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[{"key": "dc.contributor.advisor", "value": "Astikainen, Piia", "language": "", "element": "contributor", "qualifier": "advisor", "schema": "dc"}, {"key": "dc.contributor.advisor", "value": "Ruohonen, Elisa", "language": "", "element": "contributor", "qualifier": "advisor", "schema": "dc"}, {"key": "dc.contributor.author", "value": "Kattainen, Saara", "language": "", "element": "contributor", "qualifier": "author", "schema": "dc"}, {"key": "dc.contributor.author", "value": "Taskila, Anna-Elisa", "language": "", "element": "contributor", "qualifier": "author", "schema": "dc"}, {"key": "dc.date.accessioned", "value": "2018-08-02T08:40:19Z", "language": null, "element": "date", "qualifier": "accessioned", "schema": "dc"}, {"key": "dc.date.available", "value": "2018-08-02T08:40:19Z", "language": null, "element": "date", "qualifier": "available", "schema": "dc"}, {"key": "dc.date.issued", "value": "2018", "language": "", "element": "date", "qualifier": "issued", "schema": "dc"}, {"key": "dc.identifier.uri", "value": "https://jyx.jyu.fi/handle/123456789/59085", "language": null, "element": "identifier", "qualifier": "uri", "schema": "dc"}, {"key": "dc.description.abstract", "value": "Sek\u00e4 ik\u00e4\u00e4ntymisen ett\u00e4 masennuksen on osoitettu olevan yhteydess\u00e4 heikentyneeseen serotoniinij\u00e4rjestelm\u00e4n toimintaan, mik\u00e4 voi heijastua aivojen automaattisen kykyyn k\u00e4sitell\u00e4 \u00e4\u00e4nten voimakkuuksia. \u00c4\u00e4nen voimakkuuden muutoksiin syntyvien aivovasteiden tutkiminen voikin antaa tietoa niin ik\u00e4\u00e4ntymiseen kuin masennukseenkin liittyv\u00e4st\u00e4 perustavanlaatuisesta aistitiedon k\u00e4sittelyst\u00e4 ja v\u00e4litt\u00e4j\u00e4ainetoiminnasta. Kuitenkaan ik\u00e4\u00e4ntyneill\u00e4 masentuneilla aivojen automaattista kyky\u00e4 k\u00e4sitell\u00e4 \u00e4\u00e4nten voimakkuuksia ei ole aiemmin tutkittu. Toteutimme elektroenkefalografiatutkimuksen (EEG) tarkastellaksemme aivojen automaattista kyky\u00e4 k\u00e4sitell\u00e4 \u00e4\u00e4nten voimakkuuksia nuorilla ei-masentuneilla (n=18, ik\u00e4 19\u201338), nuorilla masentuneilla (n=17, ik\u00e4 18\u201340), ik\u00e4\u00e4ntyneill\u00e4 ei-masentuneilla (n=16, ik\u00e4 63\u201380) ja ik\u00e4\u00e4ntyneill\u00e4 masentuneilla (n=20, ik\u00e4 62\u201376). Tutkimuksessa hy\u00f6dynnettiin passiivista muutoksenhavaitsemistilanne-koeasetelmaa N1-, MMN- ja P3a\u2013vasteiden tutkimiseen. Muutoksenhavaitsemistilanne-koeasetelma koostui kahdesta koesarjasta: toisessa koesarjassa oli toistettujen voimakkaiden \u00e4\u00e4nten (80 dB) joukossa harvoin esiintyvi\u00e4 hiljaisia \u00e4\u00e4ni\u00e4 (60 dB), ja toisessa koesarjassa \u00e4rsyketyyppien voimakkuudet olivat p\u00e4invastaiset. Tutkimuksen tulokset osoittivat ik\u00e4\u00e4ntymisen ja ik\u00e4\u00e4ntyneiden masennuksen liittyv\u00e4n suurentuneisiin N1-amplitudeihin koesarjassa, jossa toistuvana \u00e4rsykkeen\u00e4 oli hiljainen \u00e4\u00e4ni (60 dB) ja harvoin esiintyv\u00e4n\u00e4 \u00e4rsykkeen\u00e4 oli voimakas \u00e4\u00e4ni (80 dB). T\u00e4m\u00e4 saattaa viitata ik\u00e4\u00e4ntyneiden ja ik\u00e4\u00e4ntyneiden masentuneiden heikentyneeseen \u00e4rsykepiirteiden varhaiseen koodaamiseen, inhibitiovaikeuksiin sek\u00e4 heikentyneeseen serotoniinij\u00e4rjestelm\u00e4n toimintaan. Lis\u00e4ksi P3a-vasteet harvoin esiintyviin \u00e4rsykkeisiin olivat negatiivisesti yhteydess\u00e4 masennusoireita mittaaviin pistem\u00e4\u00e4riin (Beck Depression Inventory, BDI), viitaten heikentyneeseen tarkkaavuuden suuntaamiseen masennuksessa. Tulevaisuudessa tuloksia voidaan mahdollisesti hy\u00f6dynt\u00e4\u00e4 masennuksen diagnostiikassa ja masennuksen hoitomuotojen suunnittelussa.", "language": "fi", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.abstract", "value": "Both aging and depression have been associated to serotonergic dysfunction, which can be reflected by sound intensity processing of the brain. Therefore investigating brain responses to sound intensity changes can create understanding of basic sensory information processing and neurotransmission in aging and depression. However, sound intensity processing in old age depression has not been studied earlier. We conducted an electroencephalography (EEG) study to investigate sound intensity processing in young non-depressed adults (n=18, age 19-38), young depressed adults (n=17, age 18-40), aged non-depressed adults (n=16, age 63-80) and aged depressed adults (n=20, age 62-76). Passive oddball paradigm was used for inspecting N1, MMN and P3a responses. The oddball paradigm consisted of two conditions: low intensity condition with infrequently presented silent sounds (60 dB) among frequently presented loud sounds (80 dB), and high intensity condition with reversed intensities. The results showed increased N1 amplitudes in high intensity condition related to aging and old age depression. This indicates impaired stimulus encoding but also possible serotonergic dysfunction and inhibition deficits in aging and in old age depression. Moreover, negative correlation between P3a responses to infrequent sounds and Beck Depression Inventory (BDI) scores was found in depressed participants, suggesting