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[{"key": "dc.contributor.author", "value": "Kemppainen, Titta", "language": "", "element": "contributor", "qualifier": "author", "schema": "dc"}, {"key": "dc.date.accessioned", "value": "2018-06-01T09:49:13Z", "language": null, "element": "date", "qualifier": "accessioned", "schema": "dc"}, {"key": "dc.date.available", "value": "2018-06-01T09:49:13Z", "language": null, "element": "date", "qualifier": "available", "schema": "dc"}, {"key": "dc.date.issued", "value": "2018", "language": "", "element": "date", "qualifier": "issued", "schema": "dc"}, {"key": "dc.identifier.uri", "value": "https://jyx.jyu.fi/handle/123456789/58282", "language": null, "element": "identifier", "qualifier": "uri", "schema": "dc"}, {"key": "dc.description.abstract", "value": "Kest\u00e4vyyskunnon ja kehon rasvapitoisuuden on havaittu olevan yhteydess\u00e4 useisiin kardiometabolisiin riskitekij\u00f6ihin ja niiden kasautumiseen jo lapsuudessa. Lasten metabolista oireyhtym\u00e4\u00e4 ei ole pystytty m\u00e4\u00e4rittelem\u00e4\u00e4n samaan tapaan kuin aikuisilla, mutta erityisesti ylim\u00e4\u00e4r\u00e4ist\u00e4 rasvamassaa pidet\u00e4\u00e4n haitallisena terveyden kannalta. Hyv\u00e4n kest\u00e4vyyskunnon tiedet\u00e4\u00e4n edist\u00e4v\u00e4n terveytt\u00e4 my\u00f6s lapsilla, mutta edelleen on ep\u00e4varmaa, pystyt\u00e4\u00e4nk\u00f6 hyv\u00e4ll\u00e4 kest\u00e4vyyskunnolla kompensoimaan lihavuuden aiheuttamia terveysongelmia. T\u00e4m\u00e4n tutkielman tarkoituksena oli selvitt\u00e4\u00e4 kest\u00e4vyyskunnon ja kehon rasvapitoisuuden yhteyksi\u00e4 metaboliseen oireyhtym\u00e4\u00e4n ja insuliiniresistenssiin sek\u00e4 tutkia kest\u00e4vyyskunnon yhteytt\u00e4 kardiometaboliseen riskiin lapsilla, joilla on suurentunut rasvaprosentti. \n\nT\u00e4m\u00e4 ty\u00f6 perustuu It\u00e4-Suomen yliopiston Lasten liikunta ja ravitsemus (PANIC) -tutkimuksen vuosina 2007\u20132009 toteutetun alkumittausvaiheen aineistoon. Kest\u00e4vyyskuntoa mitattiin maksimaalisella polkupy\u00f6r\u00e4ergometritestill\u00e4. Kest\u00e4vyyskunnon mittareina k\u00e4ytettiin maksimaalista ty\u00f6kuormaa suhteessa kehon kokonaismassaan (W/kg) ja rasvattomaan massaan (W/lm [lean mass]). Kehon rasvaton massa ja rasvamassa mitattiin kaksienergiaisella r\u00f6ntgenabsorptiometrialla (DXA). Metabolista oireyhtym\u00e4\u00e4 arvioitiin vy\u00f6t\u00e4r\u00f6nymp\u00e4ryksen, seerumin paastoinsuliinin, plasman paastoglukoosin, triglyseridien, HDLkolesterolin sek\u00e4 systolisen ja diastolisen verenpaineen keskiarvon avulla lasketulla kardiometabolisella riskipistem\u00e4\u00e4r\u00e4ll\u00e4 (cMetS). Insuliiniresistenssin arviointiin k\u00e4ytettiin paastoverin\u00e4ytteist\u00e4 analysoituja insuliini- ja glukoosipitoisuuksia sek\u00e4 insuliiniresistenssi\u00e4 kuvaavaa HOMA-IR-arvoa. Aineisto analysoitiin IBM SPSS Statistics 24 -ohjelmalla k\u00e4ytt\u00e4en lineaarista regressioanalyysi\u00e4 ja kovarianssianalyysi\u00e4 (ANCOVA).\n \nTutkielmaan valikoitui 452 lasta, joista tytt\u00f6j\u00e4 oli 216 (47,8 %) ja poikia 236 (52,2 %). Suurempi rasvaprosentti ja heikompi kehon kokonaismassaan suhteutettu kest\u00e4vyyskunto olivat yhteydess\u00e4 korkeampaan kardiometaboliseen riskipistem\u00e4\u00e4r\u00e4\u00e4n, insuliiniin ja HOMA-IR-arvoon sek\u00e4 tyt\u00f6ill\u00e4 ett\u00e4 pojilla (p<0,001). W/lm ei ollut yhteydess\u00e4 tulosmuuttujiin kummallakaan sukupuolella. Rasvaprosentin ja kest\u00e4vyyskunnon sukupuolispesifien mediaanien mukaan jaetuissa ryhmiss\u00e4 lapsilla, joilla oli korkeampi rasvaprosentti ja parempi W/kg, oli matalampi kardiometabolinen riskpistem\u00e4\u00e4r\u00e4, insuliini ja HOMA-IR-arvo kuin niill\u00e4, joilla oli suurempi rasvaprosentti, mutta matalampi W/kg. W/lm ei ollut yhteydess\u00e4 metabolisen oireyhtym\u00e4n ja insuliiniresistenssin kuvaajiin lapsilla, joilla oli matalampi tai korkeampi rasvaprosentti, vaan korkeampi rasvaprosentti oli yhteydess\u00e4 korkeampaan kardiometaboliseen riskipistem\u00e4\u00e4r\u00e4\u00e4n, insuliiniin ja