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[{"key": "dc.contributor.advisor", "value": "Laakkonen, Eija", "language": "", "element": "contributor", "qualifier": "advisor", "schema": "dc"}, {"key": "dc.contributor.advisor", "value": "Sipil\u00e4, Sarianna", "language": "", "element": "contributor", "qualifier": "advisor", "schema": "dc"}, {"key": "dc.contributor.author", "value": "Forsius, Pirita", "language": null, "element": "contributor", "qualifier": "author", "schema": "dc"}, {"key": "dc.date.accessioned", "value": "2017-09-05T12:43:41Z", "language": "", "element": "date", "qualifier": "accessioned", "schema": "dc"}, {"key": "dc.date.available", "value": "2017-09-05T12:43:41Z", "language": "", "element": "date", "qualifier": "available", "schema": "dc"}, {"key": "dc.date.issued", "value": "2017", "language": null, "element": "date", "qualifier": "issued", "schema": "dc"}, {"key": "dc.identifier.other", "value": "oai:jykdok.linneanet.fi:1721820", "language": null, "element": "identifier", "qualifier": "other", "schema": "dc"}, {"key": "dc.identifier.uri", "value": "https://jyx.jyu.fi/handle/123456789/55277", "language": "", "element": "identifier", "qualifier": "uri", "schema": "dc"}, {"key": "dc.description.abstract", "value": "Unen laatu heikkenee vaihdevuosien aikana. Heikentynyt unen laatu on yhteydess\u00e4 sokeri- ja rasva-aineenvaihdunnan h\u00e4iri\u00f6ihin. T\u00e4m\u00e4n pro gradu-tutkielman tarkoituksena oli selvitt\u00e4\u00e4 vaihdevuosi-ik\u00e4isten naisten unen laadun yhteytt\u00e4 kardiometabolisiin riskitekij\u00f6ihin.\r\n\r\nTutkielma perustuu Estrogeeni, vaihdevuodet ja toimintakyky (ERMA) -tutkimuksen aineistoon. Osallistujat poimittiin satunnaisotannalla v\u00e4est\u00f6rekisterist\u00e4 Jyv\u00e4skyl\u00e4n ja sen l\u00e4hikuntien 47\u201354 -vuotiaista naisista (n=6886). Mukaan valittiin ne sis\u00e4\u00e4nottokriteerit t\u00e4ytt\u00e4v\u00e4t naiset, jotka vastasivat tutkimuksen alkumittauskyselyyn ja joilta terveydentilaa selvitt\u00e4v\u00e4n haastattelun sek\u00e4 laboratoriomittausten j\u00e4lkeen saatiin luotettavasti mitattua seerumin leptiini (n=679). \r\n\r\nUnen laatua arvioitiin kysymyksill\u00e4 koetusta unen laadusta, unen pituudesta sek\u00e4 p\u00e4iv\u00e4aikaisesta v\u00e4symyksest\u00e4. Kardiometabolisista riskitekij\u00f6ist\u00e4 tarkasteltiin verensokeria, kolesteroleja, triglyseridej\u00e4 sek\u00e4 leptiinitasoja. Tutkittavat jaettiin vaihdevuosivaiheen mukaan premenopaussi-, perimenopaussi- ja postmenopaussiryhmiin. Ryhmien eroja unen ja kardiometabolisten riskitekij\u00f6iden suhteen tarkasteltiin \u03c72-testill\u00e4 sek\u00e4 yksisuuntaisella varianssianalyysill\u00e4. Unen ja kardiometabolisten riskitekij\u00f6iden yhteytt\u00e4 selvitettiin Spearmanin korrelaatioanalyysill\u00e4. Lis\u00e4ksi yhteyksi\u00e4 tarkasteltiin monimuuttujaisella lineaarisella regressiolla. Multinomiaalista logistista regressiomallinnusta k\u00e4ytettiin unen ja kardiometabolisista riskitekij\u00f6ist\u00e4 muodostettun summamuuttujan v\u00e4listen yhteyksien tarkasteluun. \r\n\r\nVaihdevuosiryhmien v\u00e4lill\u00e4 oli eroja koetussa unen laadussa (p=0.011) ja unen kestossa (p=0.001). Unen laatu heikkeni ja unen kesto lyheni vaihdevuosien edetess\u00e4. Kardiometabolisista riskitekij\u00f6ist\u00e4 kolesterolit olivat postmenopaussiryhm\u00e4ss\u00e4 muita korkeammalla tasolla (p<0.001). Perimenopaussiryhm\u00e4n leptiinitasot olivat korkeat muihin verrattuna (p=0.045). Koettu p\u00e4iv\u00e4aikainen v\u00e4symys oli heikosti yhteydess\u00e4 leptiinitasoihin (r=0.099, p<0.05). Lineaarisessa regressiomallissa kehonpainoindeksi osoittautui kuitenkin v\u00e4symyst\u00e4 (\u03b2=0.428, p<0.001) paremmin leptiinitasoa selitt\u00e4v\u00e4ksi tekij\u00e4ksi. Multinomiaalisessa regressiomallissa havaittiin postmenopausaalisilla naisilla olevan premenopaussiryhm\u00e4\u00e4 merkitt\u00e4v\u00e4mpi riski kardiometabolisten riskitekij\u00f6iden kertymiseen.