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[{"key": "dc.contributor.author", "value": "Berggren, Satu", "language": "", "element": "contributor", "qualifier": "author", "schema": "dc"}, {"key": "dc.date.accessioned", "value": "2018-08-21T06:54:53Z", "language": null, "element": "date", "qualifier": "accessioned", "schema": "dc"}, {"key": "dc.date.available", "value": "2018-08-21T06:54:53Z", "language": null, "element": "date", "qualifier": "available", "schema": "dc"}, {"key": "dc.date.issued", "value": "2018", "language": "", "element": "date", "qualifier": "issued", "schema": "dc"}, {"key": "dc.identifier.uri", "value": "https://jyx.jyu.fi/handle/123456789/59283", "language": null, "element": "identifier", "qualifier": "uri", "schema": "dc"}, {"key": "dc.description.abstract", "value": "Johdanto: Ei-alkoholiper\u00e4inen rasvamaksa (NAFLD) on riskitekij\u00e4 tyypin 2 diabetekselle ja syd\u00e4n- ja verisuonisairauksille aikuisilla. Vaikka kardiorespiratorisen kunnon on todettu olevan k\u00e4\u00e4nteisesti yhteydess\u00e4 kardiometaboliseen riskiin lapsilla, sen yhteytt\u00e4 rasvamaksan indikaattoreihin ei ole t\u00e4m\u00e4nik\u00e4isell\u00e4 v\u00e4est\u00f6ll\u00e4 aikaisemmin tutkittu. T\u00e4ss\u00e4 tutkielmassa selvitettiin lasten kardiorespiratorisen kunnon yhteyksi\u00e4 plasman alaniiniaminotransferaasi- (ALT) ja gammaglutamyylitransferaasipitoisuuksiin (GGT). \nMenetelm\u00e4t: Tutkimukseen osallistui 465 6-9-vuotiasta lasta. Kardiorespiratorinen kunto arvioitiin maksimaalisella polkupy\u00f6r\u00e4ergometritestill\u00e4 maksimaalisena ty\u00f6m\u00e4\u00e4r\u00e4n\u00e4 (Wmax), ja se suhteutettiin erikseen kehon massaan (BM) sek\u00e4 rasvattomaan massaan (LM). Kehon rasvaprosentti (BF%) m\u00e4\u00e4ritettiin kaksienergisell\u00e4 r\u00f6ntgenabsorptiometrialla (DXA). ALT- ja GGT-pitoisuudet m\u00e4\u00e4ritettiin 12 tunnin paaston j\u00e4lkeen otetusta verin\u00e4ytteest\u00e4. Analyysimenetelm\u00e4n\u00e4 k\u00e4ytettiin i\u00e4ll\u00e4 ja sukupuolella vakioitua lineaarista regressioanalyysi\u00e4. \nTulokset: Kardiorespiratorinen kunto, sek\u00e4 kehon massaan ett\u00e4 rasvattomaan massaan suhteutettuna, oli k\u00e4\u00e4nteisesti yhteydess\u00e4 GGT-pitoisuuksiin pojilla (Wmax/BM: B=\u20130,273; 95% CI=\u20130,397-(\u20130,150), P<0,001, R2adj=0,077 ja Wmax/LM: B=\u20130,180; 95% CI=\u20130,308-(\u20130,052), P=0,006, R2adj=0,034). Wmax/LM ja GGT:n yhteys s\u00e4ilyi pojilla merkitsev\u00e4n\u00e4 my\u00f6s rasvaprosentilla vakioimisen j\u00e4lkeen (B=\u20130,135; 95% CI=\u20130,262-(\u20130,009), P=0,036, R2adj=0,093). Kardiorespiratorinen kunto ei ollut yhteydess\u00e4 ALT-pitoisuuksiin pojilla eik\u00e4 ALT- tai GGT-pitoisuuksiin tyt\u00f6ill\u00e4. Rasvaprosentti oli yhteydess\u00e4 ALT- ja GGT-arvoihin pojilla ja tyt\u00f6ill\u00e4 kardiorespiratorisesta kunnosta riippumatta (P<0,022). \nPohdinta: Tulosten perusteella parempi kardiorespiratorinen kunto oli k\u00e4\u00e4nteisesti yhteydess\u00e4 GGT-pitoisuuksiin pojilla. N\u00e4m\u00e4 tulokset viittaavat siihen, ett\u00e4 pojilla matalan kest\u00e4vyyskunnon omaavilla pojilla saattaa olla kohonnut NAFLD:n riski. Tuloksia pit\u00e4\u00e4 kuitenkin tulkita varoen, sill\u00e4 maksaentsyymipitoisuudet eiv\u00e4t ole suoria maksan rasvapitoisuuden mittareita. Siit\u00e4 huolimatta havainnot korostavat riitt\u00e4v\u00e4n kest\u00e4vyyskunnon merkityst\u00e4 terveydelle, sek\u00e4 kest\u00e4vyys-kunnon seulonnan ja alhaisen kardiorespiratorisen kunnon parantamisen t\u00e4rkeytt\u00e4 lapsilla kardiometabolisen terveyden edist\u00e4miseksi.", "language": "fi", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.abstract", "value": "Background and purpose: Non-alcoholic fatty liver disease (NAFLD) is a risk factor for type 2 diabetes and cardiovascular diseases in adults. Although cardiorespiratory fitness (CRF) has been inversely associated with cardiometabolic risk in children, there are only few previous studies on the associations of CRF with the indicators of NAFLD in paediatric populations. Therefore, I examined the association of CRF with plasma alanine aminotransferase (ALT) and gamma-glutamyltransferase (GGT). \nMethods: Altogether 465 6\u20139-year-old children participated in the study. CRF was assessed by maximal cycle ergometer test and defined as maximal workload (Wmax) normalised for body mass (BM) and lean mass (LM). Body fat percentage (BF%) was assessed by dual-energy x-ray absorptiometry (DXA). ALT and GGT were assessed from venous blood samples after 12h fast. The data were analysed using linear regression analyses adjusted for age and sex. \nResults: CRF, scaled with BM or LM, was inversely associated with GGT concentration in boys (Wmax/BM: B=-0.273, 95% CI=-0.397 to -0.150, P<0.001, R2adj=0.077 and Wmax/LM: B=-0.180, 95% CI=-0.308 to -0.052, P=0.006, R2adj=0.034). The association between Wmax/LM with GGT in boys remained significant after further adjustment for BF% (B=-0.135, 95% CI=-0.262 to -0.009, P=0.036, R2adj=0.093). CRF was not associated with ALT in boys and ALT or GGT in girls. BF% was directly related to ALT and GGT in boys and girls independent of CRF (p<0.022).