| fullrecord |
[{"key": "dc.contributor.advisor", "value": "Astikainen, Piia", "language": "", "element": "contributor", "qualifier": "advisor", "schema": "dc"}, {"key": "dc.contributor.author", "value": "Marhia, Linda", "language": "", "element": "contributor", "qualifier": "author", "schema": "dc"}, {"key": "dc.contributor.author", "value": "Heinonen, Roosa", "language": "", "element": "contributor", "qualifier": "author", "schema": "dc"}, {"key": "dc.date.accessioned", "value": "2020-09-29T06:21:33Z", "language": null, "element": "date", "qualifier": "accessioned", "schema": "dc"}, {"key": "dc.date.available", "value": "2020-09-29T06:21:33Z", "language": null, "element": "date", "qualifier": "available", "schema": "dc"}, {"key": "dc.date.issued", "value": "2020", "language": "", "element": "date", "qualifier": "issued", "schema": "dc"}, {"key": "dc.identifier.uri", "value": "https://jyx.jyu.fi/handle/123456789/71915", "language": null, "element": "identifier", "qualifier": "uri", "schema": "dc"}, {"key": "dc.description.abstract", "value": "T\u00e4ll\u00e4 hetkell\u00e4 tiettyjen masennusoireiden ja oirekuvien taustalla olevat neurokemialliset h\u00e4iri\u00f6t eiv\u00e4t ole selvill\u00e4, sill\u00e4 ep\u00e4yhtenev\u00e4iset masennusoireet yksil\u00f6iden v\u00e4lill\u00e4 hankaloittavat tutkimusta. T\u00e4m\u00e4n tutkimuksen tarkoituksena oli tutkia, miten masennuksen somaattiset oireet vaikuttavat aivojen kykyyn reagoida kuulo\u00e4rsykkeiden voimakkuuden muutoksiin (engl. loudness dependence of auditory evoked potentials, LDAEP), jonka on ajateltu heijastavan ep\u00e4suorasti\naivojen serotoniinitoimintaa. Aivojen kyky\u00e4 k\u00e4sitell\u00e4 \u00e4\u00e4nen voimakkuuden muutoksia tarkasteltiin vertailemalla N1-vasteen amplitudia masennus- ja kontrolliryhmien v\u00e4lill\u00e4. Lis\u00e4ksi tutkittiin Beckin depressioasteikolla mitattujen masennuksen somaattisten oireiden vaikutusta kuulo\u00e4rsykkeiden voimakkuuden muutoksien k\u00e4sittelyyn. BDI:ll\u00e4 mitattujen unen ja ruokahalun oireiden yhteyksi\u00e4 kuulo\u00e4rsykkeiden voimakkuuden muutoksien k\u00e4sittelyyn tarkasteltiin viel\u00e4\nerikseen korrelaation avulla. Verrattuna kontrolliryhm\u00e4\u00e4n, masennusryhm\u00e4ss\u00e4 havaittiin amplitudiltaan suurempi N1-vaste voimakkaisiin \u00e4\u00e4niin. Somaattiset oireet eiv\u00e4t vaikuttaneet N1-vasteen amplitudiin, eik\u00e4 unen ja\nruokahalun oireiden sek\u00e4 N1-vasteen amplitudin v\u00e4lill\u00e4 l\u00f6ydetty yhteytt\u00e4.\nAiemmin kuulo\u00e4rsykkeiden voimakkuuden muutosten k\u00e4sittely on kyennyt erottelemaan ainoastaan masentuneiden alaryhmi\u00e4 terveist\u00e4 kontrolleista. Tiet\u00e4\u00e4ksemme t\u00e4m\u00e4 tutkimus on yksi harvoista, joka on kyennyt erottelemaan masennusryhm\u00e4n terveest\u00e4 kontrolliryhm\u00e4st\u00e4 kuulo\u00e4rsykkeiden voimakkuuden muutosten k\u00e4sittelyn avulla, mink\u00e4 mahdollisesti mahdollisti enimm\u00e4kseen nuorista naisista koostunut homogeeninen aineisto. Tutkimuksen tulokset rohkaisevat tutkimaan kuulo\u00e4rsykkeiden voimakkuuden muutosten k\u00e4sittelyn k\u00e4ytt\u00f6mahdollisuutta masennuksen biomarkkerina. Somaattisten oireiden vaikutusta kuulo\u00e4rsykkeiden voimakkuuden muutosten k\u00e4sittelyyn ei l\u00f6ydetty, eik\u00e4 my\u00f6sk\u00e4\u00e4n yhteytt\u00e4 unen ja ruokahalun oireisiin, joten tulevaisuudessa vaaditaan uusia l\u00e4hestymistapoja n\u00e4iden oireiden taustalla olevien neurokemiallisten h\u00e4iri\u00f6iden tutkimiseen.", "language": "fi", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.abstract", "value": "Currently, there is insufficient knowledge about the neurochemical dysfunctions behind specific depression symptoms since the large heterogeneity of symptoms between depressed individuals hinders research. The purpose of this study was to explore whether somatic symptoms of depression would have an effect on the loudness dependence of auditory evoked potentials (LDAEP) which is thought to be an indirect indicator of serotonergic function. The loudness dependence of auditory event related potential N1 was compared between depression and control groups and examined further in the depression group to study the effect of somatic symptoms of depression on N1 amplitude. The somatic dimension of Beck\u2019s depression inventory II was used to measure the somatic symptoms. Two questions representing sleep and appetite were studied further, and correlations between these symptoms and LDAEP were examined. The depression group showed significantly stronger LDAEP compared to the controlgroup. However, the somatic symptoms of depression had no effect on LDAEP and symptoms of sleep and appetite showed no significant correlations with LDAEP. Previously, the discriminative power of LDAEP has seemed to be restricted to some distinct populations within depression. To our knowledge this study is one of the few studies to distinguish between the depression group and the healthy control group using LDAEP which could be explained by the homogeneous sample consisting of mostly young women. The