HOMA-IR-arvoon riippumatta W/lm tasosta. \n\nTulosten mukaan kehon rasvapitoisuus on selke\u00e4sti yhteydess\u00e4 metabolisen oireyhtym\u00e4n ilment\u00e4jiin. Kest\u00e4vyyskunnon my\u00f6nteiset yhteydet kardiometaboliseen riskiin voivat selitty\u00e4 kehon rasvapitoisuuden eroilla, mik\u00e4 korostaa normaalipainoisuuden ja normaalin kehon rasvapitoisuuden merkityst\u00e4 kardiometabolisen terveyden edist\u00e4misess\u00e4 jo lapsilla. Kest\u00e4vyyskunnon merkityst\u00e4 kardiometaboliseen riskiin on kuitenkin syyt\u00e4 tutkia lis\u00e4\u00e4. T\u00e4m\u00e4n tutkielman poikkileikkausasetelman vuoksi syy-seuraussuhteita ei pystyt\u00e4 selvitt\u00e4m\u00e4\u00e4n.", "language": "fi", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.abstract", "value": "Cardiorespiratory fitness and adiposity have been found to be associated with several cardiometabolic risk factors and clustering of these risk factors already in childhood. It has not been possible to determine the metabolic syndrome in children the same way as in adults, but especially the excess fat mass is considered to be harmful in terms of health. High cardiorespiratory fitness is known to promote health also in children, but it is still uncertain if high cardiorespiratory fitness can compensate the health problems caused by obesity. The aim of this thesis was to explore the associations between cardiorespiratory fitness and body fat content in the metabolic syndrome and insulin resistance and further examine the relation between cardiorespiratory fitness and cardiometabolic risk in children with an increased body fat percentage. \n\nThis thesis is based on the data of the baseline examinations of the Physical Activity and Nutrition in Children (PANIC) study conducted by the University of Eastern Finland in 2007-2009. Cardiorespiratory fitness was measured using the maximal cycle ergometer test. The maximal workload in relation to body mass (W/kg) and lean body mass (W/lm) were used as a measure of cardiorespiratory fitness. The lean body mass and body fat mass were measured using the dual-energy X-ray absorptiometry (DXA). Metabolic syndrome was evaluated by the cardiometabolic risk score (cMetS) calculated with waist circumference, fasting serum insulin, fasting plasma glucose, triglycerides, HDL cholesterol and the average of systolic and diastolic blood pressure. Insulin and glucose concentrations analyzed from fasting blood samples as well as HOMA-IR were used to assess insulin resistance. The data was analyzed with IBM SPSS Statistics 24 software using linear regression analysis and covariance analysis (ANCOVA). \n\n452 children were selected for the thesis, of which 216 (47,8 %) were girls and 236 (52,2 %) were boys. Higher fat percentage and lower cardiorespiratory fitness in relation to body mass were associated with higher cardiometabolic risk score, insulin and HOMA-IR in both girls and boys (p<0,001). W/lm was not associated with any of the outcome variables in either sex. In groups divided by sex specific medians of fat percentage and cardiorespiratory fitness, children with higher fat percentage and higher W/kg had lower cardiometabolic risk score, insulin and HOMA-IR than children with higher fat percentage but lower W/kg. W/lm did not have associations with the indicators of metabolic syndrome in children with lower or higher fat percentage but higher BF% was associated with higher cardiometabolic risk score, insulin and HOMA-IR regardless of the level of W/lm. \n\nAccording to the results, body fat content is clearly associated with the indicators of metabolic syndrome. The positive associations of cardiorespiratory fitness to cardiometabolic risk may be explained by the differences in body fat content, which emphasizes the importance of normal body weight and body fat content in promoting cardiometabolic health already in childhood. However, the relevance of cardiorespiratory fitness to cardiometabolic risk in children should be further explored. Because of the cross-sectional design of this thesis, the