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[{"key": "dc.contributor.author", "value": "Virtanen, Juho", "language": "", "element": "contributor", "qualifier": "author", "schema": "dc"}, {"key": "dc.date.accessioned", "value": "2018-06-29T09:43:53Z", "language": null, "element": "date", "qualifier": "accessioned", "schema": "dc"}, {"key": "dc.date.available", "value": "2018-06-29T09:43:53Z", "language": null, "element": "date", "qualifier": "available", "schema": "dc"}, {"key": "dc.date.issued", "value": "2018", "language": "", "element": "date", "qualifier": "issued", "schema": "dc"}, {"key": "dc.identifier.uri", "value": "https://jyx.jyu.fi/handle/123456789/58799", "language": null, "element": "identifier", "qualifier": "uri", "schema": "dc"}, {"key": "dc.description.abstract", "value": "\u00c4\u00e4ni-intensiteetin prosessointi aivoissa on usein yhdistetty keskushermoston serotoniinij\u00e4rjestelm\u00e4n toimintaan. T\u00e4m\u00e4n serotoniinij\u00e4rjestelm\u00e4n toimintah\u00e4iri\u00f6n on ehdotettu olevan yksi piilev\u00e4 tekij\u00e4 masennuksen psykopatologian taustalla. \u00c4\u00e4ni-intensiteetin prosessointia on aikaisemmin tutkittu mittaamalla aivojen s\u00e4hk\u00f6isten j\u00e4nnitevasteiden riippuvuutta kasvavaan \u00e4\u00e4nen intensiteettiin koeasetelmissa, joissa vaihtelevien voimakkuuksien sinusoidisia \u00e4\u00e4ni\u00e4 toistetaan koehenkil\u00f6lle satunnaisessa j\u00e4rjestyksess\u00e4. Intensiteettiriippuvuutta osoittaa t\u00e4st\u00e4 laskettu LDAEP- (Loudness Dependence of Auditory Evoked Potentials) kulmakertoimen jyrkkyys. Jyrk\u00e4n LDAEP- kulmakertoimen on ajateltu olevan yhteydess\u00e4 heikompaan serotoniinij\u00e4rjestelm\u00e4n toimintaan aivoissa ja p\u00e4invastoin. Hiljattain on ehdotettu aivojen muutoksen havaitsemisen reflektoivan my\u00f6s keskushermoston serotoniinij\u00e4rjestelm\u00e4n toimintaa, jolloin oddball-asetelmassa \u00e4\u00e4nen intensiteetin muutokset ilmenev\u00e4t harvoin esiintyvin\u00e4 poikkeavina \u00e4rsykkein\u00e4. Aikaisempaa vertailua ei ole intensiteettiriippuvuuteen ja muutoksen havaitsemiseen perustuvien menetelmien kyvyst\u00e4 erotella masennusoireiset ja terveet kontrollikoehenkil\u00f6t toisistaan. T\u00e4ss\u00e4 tutkimuksessa 15 masennusoireisen ja 15 terveen kontrollin j\u00e4nnitevasteiden intensiteetti riippuvuutta ja muutoksen havaitsemista mitattiin samanaikaisesti kun koehenkil\u00f6t katsoivat mykk\u00e4elokuvaa. Tavoitteena oli selvitt\u00e4\u00e4 eroavatko masennusoireisten ja kontrollien aivovasteet toisistaan esitettyihin LDAEP ja oddball \u00e4rsykkeisiin. Oletuksena on, ett\u00e4 masennusoireisilla henkil\u00f6ill\u00e4 olisi jyrkempi LDAEP- kulmakerroin ja korkeammat N1 amplitudit oddball-asetelmassa. Toisena tavoitteena oli tutkia korreloivatko intensiteetti riippuvuus ja muutoksen havaitseminen kesken\u00e4\u00e4n. Kolmanneksi halusin selvitt\u00e4\u00e4 korreloivatko n\u00e4m\u00e4 kaksi menetelm\u00e4\u00e4 muiden masennusoiremittareiden kanssa. Tuloksista ilmeni, ett\u00e4 oddball-asetelman korkean intensiteetin deviantti \u00e4rsyke sai aikaan suurimmat N1 amplitudit molemmissa ryhmiss\u00e4 verrattuna muihin \u00e4rsykkeisiin. My\u00f6s oddball-asetelman korkean intensiteetin deviantin \u00e4rsykkeen ja intensiteetti riippuvaisen N1 ja N1/P2 peak-to-peak arvojen v\u00e4lill\u00e4 esiintyi tilastollisesti merkitsev\u00e4 korrelaatio. Vastoin odotuksia, masennusoireisten ja kontrollien v\u00e4lill\u00e4 ei l\u00f6ytynyt ryhm\u00e4eroja aivovasteissa LDAEP- tai oddball- \u00e4rsykkeisiin. Merkitsev\u00e4\u00e4 korrelaatiota ei l\u00f6ytynyt muiden masennusoiremittareiden ja LDAEP tai oddball vasteiden v\u00e4lill\u00e4. Tulokset viittaavat siihen, ett\u00e4 auditorista intensiteetti riippuvuutta ja muutoksen havaitsemista voidaan hy\u00f6dynt\u00e4\u00e4 spesifin\u00e4 