results here encourage to study further the utility of LDAEP as a possible biomarker of depression. Since these results give no indication of somatic symptoms having effect on LDAEP nor did the symptoms of appetite and sleep correlate with LDAEP, different approaches are needed to elucidate the neurochemical dysfunctions underlying somatic symptoms.", "language": "en", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Submitted by Paivi Vuorio (paelvuor@jyu.fi) on 2020-09-29T06:21:33Z\nNo. of bitstreams: 0", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Made available in DSpace on 2020-09-29T06:21:33Z (GMT). No. of bitstreams: 0\n Previous issue date: 2020", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.format.extent", "value": "34", "language": "", "element": "format", "qualifier": "extent", "schema": "dc"}, {"key": "dc.format.mimetype", "value": "application/pdf", "language": null, "element": "format", "qualifier": "mimetype", "schema": "dc"}, {"key": "dc.language.iso", "value": "eng", "language": null, "element": "language", "qualifier": "iso", "schema": "dc"}, {"key": "dc.rights", "value": "In Copyright", "language": "en", "element": "rights", "qualifier": null, "schema": "dc"}, {"key": "dc.subject.other", "value": "loudness dependence of auditory evoked potentials", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "LDAEP", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "somatic symptoms", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.title", "value": "Loudness dependence of auditory evoked potentials and somatic symptoms of depression", "language": "", "element": "title", "qualifier": null, "schema": "dc"}, {"key": "dc.type", "value": "master thesis", "language": null, "element": "type", "qualifier": null, "schema": "dc"}, {"key": "dc.identifier.urn", "value": "URN:NBN:fi:jyu-202009296000", "language": "", "element": "identifier", "qualifier": "urn", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Pro gradu -tutkielma", "language": "fi", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Master\u2019s thesis", "language": "en", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Kasvatustieteiden ja psykologian tiedekunta", "language": "fi", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Faculty of Education and Psychology", "language": "en", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Psykologian laitos", "language": "fi", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Department of Psychology", "language": "en", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "Jyv\u00e4skyl\u00e4n yliopisto", "language": "fi", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "University of Jyv\u00e4skyl\u00e4", "language": "en", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Psykologia", "language": "fi", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Psychology", "language": "en", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "yvv.contractresearch.funding", "value": "0", "language": "", "element": "contractresearch", "qualifier": "funding", "schema": "yvv"}, {"key": "dc.type.coar", "value": "http://purl.org/coar/resource_type/c_bdcc", "language": null, "element": "type", "qualifier": "coar", "schema": "dc"}, {"key": "dc.rights.accesslevel", "value": "restrictedAccess", "language": null, "element": "rights", "qualifier": "accesslevel", "schema": "dc"}, {"key": "dc.type.publication", "value": "masterThesis", "language": null, "element": "type", "qualifier": "publication", "schema": "dc"}, {"key": "dc.subject.oppiainekoodi", "value": "202", "language": "", "element": "subject", "qualifier": "oppiainekoodi", "schema": "dc"}, {"key": "dc.subject.yso", "value": "masennus", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "oireet", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "depression (mental disorders)", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "symptoms", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.format.content", "value": "fulltext", "language": null, "element": "format", "qualifier": "content", "schema": "dc"}, {"key": "dc.rights.url", "value": "https://rightsstatements.org/page/InC/1.0/", "language": null, "element": "rights", "qualifier": "url", "schema": "dc"}, {"key": "dc.rights.accessrights", "value": "The author has not given permission to make the work publicly available electronically. Therefore the material can be read only at the archival workstation at Jyv\u00e4skyl\u00e4 University Library (https://kirjasto.jyu.fi/en/workspaces/facilities).", "language": "en", "element": "rights", "qualifier": "accessrights", "schema": "dc"}, {"key": "dc.rights.accessrights", "value": "Tekij\u00e4 ei ole antanut lupaa avoimeen julkaisuun, joten aineisto on luettavissa vain Jyv\u00e4skyl\u00e4n yliopiston kirjaston arkistoty\u00f6semalta. Ks. https://kirjasto.jyu.fi/fi/tyoskentelytilat/laitteet-ja-tilat..", "language": "fi", "element": "rights", "qualifier": "accessrights", "schema": "dc"}, {"key": "dc.type.okm", "value": "G2", "language": null, "element": "type", "qualifier": "okm", "schema": "dc"}]
|