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[{"key": "dc.contributor.advisor", "value": "Lehti, Maarit", "language": "", "element": "contributor", "qualifier": "advisor", "schema": "dc"}, {"key": "dc.contributor.author", "value": "L\u00e4hteenm\u00e4ki, Emilia", "language": "", "element": "contributor", "qualifier": "author", "schema": "dc"}, {"key": "dc.date.accessioned", "value": "2020-02-10T09:53:00Z", "language": null, "element": "date", "qualifier": "accessioned", "schema": "dc"}, {"key": "dc.date.available", "value": "2020-02-10T09:53:00Z", "language": null, "element": "date", "qualifier": "available", "schema": "dc"}, {"key": "dc.date.issued", "value": "2019", "language": "", "element": "date", "qualifier": "issued", "schema": "dc"}, {"key": "dc.identifier.uri", "value": "https://jyx.jyu.fi/handle/123456789/67780", "language": null, "element": "identifier", "qualifier": "uri", "schema": "dc"}, {"key": "dc.description.abstract", "value": "Liikunnan avulla voidaan ehk\u00e4ist\u00e4 matala-asteista tulehdustilaa, joka on osallisena monien sairauksien kehittymisess\u00e4. Toisaalta liikunta voi aiheuttaa lihassoluihin mikrovaurioita laukaisten kehossa tulehdusvasteen, jonka v\u00e4litt\u00e4j\u00e4n\u00e4 toimivat mononukleaariset valkosolut. N\u00e4iden valkosolujen mitokondrioiden toimintaa pidet\u00e4\u00e4n yhten\u00e4 mahdollisena terveysindikaattorina ja t\u00e4m\u00e4 voi my\u00f6s olla hy\u00f6dyllinen tutkittaessa liikunnan vaikutuksia terveyteen. Voimaharjoittelun sek\u00e4 eksentrisen ja konsentrisen lihaskuormitusten eroja valkosolujen soluhengitykseen ei ole tutkittu. T\u00e4ss\u00e4 tutkimuksessa kaksitoista miesurheilijaa suoritti eksentrisen, konsentrisen ja n\u00e4iden yhdistelm\u00e4harjoitteen satunnaisessa j\u00e4rjestyksess\u00e4. Verin\u00e4ytteet otettiin ennen harjoitusta sek\u00e4 5 min ja 24 tuntia harjoituksen j\u00e4lkeen. Mononukleaariset valkosolut eristettiin soluhengitysmittauksia varten, jotka suoritettiin korkean erotuskyvyn respirometrill\u00e4. Hengitystasot m\u00e4\u00e4ritettiin hapen kulutuksen perusteella. Rutiinihengitys, elektroninsiirtokapasiteetti sek\u00e4 vapaa rutiinihengityksen kapasiteetti muuttuivat 5-min yhdistelm\u00e4harjoitteen j\u00e4lkeen. Eksentrisen kuormituksen vaikutus soluhengitykseen oli erilainen verrattuna toisiin kuormituksiin. Tulehdukseen ja mitokondrioihin liittyvien geenin ekpressiotasoissa ei l\u00f6ydetty huomattavaa muutosta. Akuutilla eksentrisell\u00e4 voimaharjoituksella on erilainen vaikutus valkosoluihin, kuin akuutilla konsentrisella ja yhdistelm\u00e4harjoituksella, mik\u00e4 voi johtua suuremmasta lihasvauriom\u00e4\u00e4r\u00e4st\u00e4, tulehdusvasteesta ja lihaksiston kuormittumisesta.", "language": "fi", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.abstract", "value": "Physical activity prevents chronic low-grade inflammatory state which predisposes to many diseases. Exercise causes micro damage to muscle fibers triggering a temporary inflammatory response that is mediated by peripheral blood mononuclear cells (PBMCs) which are important part of the immune system. Mitochondrial bioenergetics of PBMCs could be a useful health indicator when investigating effects of exercise. Acute effects of resistance training on cellular respiration of PBMCs has not been studied, neither if eccentric and concentric contractions have different impact on it. For investigating this, twelve young male athletes performed eccentric (ECC), concentric (CON) and combination (CEX) of these two exercises in a random order. Blood samples were taken prior exercise, 5 min and 24 hours after and PBMCs were isolated for the respiration measurements with high resolution respirometry. Respiration states were analyzed from the real-time oxygen concentration data. Routine respiration, electron transfer capacity (ET) and free routine capacity showed significant changes after CEX and between different resistance exercises. These changes were reflected in routine control ratio and excess E-R capacity factor. Expression of four genes of PBMCs related to inflammation and mitochondrial dynamics did not show statistical significant changes on them. Acute ECC has different impact on cellular respiration of PBMCs than CON and CEX which may be a result of higher muscle damage level, higher inflammation response and fatigue of muscles.", "language": "en", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Submitted by Miia Hakanen (mihakane@jyu.fi) on 2020-02-10T09:53:00Z\nNo. of bitstreams: 0", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Made available in DSpace on 2020-02-10T09:53:00Z (GMT). No. of bitstreams: 0\n Previous issue date: 