causal relationships cannot be investigated.", "language": "en", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Submitted by Paivi Vuorio (paelvuor@jyu.fi) on 2018-06-01T09:49:13Z\nNo. of bitstreams: 0", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Made available in DSpace on 2018-06-01T09:49:13Z (GMT). No. of bitstreams: 0\n Previous issue date: 2018", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.format.extent", "value": "42", "language": "", "element": "format", "qualifier": "extent", "schema": "dc"}, {"key": "dc.format.mimetype", "value": "application/pdf", "language": null, "element": "format", "qualifier": "mimetype", "schema": "dc"}, {"key": "dc.language.iso", "value": "fin", "language": null, "element": "language", "qualifier": "iso", "schema": "dc"}, {"key": "dc.rights", "value": "In Copyright", "language": "en", "element": "rights", "qualifier": null, "schema": "dc"}, {"key": "dc.subject.other", "value": "kest\u00e4vyyskunto", "language": "", "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.title", "value": "Kest\u00e4vyyskunnon ja kehon rasvapitoisuuden yhteydet metaboliseen oireyhtym\u00e4\u00e4n ja insuliiniresistenssiin 6\u20138-vuotiailla lapsilla", "language": "", "element": "title", "qualifier": null, "schema": "dc"}, {"key": "dc.type", "value": "master thesis", "language": null, "element": "type", "qualifier": null, "schema": "dc"}, {"key": "dc.identifier.urn", "value": "URN:NBN:fi:jyu-201806012985", "language": "", "element": "identifier", "qualifier": "urn", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Pro gradu -tutkielma", "language": "fi", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Master\u2019s thesis", "language": "en", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Liikuntatieteellinen tiedekunta", "language": "fi", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Faculty of Sport and Health Sciences", "language": "en", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Liikunta- ja terveystieteet", "language": "fi", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Sport and Health Sciences", "language": "en", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "Jyv\u00e4skyl\u00e4n yliopisto", "language": "fi", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "University of Jyv\u00e4skyl\u00e4", "language": "en", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Liikuntal\u00e4\u00e4ketiede", "language": "fi", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Sport Medicine", "language": "en", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "yvv.contractresearch.funding", "value": "0", "language": "", "element": "contractresearch", "qualifier": "funding", "schema": "yvv"}, {"key": "dc.type.coar", "value": "http://purl.org/coar/resource_type/c_bdcc", "language": null, "element": "type", "qualifier": "coar", "schema": "dc"}, {"key": "dc.rights.accesslevel", "value": "openAccess", "language": null, "element": "rights", "qualifier": "accesslevel", "schema": "dc"}, {"key": "dc.type.publication", "value": "masterThesis", "language": null, "element": "type", "qualifier": "publication", "schema": "dc"}, {"key": "dc.subject.oppiainekoodi", "value": "5042", "language": "", "element": "subject", "qualifier": "oppiainekoodi", "schema": "dc"}, {"key": "dc.subject.yso", "value": "lapset (ik\u00e4ryhm\u00e4t)", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "insuliiniresistenssi", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "metabolinen oireyhtym\u00e4", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "lihavuus", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.format.content", "value": "fulltext", "language": null, "element": "format", "qualifier": "content", "schema": "dc"}, {"key": "dc.rights.url", "value": "https://rightsstatements.org/page/InC/1.0/", "language": null, "element": "rights", "qualifier": "url", "schema": "dc"}, {"key": "dc.type.okm", "value": "G2", "language": null, "element": "type", "qualifier": "okm", "schema": "dc"}]
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