ty\u00f6kaluna masennuksen diagnosoinnissa pelk\u00e4n masentuneiden ja ei-masentuneiden erottelun. On my\u00f6s mahdollista, ett\u00e4 n\u00e4m\u00e4 menetelm\u00e4t eiv\u00e4t ole yhteydess\u00e4 masennusoireiden vakavuuteen, mutta n\u00e4m\u00e4 kysymykset vaativat viel\u00e4 jatkotutkimuksia.", "language": "fi", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.abstract", "value": "Brain\u2019s auditory intensity processing has been linked to the function of the central serotonergic system. The malfunction of this serotonergic system is also thought to be one of the underlying factors behind the psychopathology of depression. Auditory intensity processing has been traditionally studied measuring the Loudness Dependence of Auditory Evoked Potentials (LDAEP) in research conditions where sinusoidal sounds of different intensities are played to the participant in a randomized order. A steep LDAEP slope is thought to be related to weaker serotonergic function in the brain, and vice versa. Recently it has been suggested that intensity changes presented as rare deviant stimuli in an oddball condition would also reflect the function of the central serotonergic system. However, there is no previous literature comparing the two methods ability to dissociate dysphoric participants from healthy controls when compared within the same study. In this study the auditory intensity processing of 15 dysphoric participants and 15 healthy controls was measured using an intensity dependence and change detection condition, while the participants watched a silent film. The aim was to find out whether dysphoric participants differ from the healthy controls in their brain responses to auditory stimuli presented in LDAEP and oddball. I expected to find that dysphoric participants would have a steeper LDAEP slope in N1 and N1/P2 peak-to-peak values, and higher N1 amplitudes in the oddball condition. Secondly, the interest was to investigate if these two conditions would correlate significantly between each other. Thirdly, the aim was to figure out if these conditions correlated with the other measures of depression symptoms. The results revealed that in the oddball, the high intensity deviant stimulus elicited larger N1 amplitudes in both groups compared to other stimuli. Also, a significant correlation was found between the high intensity deviant stimulus in the oddball and LDAEP N1 and N1/P2 peak-to-peak slope values. Contrary to the hypotheses the dysphoric group and the control group did not elicit any significant group differences in their brain responses in either the LDAEP or the oddball stimuli. Also no significant correlation was found between other measures of depression symptoms and LDAEP or oddball responses. The results indicate that the auditory intensity and change detection conditions could be used as a more efficient tool in a more specific depression diagnosis, rather than dissociating between depressed and healthy individuals. Then, it could be that these conditions are not related to the severity of depression symptoms, requiring further studies on these questions.", "language": "en", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Submitted by Riitta Pitk\u00e4nen (rpitkane@jyu.fi) on 2018-06-29T09:43:53Z\nNo. of bitstreams: 0", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Made available in DSpace on 2018-06-29T09:43:53Z (GMT). No. of bitstreams: 0\n Previous issue date: 2018", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.format.extent", "value": "30", "language": "", "element": "format", "qualifier": "extent", "schema": "dc"}, {"key": "dc.format.mimetype", "value": "application/pdf", "language": null, "element": "format", "qualifier": "mimetype", "schema": "dc"}, {"key": "dc.language.iso", "value": "eng", "language": null, "element": "language", "qualifier": "iso", "schema": "dc"}, {"key": "dc.rights", "value": "In