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[{"key": "dc.contributor.advisor", "value": "Ahtiainen, Maarit", "language": "", "element": "contributor", "qualifier": "advisor", "schema": "dc"}, {"key": "dc.contributor.advisor", "value": "Kuopio, Teijo", "language": "", "element": "contributor", "qualifier": "advisor", "schema": "dc"}, {"key": "dc.contributor.author", "value": "Elomaa, Hanna", "language": "", "element": "contributor", "qualifier": "author", "schema": "dc"}, {"key": "dc.date.accessioned", "value": "2019-11-04T08:11:08Z", "language": null, "element": "date", "qualifier": "accessioned", "schema": "dc"}, {"key": "dc.date.available", "value": "2019-11-04T08:11:08Z", "language": null, "element": "date", "qualifier": "available", "schema": "dc"}, {"key": "dc.date.issued", "value": "2019", "language": "", "element": "date", "qualifier": "issued", "schema": "dc"}, {"key": "dc.identifier.uri", "value": "https://jyx.jyu.fi/handle/123456789/66133", "language": null, "element": "identifier", "qualifier": "uri", "schema": "dc"}, {"key": "dc.description.abstract", "value": "Kolorektaalisy\u00f6p\u00e4 on maailman kolmanneksi yleisin sy\u00f6p\u00e4 ja sen alttius levit\u00e4\nmuihin kudoksiin muodostamalla metastaaseja hankaloittaa hoitoa ja heikent\u00e4\u00e4\npotilaan ennustetta. Elimist\u00f6n immuunipuolustusj\u00e4rjestelm\u00e4 pyrkii eliminoimaan\nsy\u00f6p\u00e4soluja erityisesti T-lymfosyyttien avulla. Terveess\u00e4 kudoksessa on my\u00f6s Tlymfosyyttien liiallista toimintaa rajoittavia immuunivasteen tarkastuspisteit\u00e4,\nkuten PD-1 ja PD-L1. Sy\u00f6v\u00e4ss\u00e4 tarkastuspisteiden ilmeneminen on kuitenkin\nyleens\u00e4 normaalia suurempaa, mink\u00e4 vuoksi sy\u00f6pien hoitoon on kehitteill\u00e4 Tlymfosyyttien toimintaa tehostavia immuunivasteen tarkastuspisteen\nest\u00e4j\u00e4l\u00e4\u00e4kkeit\u00e4. L\u00e4\u00e4kkeiden toimivuuden ja potilaan ennusteen arvioimiseksi on\nt\u00e4rke\u00e4 selvitt\u00e4\u00e4 sy\u00f6v\u00e4n immunologinen tila, joka vaihtelee paljon sy\u00f6v\u00e4n ja\nyksitt\u00e4isten tuumorien v\u00e4lill\u00e4. Tutkimuksessa selvitettiin kolorektaalisy\u00f6v\u00e4n\nprim\u00e4\u00e4rikasvainten (N=114) sek\u00e4 niiden maksa- ja keuhkometastaasien Tlymfosyyttitiheytt\u00e4 ja PD-1/PD-L1-positiivisuutta sek\u00e4 niiden vaikutusta potilaan\nennusteeseen immunohistokemiallisesti v\u00e4rj\u00e4ttyjen tuumorin\u00e4ytteiden avulla. Tlymfosyyttitiheyden huomattiin olevan korkeampi metastaaseissa kuin\nprim\u00e4\u00e4rikasvaimissa. Lis\u00e4ksi keuhkometastaaseissa todettiin olevan eniten PD-1-\nja PD-L1-positiivisia soluja. Aiemmista tuloksista poiketen ei korkealla Tlymfosyyttitiheydell\u00e4 eik\u00e4 PD-1-positiivisuudella ollut vaikutusta potilaan\nennusteeseen. Sen sijaan keuhkometastaasien korkea PD-L1-positiivisuus oli\nyhteydess\u00e4 potilaan huonompaan selviytymiseen.", "language": "fi", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.abstract", "value": "Colorectal cancer (CRC) is the third most common cancer type worldwide and its susceptibility to metastasize worsens the prognosis of CRC patients. Immune system strives to eliminate cancer cells mainly with tumor-infiltrating lymphocytes, such as CD4 and CD8 T lymphocytes. In healthy tissue, the excessive immune response of T lymphocytes is naturally depleted by immune checkpoints, such as PD-1 and PD-L1. In cancer the immune checkpoint expression is elevated and by targeting immune checkpoints with immune checkpoint inhibitors, their immunosuppressive function can be prevented. High density of T lymphocytes has been associated with better prognosis, whereas the effect of immune checkpoints has shown divergent results. The aim of this study was to investigate the density of T lymphocytes and the expression of PD-1 and PD-L1 both in primary CRC tumors and in their liver and lung metastases as well as their impact on the survival. The study cohort included 114 primary CRC patients with 91 liver and/or 41 lung metastases. The density of T lymphocytes and PD-1/PD-L1 expression were analyzed from immunohistochemically stained tumor samples. The results showed that T lymphocyte density was higher in metastases than in primary tumors. PD-1 and PD-L1 expressions were the highest\nin lung metastases. Unlike expected, higher density of T lymphocytes and stronger immune checkpoint expression were not associated with the survival of the patient.", "language": "en", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Submitted by Miia Hakanen (mihakane@jyu.fi) on 2019-11-04T08:11:07Z\nNo. of bitstreams: 0", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Made available in DSpace on 2019-11-04T08:11:08Z (GMT). No. of bitstreams: 0\n Previous issue date: 2019", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.format.extent", "value": "45", "language": "", "element": "format", "qualifier": "extent", "schema": "dc"}, {"key": "dc.format.mimetype", "value": "application/pdf", "language": null, "element": "format", "qualifier": "mimetype", "schema": "dc"}, {"key": "dc.language.iso", "value": "eng", "language": null, "element": "language", "qualifier": "iso", "schema": "dc"}, {"key": "dc.rights", "value": "In