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[{"key": "dc.contributor.advisor", "value": "Vehni\u00e4inen, Eeva-Riikka", "language": "", "element": "contributor", "qualifier": "advisor", "schema": "dc"}, {"key": "dc.contributor.advisor", "value": "Eriksson, Andreas", "language": "", "element": "contributor", "qualifier": "advisor", "schema": "dc"}, {"key": "dc.contributor.author", "value": "K\u00f6n\u00f6nen, Iina", "language": "", "element": "contributor", "qualifier": "author", "schema": "dc"}, {"key": "dc.date.accessioned", "value": "2018-06-15T07:32:02Z", "language": "", "element": "date", "qualifier": "accessioned", "schema": "dc"}, {"key": "dc.date.available", "value": "2018-06-15T07:32:02Z", "language": "", "element": "date", "qualifier": "available", "schema": "dc"}, {"key": "dc.date.issued", "value": "2018", "language": "", "element": "date", "qualifier": "issued", "schema": "dc"}, {"key": "dc.identifier.uri", "value": "https://jyx.jyu.fi/handle/123456789/58580", "language": "", "element": "identifier", "qualifier": "uri", "schema": "dc"}, {"key": "dc.description.abstract", "value": "Hartsihapot ovat puun luonnollisia uuteaineita, joita p\u00e4\u00e4tyy vesist\u00f6ihin sellu- ja\r\npaperitehtaiden j\u00e4tevesien mukana. Niiden on osoitettu olevan kaloille ja muille\r\nvesieli\u00f6ille haitallisia yhdisteit\u00e4. Etenkin aikaiset kalanpoikasten kehitysvaiheet\r\novat herkki\u00e4 vierasaineille, sill\u00e4 altistuminen voi aiheuttaa kehitysh\u00e4iri\u00f6it\u00e4.\r\nDehydroabietiinihappo (DHAA) on yksi sellutehtaiden j\u00e4tevesien yleisimmist\u00e4 ja\r\nseuratuimmista hartsihapoista. T\u00e4m\u00e4n tutkimuksen tarkoituksena oli tutkia\r\nymp\u00e4rist\u00f6n kannalta relevanttien DHAA-pitoisuuksien vaikutuksia j\u00e4rvitaimenen\r\n(Salmo trutta lacustris) vastakuoriutuneiden poikasten kehitykselle. Laboratoriossa\r\nsuoritettiin 13 p\u00e4iv\u00e4n DHAA-altistus, jonka aikana seurattiin poikasten\r\nkuolleisuutta. Altistuksen j\u00e4lkeen poikasista todettiin ruskuaispussitaudin oireita,\r\nkuten ruskuaispussin ja syd\u00e4npussin edeemia. My\u00f6s poikasten kasvua ja energian\r\nkulutusta seurattiin mittaamalla poikasten pituus ja tasomainen ruskuaispussin\r\npinta-ala altistuksen j\u00e4lkeen. DHAA on polyaromaattisten hiilivetyjen esiaste, joten\r\nsen aryylihiilivetyreseptorin (AhR) aktivaatiota tutkittiin cyp1a-geenin ekspression\r\navulla yhden p\u00e4iv\u00e4n DHAA-akuuttialtistuksen j\u00e4lkeen. Tutkimuksessa\r\npositiivisena kontrollina k\u00e4ytetty reteeni aiheutti poikasissa suurimmat\r\nvaikutukset. Ep\u00e4muodostumia havaittiin kaikissa tutkituissa DHAApitoisuuksissa.\r\nSuuren toistok\u00e4sittelyjen v\u00e4lisen vaihtelun vuoksi selkeit\u00e4 DHAAannosriippuvaisia\r\njohtop\u00e4\u00e4t\u00f6ksi\u00e4 ei voitu tehd\u00e4 poikasten pituuden ja\r\nruskuaispussin pinta-alan osalta, kun saatuja tuloksia verrattiin nollakontrolliin.\r\nMik\u00e4\u00e4n k\u00e4sittelyryhm\u00e4 ei aiheuttanut tilastollisesti merkitsev\u00e4\u00e4 AhR-aktivaatiota,\r\njoten ep\u00e4muodostuvat syntyv\u00e4t luultavasti jollain muulla mekanismilla. Tulokset\r\nkuitenkin antavat syyn uskoa, ett\u00e4 DHAA voisi aiheuttaa kehitysh\u00e4iri\u00f6it\u00e4\r\nj\u00e4rvitaimenen poikasissa. Sellutehtaiden jatkuvat p\u00e4\u00e4st\u00f6t vesist\u00f6ihin ja\r\nkalanpoikasten krooninen altistuminen j\u00e4tevesien komponenteille voi siten\r\naiheuttaa kehitysh\u00e4iri\u00f6it\u00e4 kalanpoikasille sellu- ja paperitehtaiden alapuolisissa\r\nvesist\u00f6iss\u00e4. Lis\u00e4\u00e4 tutkimusta tarvitaan, jotta mekanismi mahdollisten\r\nep\u00e4muodostumien syntyyn selvi\u00e4isi.", "language": "fi", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.abstract", "value": "Resin acids are natural wood extractives released into aquatic environments along\r\nwith pulp and paper mill waste water effluents. Resin acids have previously been\r\nshown to cause adverse effects on aquatic organisms, such as fish. Especially the\r\nearly-life stages of fish are vulnerable, since the exposure may lead to\r\ndevelopmental defects. One of the most abundant and monitored resin acid in pulp\r\nmill effluents is dehydroabietic acid (DHAA). The aim of this study was to find out\r\nthe effects of DHAA to newly hatched brown trout larvae (Salmo trutta lacustris) at\r\nenvironmentally relevant concentrations. Measured endpoints following the 13-day\r\nsub-chronic DHAA laboratory exposure were the symptoms of blue sac disease:\r\nmortality and deformities, e.g., yolk sac edemas and pericardial edemas. Also, the\r\nbody length and planar yolk sac area of the larvae were measured. As DHAA is a\r\nprecursor for polycyclic aromatic hydrocarbons, the aryl hydrocarbon receptor\r\n(AhR) activation was measured as cyp1a gene expression after 1-day acute DHAA\r\nexposure. Following the laboratory exposures, the positive control treatment,\r\nretene, caused most of the observed effects of measured endpoints. Yolk sac and\r\npericardial edemas were detected even in the lowest DHAA concentrations. Due to\r\nlarge variations between replicate treatments, no clear DHAA dose dependent\r\ntrend was found in body length or planar yolk sac area of the larvae compared to\r\nnegative solvent control (DMSO) treatment. None of the treatments caused\r\nstatistically significant AhR activation. However, the results of this study showed\r\nthe potential of DHAA to cause adverse effects on developing S. trutta larvae. The\r\ncontinuous resin acid load in aquatic environments and chronic exposure of DHAA\r\nmay harm the normal development of fish larvae downstream from pulp and paper\r\nmills. Further research on the mechanisms leading up to developmental defects and\r\ndeformities is needed.", "language": "en", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Submitted by Riitta Pitk\u00e4nen (rpitkane@jyu.fi) on 2018-06-15T07:32:02Z\r\nNo. of bitstreams: 0", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Made available in DSpace on 2018-06-15T07:32:02Z (GMT). No. of bitstreams: 0\r\n Previous issue date: 2018", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.format.extent", "value": "59", "language": "", "element": "format", "qualifier": "extent", "schema": "dc"}, {"key": "dc.format.mimetype", "value": "application/pdf", "language": null, "element": "format", "qualifier": "mimetype", "schema": "dc"}, {"key": "dc.language.iso", "value": "eng", "language": null, "element": "language", "qualifier": "iso", "schema": "dc"}, {"key": "dc.rights", "value": "In Copyright", "language": "en", "element": "rights", "qualifier": null, "schema": "dc"}, {"key": "dc.subject.other", "value": "aryl hydrocarbon receptor", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "aquatic environments", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "early-life stage toxicity", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "pulp mill effluent", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "resin acid", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.title", "value": "Does dehydroabietic acid (DHAA) at environmentally relevant concentrations cause developmental defects in brown trout larvae (Salmo trutta lacustris)?", "language": "", "element": "title", "qualifier": null, "schema": "dc"}, {"key": "dc.type", "value": "master thesis", "language": null, "element": "type", "qualifier": null, "schema": "dc"}, {"key": "dc.identifier.urn", "value": "URN:NBN:fi:jyu-201806153236", "language": "", "element": "identifier", "qualifier": "urn", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Pro gradu -tutkielma", "language": "fi", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Master\u2019s thesis", "language": "en", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Matemaattis-luonnontieteellinen tiedekunta", "language": "fi", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Faculty of Sciences", "language": "en", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Bio- ja ymp\u00e4rist\u00f6tieteiden laitos", "language": "fi", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Department of Biological and Environmental Science", "language": "en", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "Jyv\u00e4skyl\u00e4n yliopisto", "language": "fi", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "University of Jyv\u00e4skyl\u00e4", "language": "en", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Ymp\u00e4rist\u00f6tiede ja -teknologia", "language": "fi", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Environmental science and technology", "language": "en", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "yvv.contractresearch.funding", "value": "0", "language": "", "element": "contractresearch", "qualifier": "funding", "schema": "yvv"}, {"key": "dc.type.coar", "value": "http://purl.org/coar/resource_type/c_bdcc", "language": null, "element": "type", "qualifier": "coar", "schema": "dc"}, {"key": "dc.rights.accesslevel", "value": "openAccess", "language": null, "element": "rights", "qualifier": "accesslevel", "schema": "dc"}, {"key": "dc.type.publication", "value": "masterThesis", "language": null, "element": "type", "qualifier": "publication", "schema": "dc"}, {"key": "dc.subject.oppiainekoodi", "value": "4015", "language": "", "element": "subject", "qualifier": "oppiainekoodi", "schema": "dc"}, {"key": "dc.subject.yso", "value": "j\u00e4tevesi", "language": "", "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "paperiteollisuus", "language": "", "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "kalat (el\u00e4imet)", "language": "", "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "ymp\u00e4rist\u00f6myrkyt", "language": "", "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "sewage", "language": "", "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "paper industry", "language": "", "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "fishes", "language": "", "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "environmental toxins", "language": "", "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.format.content", "value": "fulltext", "language": null, "element": "format", "qualifier": "content", "schema": "dc"}, {"key": "dc.rights.url", "value": "https://rightsstatements.org/page/InC/1.0/", "language": null, "element": "rights", "qualifier": "url", "schema": "dc"}, {"key": "dc.type.okm", "value": "G2", "language": null, "element": "type", "qualifier": "okm", "schema": "dc"}]
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