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[{"key": "dc.contributor.advisor", "value": "Penttil\u00e4, Heikki", "language": "", "element": "contributor", "qualifier": "advisor", "schema": "dc"}, {"key": "dc.contributor.advisor", "value": "Boman, Eeva", "language": "", "element": "contributor", "qualifier": "advisor", "schema": "dc"}, {"key": "dc.contributor.author", "value": "Nadhum, Miia", "language": "", "element": "contributor", "qualifier": "author", "schema": "dc"}, {"key": "dc.date.accessioned", "value": "2019-07-11T09:41:49Z", "language": null, "element": "date", "qualifier": "accessioned", "schema": "dc"}, {"key": "dc.date.available", "value": "2019-07-11T09:41:49Z", "language": null, "element": "date", "qualifier": "available", "schema": "dc"}, {"key": "dc.date.issued", "value": "2019", "language": "", "element": "date", "qualifier": "issued", "schema": "dc"}, {"key": "dc.identifier.uri", "value": "https://jyx.jyu.fi/handle/123456789/65033", "language": null, "element": "identifier", "qualifier": "uri", "schema": "dc"}, {"key": "dc.description.abstract", "value": "T\u00e4ss\u00e4 ty\u00f6ss\u00e4 tutkittiin nelj\u00e4\u00e4 s\u00e4dehoitotekniikkaa eturauhasen s\u00e4dehoitoon lonkkaproteesillisilla potilailla ja vertailtiin kohdealueen annoksen muutoksia, joita proteesin mahdollinen liike aiheuttaa. Tutkittavat tekniikat k\u00e4yttiv\u00e4t nykyaikaista kaarihoitotekniikkaa (Volumetric modulated arc therapy, VMAT) nelj\u00e4ll\u00e4 eri asetuksella: 1) pelk\u00e4t VMAT hoitokaaret (VMATonly); 2) VMAT hoitokaaret, joissa proteesin l\u00e4pi s\u00e4teilytt\u00e4mist\u00e4 estettiin v\u00e4ist\u00f6sektoreilla (avoidance sectors) (VMATavoid); 3) kuten kohta 2, mutta lis\u00e4n\u00e4 proteesin l\u00e4pi s\u00e4teilytt\u00e4v\u00e4 staattinen hoitokentt\u00e4 v\u00e4ist\u00f6sektorin kohdalle (VMAT+stat); 4) VMAT hoitokaaret, joille optimoinnissa annettiin ehto, joka esti lonkkaproteesin l\u00e4pi kohdealueen s\u00e4teilytt\u00e4misen (VMATautoavoid). Aineistoksi valittiin retrospektiivisesti 15 Tampereen yliopistollisessa sairaalassa jo s\u00e4dehoidetun potilaan annossuunnittelukuvat. Potilaista viidell\u00e4 oli lonkkaproteesi oikeassa lonkassa, viidell\u00e4 vasemmassa lonkassa ja viidell\u00e4 molemmissa. Kaikille potilaille tehtiin annossuunnitelmat jokaisella nelj\u00e4ll\u00e4 tekniikalla. Proteesin mahdollista liikett\u00e4 tutkittiin siirt\u00e4m\u00e4ll\u00e4 proteesia ventraalisesti ja dorsaalisesti ja suorittamalla annoslaskenta uudestaan samoilla kentt\u00e4parametreill\u00e4 kuin ilman siirtoa.\nEri tekniikoita vertailtiin kohdealueen annoskattavuuden, maksimeiden ja kriittisten elinten annoksien osalta. Vertailtavista tekniikoista VMATavoid-tekniikalla kohdealueen annoskattavuus oli huonoin ja kriittisten elinten annokset olivat suurimmat. Proteesin siirto huononsi kohdealueen annosta eniten VMAT+stat-tekniikalla. VMATonly ja VMATautoavoid t\u00e4yttiv\u00e4t parhaiten annossuunnittelukriteerit, kun huomioitiin proteesin liikkeest\u00e4 aiheutuvat muutokset. VMATonly s\u00e4teilytt\u00e4\u00e4 lonkkaproteesin l\u00e4pi enemm\u00e4n kuin VMATautoavoid. T\u00e4m\u00e4 kasvattaa annosta proteesin pinnassa ja voi mahdollisesti aiheuttaa komplikaatioita esimerkiksi proteesin kiinnittymisess\u00e4. T\u00e4m\u00e4n vuoksi VMATautoavoid vaikutti k\u00e4ytt\u00f6kelpoisimmalta tekniikalta eturauhasen hoitoon lonkkaproteesillisilla potilailla.", "language": "fi", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.abstract", "value": "The main focus of this study was investigate four treatment techniques for prostate cancer patients with hip prosthesis and compare changes in the dose of the target area caused by the possible movement of the prosthesis. The used VMAT (Volumetric modulated arc therapy) treatment planning techniques with four different setups were: 1) full VMAT arcs (VMATonly); 2) full VMAT arcs with avoidance sectors to avoid direct irradiation through the prosthesis (VMATavoid); 3) as in 2, but adding a static field radiating through the prosthesis (VMAT+stat); 4) full VMAT arcs with automated structure avoidance option to avoid irradiation through the prosthesis (VMATautoavoid). Fifteen previously treated prostate patients from TAYS were selected to this study. Five of the patients had the prosthesis in the right hip, five in the left and five had the prosthesis in both hips. Treatment plans were created for all patients using all four techniques. The prosthesis misalignment in the treatment were modelled by transferring the prosthesis using ventral and dorsal constant movements and the dose was recalculated.