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[{"key": "dc.contributor.advisor", "value": "Nissinen, Maija", "language": null, "element": "contributor", "qualifier": "advisor", "schema": "dc"}, {"key": "dc.contributor.author", "value": "Happonen, Lauri", "language": null, "element": "contributor", "qualifier": "author", "schema": "dc"}, {"key": "dc.date.accessioned", "value": "2018-01-02T12:37:28Z", "language": null, "element": "date", "qualifier": "accessioned", "schema": "dc"}, {"key": "dc.date.available", "value": "2018-01-02T12:37:28Z", "language": null, "element": "date", "qualifier": "available", "schema": "dc"}, {"key": "dc.date.issued", "value": "2017", "language": null, "element": "date", "qualifier": "issued", "schema": "dc"}, {"key": "dc.identifier.other", "value": "oai:jykdok.linneanet.fi:1809935", "language": null, "element": "identifier", "qualifier": "other", "schema": "dc"}, {"key": "dc.identifier.uri", "value": "https://jyx.jyu.fi/handle/123456789/56566", "language": null, "element": "identifier", "qualifier": "uri", "schema": "dc"}, {"key": "dc.description.abstract", "value": "Tutkielman kirjallisessa osassa tarkastellaan foldameerej\u00e4 is\u00e4nt\u00e4-vieraskemian n\u00e4k\u00f6kulmasta. Foldameerit voivat sitoa rakenteeseensa erilaisia vierasmolekyylej\u00e4, jolloin muodostuu is\u00e4nt\u00e4-vieraskomplekseja. Kirjallisuudesta valittiin tarkasteluun mielenkiintoisimpia anioneja, kationeja ja neutraaleja vierasmolekyylej\u00e4 sitovia foldameereja ja perehdyttiin niiden vuorovaikutuksiin. Lis\u00e4ksi tarkasteltiin vierasmolekyylin sitoutumisen aikaansaamia muutoksia foldameerien konformaatiossa.\nKokeellisen osan tarkoituksena oli syntetisoida pitk\u00e4, 11 aromaattista rengasta sis\u00e4lt\u00e4v\u00e4 aryyliamidifoldameeri k\u00e4ytt\u00e4en hyv\u00e4ksi p\u00e4\u00e4asiassa peptidikytkent\u00e4reaktioita. Koska synteesi osoittautui eritt\u00e4in haasteelliseksi, pyrittiin selvitt\u00e4m\u00e4\u00e4n erilaisilla testireaktiolla ne tekij\u00e4t, jotka est\u00e4v\u00e4t synteesin etenemisen. Koska foldameerin synteesi valitulla synteesireitill\u00e4 ei onnistunut, niin synteesiss\u00e4 k\u00e4ytetty dihappo muutettiin orto-isomeerista meta-isomeeriksi, jolloin pystyttiin valmistamaan v\u00e4lituote, josta on mahdollista valmistaa pidempiketjuisia foldameereja.\nKirjallisen osuuden aineisto haettiin k\u00e4ytt\u00e4m\u00e4ll\u00e4 p\u00e4\u00e4asiassa Google Scholar- ja Scifinder - hakukoneita. Hakusanoina k\u00e4ytettiin muun muassa foldamers, anion binding foldamers, cation binding foldamers, host-guest chemistry ja host-guest chemistry of foldamers. Molekyylit on numeroitu esiintymisj\u00e4rjestyksess\u00e4 1-55 ja numerointi alkaa teknisist\u00e4 syist\u00e4 alusta kokeelliseen osaan siirrytt\u00e4ess\u00e4.", "language": "fi", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Submitted using Plone Publishing form by Lauri Happonen (lailhapp) on 2018-01-02 12:37:27.285624. Form: Pro gradu -lomake (https://kirjasto.jyu.fi/julkaisut/julkaisulomakkeet/pro-gradu-lomake). JyX data: [jyx_publishing-allowed (fi) =True]", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Submitted by jyx lomake-julkaisija (jyx-julkaisija.group@korppi.jyu.fi) on 2018-01-02T12:37:28Z\nNo. of bitstreams: 2\nURN:NBN:fi:jyu-201801021014.pdf: 3238178 bytes, checksum: abf22b8631b78d1727f43cb3a3f08dc4 (MD5)\nlicense.html: 4790 bytes, checksum: 1a1c11727add94ef771e3d034bb7f942 (MD5)", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Made available in DSpace on 2018-01-02T12:37:28Z (GMT). No. of bitstreams: 2\nURN:NBN:fi:jyu-201801021014.pdf: 3238178 bytes, checksum: abf22b8631b78d1727f43cb3a3f08dc4 (MD5)\nlicense.html: 4790 bytes, checksum: 1a1c11727add94ef771e3d034bb7f942 (MD5)\n Previous issue date: 2017", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.format.extent", "value": "1 