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[{"key": "dc.contributor.advisor", "value": "Sillanp\u00e4\u00e4, Elina", "language": "", "element": "contributor", "qualifier": "advisor", "schema": "dc"}, {"key": "dc.contributor.author", "value": "M\u00e5rtensson, Susanna", "language": "", "element": "contributor", "qualifier": "author", "schema": "dc"}, {"key": "dc.date.accessioned", "value": "2020-05-27T07:10:27Z", "language": null, "element": "date", "qualifier": "accessioned", "schema": "dc"}, {"key": "dc.date.available", "value": "2020-05-27T07:10:27Z", "language": null, "element": "date", "qualifier": "available", "schema": "dc"}, {"key": "dc.date.issued", "value": "2020", "language": "", "element": "date", "qualifier": "issued", "schema": "dc"}, {"key": "dc.identifier.uri", "value": "https://jyx.jyu.fi/handle/123456789/69253", "language": null, "element": "identifier", "qualifier": "uri", "schema": "dc"}, {"key": "dc.description.abstract", "value": "Epigeneettisell\u00e4 ik\u00e4\u00e4ntymisell\u00e4 tarkoitetaan yksil\u00f6-, ymp\u00e4rist\u00f6- ja elintapatekij\u00f6iden vaikutusta geenien ilmentymiseen vaikuttaviin s\u00e4\u00e4telymekanismeihin, joiden on osoitettu olevan merkitt\u00e4v\u00e4ss\u00e4 roolissa ihmiselimist\u00f6n ik\u00e4\u00e4ntymisess\u00e4. Tunnetuin epigeneettisist\u00e4 mekanismeista on DNA-metylaatio. Epigeneettiset kellot ovat DNA-metylaatioon perustuvia algoritmeja, jotka mahdollistavat epigeneettist\u00e4 ik\u00e4\u00e4ntymisnopeutta kuvaavien arvojen luomisen. Uudet epigeneettiset kellot mahdollistavat elintapatekij\u00f6iden ja epigeneettisen ik\u00e4\u00e4ntymisen v\u00e4listen yhteyksien tutkimisen. Ravitsemuksen merkitys kroonisten sairauksien ennaltaehk\u00e4isyss\u00e4 on suuri, mutta ravitsemuksen ja epigeneettisen ik\u00e4\u00e4ntymisen v\u00e4lisi\u00e4 yhteyksi\u00e4 on tutkittu vasta v\u00e4h\u00e4n.\n T\u00e4m\u00e4n pro gradu -tutkielman tarkoituksena oli selvitt\u00e4\u00e4\n ravitsemuksen yhteytt\u00e4 epigeneettiseen ik\u00e4\u00e4ntymisnopeuteen nuorilla aikuisilla.\n Tutkielman tarkoitus on vastata seuraaviin tutkimuskysymyksiin: 1) Onko ravitsemus yhteydess\u00e4 epigeneettiseen ik\u00e4\u00e4ntymisnopeuteen nuorilla 23-28-vuotiailla aikuisilla? 2)\n Selittyyk\u00f6 mahdollinen yhteys sukupuolella ja painoindeksill\u00e4?\nAineistona k\u00e4ytettiin Nuorten Kaksosten Terveystutkimusta (Finntwin16) nuorten 23-28- vuotiaiden aikuisten ruuank\u00e4ytt\u00f6kyselyn ja terveystietojen osalta (n= 240). Tutkittavilta ker\u00e4ttiin kokoverin\u00e4ytteet, joista eristettiin DNA. DNA-n\u00e4ytteest\u00e4 m\u00e4\u00e4ritettiin genomin laajuisia DNA-metylaatiotasoja mikrosirutekniikan avulla (Illumina 450 Array). Epigeneettisen i\u00e4n muuttujana k\u00e4ytettiin uusimman ja luotettavimman epigeneettisen kellon,\nGrimAgen, laskenta-algoritmin mukaista DNA-metylaatioik\u00e4\u00e4. Epigeneettisen ik\u00e4\u00e4ntymisnopeuden muuttuja muodostettiin kronologisen i\u00e4n ja DNA-metylaatioi\u00e4n lineaarisen regression j\u00e4\u00e4nn\u00f6ksien avulla. Nuorten aikuisten ruuank\u00e4ytt\u00f6\u00e4 arvioitiin frekvenssikyselyn vastausten perusteella. Frekvenssikyselyss\u00e4 kartoitettiin ruoka-aineiden ja - ryhmien k\u00e4ytt\u00f6\u00e4 kuukausitasolla asteikkolla 1-5.\nRavitsemustottumusten faktorirakennetta selvitettiin eksploratiivisen faktorianalyysin avulla. Sen perusteella muodostettiin 4 summamuuttujaa: 1) kalan ja kasvisten 2) lihan 3) suolaisten ja makeiden naposteltavien sek\u00e4 4) pikaruuan kulutus. Ravitsemusfaktoreiden ja epigeneettisen ik\u00e4\u00e4ntymisnopeuden yhteytt\u00e4 tarkasteltiin lineaarisella regressioanalyysill\u00e4.