\nConclusions: The present results showed that CRF was inversely associated with lower GGT concentration in boys. These results suggest that boys with lower CRF may be at increased risk of NAFLD already in childhood. However, these results should be interpreted cautiously as liver enzymes are not direct indicators of liver fat. Nevertheless, these observations highlight the im-portance of screening and support interventional approach with children with low CRF in order to improve their cardiometabolic health.", "language": "en", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Submitted by Riitta Pitk\u00e4nen (rpitkane@jyu.fi) on 2018-08-21T06:54:53Z\nNo. of bitstreams: 0", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Made available in DSpace on 2018-08-21T06:54:53Z (GMT). No. of bitstreams: 0\n Previous issue date: 2018", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.format.extent", "value": "48", "language": "", "element": "format", "qualifier": "extent", "schema": "dc"}, {"key": "dc.format.mimetype", "value": "application/pdf", "language": null, "element": "format", "qualifier": "mimetype", "schema": "dc"}, {"key": "dc.language.iso", "value": "eng", "language": null, "element": "language", "qualifier": "iso", "schema": "dc"}, {"key": "dc.rights", "value": "In Copyright", "language": "en", "element": "rights", "qualifier": null, "schema": "dc"}, {"key": "dc.subject.other", "value": "cardiorespiratory fitness", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "liver enzymes", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "fatty liver", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.title", "value": "Associations of cardiorespiratory fitness with alanine aminotransferase and gamma-glutamyltransferase concentrations in 6-9-year-old children", "language": "", "element": "title", "qualifier": null, "schema": "dc"}, {"key": "dc.type", "value": "master thesis", "language": null, "element": "type", "qualifier": null, "schema": "dc"}, {"key": "dc.identifier.urn", "value": "URN:NBN:fi:jyu-201808213880", "language": "", "element": "identifier", "qualifier": "urn", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Pro gradu -tutkielma", "language": "fi", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Master\u2019s thesis", "language": "en", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Liikuntatieteellinen tiedekunta", "language": "fi", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Faculty of Sport and Health Sciences", "language": "en", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Liikunta- ja terveystieteet", "language": "fi", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Sport and Health Sciences", "language": "en", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "Jyv\u00e4skyl\u00e4n yliopisto", "language": "fi", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "University of Jyv\u00e4skyl\u00e4", "language": "en", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Liikuntal\u00e4\u00e4ketiede", "language": "fi", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Sport Medicine", "language": "en", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "yvv.contractresearch.funding", "value": "0", "language": "", "element": "contractresearch", "qualifier": "funding", "schema": "yvv"}, {"key": "dc.type.coar", "value": "http://purl.org/coar/resource_type/c_bdcc", "language": null, "element": "type", "qualifier": "coar", "schema": "dc"}, {"key": "dc.rights.accesslevel", "value": "restrictedAccess", "language": null, "element": "rights", "qualifier": "accesslevel", "schema": "dc"}, {"key": "dc.type.publication", "value": "masterThesis", "language": null, "element": "type", "qualifier": "publication", "schema": "dc"}, {"key": "dc.subject.oppiainekoodi", "value": "5042", "language": "", "element": "subject", "qualifier": "oppiainekoodi", "schema": "dc"}, {"key": "dc.subject.yso", "value": "lapset (ik\u00e4ryhm\u00e4t)", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "riskitekij\u00e4t", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "rasvamaksa", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "syd\u00e4n- ja verisuonitaudit", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "children (age groups)", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "risk factors", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "fatty liver", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "cardiovascular diseases", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.format.content", "value": "fulltext", "language": null, "element": "format", "qualifier": "content", "schema": "dc"}, {"key": "dc.rights.url", "value": "https://rightsstatements.org/page/InC/1.0/", "language": null, "element": "rights", "qualifier": "url", "schema": "dc"}, {"key": "dc.rights.accessrights", "value": "The author has not given permission to make the work publicly available electronically. Therefore the material can be read only at the archival workstation at Jyv\u00e4skyl\u00e4 University Library (https://kirjasto.jyu.fi/en/workspaces/facilities).", "language": "en", "element": "rights", "qualifier": "accessrights", "schema": "dc"}, {"key": "dc.rights.accessrights", "value": "Tekij\u00e4 ei ole antanut lupaa avoimeen julkaisuun, joten aineisto on luettavissa vain Jyv\u00e4skyl\u00e4n yliopiston kirjaston arkistoty\u00f6semalta. Ks. https://kirjasto.jyu.fi/fi/tyoskentelytilat/laitteet-ja-tilat..", "language": "fi", "element": "rights", "qualifier": "accessrights", "schema": "dc"}, {"key": "dc.type.okm", "value": "G2", "language": null, "element": "type", "qualifier": "okm", "schema": "dc"}]
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