\nUsing VMATavoid OARs (organs at risk) doses were the highest and the dose coverage of the target area was the poorest. Using VMAT+stat the movement of the prosthesis affected most to the dose in the target area. VMATonly and VMATautoavoid fulfilled best planning criteria, when the prosthesis movement was taken into account. VMATonly radiates through the prosthesis more than VMATautoavoid. This increases the dose on the prosthesis surface and increases the risk of complications in the prosthesis. Thus VMATautoavoid technique is recommended as a planning technique for a prostate cancer with hip prosthesis.", "language": "en", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Submitted by Miia Hakanen (mihakane@jyu.fi) on 2019-07-11T09:41:49Z\nNo. of bitstreams: 0", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Made available in DSpace on 2019-07-11T09:41:49Z (GMT). No. of bitstreams: 0\n Previous issue date: 2019", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.format.extent", "value": "127", "language": "", "element": "format", "qualifier": "extent", "schema": "dc"}, {"key": "dc.format.mimetype", "value": "application/pdf", "language": null, "element": "format", "qualifier": "mimetype", "schema": "dc"}, {"key": "dc.language.iso", "value": "fin", "language": null, "element": "language", "qualifier": "iso", "schema": "dc"}, {"key": "dc.rights", "value": "In Copyright", "language": "en", "element": "rights", "qualifier": null, "schema": "dc"}, {"key": "dc.subject.other", "value": "annossuunnittelu", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "VMAT", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "lonkkaproteesi", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.title", "value": "Lonkkaproteesillisten eturauhaspotilaiden s\u00e4dehoitotekniikan kehitt\u00e4minen", "language": "", "element": "title", "qualifier": null, "schema": "dc"}, {"key": "dc.type", "value": "master thesis", "language": null, "element": "type", "qualifier": null, "schema": "dc"}, {"key": "dc.identifier.urn", "value": "URN:NBN:fi:jyu-201907113616", "language": "", "element": "identifier", "qualifier": "urn", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Pro gradu -tutkielma", "language": "fi", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Master\u2019s thesis", "language": "en", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Matemaattis-luonnontieteellinen tiedekunta", "language": "fi", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Faculty of Sciences", "language": "en", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Fysiikan laitos", "language": "fi", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Department of Physics", "language": "en", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "Jyv\u00e4skyl\u00e4n yliopisto", "language": "fi", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "University of Jyv\u00e4skyl\u00e4", "language": "en", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Soveltava fysiikka", "language": "fi", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Applied Physics", "language": "en", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "yvv.contractresearch.collaborator", "value": "public", "language": "", "element": "contractresearch", "qualifier": "collaborator", "schema": "yvv"}, {"key": "yvv.contractresearch.funding", "value": "0", "language": "", "element": "contractresearch", "qualifier": "funding", "schema": "yvv"}, {"key": "yvv.contractresearch.initiative", "value": "student", "language": "", "element": "contractresearch", "qualifier": "initiative", "schema": "yvv"}, {"key": "dc.type.coar", "value": "http://purl.org/coar/resource_type/c_bdcc", "language": null, "element": "type", "qualifier": "coar", "schema": "dc"}, {"key": "dc.rights.accesslevel", "value": "openAccess", "language": null, "element": "rights", "qualifier": "accesslevel", "schema": "dc"}, {"key": "dc.type.publication", "value": "masterThesis", "language": null, "element": "type", "qualifier": "publication", "schema": "dc"}, {"key": "dc.subject.oppiainekoodi", "value": "4023", "language": "", "element": "subject", "qualifier": "oppiainekoodi", "schema": "dc"}, {"key": "dc.subject.yso", "value": "proteesit", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "lonkka", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "s\u00e4dehoito", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "eturauhanen", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.format.content", "value": "fulltext", "language": null, "element": "format", "qualifier": "content", "schema": "dc"}, {"key": "dc.rights.url", "value": "https://rightsstatements.org/page/InC/1.0/", "language": null, "element": "rights", "qualifier": "url", "schema": "dc"}, {"key": "dc.type.okm", "value": "G2", "language": null, "element": "type", "qualifier": "okm", "schema": "dc"}]
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