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[{"key": "dc.contributor.advisor", "value": "Lensu, Sanna", "language": "", "element": "contributor", "qualifier": "advisor", "schema": "dc"}, {"key": "dc.contributor.author", "value": "M\u00e4kinen, Elina", "language": "", "element": "contributor", "qualifier": "author", "schema": "dc"}, {"key": "dc.date.accessioned", "value": "2018-06-21T07:25:11Z", "language": null, "element": "date", "qualifier": "accessioned", "schema": "dc"}, {"key": "dc.date.available", "value": "2018-06-21T07:25:11Z", "language": null, "element": "date", "qualifier": "available", "schema": "dc"}, {"key": "dc.date.issued", "value": "2018", "language": "", "element": "date", "qualifier": "issued", "schema": "dc"}, {"key": "dc.identifier.uri", "value": "https://jyx.jyu.fi/handle/123456789/58695", "language": null, "element": "identifier", "qualifier": "uri", "schema": "dc"}, {"key": "dc.description.abstract", "value": "Fyysisen aktiivisuuden ja suorituskyvyn on useissa humaanitutkimuksissa havaittu korreloivan positiivisesti kognitioon ja aivojen terveyteen. Sama on havaittu my\u00f6s hyv\u00e4n ja huonon aerobisen kapasiteetin perusteella jalostetulla rottakannalla, HCR ja LCR rotilla, joita on hy\u00f6dynnetty tutkittaessa perinn\u00f6llisen aerobisen kapasiteetin yhteytt\u00e4 fysiologisiin muuttujiin. Aivojen dopaminergiset (DAergiset) alueet, s\u00e4\u00e4telev\u00e4t motorista kontrollia, oppimista ja muistia. T\u00e4m\u00e4n tutkimuksen tavoitteena oli selvitt\u00e4\u00e4, onko perityll\u00e4 aerobisella kapasiteetilla yhteytt\u00e4 aivojen DAergiseen j\u00e4rjestelm\u00e4\u00e4n. Hypoteesina oli, ett\u00e4 HCR rotat ilment\u00e4isiv\u00e4t enemm\u00e4n DAergisi\u00e4 proteiineja verrattuna LCR rottiin jo nuorella i\u00e4ll\u00e4. Ty\u00f6ss\u00e4 tutkittiin dopamiinin signalointiin liittyvien proteiinien, kuten tyrosiinihydroksylaasin (TH) ja DA reseptoreiden ilmentymist\u00e4 immunohistokemiallisten menetelmien avulla. ja kvantitatiivisesti analysoimalla ImageJ ja Matlab \u2013ohjelmilla. Saatujen tulosten mukaan HCR rotilla on merkitt\u00e4v\u00e4sti enemm\u00e4n TH:n ilmentymist\u00e4 striatumin alueella, vastaavasti LCR rotilla oli enemm\u00e4n D1 dopamiinireseptoreita samalla alueella. Tulosten mukaan peritty synnynn\u00e4inen aerobinen kapasiteetti n\u00e4ytt\u00e4isi olevan yhteydess\u00e4 dopamiinin tuotannon m\u00e4\u00e4r\u00e4\u00e4n striatumin alueella. Johtop\u00e4\u00e4t\u00f6s on, ett\u00e4 valinta synnynn\u00e4isen aerobisen kapasiteetin perusteella luo geneettist\u00e4 variaatiota my\u00f6s aivojen DAergiseen systeemiin. T\u00e4m\u00e4 voi selitt\u00e4\u00e4 yhteytt\u00e4 aerobisen kapasiteetin ja oppimisen v\u00e4lill\u00e4.", "language": "fi", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.abstract", "value": "Physical activity and fitness are shown to positively correlate with cognition and brain health in humans. Similar results have been observed in a heterogeneous rat model bred for high and low capacity running (HCR and LCR, respectively), developed to study the effects of intrinsic aerobic capacity on multiple physiological factors. Dopaminergic areas in the brain, particularly the basal ganglia, are associated with motor control, learning and memory. The Aim of this study was to investigate whether the inherited aerobic capacity is reflected in the brain dopaminergic system. Our hypothesis was that HCR rats have more dopaminergic cells or other dopaminergic proteins compared to LCR rats, already at young age. The expression of tyrosine hydroxylase (TH), dopamine receptors and other proteins involved in dopaminergic signaling, were assessed by immunohistochemical methods. Staining results were analysed by ImageJ and Matlab. The results show that HCR rats have significantly more TH expression in the striatum, whereas LCR rats have significantly more dopamine D1 receptor expression in the same area. These results indicate that together with inherited differences in intrinsic aerobic capacity, rats have inherited differences in their dopaminergic system. To conclude, the selection for intrinsic aerobic capacity seems to create genetic variation also to the brain dopaminergic system. This could be one factor mediating the connections between aerobic capacity and learning.", "language": "en", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Submitted by Paivi Vuorio (paelvuor@jyu.fi) on 