\r\n\r\nVaikka ty\u00f6ss\u00e4 k\u00e4ytetty poikittaisasetelma ei mahdollista suorien kausaalip\u00e4\u00e4ttelyiden tekemist\u00e4, vaikuttaa koettu unen laatu heikkenev\u00e4n ja unen kesto lyhenev\u00e4n vaihdevuosien aikana. My\u00f6s rasva-aineenvaihdunnassa tapahtuu muutoksia, joiden seurauksena kolesterolien m\u00e4\u00e4r\u00e4 verenkierrossa nousee. Leptiinin m\u00e4\u00e4r\u00e4 verenkierrossa saattaa nousta perimenopaussin aikana, mutta postmenopausaalisilla naisilla se on l\u00e4hes samalla tasolla kuin premenopausaalisilla. Postmenopaussi lis\u00e4\u00e4 kardiometabolisten riskitekij\u00f6iden kertymisen riski\u00e4. Unen laatu ei t\u00e4m\u00e4n tutkielman perusteella ole suoraan yhteydess\u00e4 kardiometabolisen riskin suurenemiseen. Unella on kuitenkin yhteys kehonpainoindeksiin, jonka merkitys v\u00e4litt\u00e4v\u00e4n\u00e4 tekij\u00e4n\u00e4 tulee huomioida.", "language": "fi", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.abstract", "value": "Menopause is known to decrease the quality of sleep. The impaired sleep quality is associated with disorders in glucose and lipid metabolism. The purpose of this study was to investigate the interactions between sleep quality and cardiometabolic risk factors on menopausal women.\r\n\r\nThis study is based on the data of Estrogenic Regulation of Muscle Apoptosis (ERMA) -study. The participants were a random sample of 47\u201355 -year women living in Jyv\u00e4skyl\u00e4 area gleaned from the Finnish population register (n=6886). The study sample was limited to wom-en who had responded to the initial survey measurement of ERMA -study and who had un-dergone the interview considering the state of health and laboratory measurements. The final sample consisted of the women whose leptin levels were being reliably measured (n=679).\r\n\r\nThe quality of sleep was evaluated with questionnaire considering perceived sleep quality, duration of sleep and daytime sleepiness. Blood glucose, cholesterols, triglycerides and leptin levels were examined as cardiometabolic risk factors. The participants were divided into three groups according to the status of the menopause: premenopausal-, perimenopausal- and post-menopausal groups. Differences between groups in the quality of sleep and cardiometabolic risk factors were tested with \u03c72-test and one-way analysis of variance. The association be-tween sleep quality and cardiometabolic risk factors was tested with Spearman correlation analysis and multiple linear regression. Finally, a sum variable was formed from the cardi-ometabolic risk factors. The association of sleep quality with the sum variable was tested with multinomial logistic regression.\r\n\r\nThis study found differences between the menopause groups in the perceived quality of sleep (p=0.011) and duration of sleep (p=0.001). The quality of sleep declined and the duration of sleep shortened during the menopause. Cholesterols were higher in the postmenopausal group than in the two other groups (p<0.001). Leptin levels were highest in the perimenopausal group (p=0.045). Daytime sleepiness was weakly associated with higher leptin levels (r=0.099, p<0.05). However, in the linear regression model, body mass index turned out to explain the leptin levels better than daytime sleepiness (\u03b2=0.428, p<0.001). Multinomial regression model showed that women in postmenopause have greater risk of cumulative cardiometabolic risk than women in premenopause.