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[{"key": "dc.contributor.advisor", "value": "Vehni\u00e4inen, Eeva-Riikka", "language": "", "element": "contributor", "qualifier": "advisor", "schema": "dc"}, {"key": "dc.contributor.advisor", "value": "Kukkonen, Jussi", "language": "", "element": "contributor", "qualifier": "advisor", "schema": "dc"}, {"key": "dc.contributor.author", "value": "Halttunen, Teemu", "language": "", "element": "contributor", "qualifier": "author", "schema": "dc"}, {"key": "dc.date.accessioned", "value": "2019-11-15T06:50:37Z", "language": "", "element": "date", "qualifier": "accessioned", "schema": "dc"}, {"key": "dc.date.available", "value": "2019-11-15T06:50:37Z", "language": "", "element": "date", "qualifier": "available", "schema": "dc"}, {"key": "dc.date.issued", "value": "2019", "language": "", "element": "date", "qualifier": "issued", "schema": "dc"}, {"key": "dc.identifier.uri", "value": "https://jyx.jyu.fi/handle/123456789/66378", "language": "", "element": "identifier", "qualifier": "uri", "schema": "dc"}, {"key": "dc.description.abstract", "value": "Polysyklisi\u00e4 aromaattisia hiilivetyj\u00e4 (PAH) yhdisteit\u00e4 pidet\u00e4\u00e4n yleisesti haitallisina yhdistein\u00e4. Joidenkin PAH-yhdisteiden on havaittu muun muassa heikent\u00e4v\u00e4n j eli\u00f6iden lis\u00e4\u00e4ntymiskyky\u00e4. PAH-yhdisteit\u00e4 muodostuu ep\u00e4t\u00e4ydellisen orgaanisen materiaalin palamisen yhteydess\u00e4 ja my\u00f6s raaka\u00f6ljy sis\u00e4lt\u00e4\u00e4 runsaasti PAH-yhdisteit\u00e4. PAH-yhdisteit\u00e4 p\u00e4\u00e4tyy ymp\u00e4rist\u00f6\u00f6n esimerkiksi laskeumien, hulevesien ja \u00f6ljyonnettomuuksien takia. Monivierasainevastustuskyky (MXR) on proteiinipohjainen eli\u00f6iden kyky vastustaa haitallisten aineiden kertymist\u00e4 soluihin. MXR-mekanismia esiintyy niin aito- kuin esitumaisilla eli\u00f6ill\u00e4. MXR-mekanismin toiminta voi esty\u00e4 erilaisten yhdisteiden vaikutuksesta, joita on niin luonnollisia kuin ihmisen valmistamiakin. T\u00e4ss\u00e4 ty\u00f6ss\u00e4 tutkittiin ovatko PAH-yhdisteet antraseeni, kryseeni ja pyreeni vesikirpun Daphnia magna ja harvasukamadon Lumbriculus variegatus MXR-mekanismin inhibitoreita. Kokeet suorittiin siten, ett\u00e4 kumpikin koe-eli\u00f6 altistettiin kullekin PAH-yhdisteelle erikseen. Altistuksen j\u00e4lkeen mitattiin, kuinka paljon koe-eli\u00f6n oli kertynyt fluoresoivaa merkkiainetta ja verrattiin t\u00e4t\u00e4 sek\u00e4 normaalia ett\u00e4 ihbitiotilannetta kuvastaviin kontroleihin. Tutkimuksessa havaittiin, ett\u00e4 pyreeni poikkesi muista tukituista PAH-yhdisteist\u00e4. Harvasukamadolla ilmeni MXR-j\u00e4rjestelm\u00e4n voimistumista. Vesikirppu eritti ulos jotakin pyreenin metaboliittia. Havainnot osoittavat, ett\u00e4 mik\u00e4\u00e4n PAH-yhdisteist\u00e4 ei ollut MXR-j\u00e4rjestelm\u00e4n inhibiittori eli tutkitut PAH-yhdisteet eiv\u00e4t yksitt\u00e4isin\u00e4 aiheuttaisi haitallisten aineiden kertymist\u00e4 tutkittujen eli\u00f6iden soluihin.", "language": "fi", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.abstract", "value": "Usually polycyclic aromatic hydrocarbons (PAHs) are considered harmful compounds. For example, some PAHs are known to lower the reproduction of some organisms. PAHs are formed by uncomplete burning processes, and crude oil also contains high concentrations of PAH compounds. PAH compounds end up in the environment via precipitations, storm waters and oil accidents. Multixenobiotics resistance (MXR) is a protein-based defend mechanism, which allows the organisms to prevent the accumulation of harmful substances in the cells. The MXR mechanism occurs in both eukaryote and prokaryote organisms. MXR mechanism can be inhibited by differend kind of compounds. Some of inhibitors are natural orgin and some ones are artificial. The aim of this work was studying if anthracene, chrysene and pyrene are inhibitors of MXR mechanism in water flea Daphnia magna and oligochaeta Lumriculus variegatus. In studyings both of test organisms were treated separatetly to each tested PAH compound in three different concen-trations and one group with only fluorescent compound and other group whit fluorescent and known inhibitor. After of test the amount of fluorecence was measured and compared between every treatment group. Pyrene differed from other PAHs in this study. Pyrene acted as an inducer of MXR in Lumriculus variegatus, and