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[{"key": "dc.contributor.advisor", "value": "Karvinen, Sira", "language": "", "element": "contributor", "qualifier": "advisor", "schema": "dc"}, {"key": "dc.contributor.author", "value": "Siev\u00e4nen, Tero", "language": "", "element": "contributor", "qualifier": "author", "schema": "dc"}, {"key": "dc.date.accessioned", "value": "2019-06-20T05:53:10Z", "language": null, "element": "date", "qualifier": "accessioned", "schema": "dc"}, {"key": "dc.date.available", "value": "2019-06-20T05:53:10Z", "language": null, "element": "date", "qualifier": "available", "schema": "dc"}, {"key": "dc.date.issued", "value": "2019", "language": "", "element": "date", "qualifier": "issued", "schema": "dc"}, {"key": "dc.identifier.uri", "value": "https://jyx.jyu.fi/handle/123456789/64735", "language": null, "element": "identifier", "qualifier": "uri", "schema": "dc"}, {"key": "dc.description.abstract", "value": "Elimist\u00f6ss\u00e4 kiert\u00e4v\u00e4t mikro-RNAt (ci-miRNAt) s\u00e4\u00e4telev\u00e4t geenien toimintaa ja toimivat viestimolekyylein\u00e4 kudosten v\u00e4lill\u00e4. T\u00e4m\u00e4n vuoksi niit\u00e4 on mahdollista hy\u00f6dynt\u00e4\u00e4 merkkimolekyylein\u00e4 mm. tutkittaessa liikunnan aiheuttamia vasteita kehossa. Hyv\u00e4 merkkimolekyyli on helposti ker\u00e4tt\u00e4viss\u00e4 ilman invasiivisia menetelmi\u00e4. Hien on uskottu olevan sopiva t\u00e4h\u00e4n k\u00e4ytt\u00f6tarkoitukseen. T\u00e4ss\u00e4 tutkielmassa tutkittiin, ett\u00e4 voidaanko hiest\u00e4 l\u00f6yt\u00e4\u00e4 ci-miRNA:ta ja korreloivatko mahdolliset l\u00f6yd\u00f6kset my\u00f6s veren seerumin kanssa. Tutkimuksessa havaittiin ci-miRNA:ta l\u00f6ytyv\u00e4n hiest\u00e4 ja ci-miRNA-146a pitoisuuden nousseen hiess\u00e4 VO2 max testin j\u00e4lkeen, mutta veress\u00e4 ei havaittu mit\u00e4\u00e4n vasteita. My\u00f6s korrelaatiot veren ja hien v\u00e4lill\u00e4 olivat eritt\u00e4in heikot. T\u00e4m\u00e4n vuoksi ci-miRNA:ja ei voida pit\u00e4\u00e4 luotettavina merkkimolekyylein\u00e4 VO2 max testille eik\u00e4 hienkeruuta voida suositella merkkimolekyylien ker\u00e4\u00e4miseen toistaiseksi. ci-miRNA:ja voidaan kuitenkin yh\u00e4 pit\u00e4\u00e4 potentiaalisia merkkimolekyylein\u00e4 liikunnalle. Lis\u00e4tutkimusta ci-miRNA:en toiminnasta ja tutkimismenetelmist\u00e4 vaaditaan viel\u00e4 runsaasti.", "language": "fi", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.abstract", "value": "The potential use of circulating micro-RNAs (ci-miRNAs) as non-invasive biomarkers to monitor exercise adaptation has raised interest recently. Sweat is held as suitable candidate for such non-invasive biomarker harvest as it is easily collected without invasive methods. Thus, the aims of the study were to investigate if ci-miRNAs can be detected from sweat and to further examine circulating profiles of the same ci-miRNAs as acute response to VO2 max test in sweat and serum. Also, it was examined whether the ci-miRNA profiles correlated between the body fluids. It was observed, for the first time, that sweat contained ci-miRNAs and the expression of ci-miRNA-146a was upregulated after acute exercise. However, the ci-miRNA correlations between the body fluids were weak. Based on our observations, sweat harvesting cannot be supported after VO2 max test and ci-miRNAs cannot be utilized as VO2 max biomarkers currently, but they hold potential to function as such in the future. Until then, several obstacles regarding to exercise study designs and miRNA overall methodology should be overcome.", "language": "en", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Submitted by Paivi Vuorio (paelvuor@jyu.fi) on 2019-06-20T05:53:10Z\nNo. of bitstreams: 0", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Made available in DSpace on 2019-06-20T05:53:10Z (GMT). No. of bitstreams: 0\n Previous issue date: 2019", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.format.extent", "value": "47", "language": "", "element": "format", "qualifier": "extent", "schema": "dc"}, {"key": "dc.format.mimetype", "value": "application/pdf", "language": null, "element": "format", "qualifier": "mimetype", "schema": "dc"}, {"key": "dc.language.iso", "value": "eng", "language": null, "element": "language", "qualifier": "iso", "schema": "dc"}, {"key": "dc.rights", "value": "In