| fullrecord |
[{"key": "dc.contributor.advisor", "value": "Lipponen, Arto", "language": "", "element": "contributor", "qualifier": "advisor", "schema": "dc"}, {"key": "dc.contributor.advisor", "value": "Nokia, Miriam", "language": "", "element": "contributor", "qualifier": "advisor", "schema": "dc"}, {"key": "dc.contributor.author", "value": "Vaarala, Johanna", "language": "", "element": "contributor", "qualifier": "author", "schema": "dc"}, {"key": "dc.date.accessioned", "value": "2019-06-20T07:58:08Z", "language": null, "element": "date", "qualifier": "accessioned", "schema": "dc"}, {"key": "dc.date.available", "value": "2019-06-20T07:58:08Z", "language": null, "element": "date", "qualifier": "available", "schema": "dc"}, {"key": "dc.date.issued", "value": "2019", "language": "", "element": "date", "qualifier": "issued", "schema": "dc"}, {"key": "dc.identifier.uri", "value": "https://jyx.jyu.fi/handle/123456789/64760", "language": null, "element": "identifier", "qualifier": "uri", "schema": "dc"}, {"key": "dc.description.abstract", "value": "Tutkimuksessa tarkastellaan assosiatiivista oppimista ja unen patologisia piirteit\u00e4 Alzheimerin taudin APP/PS1 -hiirimallissa. Koe-el\u00e4imin\u00e4 oli kolme 10-11 kuukauden ik\u00e4ist\u00e4 C57BL/6 -hiirt\u00e4, joista yksi oli transgeeninen APP/PS1 -hiiri ja kaksi perim\u00e4lt\u00e4\u00e4n tavallista hiirt\u00e4. Assosiatiivisen oppimisen mallina k\u00e4ytettiin silm\u00e4niskuehdollistamisen aikav\u00e4liasetelmaa. El\u00e4imilt\u00e4 mitattiin lis\u00e4ksi hippokampuksen CA1-alueen aktiivisuutta luonnollisen unen aikana kroonisesti implantoiduilla tetrodeilla. Unesta tarkasteltiin hippokampuksen aktivaatiopurskeita ja REM-unijaksojen pituutta. Silm\u00e4niskuehdollistamisessa koulutettiin yksi transgeeninen ja yksi ei-transgeeninen hiiri. Transgeeninen hiiri suoriutui silm\u00e4niskuteht\u00e4v\u00e4ss\u00e4 heikommin kuin ei-transgeeninen hiiri. Koulutuksen lopussa transgeenisen hiiri tuotti opitun vasteen 38% koulutuskerran toistoista ja ei-transgeeninen 85% toistoista. Tutkimuksessa k\u00e4ytetty silm\u00e4niskuehdollistamisen asetelma voi paljastaa transgeenisten APP/PS1 -hiirten kognitiivisen heikentymisen, mutta ero tulee varmistaa suuremmalla m\u00e4\u00e4r\u00e4ll\u00e4 koe-el\u00e4imi\u00e4. Unta mitattiin yhdelt\u00e4 transgeeniselta ja kahdelta ei-transgeeniselta hiirelt\u00e4. El\u00e4inten v\u00e4lill\u00e4 oli keskin\u00e4isi\u00e4 eroja aktivaatiopurskeiden esiintymisess\u00e4: toisella ei-transgeenisista hiirist\u00e4 esiintyi v\u00e4hemm\u00e4n aktivaatiopurskeita verrattuna kahteen muuhun el\u00e4imeen. Eroja havaittiin my\u00f6s REM-unijaksojen pituudessa: transgeenisen hiiren REM-unijaksot olivat lyhyempi\u00e4 kuin ei-transgeenisten hiirten. Transgeenisen ja ei-transgeenisten hiirten unessa n\u00e4hdyt erot tulisi varmistaa suuremmalla m\u00e4\u00e4r\u00e4ll\u00e4 koe-el\u00e4imi\u00e4. APP/PS1-hiirill\u00e4 n\u00e4ht\u00e4vien unen patologisten piirteiden yhteytt\u00e4 oppimisteht\u00e4v\u00e4ss\u00e4 suoriutumiseen tulisi my\u00f6s tutkia tulevaisuudessa. Alzheimerin tautiin liittyvien neuraalisen ja k\u00e4ytt\u00e4ytymisen tason patologisten piirteiden tunnistaminen on t\u00e4rke\u00e4\u00e4 taudin diagnostiikan ja hoidon kehitt\u00e4misen kannalta.", "language": "fi", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Submitted by Paivi Vuorio (paelvuor@jyu.fi) on 2019-06-20T07:58:08Z\nNo. of bitstreams: 0", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Made available in DSpace on 2019-06-20T07:58:08Z (GMT). No. of