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[{"key": "dc.contributor.advisor", "value": "Pihko, Petri", "language": "", "element": "contributor", "qualifier": "advisor", "schema": "dc"}, {"key": "dc.contributor.author", "value": "Taskinen, Elina", "language": "", "element": "contributor", "qualifier": "author", "schema": "dc"}, {"key": "dc.date.accessioned", "value": "2020-06-16T10:22:09Z", "language": null, "element": "date", "qualifier": "accessioned", "schema": "dc"}, {"key": "dc.date.available", "value": "2020-06-16T10:22:09Z", "language": null, "element": "date", "qualifier": "available", "schema": "dc"}, {"key": "dc.date.issued", "value": "2020", "language": "", "element": "date", "qualifier": "issued", "schema": "dc"}, {"key": "dc.identifier.uri", "value": "https://jyx.jyu.fi/handle/123456789/69973", "language": null, "element": "identifier", "qualifier": "uri", "schema": "dc"}, {"key": "dc.description.abstract", "value": "T\u00e4m\u00e4n Pro Gradu -tutkielman kirjallinen osa k\u00e4sittelee ohjattua orto-litiointia ja sen sovel-luksia orgaanisessa synteesikemiassa. L\u00e4ht\u00f6aineiden kohdalla aihe on rajattu koskemaan substituoituja aryylirenkaita, kun taas em\u00e4sten kohdalla keskityt\u00e4\u00e4n organolitiumyhdisteisiin. Tehtyjen rajausten pohjana toimi kokeellisessa osassa tehty tutkimus, jota kirjallisen osan aihevalinnan haluttiin tukevan parhaalla mahdollisella tavalla. Tutkielman tiedonhakuun k\u00e4ytettiin p\u00e4\u00e4osin Reaxysi\u00e4 sek\u00e4 Google Scholaria.\n\nOhjattu orto-litiointi on pitk\u00e4\u00e4n tunnettu reaktio, joka on osoittautunut eritt\u00e4in hy\u00f6dylliseksi synteesikemian ty\u00f6kaluksi. Ohjattu orto-litiointi on kuitenkin todella riippuvainen k\u00e4ytetyist\u00e4 reagensseista sek\u00e4 reaktio-olosuhteita, ja n\u00e4iden tekij\u00f6iden vaikutuksia reaktioon k\u00e4sitell\u00e4\u00e4nkin tutkielmassani perusteellisesti. T\u00e4m\u00e4n lis\u00e4ksi k\u00e4yd\u00e4\u00e4n l\u00e4pi litiointia ohjaavia ryhmi\u00e4 sek\u00e4 vertaillaan n\u00e4iden ryhmien heikkouksia ja vahvuuksia. Useista ohjattua orto-litiointia k\u00e4sittelevist\u00e4 tutkimuksista huolimatta tutkijat eiv\u00e4t ole p\u00e4\u00e4sseet yksimielisyyteen reaktion mekanismista, mink\u00e4 vuoksi reaktiolle ehdotettuja mekanismeja tarkastellaankin niit\u00e4 tukevien tutkimusten kanssa. Kirjallisen osan lopuksi k\u00e4yd\u00e4\u00e4n viel\u00e4 l\u00e4pi joitakin esimerkkej\u00e4 ohjatun orto-litioinnin k\u00e4yt\u00f6st\u00e4 osana luonnonaineiden kokonaissynteesi\u00e4 tai l\u00e4\u00e4keainesynteesi\u00e4.\n\nTutkielmani kokeellisessa osassa keskityt\u00e4\u00e4n ohjatun orto-litioinnin soveltamiseen valterio-ni C:n kokonaissynteesiin t\u00e4ht\u00e4\u00e4v\u00e4ss\u00e4 tutkimuksessa. T\u00e4m\u00e4n 4-kinolonialkaloidin oksabisyk-lisen rungon synteesi on jo aikaisemmin toteutettu Mari-Ella M\u00e4kisen opinn\u00e4ytety\u00f6n\u00e4, ja n\u00e4in saadut tulokset toimivat my\u00f6s oman tutkimukseni l\u00e4ht\u00f6kohtana. Luonnonaineen vii-meistelemiseksi runkorakenteen aromaattiseen renkaaseen t\u00e4ytyisi saada liitetty\u00e4 esteriryhm\u00e4, mit\u00e4 p\u00e4\u00e4tettiin yritt\u00e4\u00e4 ohjatun orto-litioinnin avulla. Useista yrityksist\u00e4 huolimatta t\u00e4t\u00e4 l\u00e4hestymistapaa ei kuitenkaan saatu toimimaan, mink\u00e4 vuoksi tutkimuksessa siirryttiin tarkastelemaan aromaattisen renkaan jodausta sek\u00e4 palladiumkatalysoitua suoraa CAr\u2013H-sidoksen aktivointia vaihtoehtoisina keinoina. N\u00e4m\u00e4k\u00e4\u00e4n tutkimukset eiv\u00e4t lopulta johtaneet haluttuun tuotteeseen, ja kokeellisen osan lopussa pohditaankin seuraavia mahdollisia l\u00e4hes-tymistapoja orto-aseman funktionalisoimiseksi.", "language": "fi", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Submitted