Copyright", "language": "en", "element": "rights", "qualifier": null, "schema": "dc"}, {"key": "dc.subject.other", "value": "exercise", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "exosome", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "extracellular vesicle", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.title", "value": "The potential role of circulating-micro-RNA-21, -146a, -221 and -222 as non-invasive biomarkers in acute exercise training", "language": "", "element": "title", "qualifier": null, "schema": "dc"}, {"key": "dc.type", "value": "master thesis", "language": null, "element": "type", "qualifier": null, "schema": "dc"}, {"key": "dc.identifier.urn", "value": "URN:NBN:fi:jyu-201906203322", "language": "", "element": "identifier", "qualifier": "urn", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Pro gradu -tutkielma", "language": "fi", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Master\u2019s thesis", "language": "en", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Matemaattis-luonnontieteellinen tiedekunta", "language": "fi", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Faculty of Sciences", "language": "en", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Bio- ja ymp\u00e4rist\u00f6tieteiden laitos", "language": "fi", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Department of Biological and Environmental Science", "language": "en", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "Jyv\u00e4skyl\u00e4n yliopisto", "language": "fi", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "University of Jyv\u00e4skyl\u00e4", "language": "en", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Solu- ja molekyylibiologia", "language": "fi", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Cell and molecular biology", "language": "en", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "yvv.contractresearch.collaborator", "value": "business", "language": "", "element": "contractresearch", "qualifier": "collaborator", "schema": "yvv"}, {"key": "yvv.contractresearch.funding", "value": "2500", "language": "", "element": "contractresearch", "qualifier": "funding", "schema": "yvv"}, {"key": "yvv.contractresearch.initiative", "value": "university", "language": "", "element": "contractresearch", "qualifier": "initiative", "schema": "yvv"}, {"key": "dc.type.coar", "value": "http://purl.org/coar/resource_type/c_bdcc", "language": null, "element": "type", "qualifier": "coar", "schema": "dc"}, {"key": "dc.rights.accesslevel", "value": "restrictedAccess", "language": null, "element": "rights", "qualifier": "accesslevel", "schema": "dc"}, {"key": "dc.type.publication", "value": "masterThesis", "language": null, "element": "type", "qualifier": "publication", "schema": "dc"}, {"key": "dc.subject.oppiainekoodi", "value": "4013", "language": "", "element": "subject", "qualifier": "oppiainekoodi", "schema": "dc"}, {"key": "dc.subject.yso", "value": "hiki", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "mikro-RNA", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "harjoittelu", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "sweat", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "microRNA", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "training", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.format.content", "value": "fulltext", "language": null, "element": "format", "qualifier": "content", "schema": "dc"}, {"key": "dc.rights.url", "value": "https://rightsstatements.org/page/InC/1.0/", "language": null, "element": "rights", "qualifier": "url", "schema": "dc"}, {"key": "dc.rights.accessrights", "value": "The author has not given permission to make the work publicly available electronically. Therefore the material can be read only at the archival workstation at Jyv\u00e4skyl\u00e4 University Library (https://kirjasto.jyu.fi/en/workspaces/facilities).", "language": "en", "element": "rights", "qualifier": "accessrights", "schema": "dc"}, {"key": "dc.rights.accessrights", "value": "Tekij\u00e4 ei ole antanut lupaa avoimeen julkaisuun, joten aineisto on luettavissa vain Jyv\u00e4skyl\u00e4n yliopiston kirjaston arkistoty\u00f6semalta. Ks. https://kirjasto.jyu.fi/fi/tyoskentelytilat/laitteet-ja-tilat..", "language": "fi", "element": "rights", "qualifier": "accessrights", "schema": "dc"}, {"key": "dc.type.okm", "value": "G2", "language": null, "element": "type", "qualifier": "okm", "schema": "dc"}]
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