Copyright", "language": "en", "element": "rights", "qualifier": null, "schema": "dc"}, {"key": "dc.title", "value": "Dissociating dysphoric and healthy control participants in brain\u2019s electrical responses to sound intensity changes", "language": "", "element": "title", "qualifier": null, "schema": "dc"}, {"key": "dc.type", "value": "master thesis", "language": null, "element": "type", "qualifier": null, "schema": "dc"}, {"key": "dc.identifier.urn", "value": "URN:NBN:fi:jyu-201806293425", "language": "", "element": "identifier", "qualifier": "urn", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Pro gradu -tutkielma", "language": "fi", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Master\u2019s thesis", "language": "en", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Kasvatustieteiden ja psykologian tiedekunta", "language": "fi", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Faculty of Education and Psychology", "language": "en", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Psykologian laitos", "language": "fi", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Department of Psychology", "language": "en", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "Jyv\u00e4skyl\u00e4n yliopisto", "language": "fi", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "University of Jyv\u00e4skyl\u00e4", "language": "en", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Psykologia", "language": "fi", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Psychology", "language": "en", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "yvv.contractresearch.funding", "value": "0", "language": "", "element": "contractresearch", "qualifier": "funding", "schema": "yvv"}, {"key": "dc.type.coar", "value": "http://purl.org/coar/resource_type/c_bdcc", "language": null, "element": "type", "qualifier": "coar", "schema": "dc"}, {"key": "dc.rights.accesslevel", "value": "restrictedAccess", "language": null, "element": "rights", "qualifier": "accesslevel", "schema": "dc"}, {"key": "dc.type.publication", "value": "masterThesis", "language": null, "element": "type", "qualifier": "publication", "schema": "dc"}, {"key": "dc.subject.oppiainekoodi", "value": "202", "language": "", "element": "subject", "qualifier": "oppiainekoodi", "schema": "dc"}, {"key": "dc.subject.yso", "value": "aivot", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "masennus", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "brain", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "depression (mental disorders)", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.format.content", "value": "fulltext", "language": null, "element": "format", "qualifier": "content", "schema": "dc"}, {"key": "dc.rights.url", "value": "https://rightsstatements.org/page/InC/1.0/", "language": null, "element": "rights", "qualifier": "url", "schema": "dc"}, {"key": "dc.rights.accessrights", "value": "The author has not given permission to make the work publicly available electronically. Therefore the material can be read only at the archival workstation at Jyv\u00e4skyl\u00e4 University Library (https://kirjasto.jyu.fi/en/workspaces/facilities).", "language": "en", "element": "rights", "qualifier": "accessrights", "schema": "dc"}, {"key": "dc.rights.accessrights", "value": "Tekij\u00e4 ei ole antanut lupaa avoimeen julkaisuun, joten aineisto on luettavissa vain Jyv\u00e4skyl\u00e4n yliopiston kirjaston arkistoty\u00f6semalta. Ks. https://kirjasto.jyu.fi/fi/tyoskentelytilat/laitteet-ja-tilat..", "language": "fi", "element": "rights", "qualifier": "accessrights", "schema": "dc"}, {"key": "dc.type.okm", "value": "G2", "language": null, "element": "type", "qualifier": "okm", "schema": "dc"}]
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