by Miia Hakanen (mihakane@jyu.fi) on 2020-06-16T10:22:09Z\nNo. of bitstreams: 0", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Made available in DSpace on 2020-06-16T10:22:09Z (GMT). No. of bitstreams: 0\n Previous issue date: 2020", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.format.extent", "value": "129", "language": "", "element": "format", "qualifier": "extent", "schema": "dc"}, {"key": "dc.format.mimetype", "value": "application/pdf", "language": null, "element": "format", "qualifier": "mimetype", "schema": "dc"}, {"key": "dc.language.iso", "value": "fin", "language": null, "element": "language", "qualifier": "iso", "schema": "dc"}, {"key": "dc.rights", "value": "In Copyright", "language": "en", "element": "rights", "qualifier": null, "schema": "dc"}, {"key": "dc.title", "value": "Substituoitujen aryylirenkaiden ohjattu orto-litiointi ja sen hy\u00f6dynt\u00e4minen valterioni C:n kokonaissynteesiss\u00e4", "language": "", "element": "title", "qualifier": null, "schema": "dc"}, {"key": "dc.type", "value": "master thesis", "language": null, "element": "type", "qualifier": null, "schema": "dc"}, {"key": "dc.identifier.urn", "value": "URN:NBN:fi:jyu-202006164206", "language": "", "element": "identifier", "qualifier": "urn", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Pro gradu -tutkielma", "language": "fi", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Master\u2019s thesis", "language": "en", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Matemaattis-luonnontieteellinen tiedekunta", "language": "fi", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Faculty of Sciences", "language": "en", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Kemian laitos", "language": "fi", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Department of Chemistry", "language": "en", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "Jyv\u00e4skyl\u00e4n yliopisto", "language": "fi", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "University of Jyv\u00e4skyl\u00e4", "language": "en", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Orgaaninen kemia", "language": "fi", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Organic Chemistry", "language": "en", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "yvv.contractresearch.funding", "value": "0", "language": "", "element": "contractresearch", "qualifier": "funding", "schema": "yvv"}, {"key": "dc.type.coar", "value": "http://purl.org/coar/resource_type/c_bdcc", "language": null, "element": "type", "qualifier": "coar", "schema": "dc"}, {"key": "dc.rights.accesslevel", "value": "openAccess", "language": null, "element": "rights", "qualifier": "accesslevel", "schema": "dc"}, {"key": "dc.type.publication", "value": "masterThesis", "language": null, "element": "type", "qualifier": "publication", "schema": "dc"}, {"key": "dc.subject.oppiainekoodi", "value": "4035", "language": "", "element": "subject", "qualifier": "oppiainekoodi", "schema": "dc"}, {"key": "dc.subject.yso", "value": "kemia", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "orgaaninen kemia", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "luonnonaineet", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "reaktiot", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "reaktiomekanismit", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.format.content", "value": "fulltext", "language": null, "element": "format", "qualifier": "content", "schema": "dc"}, {"key": "dc.rights.url", "value": "https://rightsstatements.org/page/InC/1.0/", "language": null, "element": "rights", "qualifier": "url", "schema": "dc"}, {"key": "dc.type.okm", "value": "G2", "language": null, "element": "type", "qualifier": "okm", "schema": "dc"}]
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