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[{"key": "dc.contributor.advisor", "value": "Vihola, Matti", "language": "", "element": "contributor", "qualifier": "advisor", "schema": "dc"}, {"key": "dc.contributor.author", "value": "Karppinen, Santeri", "language": "", "element": "contributor", "qualifier": "author", "schema": "dc"}, {"key": "dc.date.accessioned", "value": "2018-09-21T05:28:59Z", "language": null, "element": "date", "qualifier": "accessioned", "schema": "dc"}, {"key": "dc.date.available", "value": "2018-09-21T05:28:59Z", "language": null, "element": "date", "qualifier": "available", "schema": "dc"}, {"key": "dc.date.issued", "value": "2018", "language": "", "element": "date", "qualifier": "issued", "schema": "dc"}, {"key": "dc.identifier.uri", "value": "https://jyx.jyu.fi/handle/123456789/59607", "language": null, "element": "identifier", "qualifier": "uri", "schema": "dc"}, {"key": "dc.description.abstract", "value": "Lasten akuutin lymfoblastileukemian yll\u00e4pitovaiheen hoidossa teht\u00e4v\u00e4t l\u00e4\u00e4keannostusp\u00e4\u00e4t\u00f6kset pohjataan nykyisin potilaan veren valkosolupitoisuuteen, joka on hoidon tehokkuudesta kertova tekij\u00e4. Potilaalle sopiva l\u00e4\u00e4keannostus on hoidon onnistumisen ja turvallisuuden kannalta t\u00e4rke\u00e4, mutta sen l\u00f6yt\u00e4minen on vaikeaa, sill\u00e4 annettu l\u00e4\u00e4kitys n\u00e4kyy\nvalkosolupitoisuudessa viiveell\u00e4, ja potilaiden elimist\u00f6n reagointi l\u00e4\u00e4kitykseen on yksil\u00f6llist\u00e4. Sopivan l\u00e4\u00e4keannostuksen l\u00f6yt\u00e4mist\u00e4 hankaloittavat my\u00f6s hoidonaikaiset tulehdukset, jotka voivat muuttaa valkosolupitoisuutta hetkellisesti.\nTy\u00f6 k\u00e4sittelee akuuttiin lymfoblastileukemiaan sairastuneiden suomalaisten potilaiden veren valkosolupitoisuuden mallintamista kahdella bayesilaisella mallilla, differentiaaliyht\u00e4l\u00f6mallilla sek\u00e4 ep\u00e4lineaarisella tila-avaruusmallilla, jotka pohjautuvat kirjallisuudessa esitettyihin malleihin. Ty\u00f6ss\u00e4 esitell\u00e4\u00e4n ja laajennetaan kirjallisuudessa ehdotettuja\nmalleja. Mallien estimointi tehd\u00e4\u00e4n suomalaisista potilaista koostuvaa aikasarja-aineistoa hy\u00f6dynt\u00e4en. Tila-avaruusmalleja sek\u00e4 potilaan tulehdusarvoa hy\u00f6dynnet\u00e4\u00e4n ensimm\u00e4ist\u00e4 kertaa ilmi\u00f6n mallintamisessa. Potilaan hoidonaikainen tulehdusarvo havaitaan hy\u00f6dylliseksi muuttujaksi valkosolupitoisuuteen liittyv\u00e4n ep\u00e4varmuuden mallintamisessa.", "language": "fi", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Submitted by Riitta Pitk\u00e4nen (rpitkane@jyu.fi) on 2018-09-21T05:28:59Z\nNo. of bitstreams: 0", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Made available in DSpace on 2018-09-21T05:28:59Z (GMT). No. of bitstreams: 0\n Previous issue date: 2018", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.format.extent", "value": "60", "language": "", "element": "format", "qualifier": "extent", "schema": "dc"}, {"key": "dc.format.mimetype", "value": "application/pdf", "language": null, "element": "format", "qualifier": "mimetype", "schema": "dc"}, {"key": "dc.language.iso", "value": "fin", "language": null, "element": "language", "qualifier": "iso", "schema": "dc"}, {"key": "dc.rights", "value": "In Copyright", "language": "en", "element": "rights", "qualifier": null, "schema": "dc"}, {"key": "dc.subject.other", "value": "bayesilainen ep\u00e4lineaarinen tila-avaruusmalli", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "bayesilainen differentiaaliyht\u00e4l\u00f6malli", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "laajennettu Kalman-suodin", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "adaptiivinen MCMC-algoritmi", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.title", "value": "Valkosolupitoisuuksien bayesilainen mallintaminen lasten leukemian yll\u00e4pitohoidossa", "language": "", "element": "title", "qualifier": null, "schema": "dc"}, {"key": "dc.type", "value": "master thesis", "language": null, "element": "type", "qualifier": null, "schema": "dc"}, {"key": "dc.identifier.urn", "value": "URN:NBN:fi:jyu-201809214197", "language": "", "element": "identifier", "qualifier": "urn", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Pro gradu -tutkielma", "language": "fi", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Master\u2019s thesis", "language": "en", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Matemaattis-luonnontieteellinen tiedekunta", "language": "fi", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Faculty of Sciences", "language": "en", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Matematiikan ja tilastotieteen laitos", "language": "fi", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Department of Mathematics and Statistics", "language": "en", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "Jyv\u00e4skyl\u00e4n yliopisto", "language": "fi", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "University of Jyv\u00e4skyl\u00e4", "language": "en", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Tilastotiede", "language": "fi", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Statistics", "language": "en", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "yvv.contractresearch.funding", "value": "0", "language": "", "element": "contractresearch", "qualifier": "funding", "schema": "yvv"}, {"key": "dc.type.coar", "value": "http://purl.org/coar/resource_type/c_bdcc", "language": null, "element": "type", "qualifier": "coar", "schema": "dc"}, {"key": "dc.rights.accesslevel", "value": "openAccess", "language": null, "element": "rights", "qualifier": "accesslevel", "schema": "dc"}, {"key": "dc.type.publication", "value": "masterThesis", "language": null, "element": "type", "qualifier": "publication", "schema": "dc"}, {"key": "dc.subject.oppiainekoodi", "value": "4043", "language": "", "element": "subject", "qualifier": "oppiainekoodi", "schema": "dc"}, {"key": "dc.subject.yso", "value": "bayesilainen menetelm\u00e4", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "aikasarjat", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "estimointi", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "valkosolut", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "matemaattiset mallit", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "tilastomenetelm\u00e4t", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.format.content", "value": "fulltext", "language": null, "element": "format", "qualifier": "content", "schema": "dc"}, {"key": "dc.rights.url", 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