2018-06-21T07:25:11Z\nNo. of bitstreams: 0", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Made available in DSpace on 2018-06-21T07:25:11Z (GMT). No. of bitstreams: 0\n Previous issue date: 2018", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.format.extent", "value": "48", "language": "", "element": "format", "qualifier": "extent", "schema": "dc"}, {"key": "dc.language.iso", "value": "eng", "language": null, "element": "language", "qualifier": "iso", "schema": "dc"}, {"key": "dc.rights", "value": "In Copyright", "language": "en", "element": "rights", "qualifier": null, "schema": "dc"}, {"key": "dc.subject.other", "value": "HCR", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "LCR", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "dopamine receptors", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.title", "value": "Brain dopaminergic system of young high and low capacity running rats", "language": "", "element": "title", "qualifier": null, "schema": "dc"}, {"key": "dc.type", "value": "master thesis", "language": null, "element": "type", "qualifier": null, "schema": "dc"}, {"key": "dc.identifier.urn", "value": "URN:NBN:fi:jyu-201806213315", "language": "", "element": "identifier", "qualifier": "urn", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Master\u2019s thesis", "language": "en", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Pro gradu -tutkielma", "language": "fi", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Matemaattis-luonnontieteellinen tiedekunta", "language": "fi", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Faculty of Sciences", "language": "en", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Bio- ja ymp\u00e4rist\u00f6tieteiden laitos", "language": "fi", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Department of Biological and Environmental Science", "language": "en", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "Jyv\u00e4skyl\u00e4n yliopisto", "language": "fi", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "University of Jyv\u00e4skyl\u00e4", "language": "en", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Solu- ja molekyylibiologia", "language": "fi", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Cell and molecular biology", "language": "en", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "yvv.contractresearch.funding", "value": "0", "language": "", "element": "contractresearch", "qualifier": "funding", "schema": "yvv"}, {"key": "dc.type.coar", "value": "http://purl.org/coar/resource_type/c_bdcc", "language": null, "element": "type", "qualifier": "coar", "schema": "dc"}, {"key": "dc.rights.accesslevel", "value": "restrictedAccess", "language": null, "element": "rights", "qualifier": "accesslevel", "schema": "dc"}, {"key": "dc.type.publication", "value": "masterThesis", "language": null, "element": "type", "qualifier": "publication", "schema": "dc"}, {"key": "dc.subject.oppiainekoodi", "value": "4013", "language": "", "element": "subject", "qualifier": "oppiainekoodi", "schema": "dc"}, {"key": "dc.subject.yso", "value": "aerobinen suorituskyky", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "dopamiini", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "aivot", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "aerobic capacity", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "dopamine", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "brain", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.rights.url", "value": "https://rightsstatements.org/page/InC/1.0/", "language": null, "element": "rights", "qualifier": "url", "schema": "dc"}, {"key": "dc.rights.accessrights", "value": "The author has not given permission to make the work publicly available electronically. Therefore the material can be read only at the archival workstation at Jyv\u00e4skyl\u00e4 University Library (https://kirjasto.jyu.fi/en/workspaces/facilities).", "language": "en", "element": "rights", "qualifier": "accessrights", "schema": "dc"}, {"key": "dc.rights.accessrights", "value": "Tekij\u00e4 ei ole antanut lupaa avoimeen julkaisuun, joten aineisto on luettavissa vain Jyv\u00e4skyl\u00e4n yliopiston kirjaston arkistoty\u00f6semalta. Ks. https://kirjasto.jyu.fi/fi/tyoskentelytilat/laitteet-ja-tilat..", "language": "fi", "element": "rights", "qualifier": "accessrights", "schema": "dc"}]
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