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[{"key": "dc.contributor.advisor", "value": "Tarkka, Ina", "language": "", "element": "contributor", "qualifier": "advisor", "schema": "dc"}, {"key": "dc.contributor.author", "value": "McLellan, Susanna", "language": "", "element": "contributor", "qualifier": "author", "schema": "dc"}, {"key": "dc.date.accessioned", "value": "2019-06-10T07:04:14Z", "language": null, "element": "date", "qualifier": "accessioned", "schema": "dc"}, {"key": "dc.date.available", "value": "2019-06-10T07:04:14Z", "language": null, "element": "date", "qualifier": "available", "schema": "dc"}, {"key": "dc.date.issued", "value": "2019", "language": "", "element": "date", "qualifier": "issued", "schema": "dc"}, {"key": "dc.identifier.uri", "value": "https://jyx.jyu.fi/handle/123456789/64445", "language": null, "element": "identifier", "qualifier": "uri", "schema": "dc"}, {"key": "dc.description.abstract", "value": "Magnetoenkefalografialla (MEG) voidaan mitata aivojen s\u00e4hk\u00f6ist\u00e4 toimintaa kallon ulkopuolelta reaaliajassa. Ajallisen erottelukyvyn ansiosta MEG soveltuu kipututkimuksessa hyvin ensimm\u00e4isten aivovasteiden tarkasteluun. Liikunnan kipua lievent\u00e4v\u00e4st\u00e4 vaikutuksesta (Exercise Induced Hypoalgesia EIH) on olemassa n\u00e4ytt\u00f6\u00e4, mutta sen vaikutusmekanismit ovat osin ep\u00e4selvi\u00e4. Tutkimuksen tarkoituksena oli a) testata intrakutaania s\u00e4hk\u00f6ist\u00e4 stimulaatiomenetelm\u00e4\u00e4 ja tarkastella sen aikaansaamia kipuvasteita aivojen somatosensorisilla alueilla ja b) tarkastella isometrisen lihasrasituksen mahdollisia vaikutuksia kivun somatosensoriseen prosessointiin.\n\nAineisto ker\u00e4ttiin Mattilanniemess\u00e4 306-kanavaisella Elekta Neuromag Triux -magnetoenkefalografilla. Koehenkil\u00f6t olivat 26\u201343 -vuotiaita oikeak\u00e4tisi\u00e4 naisia (n = 5), joilla ei ollut masennus- tai ahdistusoireilua tai neurologisia sairauksia. Intrakutaanin s\u00e4hk\u00f6stimuluksen intensiteetti s\u00e4\u00e4dettiin yksil\u00f6llisesti vastaamaan kiputuntemuksen voimakkuutta 5\u20137 VAS-kipujanaa k\u00e4ytt\u00e4en. Koehenkil\u00f6lle annettiin 31 intrakutaania kipustimulusta 5,5\u20137,5 sekunnin v\u00e4lein. Seitsem\u00e4n minuutin levon j\u00e4lkeen koehenkil\u00f6 suoritti kolmen minuutin isometrisen k\u00e4denpuristuksen hydraulisella dynamometrill\u00e4 30 % maksimipuristusvoimasta. V\u00e4litt\u00f6m\u00e4sti t\u00e4m\u00e4n j\u00e4lkeen seurasi toinen stimulussarja. Kunkin stimulussarjan j\u00e4lkeen koehenkil\u00f6 ilmoitti koetun kivun voimakkuuden VAS-janalla. Kaikki koehenkil\u00f6t kuvasivat kivun hyvin paikantuvaksi, mik\u00e4 viittaa kipuviestin v\u00e4littyneen p\u00e4\u00e4osin A-deltas\u00e4ikeit\u00e4 pitkin. MEG-aineisto analysoitiin Brainstorm-ohjelmalla ja tilastolliset testit laskettiin IBM SPSS-ohjelmalla Wilcoxonin merkittyjen sijalukujen eksaktilla testill\u00e4.\n\nIntrakutaani s\u00e4hk\u00f6stimulus sai aikaan her\u00e4tevasteen, jonka ensimm\u00e4inen komponentti oli havaittavissa noin 48 ms stimuluksen j\u00e4lkeen paikantuen kontralateraaliselle primaarille somatosensoriselle korteksille. Her\u00e4tevasteen toinen komponentti havaittiin noin 97 ms stimuluksen j\u00e4lkeen paikantuen p\u00e4\u00e4asiallisesti bilateraalisesti sekundaarille somatosensoriselle korteksille. Her\u00e4tevasteen kolmas komponentti noin 207 ms stimuluksesta ei ollut yht\u00e4 selke\u00e4sti paikannettavissa.