Daphnia magna secreted some unknown metabolite of pyrene. None of the tested PAHs were inhibitors to any of tested organisms, so they do not behave as chemosensitizer.", "language": "en", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Submitted by Paivi Vuorio (paelvuor@jyu.fi) on 2019-11-15T06:50:37Z\r\nNo. of bitstreams: 0", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Made available in DSpace on 2019-11-15T06:50:37Z (GMT). No. of bitstreams: 0\r\n Previous issue date: 2019", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.format.extent", "value": "42", "language": "", "element": "format", "qualifier": "extent", "schema": "dc"}, {"key": "dc.format.mimetype", "value": "application/pdf", "language": null, "element": "format", "qualifier": "mimetype", "schema": "dc"}, {"key": "dc.language.iso", "value": "fin", "language": null, "element": "language", "qualifier": "iso", "schema": "dc"}, {"key": "dc.rights", "value": "In Copyright", "language": "en", "element": "rights", "qualifier": null, "schema": "dc"}, {"key": "dc.subject.other", "value": "MXR", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "antraseeni", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "pyreeni", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "kryseeni", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "Lumbriculus variegatus", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "Daphnia magna", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.title", "value": "Polysyklisten aromaattisten hiilivetyjen vaikutus vesikirpun Daphnia magna ja harvasukamadon Lumbriculus variegatus monivierasaineresistenssiin", "language": "", "element": "title", "qualifier": null, "schema": "dc"}, {"key": "dc.type", "value": "master thesis", "language": null, "element": "type", "qualifier": null, "schema": "dc"}, {"key": "dc.identifier.urn", "value": "URN:NBN:fi:jyu-201911154882", "language": "", "element": "identifier", "qualifier": "urn", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Pro gradu -tutkielma", "language": "fi", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Master\u2019s thesis", "language": "en", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Matemaattis-luonnontieteellinen tiedekunta", "language": "fi", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Faculty of Sciences", "language": "en", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Bio- ja ymp\u00e4rist\u00f6tieteiden laitos", "language": "fi", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Department of Biological and Environmental Science", "language": "en", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "Jyv\u00e4skyl\u00e4n yliopisto", "language": "fi", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "University of Jyv\u00e4skyl\u00e4", "language": "en", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Ymp\u00e4rist\u00f6tiede ja -teknologia", "language": "fi", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Environmental science and technology", "language": "en", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "yvv.contractresearch.funding", "value": "0", "language": "", "element": "contractresearch", "qualifier": "funding", "schema": "yvv"}, {"key": "dc.type.coar", "value": "http://purl.org/coar/resource_type/c_bdcc", "language": null, "element": "type", "qualifier": "coar", "schema": "dc"}, {"key": "dc.rights.accesslevel", "value": "openAccess", "language": null, "element": "rights", "qualifier": "accesslevel", "schema": "dc"}, {"key": "dc.type.publication", "value": "masterThesis", "language": null, "element": "type", "qualifier": "publication", "schema": "dc"}, {"key": "dc.subject.oppiainekoodi", "value": "4015", "language": "", "element": "subject", "qualifier": "oppiainekoodi", "schema": "dc"}, {"key": "dc.subject.yso", "value": "vesikirput", "language": "", "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "PAH-yhdisteet", "language": "", "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.format.content", "value": "fulltext", "language": null, "element": "format", "qualifier": "content", "schema": "dc"}, {"key": "dc.rights.url", "value": "https://rightsstatements.org/page/InC/1.0/", "language": null, "element": "rights", "qualifier": "url", "schema": "dc"}, {"key": "dc.type.okm", "value": "G2", "language": null, "element": "type", "qualifier": "okm", "schema": "dc"}]
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