verkkoaineisto (95 sivua)", "language": null, "element": "format", "qualifier": "extent", "schema": "dc"}, {"key": "dc.format.mimetype", "value": "application/pdf", "language": null, "element": "format", "qualifier": "mimetype", "schema": "dc"}, {"key": "dc.language.iso", "value": "fin", "language": null, "element": "language", "qualifier": "iso", "schema": "dc"}, {"key": "dc.rights", "value": "In Copyright", "language": "en", "element": "rights", "qualifier": null, "schema": "dc"}, {"key": "dc.subject.other", "value": "foldameerit", "language": null, "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "aryyliamidifoldameeri", "language": null, "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "peptidikytkent\u00e4", "language": null, "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.title", "value": "Foldameerien is\u00e4nt\u00e4-vieraskemia", "language": null, "element": "title", "qualifier": null, "schema": "dc"}, {"key": "dc.type", "value": "master thesis", "language": null, "element": "type", "qualifier": null, "schema": "dc"}, {"key": "dc.identifier.urn", "value": "URN:NBN:fi:jyu-201801021014", "language": null, "element": "identifier", "qualifier": "urn", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Pro gradu -tutkielma", "language": "fi", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.type.ontasot", "value": "Master\u2019s thesis", "language": "en", "element": "type", "qualifier": "ontasot", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Matemaattis-luonnontieteellinen tiedekunta", "language": "fi", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.faculty", "value": "Faculty of Sciences", "language": "en", "element": "contributor", "qualifier": "faculty", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Kemian laitos", "language": "fi", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.department", "value": "Department of Chemistry", "language": "en", "element": "contributor", "qualifier": "department", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "University of Jyv\u00e4skyl\u00e4", "language": "en", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "Jyv\u00e4skyl\u00e4n yliopisto", "language": "fi", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Orgaaninen kemia", "language": "fi", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Organic Chemistry", "language": "en", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "dc.date.updated", "value": "2018-01-02T12:37:28Z", "language": null, "element": "date", "qualifier": "updated", "schema": "dc"}, {"key": "yvv.contractresearch.funding", "value": "0", "language": null, "element": "contractresearch", "qualifier": "funding", "schema": "yvv"}, {"key": "dc.type.coar", "value": "http://purl.org/coar/resource_type/c_bdcc", "language": null, "element": "type", "qualifier": "coar", "schema": "dc"}, {"key": "dc.rights.accesslevel", "value": "openAccess", "language": "fi", "element": "rights", "qualifier": "accesslevel", "schema": "dc"}, {"key": "dc.type.publication", "value": "masterThesis", "language": null, "element": "type", "qualifier": "publication", "schema": "dc"}, {"key": "dc.subject.oppiainekoodi", "value": "4035", "language": null, "element": "subject", "qualifier": "oppiainekoodi", "schema": "dc"}, {"key": "dc.subject.yso", "value": "kationit", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "anionit", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.format.content", "value": "fulltext", "language": null, "element": "format", "qualifier": "content", "schema": "dc"}, {"key": "dc.rights.url", "value": "https://rightsstatements.org/page/InC/1.0/", "language": null, "element": "rights", "qualifier": "url", "schema": "dc"}, {"key": "dc.type.okm", "value": "G2", "language": null, "element": "type", "qualifier": "okm", "schema": "dc"}]
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