| fullrecord |
[{"key": "dc.contributor.advisor", "value": "Vehni\u00e4inen, Eeva-Riikka", "language": "", "element": "contributor", "qualifier": "advisor", "schema": "dc"}, {"key": "dc.contributor.advisor", "value": "Kukkonen, Jussi", "language": "", "element": "contributor", "qualifier": "advisor", "schema": "dc"}, {"key": "dc.contributor.author", "value": "Rahkonen, Terhi", "language": "", "element": "contributor", "qualifier": "author", "schema": "dc"}, {"key": "dc.date.accessioned", "value": "2018-06-06T06:03:19Z", "language": "", "element": "date", "qualifier": "accessioned", "schema": "dc"}, {"key": "dc.date.available", "value": "2018-06-06T06:03:19Z", "language": "", "element": "date", "qualifier": "available", "schema": "dc"}, {"key": "dc.date.issued", "value": "2018", "language": "", "element": "date", "qualifier": "issued", "schema": "dc"}, {"key": "dc.identifier.uri", "value": "https://jyx.jyu.fi/handle/123456789/58367", "language": "", "element": "identifier", "qualifier": "uri", "schema": "dc"}, {"key": "dc.description.abstract", "value": "Polyaromaattisest hiilivedyt (PAH) ovat p\u00e4\u00e4st\u00f6j\u00e4 \u00f6ljyper\u00e4isist\u00e4 l\u00e4hteist\u00e4 ja ep\u00e4t\u00e4ydellisen polton prosesseista ja niit\u00e4 esiintyy yleisesti moninaisina seoksina kaikkialla ymp\u00e4rist\u00f6ss\u00e4. Reteeni (1-metyyli-7-isopropyylifenantreeni) toimii AHR-agonistina eli aryylihiilivetyreseptorille kiinnittyv\u00e4n\u00e4 yhdisteen\u00e4, joka k\u00e4ynnist\u00e4\u00e4 AHR-signaalireitin ja tuottaa mm. CYP1A1-entsyymi\u00e4 haitta-ainemetaboliaa varten. Fluoranteeni (1,2-benzacenaphthene) toimii soluissa CYP1A-inhibiittorina, joka est\u00e4\u00e4 tai v\u00e4hent\u00e4\u00e4 AHR-agonistin metaboliaa inhiboimalla CYP1A-entsyymin toimintaa, mik\u00e4 johtaa emoyhdisteiden puoliintuumisajan pidentymiseen. Ty\u00f6ss\u00e4 tutkittiin reteenin (3,2; 10 ja 32 \u00b5g/l) ja fluoranteenin (5, 50 ja 500 \u00b5g/l) yhteisvaikusta kirjolohen (Oncorhynchus mykiss) poikasiin yhdeks\u00e4np\u00e4iv\u00e4isess\u00e4 altistuskokeessa, jossa mitattavia vasteita olivat ruskuaispussitaudin oireiden ilmeneminen, pituus, ruskuaispussin pinta-ala ja cyp1a1-geeniekspression m\u00e4\u00e4r\u00e4. Reteeni- ja fluoranteenialtistuksen kasvaessa poikaset k\u00e4yttiv\u00e4t energiaa kasvun sijasta haitta-ainemetaboliaan. Cyp1a1-geeniekspressio lis\u00e4\u00e4ntyi l\u00e4hes j\u00e4rjest\u00e4en, kun yhdisteiden altistuspitoisuudet nousivat. Tulosten mukaan reteenin ja fluoranteenin yhteisaltistus ei v\u00e4henn\u00e4 reteenin haitallisuutta kirjolohen poikasilla, vaan niiden yhteisaltistus lis\u00e4\u00e4 ruskuaispussitaudin oireiden ilmenemist\u00e4 ja vakavuutta. Tutkimuksen tuloksia voidaan pit\u00e4\u00e4 muuten luotettavina paitsi altistusvedest\u00e4 analysoitujen haitta-ainepitoisuusien osalta.", "language": "fi", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.abstract", "value": "Polyaromatic hydrocarbons (PAHs) are ubiquitous environmental contaminants which are formed in petrogenic and pyrogenic processes and occur as complex mixtures. Retene (7-isopropyl-1-methyl phenanthrene) is an agonist of the aryl hydrocarbon receptor (AHR) which induces xenobiotic metabolizing enzymes e.g. CYP1A1. The activation of the AHR-pathway by certain PAHs leads to developmental toxicity in fish larvae. Fluoranthene (1,2-benzacenaphthene) is a CYP1A inhibitor which blocks the AHR-mediated induction of CYP1A activity and restrains the metabolism and excretion of some PAHs. In this thesis, the co-exposure of retene (3,2; 10 and 32 \u00b5g/l) and fluoranthene (5, 50 and 500 \u00b5g/l) on rainbow trout (Oncorhynchus mykiss) larvae was studied. The newly hatched larvae where exposed for the componds and their mixtures for nine days and evaluated for blue sac disease (BSD) symptoms, growth, yolk sac area and cyp1a1 gene expression. When the concentration of both compounds increased, the larvae used energy for the metabolism of the substances instead of the growth. The expression of cyp1a1 gene increased as the concentrations of retene and fluoranthene increased. The results show that fluoranthene did not diminish the toxicity of retene on the rainbow trout larvae and the co-exposure of retene and fluoranthene increased the BSD symptoms and their severity.", "language": "en", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Submitted by Paivi Vuorio (paelvuor@jyu.fi) on 2018-06-06T06:03:19Z\r\nNo. of bitstreams: 0", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Made available in DSpace on 2018-06-06T06:03:19Z (GMT). No. of bitstreams: 0\r\n Previous issue date: 2018", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.format.extent", "value": "80", "language": "", "element": "format", "qualifier": "extent", "schema": "dc"}, {"key": "dc.format.mimetype", "value": "application/pdf", "language": null, "element": "format", "qualifier": "mimetype", "schema": "dc"}, {"key": "dc.language.iso", "value": "fin", "language": null, "element": "language", "qualifier": "iso", "schema": "dc"}, {"key": "dc.rights", "value": "In Copyright", "language": "en", "element": "rights", "qualifier": null, "schema": "dc"}, {"key": "dc.subject.other", "value": "AHR", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "AHR-agonisti", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "BSD", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "cyp1a1", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "CYP1A-inhibiittori", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "geeniekspressio", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "kalanpoikanen", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "kehitystoksikologia", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "PAH", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "ruskuaispussitauti", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.title", "value": "Reteenin ja fluoranteenin yhteisvaikutus Oncorhynchus mykiss -poikasten varhaiskehitykseen", "language": "", "element": "title", "qualifier": null, "schema": "dc"}, {"key": "dc.type", "value": "master thesis", "language": null, "element": "type", "qualifier": null, "schema": "dc"}, {"key": "dc.identifier.urn", "value": "URN:NBN:fi:jyu-201806063021", "language": "", "element": "identifier", "qualifier": "urn", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Pro gradu -tutkielma", "language": "fi", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Master\u2019s thesis", "language": "en", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Matemaattis-luonnontieteellinen tiedekunta", "language": "fi", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Faculty of Sciences", "language": "en", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Bio- ja ymp\u00e4rist\u00f6tieteiden laitos", "language": "fi", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Department of Biological and Environmental Science", "language": "en", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "Jyv\u00e4skyl\u00e4n yliopisto", "language": "fi", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "University of Jyv\u00e4skyl\u00e4", "language": "en", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Ymp\u00e4rist\u00f6tiede ja -teknologia", "language": "fi", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Environmental science and technology", "language": "en", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "yvv.contractresearch.funding", "value": "0", "language": "", "element": "contractresearch", "qualifier": "funding", "schema": "yvv"}, {"key": "dc.type.coar", "value": "http://purl.org/coar/resource_type/c_bdcc", "language": null, "element": "type", "qualifier": "coar", "schema": "dc"}, {"key": "dc.rights.accesslevel", "value": "openAccess", "language": null, "element": "rights", "qualifier": "accesslevel", "schema": "dc"}, {"key": "dc.type.publication", "value": "masterThesis", "language": null, "element": "type", "qualifier": "publication", "schema": "dc"}, {"key": "dc.subject.oppiainekoodi", "value": "4015", "language": "", "element": "subject", "qualifier": "oppiainekoodi", "schema": "dc"}, {"key": "dc.subject.yso", "value": "kasvu", "language": "", "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "vierasaineet", "language": "", "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "RNA", "language": "", "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "geenit", "language": "", "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "kirjolohi", "language": "", "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.format.content", "value": "fulltext", "language": null, "element": "format", "qualifier": "content", "schema": "dc"}, {"key": "dc.rights.url", "value": "https://rightsstatements.org/page/InC/1.0/", "language": null, "element": "rights", "qualifier": "url", "schema": "dc"}, {"key": "dc.type.okm", "value": "G2", "language": null, "element": "type", "qualifier": "okm", "schema": "dc"}]
|