Mechanisms of action of caffeine in a non-fatigued state and during fatiguing exercise responders versus non-responders

Several studies have documented the ergogenic effects of caffeine, but its mechanisms of action are not fully understood yet. The purpose of this study was to investigate the underlying mechanisms that may explain any caffeine-induced effects in a non-fatigued state and during exhaustive stretch-sho...

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Main Author: Mesquita, Ricardo N. O.
Other Authors: Liikuntatieteellinen tiedekunta, Faculty of Sport and Health Sciences, Sport and Health Sciences, Liikunta- ja terveystieteet, University of Jyväskylä, Jyväskylän yliopisto
Format: Master's thesis
Language:eng
Published: 2017
Subjects:
Online Access: https://jyx.jyu.fi/handle/123456789/55591
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author Mesquita, Ricardo N. O.
author2 Liikuntatieteellinen tiedekunta Faculty of Sport and Health Sciences Sport and Health Sciences Liikunta- ja terveystieteet University of Jyväskylä Jyväskylän yliopisto
author_facet Mesquita, Ricardo N. O. Liikuntatieteellinen tiedekunta Faculty of Sport and Health Sciences Sport and Health Sciences Liikunta- ja terveystieteet University of Jyväskylä Jyväskylän yliopisto Mesquita, Ricardo N. O. Liikuntatieteellinen tiedekunta Faculty of Sport and Health Sciences Sport and Health Sciences Liikunta- ja terveystieteet University of Jyväskylä Jyväskylän yliopisto
author_sort Mesquita, Ricardo N. O.
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description Several studies have documented the ergogenic effects of caffeine, but its mechanisms of action are not fully understood yet. The purpose of this study was to investigate the underlying mechanisms that may explain any caffeine-induced effects in a non-fatigued state and during exhaustive stretch-shortening cycle exercise (SSC). Eighteen males participated in this randomised, double-blind, placebo-controlled crossover trial. Baseline measures of plantarflexion force, drop jump, squat jump, voluntary activation, neuromuscular transmission, contractile properties, H-reflex, corticospinal excitability, short-intracortical inhibition, intracortical facilitation (ICF), corticospinal silent period (CSP) and blood biomarkers were made before administration of caffeine (6 mg•kg-1 ) or placebo. After a 1-hour rest, participants repeated the baseline measures, followed by a fatigue protocol that consisted of SSC exercise until exhaustion on a sledge apparatus by repeating series of 40 bilateral rebound jumps, with resting periods of 3 min. Neuromuscular testing was carried out throughout and after the fatigue protocol. Caffeine enhanced pre to postcapsule drop jump height, decreased CSP, suppressed a time-related decrease in ICF and mobilized free fatty acids. At the group level, caffeine did not alter the number of sets completed. However, ten responders were identified and pre to postcapsule changes in inhibitory mechanisms were significantly correlated with the number of sets completed in the caffeine trial. Responders also benefited from a decreased sense of effort during exercise and from an accelerated recovery of neuromuscular transmission failure after fatigue. The observed effects of this drug on the neuromuscular system may be explained by the reversal of inhibitory effects of adenosine. Effects of caffeine are highly dependent on individual responsiveness and thus, examination of its effects on an individual basis is highly recommended.
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The purpose of this study was to investigate the underlying mechanisms that may explain any caffeine-induced effects in a non-fatigued state and during exhaustive stretch-shortening cycle exercise (SSC). Eighteen males participated in this randomised, double-blind, placebo-controlled crossover trial. Baseline measures of plantarflexion force, drop jump, squat jump, voluntary activation, neuromuscular transmission, contractile properties, H-reflex, corticospinal excitability, short-intracortical inhibition, intracortical facilitation (ICF), corticospinal silent period (CSP) and blood biomarkers were made before administration of caffeine (6 mg\u2022kg-1 ) or placebo. After a 1-hour rest, participants repeated the baseline measures, followed by a fatigue protocol that \r\nconsisted of SSC exercise until exhaustion on a sledge apparatus by repeating series of 40 bilateral rebound jumps, with resting periods of 3 min. 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spellingShingle Mesquita, Ricardo N. O. Mechanisms of action of caffeine in a non-fatigued state and during fatiguing exercise : responders versus non-responders fatigue central fatigue peripheral fatigue peripheral transmission failure transcranial magnetic stimulation rate of perceived exertion exercise performance exertion soleus Liikuntafysiologia Exercise Physiology Vaihtovuoroinen tutkimus 5011 transkraniaalinen magneettistimulaatio rasituskokeet lihakset rasitus väsyminen suorituskyky kofeiini liikuntafysiologia
title Mechanisms of action of caffeine in a non-fatigued state and during fatiguing exercise : responders versus non-responders
title_full Mechanisms of action of caffeine in a non-fatigued state and during fatiguing exercise : responders versus non-responders
title_fullStr Mechanisms of action of caffeine in a non-fatigued state and during fatiguing exercise : responders versus non-responders Mechanisms of action of caffeine in a non-fatigued state and during fatiguing exercise : responders versus non-responders
title_full_unstemmed Mechanisms of action of caffeine in a non-fatigued state and during fatiguing exercise : responders versus non-responders Mechanisms of action of caffeine in a non-fatigued state and during fatiguing exercise : responders versus non-responders
title_short Mechanisms of action of caffeine in a non-fatigued state and during fatiguing exercise
title_sort mechanisms of action of caffeine in a non fatigued state and during fatiguing exercise responders versus non responders
title_sub responders versus non-responders
title_txtP Mechanisms of action of caffeine in a non-fatigued state and during fatiguing exercise : responders versus non-responders
topic fatigue central fatigue peripheral fatigue peripheral transmission failure transcranial magnetic stimulation rate of perceived exertion exercise performance exertion soleus Liikuntafysiologia Exercise Physiology Vaihtovuoroinen tutkimus 5011 transkraniaalinen magneettistimulaatio rasituskokeet lihakset rasitus väsyminen suorituskyky kofeiini liikuntafysiologia
topic_facet 5011 Exercise Physiology Liikuntafysiologia Vaihtovuoroinen tutkimus central fatigue exercise performance exertion fatigue kofeiini lihakset liikuntafysiologia peripheral fatigue peripheral transmission failure rasitus rasituskokeet rate of perceived exertion soleus suorituskyky transcranial magnetic stimulation transkraniaalinen magneettistimulaatio väsyminen
url https://jyx.jyu.fi/handle/123456789/55591 http://www.urn.fi/URN:NBN:fi:jyu-201710093965
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