\nSuurempi lihatuotteiden kulutus oli yhteydess\u00e4 kiihtyneemp\u00e4\u00e4n epigeneettiseen ik\u00e4\u00e4ntymisnopeuteen (p=0.010). Yhteys s\u00e4ilyi tilastollisesti merkitsev\u00e4n\u00e4 malleissa, joissa vakioivina tekij\u00f6in\u00e4 k\u00e4ytettiin painoindeksi\u00e4 (p=0.014) ja sukupuolta (p=0.037). Mallissa, jossa oli mukana molemmat vakioivat tekij\u00e4t, yhteys s\u00e4ilyi tilastollisesti merkitsev\u00e4n\u00e4 (p=0.047). Muut ravitsemusmuuttujat eiv\u00e4t olleet tilastollisesti merkitsev\u00e4sti yhteydess\u00e4 epigeneettiseen ik\u00e4\u00e4ntymisnopeuteen.\nTulokset tukevat aikaisempia havaintoja ravitsemussuositusten mukaisen ravitsemuksen terveellisyydest\u00e4. Uusia viitteit\u00e4 saatiin ravitsemuksen vaikutuksista elimist\u00f6n biologiseen ik\u00e4\u00e4ntymisprosessiin. Tulosten perusteella vaikutukset ovat havaittavissa jo melko nuorilla.", "language": "fi", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.abstract", "value": "Epigenetic aging refers to the influence of individual, environmental, and lifestyle factors on the regulation of gene function and expression, which regulate the biological ageing process (Lu et al. 2019). Epigenetic clocks are models, which allow the generation of epigenetic aging rate values using algorithms based on DNA methylation. Nutrition plays a major role in the prevention of several chronic diseases. New epigenetic clocks enable studies regarding associations between epigenetic aging and nutrition. The purpose of this Master\u2019s thesis was to investigate the role of nutrition in epigenetic aging in young adults.\nThis thesis aims to answer the following research questions: 1) is nutrition associated with epigenetic aging rate in young adults aged 23-28? 2) Is the possible association explained by gender and body mass index?\nThis study used data collected as part of the Finnish twin cohort. Finntwin16 subsample includes dietary and health information of young adults aged 23-28 (n=240). DNA samples were extracted from whole blood samples. Subsequent genome-wide DNA methylation was performed with Illumina 450k Array. The DNA methylation age according to the latest and most reliable epigenetic clock, the GrimAge algorithm, was produced using the online calculator. The epigenetic age acceleration variables were generated from residuals of linear regression of chronological age and DNA methylation age. The epigenetic age acceleration describes whether the individual is biologically young or old according to the epigenetic clock. The dietary intake of young adults was evaluated based on the frequency questionnaire.\nThe factor structure of dietary habits was investigated by exploratory factor analysis. The sum variables were conducted as follows: 1) fish and vegetable, 2) meat, 3) salty and sweet snacks and 4) fast food consumption. To examine the association between nutrition intake and epigenetic aging, the data was analyzed in four sections using linear regression analysis.\nHigher consumption of meat products was associated with accelerated epigenetic aging rate (p=0.010). The association remained statistically significant in models using body mass index (p=0.014) and gender (p=0.037) as adjusting factors. Adjusting the model for both factors, the association remained statistically significant (p=0.047). Other nutritional variables were not statistically significantly associated with epigenetic aging rate.\nThe results support the previous findings on the health benefits of recommended nutrition. This study indicated that nutrition may play a role the biological aging prosecess of human body. This study provides evidence that the effects of lifestyle factors on the epigenetic aging process may occur in relatively young subjects.", "language": "en", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Submitted by Paivi Vuorio (paelvuor@jyu.fi) on 2020-05-27T07:10:27Z\nNo. of bitstreams: 0", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Made available in DSpace on 2020-05-27T07:10:27Z (GMT). No. of bitstreams: 0\n Previous issue