai topoisomeraasi-inhibiittoreina, mutta my\u00f6s muiden reseptoreihin ja biokemiallisiin mekanismeihin vaikuttavia yhdisteit\u00e4 on l\u00f6ydetty. Er\u00e4s aryyliamidien etu on niiden selektiivisyys, usealla yhdisteill\u00e4 havaittiin hyvin tarkasti kohdistettuja vaikutuksia haluttuun solukkoon, mik\u00e4 v\u00e4hent\u00e4\u00e4 niiden haittavaikutuksia l\u00e4\u00e4keaineina.\nBiologisessa ymp\u00e4rist\u00f6ss\u00e4 vaikuttavilta yhdisteilt\u00e4 vaaditaan tarkkaa rakennetta. L\u00e4\u00e4keaine-amideille tyypillisi\u00e4 ominaisuuksia ovat heterosykliset rengasrakenteet ja pysyv\u00e4 kolmiulotteinen rakenne. Yleisi\u00e4 heteroatomeja yhdisteiss\u00e4 ovat typen ja hapen lis\u00e4ksi rikki, fluori ja kloori. Erityisesti entsyymeihin tai niiden reseptoreihin sitoutuville l\u00e4\u00e4keaineille on t\u00e4rke\u00e4\u00e4, ett\u00e4 ne pystyv\u00e4t sitoutumaan juuri oikeaan tietynlaiseen sitoutumiskohtaan halutun lopputuloksen aikaansaamiseksi.", "language": "fi", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Submitted by Paivi Vuorio (paelvuor@jyu.fi) on 2020-11-16T07:26:52Z\nNo. of bitstreams: 0", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Made available in DSpace on 2020-11-16T07:26:52Z (GMT). No. of bitstreams: 0\n Previous issue date: 2020", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.format.extent", "value": "43", "language": "", "element": "format", "qualifier": "extent", "schema": "dc"}, {"key": "dc.language.iso", "value": "fin", "language": null, "element": "language", "qualifier": "iso", "schema": "dc"}, {"key": "dc.rights", "value": "In Copyright", "language": "en", "element": "rights", "qualifier": null, "schema": "dc"}, {"key": "dc.title", "value": "Aryyliamidien ja vastaavien yhdisteiden bioaktiiviset ominaisuudet", "language": "", "element": "title", "qualifier": null, "schema": "dc"}, {"key": "dc.type", "value": "bachelor thesis", "language": null, "element": "type", "qualifier": null, "schema": "dc"}, {"key": "dc.identifier.urn", "value": "URN:NBN:fi:jyu-202011166650", "language": "", "element": "identifier", "qualifier": "urn", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Bachelor's thesis", "language": "en", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Kandidaatinty\u00f6", "language": "fi", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Matemaattis-luonnontieteellinen tiedekunta", "language": "fi", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Faculty of Sciences", "language": "en", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Kemian laitos", "language": "fi", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Department of Chemistry", "language": "en", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "Jyv\u00e4skyl\u00e4n yliopisto", "language": "fi", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "University of Jyv\u00e4skyl\u00e4", "language": "en", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Orgaaninen kemia", "language": "fi", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Organic Chemistry", "language": "en", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "yvv.contractresearch.funding", "value": "0", "language": "", "element": "contractresearch", "qualifier": "funding", "schema": "yvv"}, {"key": "dc.type.coar", "value": "http://purl.org/coar/resource_type/c_7a1f", "language": null, "element": "type", "qualifier": "coar", "schema": "dc"}, {"key": "dc.rights.accesslevel", "value": "openAccess", "language": null, "element": "rights", "qualifier": "accesslevel", "schema": "dc"}, {"key": "dc.type.publication", "value": "bachelorThesis", "language": null, "element": "type", "qualifier": "publication", "schema": "dc"}, {"key": "dc.subject.oppiainekoodi", "value": "4035", "language": "", "element": "subject", "qualifier": "oppiainekoodi", "schema": "dc"}, {"key": "dc.subject.yso", "value": "l\u00e4\u00e4keaineet", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "entsyymit", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "sy\u00f6p\u00e4taudit", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "orgaaniset yhdisteet", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "molekyylit", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "amidit", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "bioaktiiviset yhdisteet", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "reseptorit", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "inhibiittorit", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.rights.url", "value": "https://rightsstatements.org/page/InC/1.0/", "language": null, "element": "rights", "qualifier": "url", "schema": "dc"}]
|