Copyright", "language": "en", "element": "rights", "qualifier": null, "schema": "dc"}, {"key": "dc.subject.other", "value": "CRC", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "FFPE", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "immune checkpoint", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "immune checkpoint inhibitor", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "PD-1", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "PD-L1", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.title", "value": "Immune contexture of colorectal cancer and matched liver and lung metastases", "language": "", "element": "title", "qualifier": null, "schema": "dc"}, {"key": "dc.type", "value": "master thesis", "language": null, "element": "type", "qualifier": null, "schema": "dc"}, {"key": "dc.identifier.urn", "value": "URN:NBN:fi:jyu-201911044700", "language": "", "element": "identifier", "qualifier": "urn", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Pro gradu -tutkielma", "language": "fi", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Master\u2019s thesis", "language": "en", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Matemaattis-luonnontieteellinen tiedekunta", "language": "fi", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Faculty of Sciences", "language": "en", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Bio- ja ymp\u00e4rist\u00f6tieteiden laitos", "language": "fi", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Department of Biological and Environmental Science", "language": "en", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "Jyv\u00e4skyl\u00e4n yliopisto", "language": "fi", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "University of Jyv\u00e4skyl\u00e4", "language": "en", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Solu- ja molekyylibiologia", "language": "fi", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Cell and molecular biology", "language": "en", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "yvv.contractresearch.collaborator", "value": "public", "language": "", "element": "contractresearch", "qualifier": "collaborator", "schema": "yvv"}, {"key": "yvv.contractresearch.funding", "value": "0", "language": "", "element": "contractresearch", "qualifier": "funding", "schema": "yvv"}, {"key": "yvv.contractresearch.initiative", "value": "student", "language": "", "element": "contractresearch", "qualifier": "initiative", "schema": "yvv"}, {"key": "dc.type.coar", "value": "http://purl.org/coar/resource_type/c_bdcc", "language": null, "element": "type", "qualifier": "coar", "schema": "dc"}, {"key": "dc.rights.accesslevel", "value": "restrictedAccess", "language": null, "element": "rights", "qualifier": "accesslevel", "schema": "dc"}, {"key": "dc.type.publication", "value": "masterThesis", "language": null, "element": "type", "qualifier": "publication", "schema": "dc"}, {"key": "dc.subject.oppiainekoodi", "value": "4013", "language": "", "element": "subject", "qualifier": "oppiainekoodi", "schema": "dc"}, {"key": "dc.subject.yso", "value": "et\u00e4pes\u00e4kkeet", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "sy\u00f6p\u00e4taudit", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "sy\u00f6p\u00e4solut", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "immuunij\u00e4rjestelm\u00e4", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "lymfosyytit", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "metastases", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "cancerous diseases", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "cancer cells", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "immune system", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "lymphocytes", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.format.content", "value": "fulltext", "language": null, "element": "format", "qualifier": "content", "schema": "dc"}, {"key": "dc.rights.url", "value": "https://rightsstatements.org/page/InC/1.0/", "language": null, "element": "rights", "qualifier": "url", "schema": "dc"}, {"key": "dc.rights.accessrights", "value": "The author has not given permission to make the work publicly available electronically. Therefore the material can be read only at the archival workstation at Jyv\u00e4skyl\u00e4 University Library (https://kirjasto.jyu.fi/en/workspaces/facilities).", "language": "en", "element": "rights", "qualifier": "accessrights", "schema": "dc"}, {"key": "dc.rights.accessrights", "value": "Tekij\u00e4 ei ole antanut lupaa avoimeen julkaisuun, joten aineisto on luettavissa vain Jyv\u00e4skyl\u00e4n yliopiston kirjaston arkistoty\u00f6semalta. Ks. https://kirjasto.jyu.fi/fi/tyoskentelytilat/laitteet-ja-tilat..", "language": "fi", "element": "rights", "qualifier": "accessrights", "schema": "dc"}, {"key": "dc.type.okm", "value": "G2", "language": null, "element": "type", "qualifier": "okm", "schema": "dc"}]
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