date: 2020", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.format.extent", "value": "77", "language": "", "element": "format", "qualifier": "extent", "schema": "dc"}, {"key": "dc.format.mimetype", "value": "application/pdf", "language": null, "element": "format", "qualifier": "mimetype", "schema": "dc"}, {"key": "dc.language.iso", "value": "fin", "language": null, "element": "language", "qualifier": "iso", "schema": "dc"}, {"key": "dc.rights", "value": "In Copyright", "language": "en", "element": "rights", "qualifier": null, "schema": "dc"}, {"key": "dc.subject.other", "value": "epigeneettinen ik\u00e4\u00e4ntymisnopeus", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "DNA-metylaatioik\u00e4", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "epigeneettinen kello", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "biologinen ik\u00e4\u00e4ntyminen", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.title", "value": "Ravitsemuksen yhteys epigeneettiseen ik\u00e4\u00e4ntymisnopeuteen", "language": "", "element": "title", "qualifier": null, "schema": "dc"}, {"key": "dc.type", "value": "master thesis", "language": null, "element": "type", "qualifier": null, "schema": "dc"}, {"key": "dc.identifier.urn", "value": "URN:NBN:fi:jyu-202005273505", "language": "", "element": "identifier", "qualifier": "urn", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Pro gradu -tutkielma", "language": "fi", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Master\u2019s thesis", "language": "en", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Liikuntatieteellinen tiedekunta", "language": "fi", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Faculty of Sport and Health Sciences", "language": "en", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Liikunta- ja terveystieteet", "language": "fi", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Sport and Health Sciences", "language": "en", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "Jyv\u00e4skyl\u00e4n yliopisto", "language": "fi", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "University of Jyv\u00e4skyl\u00e4", "language": "en", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Gerontologia ja kansanterveys", "language": "fi", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Gerontology and Public Health", "language": "en", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "yvv.contractresearch.funding", "value": "0", "language": "", "element": "contractresearch", "qualifier": "funding", "schema": "yvv"}, {"key": "dc.type.coar", "value": "http://purl.org/coar/resource_type/c_bdcc", "language": null, "element": "type", "qualifier": "coar", "schema": "dc"}, {"key": "dc.rights.accesslevel", "value": "openAccess", "language": null, "element": "rights", "qualifier": "accesslevel", "schema": "dc"}, {"key": "dc.type.publication", "value": "masterThesis", "language": null, "element": "type", "qualifier": "publication", "schema": "dc"}, {"key": "dc.subject.oppiainekoodi", "value": "50423", "language": "", "element": "subject", "qualifier": "oppiainekoodi", "schema": "dc"}, {"key": "dc.subject.yso", "value": "nuoret aikuiset", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "ravitsemus", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "ik\u00e4\u00e4ntyminen", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "ruokatottumukset", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.format.content", "value": "fulltext", "language": null, "element": "format", "qualifier": "content", "schema": "dc"}, {"key": "dc.rights.url", "value": "https://rightsstatements.org/page/InC/1.0/", "language": null, "element": "rights", "qualifier": "url", "schema": "dc"}, {"key": "dc.type.okm", "value": "G2", "language": null, "element": "type", "qualifier": "okm", "schema": "dc"}]
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