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[{"key": "dc.contributor.advisor", "value": "Wikgren, Jan", "language": "", "element": "contributor", "qualifier": "advisor", "schema": "dc"}, {"key": "dc.contributor.author", "value": "Ilom\u00e4ki, Miro", "language": "", "element": "contributor", "qualifier": "author", "schema": "dc"}, {"key": "dc.contributor.author", "value": "Salonen, Markus", "language": "", "element": "contributor", "qualifier": "author", "schema": "dc"}, {"key": "dc.date.accessioned", "value": "2018-09-24T11:51:53Z", "language": null, "element": "date", "qualifier": "accessioned", "schema": "dc"}, {"key": "dc.date.available", "value": "2018-09-24T11:51:53Z", "language": null, "element": "date", "qualifier": "available", "schema": "dc"}, {"key": "dc.date.issued", "value": "2018", "language": "", "element": "date", "qualifier": "issued", "schema": "dc"}, {"key": "dc.identifier.uri", "value": "https://jyx.jyu.fi/handle/123456789/59649", "language": null, "element": "identifier", "qualifier": "uri", "schema": "dc"}, {"key": "dc.description.abstract", "value": "Frontomediaalisen alueen theta-oskillaatioilla on todettu olevan merkitsev\u00e4 yhteys ty\u00f6muistiin sek\u00e4 tarkkaavuuden yll\u00e4pitoon liittyviin prosesseihin. N\u00e4iden oskillaatioiden yhteytt\u00e4 oppimiseen, kuten mieleen painamiseen ja konsolidaatioon, on tutkittu melko v\u00e4h\u00e4n ihmisill\u00e4. El\u00e4intutkimuksissa skopolamiinin on osoitettu haittaavan ehdollistumista ja alentavan hippokampuksen neuraalista toimintaa sek\u00e4 theta-aktiivisuuden m\u00e4\u00e4r\u00e4\u00e4. Joidenkin tutkimusten mukaan skopolamiini aiheuttaa hippokampuksen h\u00e4iriintynytt\u00e4 toimintaa my\u00f6s ihmisill\u00e4. T\u00e4ss\u00e4 tutkimuksessa, noudattaen kaksoissokkoasetelmaa, koehenkil\u00f6ille annettiin 1mg/72h skopolamiinilaastari, jolla heikennettiin oppimiseen ja muistiin liittyvi\u00e4 toimintoja. Puolet koehenkil\u00f6ist\u00e4 altistuivat skopolamiinille, ja puolelle koehenkil\u00f6ist\u00e4 annettiin plasebolaastari. Oppimis- ja muistisuoriutumista mitattiin silm\u00e4niskuehdollistamiskokeen sek\u00e4 WMS-R -testist\u00f6n loogisen muistin teht\u00e4vien ja sanapariteht\u00e4vien avulla. Ehdollistamiskokeen aikana mitattiin frontomediaalisen alueen EEG-aktiivisuutta. Skopolamiini heikensi mieleenpainamista sanapari- ja loogisen muistin teht\u00e4viss\u00e4 sek\u00e4 alensi ehdollisen vasteen esiintymistodenn\u00e4k\u00f6isyytt\u00e4 ehdollistamiskokeessa. Ehdollisen \u00e4rsykkeen aiheuttama frontomediaalisen alueen theta-aktiivisuus oli merkitsev\u00e4sti suurempaa kontrolliryhm\u00e4ll\u00e4. Alfa-aktiivisuudessa ei ollut eroa ryhmien v\u00e4lill\u00e4. T\u00e4m\u00e4n tutkimuksen tulokset laajentavat n\u00e4k\u00f6kulmaa frontomediaalisen thetaaktiivisuuden yhteyksist\u00e4 kognitiivisiin toimintoihin.", "language": "fi", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.abstract", "value": "The role of theta oscillations in and around the frontal midline have been well documented in working memory and sustained attention related processes. However, the role of these oscillations in relation to learning processes, such as encoding and consolidation, have not yet been thoroughly studied in humans. In animal studies, scopolamine has been shown to hinder conditioning as well as decrease the hippocampal neural response and amount of theta. Some studies have also reported scopolamine induced disruption in hippocampal activity in humans. Using a double-blind setting, the present study used 1mg/72h transdermal scopolamine to hinder learning and memory functions in half of the sample while measuring memory performance with WMS-R logical memory and word pairs tasks, and learning performance in a trace eyeblink classical conditioning setting while measuring a frontal midline EEG activity. Scopolamine caused a decrement in encoding performance in WMS-R logical memory and word pairs tasks, and a slower rate of acquisition in trace-EBCC. Conditioned stimulus evoked frontal midline theta activity was more prominent in the control group. Groups did not differ based on alpha activity during any of the measured segments. The findings of the present study provide leeway for another interpretation of frontal midline theta activity besides its prevalence observed during working memory load and sustained attention.", "language": "en", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Submitted by Riitta Pitk\u00e4nen (rpitkane@jyu.fi) on 2018-09-24T11:51:53Z\nNo. of bitstreams: 0", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Made available in DSpace on 2018-09-24T11:51:53Z (GMT). No. of bitstreams: 0\n Previous issue date: 2018", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.format.extent", "value": "30", "language": "", "element": "format", "qualifier": "extent", "schema": "dc"}, {"key": "dc.format.mimetype", "value": "application/pdf", "language": null, "element": "format", "qualifier": "mimetype", "schema": "dc"}, {"key": "dc.language.iso", "value": "eng", "language": null, "element": "language", "qualifier": "iso", "schema": "dc"}, {"key": "dc.rights", "value": "In Copyright", "language": "en", "element": "rights", "qualifier": null, "schema": "dc"}, {"key": "dc.subject.other", "value": "scopolamine", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "frontal midline theta", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "learning", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "declarative memory", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "EEG", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "classical conditioning", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "EBCC", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.title", "value": "The effect of scopolamine on declarative learning and frontal midline theta activity", "language": "", "element": "title", "qualifier": null, "schema": "dc"}, {"key": "dc.type", "value": "master thesis", "language": null, "element": "type", "qualifier": null, "schema": "dc"}, {"key": "dc.identifier.urn", "value": "URN:NBN:fi:jyu-201809244223", "language": "", "element": "identifier", "qualifier": "urn", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Pro gradu -tutkielma", "language": "fi", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Master\u2019s thesis", "language": "en", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Kasvatustieteiden ja psykologian tiedekunta", "language": "fi", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Faculty of Education and Psychology", "language": "en", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Psykologian laitos", "language": "fi", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Department of Psychology", "language": "en", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "Jyv\u00e4skyl\u00e4n yliopisto", "language": "fi", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "University of Jyv\u00e4skyl\u00e4", "language": "en", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Psykologia", "language": "fi", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Psychology", "language": "en", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "yvv.contractresearch.funding", "value": "0", "language": "", "element": "contractresearch", "qualifier": "funding", "schema": "yvv"}, {"key": "dc.type.coar", "value": "http://purl.org/coar/resource_type/c_bdcc", "language": null, "element": "type", "qualifier": "coar", "schema": "dc"}, {"key": "dc.rights.accesslevel", "value": "openAccess", "language": null, "element": "rights", "qualifier": "accesslevel", 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