bitstreams: 0\n Previous issue date: 2019", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.format.extent", "value": "31", "language": "", "element": "format", "qualifier": "extent", "schema": "dc"}, {"key": "dc.format.mimetype", "value": "application/pdf", "language": null, "element": "format", "qualifier": "mimetype", "schema": "dc"}, {"key": "dc.language.iso", "value": "fin", "language": null, "element": "language", "qualifier": "iso", "schema": "dc"}, {"key": "dc.rights", "value": "In Copyright", "language": "en", "element": "rights", "qualifier": null, "schema": "dc"}, {"key": "dc.subject.other", "value": "amyloidipatologia", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "silm\u00e4niskuehdollistaminen", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "episodinen muisti", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.title", "value": "Assosiatiivinen oppiminen ja uni Alzheimerin taudin hiirimallissa", "language": "", "element": "title", "qualifier": null, "schema": "dc"}, {"key": "dc.type", "value": "master thesis", "language": null, "element": "type", "qualifier": null, "schema": "dc"}, {"key": "dc.identifier.urn", "value": "URN:NBN:fi:jyu-201906203346", "language": "", "element": "identifier", "qualifier": "urn", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Pro gradu -tutkielma", "language": "fi", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Master\u2019s thesis", "language": "en", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Kasvatustieteiden ja psykologian tiedekunta", "language": "fi", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Faculty of Education and Psychology", "language": "en", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Psykologian laitos", "language": "fi", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Department of Psychology", "language": "en", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "Jyv\u00e4skyl\u00e4n yliopisto", "language": "fi", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "University of Jyv\u00e4skyl\u00e4", "language": "en", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Psykologia", "language": "fi", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Psychology", "language": "en", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "yvv.contractresearch.funding", "value": "0", "language": "", "element": "contractresearch", "qualifier": "funding", "schema": "yvv"}, {"key": "dc.type.coar", "value": "http://purl.org/coar/resource_type/c_bdcc", "language": null, "element": "type", "qualifier": "coar", "schema": "dc"}, {"key": "dc.rights.accesslevel", "value": "openAccess", "language": null, "element": "rights", "qualifier": "accesslevel", "schema": "dc"}, {"key": "dc.type.publication", "value": "masterThesis", "language": null, "element": "type", "qualifier": "publication", "schema": "dc"}, {"key": "dc.subject.oppiainekoodi", "value": "202", "language": "", "element": "subject", "qualifier": "oppiainekoodi", "schema": "dc"}, {"key": "dc.subject.yso", "value": "uni (lepotila)", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "Alzheimerin tauti", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.format.content", "value": "fulltext", "language": null, "element": "format", "qualifier": "content", "schema": "dc"}, {"key": "dc.rights.url", "value": "https://rightsstatements.org/page/InC/1.0/", "language": null, "element": "rights", "qualifier": "url", "schema": "dc"}, {"key": "dc.type.okm", "value": "G2", "language": null, "element": "type", "qualifier": "okm", "schema": "dc"}]
|