\n\nK\u00e4ytt\u00e4m\u00e4\u00e4mme intrakutaania s\u00e4hk\u00f6stimulusmenetelm\u00e4\u00e4 ei ole raportoitu muissa magnetoenkefalografilla tehdyiss\u00e4 kipututkimuksissa. Isometrinen lihasrasitus ei tulosten mukaan muuntanut kivun prosessointia somatosensorisilla alueilla ajallisesti tai sijainnin suhteen n\u00e4iss\u00e4 tutkituissa komponenteissa. \n\nTulosten tulkinnassa on otettava huomioon koehenkil\u00f6iden m\u00e4\u00e4r\u00e4 sek\u00e4 mahdolliset ep\u00e4tarkkuudet MEG-aineiston preprosessoinnissa ja analysoinnissa.", "language": "fi", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.abstract", "value": "Magnetoencephalography (MEG) is an ideal method to study cortical activity, especially the early event-related responses, thanks to its millisecond temporal resolution and non-invasiveness. Even though different forms of exercise have been found to relieve pain in many chronic pain conditions, the mechanisms behind Exercise Induced Hypoalgesia (EIH) are not fully known. Our aim was to a) test an intracutaneous electrical stimulation method to produce and to identify evoked pain-related responses in somatosensory cortical areas, b) examine whether isometric exercise can modulate somatosensory pain processing.\n\nThe data was recorded at University of Jyv\u00e4skyl\u00e4 with 306-channel Elekta Neuromag Triux -magnetoencephalography. The participants were healthy 26\u201343 years old right-handed women with no symptoms of depression or anxiety. The intensity of intracutaneous electrical stimulation was individually adjusted to correlate the subjective pain rating 5\u20137 on Visual Analog Scale (VAS) 0\u201310. There were 31 stimuli delivered on the right hand\u2019s third fingertip followed by 7 minutes rest. The interstimulus interval between the stimuli was 5,5\u20137,5 s. The 3 minutes isometric handgrip contraction was performed with left hand at 30 % of maximal voluntary strength. The second set of 31 stimuli was delivered after contraction. Immediately after the both stimuli set the participants were asked to evaluate their subjective pain rating on VAS 0\u201310. The pain sensation was described as well-localized by all participants referring to primarily A-delta fiber activation. The MEG data was analysed with Brainstorm software and the statistical tests were performed using IBM SPSS -software.\n\nThe evoked magnetic fields showed two clear components at around 48 ms and 97 ms generated mainly in the vicinity of SI contralaterally and SII bilaterally. The component at around 207 ms was more difficult to localize; the probable source locating in SII contralaterally.\n\nThe intracutaneous electrical stimulus method has not been used in any similar protocol earlier. According to the present analysis, the 3 minutes isometric exercise contralateral to stimulated site did not seem to have an effect on peak latency, intensity or location of the evoked fields in the primary somatosensory cortex contralaterally or in the secondary somatosensory cortex bilaterally. The interpretation of the results should be made with caution because of the limited accuracy on the pre-processing and the analysis of the MEG data and because of the small number of the participants.", "language": "en", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Submitted by Miia Hakanen (mihakane@jyu.fi) on 2019-06-10T07:04:14Z\nNo. of bitstreams: 0", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Made available in DSpace on 2019-06-10T07:04:14Z (GMT). No. of bitstreams: 0\n Previous issue date: 2019", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.format.extent", "value": "65", "language": "", "element": "format", "qualifier": "extent", "schema": "dc"}, {"key": "dc.format.mimetype", "value": "application/pdf", "language": null, "element": "format", "qualifier": "mimetype", "schema": "dc"}, {"key": "dc.language.iso", "value": "fin", "language": null, "element": "language", "qualifier": "iso", "schema": "dc"}, {"key": "dc.rights", "value": "In Copyright", "language": "en", "element": "rights", "qualifier": null, "schema": "dc"}, {"key": "dc.subject.other", "value": "isometrinen