2019", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.format.extent", "value": "46", "language": "", "element": "format", "qualifier": "extent", "schema": "dc"}, {"key": "dc.format.mimetype", "value": "application/pdf", "language": null, "element": "format", "qualifier": "mimetype", "schema": "dc"}, {"key": "dc.language.iso", "value": "eng", "language": null, "element": "language", "qualifier": "iso", "schema": "dc"}, {"key": "dc.rights", "value": "In Copyright", "language": "en", "element": "rights", "qualifier": null, "schema": "dc"}, {"key": "dc.subject.other", "value": "mitochondrion", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "eccentric", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "concentric", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.title", "value": "Effect of acute strength training on cellular respiration and gene expression of peripheral blood mononuclear cells", "language": "", "element": "title", "qualifier": null, "schema": "dc"}, {"key": "dc.type", "value": "master thesis", "language": null, "element": "type", "qualifier": null, "schema": "dc"}, {"key": "dc.identifier.urn", "value": "URN:NBN:fi:jyu-202002102027", "language": "", "element": "identifier", "qualifier": "urn", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Pro gradu -tutkielma", "language": "fi", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Master\u2019s thesis", "language": "en", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Matemaattis-luonnontieteellinen tiedekunta", "language": "fi", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Faculty of Sciences", "language": "en", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Bio- ja ymp\u00e4rist\u00f6tieteiden laitos", "language": "fi", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Department of Biological and Environmental Science", "language": "en", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "Jyv\u00e4skyl\u00e4n yliopisto", "language": "fi", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "University of Jyv\u00e4skyl\u00e4", "language": "en", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Solu- ja molekyylibiologia", "language": "fi", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Cell and molecular biology", "language": "en", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "yvv.contractresearch.funding", "value": "0", "language": "", "element": "contractresearch", "qualifier": "funding", "schema": "yvv"}, {"key": "dc.type.coar", "value": "http://purl.org/coar/resource_type/c_bdcc", "language": null, "element": "type", "qualifier": "coar", "schema": "dc"}, {"key": "dc.rights.accesslevel", "value": "restrictedAccess", "language": null, "element": "rights", "qualifier": "accesslevel", "schema": "dc"}, {"key": "dc.type.publication", "value": "masterThesis", "language": null, "element": "type", "qualifier": "publication", "schema": "dc"}, {"key": "dc.subject.oppiainekoodi", "value": "4013", "language": "", "element": "subject", "qualifier": "oppiainekoodi", "schema": "dc"}, {"key": "dc.subject.yso", "value": "geeniekspressio", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "valkosolut", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "tulehdus", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "hengitys", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "gene expression", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "white blood cells", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "inflammation", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "respiration", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.format.content", "value": "fulltext", "language": null, "element": "format", "qualifier": "content", "schema": "dc"}, {"key": "dc.rights.url", "value": "https://rightsstatements.org/page/InC/1.0/", "language": null, "element": "rights", "qualifier": "url", "schema": "dc"}, {"key": "dc.rights.accessrights", "value": "The author has not given permission to make the work publicly available electronically. Therefore the material can be read only at the archival workstation at Jyv\u00e4skyl\u00e4 University Library (https://kirjasto.jyu.fi/en/workspaces/facilities).", "language": "en", "element": "rights", "qualifier": "accessrights", "schema": "dc"}, {"key": "dc.rights.accessrights", "value": "Tekij\u00e4 ei ole antanut lupaa avoimeen julkaisuun, joten aineisto on luettavissa vain Jyv\u00e4skyl\u00e4n yliopiston kirjaston arkistoty\u00f6semalta. Ks. https://kirjasto.jyu.fi/fi/tyoskentelytilat/laitteet-ja-tilat..", "language": "fi", "element": "rights", "qualifier": "accessrights", "schema": "dc"}, {"key": "dc.type.okm", "value": "G2", "language": null, "element": "type", "qualifier": "okm", "schema": "dc"}]
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