impaired orientation of attention related to depression. The results can possibly be utilized in future in diagnostics and in prediction of the treatment for depression.", "language": "en", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Submitted by Paivi Vuorio (paelvuor@jyu.fi) on 2018-08-02T08:40:19Z\nNo. of bitstreams: 0", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Made available in DSpace on 2018-08-02T08:40:19Z (GMT). No. of bitstreams: 0\n Previous issue date: 2018", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.format.extent", "value": "47", "language": "", "element": "format", "qualifier": "extent", "schema": "dc"}, {"key": "dc.format.mimetype", "value": "application/pdf", "language": null, "element": "format", "qualifier": "mimetype", "schema": "dc"}, {"key": "dc.language.iso", "value": "eng", "language": null, "element": "language", "qualifier": "iso", "schema": "dc"}, {"key": "dc.rights", "value": "In Copyright", "language": "en", "element": "rights", "qualifier": null, "schema": "dc"}, {"key": "dc.subject.other", "value": "automatic information processing", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "N1", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "MMN", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "P3a", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.title", "value": "Brain responses to sound intensity changes in aging and in depression", "language": "", "element": "title", "qualifier": null, "schema": "dc"}, {"key": "dc.type", "value": "master thesis", "language": null, "element": "type", "qualifier": null, "schema": "dc"}, {"key": "dc.identifier.urn", "value": "URN:NBN:fi:jyu-201808023721", "language": "", "element": "identifier", "qualifier": "urn", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Pro gradu -tutkielma", "language": "fi", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Master\u2019s thesis", "language": "en", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Kasvatustieteiden ja psykologian tiedekunta", "language": "fi", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Faculty of Education and Psychology", "language": "en", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Psykologian laitos", "language": "fi", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Department of Psychology", "language": "en", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "Jyv\u00e4skyl\u00e4n yliopisto", "language": "fi", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "University of Jyv\u00e4skyl\u00e4", "language": "en", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Psykologia", "language": "fi", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Psychology", "language": "en", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "yvv.contractresearch.funding", "value": "0", "language": "", "element": "contractresearch", "qualifier": "funding", "schema": "yvv"}, {"key": "dc.type.coar", "value": "http://purl.org/coar/resource_type/c_bdcc", "language": null, "element": "type", "qualifier": "coar", "schema": "dc"}, {"key": "dc.rights.accesslevel", "value": "restrictedAccess", "language": null, "element": "rights", "qualifier": "accesslevel", "schema": "dc"}, {"key": "dc.type.publication", "value": "masterThesis", "language": null, "element": "type", "qualifier": "publication", "schema": "dc"}, {"key": "dc.subject.oppiainekoodi", "value": "202", "language": "", "element": "subject", "qualifier": "oppiainekoodi", "schema": "dc"}, {"key": "dc.subject.yso", "value": "\u00e4\u00e4nenvoimakkuus", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "masennus", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "ik\u00e4\u00e4ntyminen", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "EEG", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "sound intensity", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "depression (mental disorders)", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "ageing", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "EEG", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.format.content", "value": "fulltext", "language": null, "element": "format", "qualifier": "content", "schema": "dc"}, {"key": "dc.rights.url", "value": "https://rightsstatements.org/page/InC/1.0/", "language": null, "element": "rights", "qualifier": "url", "schema": "dc"}, {"key": "dc.rights.accessrights", "value": "The author has not given permission to make the work publicly available electronically. Therefore the material can be read only at the archival workstation at Jyv\u00e4skyl\u00e4 University Library (https://kirjasto.jyu.fi/en/workspaces/facilities).", "language": "en", "element": "rights", "qualifier": "accessrights", "schema": "dc"}, {"key": "dc.rights.accessrights", "value": "Tekij\u00e4 ei ole antanut lupaa avoimeen julkaisuun, joten aineisto on luettavissa vain Jyv\u00e4skyl\u00e4n yliopiston kirjaston arkistoty\u00f6semalta. Ks. https://kirjasto.jyu.fi/fi/tyoskentelytilat/laitteet-ja-tilat..", "language": "fi", "element": "rights", "qualifier": "accessrights", "schema": "dc"}, {"key": "dc.type.okm", "value": "G2", "language": null, "element": "type", "qualifier": "okm", "schema": "dc"}]
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