rasitus", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "magnetoenkefalografia", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "her\u00e4tevaste", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "intrakutaani stimulus", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "somatosensorinen aivokuori", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.title", "value": "Isometrisen lihasrasituksen vaikutus kivun prosessointiin aivokuorella : MEG-tutkimus", "language": "", "element": "title", "qualifier": null, "schema": "dc"}, {"key": "dc.type", "value": "master thesis", "language": null, "element": "type", "qualifier": null, "schema": "dc"}, {"key": "dc.identifier.urn", "value": "URN:NBN:fi:jyu-201906103084", "language": "", "element": "identifier", "qualifier": "urn", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Pro gradu -tutkielma", "language": "fi", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Master\u2019s thesis", "language": "en", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Liikuntatieteellinen tiedekunta", "language": "fi", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Faculty of Sport and Health Sciences", "language": "en", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Liikunta- ja terveystieteet", "language": "fi", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Sport and Health Sciences", "language": "en", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "Jyv\u00e4skyl\u00e4n yliopisto", "language": "fi", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "University of Jyv\u00e4skyl\u00e4", "language": "en", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Liikuntal\u00e4\u00e4ketiede", "language": "fi", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Sport Medicine", "language": "en", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "yvv.contractresearch.funding", "value": "0", "language": "", "element": "contractresearch", "qualifier": "funding", "schema": "yvv"}, {"key": "dc.type.coar", "value": "http://purl.org/coar/resource_type/c_bdcc", "language": null, "element": "type", "qualifier": "coar", "schema": "dc"}, {"key": "dc.rights.accesslevel", "value": "restrictedAccess", "language": null, "element": "rights", "qualifier": "accesslevel", "schema": "dc"}, {"key": "dc.type.publication", "value": "masterThesis", "language": null, "element": "type", "qualifier": "publication", "schema": "dc"}, {"key": "dc.subject.oppiainekoodi", "value": "5042", "language": "", "element": "subject", "qualifier": "oppiainekoodi", "schema": "dc"}, {"key": "dc.subject.yso", "value": "kipu", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "MEG", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.format.content", "value": "fulltext", "language": null, "element": "format", "qualifier": "content", "schema": "dc"}, {"key": "dc.rights.url", "value": "https://rightsstatements.org/page/InC/1.0/", "language": null, "element": "rights", "qualifier": "url", "schema": "dc"}, {"key": "dc.rights.accessrights", "value": "The author has not given permission to make the work publicly available electronically. Therefore the material can be read only at the archival workstation at Jyv\u00e4skyl\u00e4 University Library (https://kirjasto.jyu.fi/en/workspaces/facilities).", "language": "en", "element": "rights", "qualifier": "accessrights", "schema": "dc"}, {"key": "dc.rights.accessrights", "value": "Tekij\u00e4 ei ole antanut lupaa avoimeen julkaisuun, joten aineisto on luettavissa vain Jyv\u00e4skyl\u00e4n yliopiston kirjaston arkistoty\u00f6semalta. Ks. https://kirjasto.jyu.fi/fi/tyoskentelytilat/laitteet-ja-tilat..", "language": "fi", "element": "rights", "qualifier": "accessrights", "schema": "dc"}, {"key": "dc.type.okm", "value": "G2", "language": null, "element": "type", "qualifier": "okm", "schema": "dc"}]
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