\r\n\r\nBecause of the cross-sectional research frame, making any assumptions of causality is not pos-sible. However, it seems that the quality of sleep decreases and the duration of sleep shortens during the menopause. Changes in the lipid metabolism seem to cause the rise of cholesterol levels in the circulation. The leptin levels may temporarily rise during the perimenopause, but in postmenopause they return near the same level of premenopausal women. Postmenopause is increasing the risk of cumulating cardiometabolic risk factors. According to this study, sleep quality is not directly associated with an increase in cardiometabolic risk. Sleep has, however, a connection on body mass index, which may act as an intermediator in the association with cardiometabolic risk.", "language": "en", "element": "description", "qualifier": "abstract", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Submitted using Plone Publishing form by Pirita Forsius (tepifors) on 2017-09-05 12:43:41.172956. Form: Pro gradu -lomake (https://kirjasto.jyu.fi/julkaisut/julkaisulomakkeet/pro-gradu-lomake). JyX data: [jyx_publishing-allowed (fi) =True]", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Submitted by jyx lomake-julkaisija (jyx-julkaisija.group@korppi.jyu.fi) on 2017-09-05T12:43:41Z\r\nNo. of bitstreams: 2\r\nURN:NBN:fi:jyu-201709053665.pdf: 439663 bytes, checksum: 2ea9f718acfb0903e44b2e18aa271105 (MD5)\r\nlicense.html: 4884 bytes, checksum: dd56601066d34ae4f41aea858ba879df (MD5)", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.description.provenance", "value": "Made available in DSpace on 2017-09-05T12:43:41Z (GMT). No. of bitstreams: 2\r\nURN:NBN:fi:jyu-201709053665.pdf: 439663 bytes, checksum: 2ea9f718acfb0903e44b2e18aa271105 (MD5)\r\nlicense.html: 4884 bytes, checksum: dd56601066d34ae4f41aea858ba879df (MD5)\r\n Previous issue date: 2017", "language": "en", "element": "description", "qualifier": "provenance", "schema": "dc"}, {"key": "dc.format.extent", "value": "1 verkkoaineisto (57 sivua)", "language": null, "element": "format", "qualifier": "extent", "schema": "dc"}, {"key": "dc.format.mimetype", "value": "application/pdf", "language": null, "element": "format", "qualifier": "mimetype", "schema": "dc"}, {"key": "dc.language.iso", "value": "fin", "language": null, "element": "language", "qualifier": "iso", "schema": "dc"}, {"key": "dc.rights", "value": "In Copyright", "language": "en", "element": "rights", "qualifier": null, "schema": "dc"}, {"key": "dc.subject.other", "value": "unen laatu", "language": null, "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "kardiometabolia", "language": null, "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "sleep quality", "language": null, "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "menopause", "language": null, "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "cardiometabolic risk", "language": null, "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.subject.other", "value": "sleep", "language": null, "element": "subject", "qualifier": "other", "schema": "dc"}, {"key": "dc.title", "value": "Uni ja kardiometabolia : vaihdevuosi-ik\u00e4isten naisten unen laadun yhteys sokeri- ja rasva-aineenvaihduntaan ja leptiinitasoihin", "language": null, "element": "title", "qualifier": null, "schema": "dc"}, {"key": "dc.type", "value": "master thesis", "language": null, "element": "type", "qualifier": null, 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Jyv\u00e4skyl\u00e4", "language": "en", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.contributor.organization", "value": "Jyv\u00e4skyl\u00e4n yliopisto", "language": "fi", "element": "contributor", "qualifier": "organization", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Gerontologia ja kansanterveys", "language": "fi", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "dc.subject.discipline", "value": "Gerontology and Public Health", "language": "en", "element": "subject", "qualifier": "discipline", "schema": "dc"}, {"key": "dc.date.updated", "value": "2017-09-05T12:43:41Z", "language": "", "element": "date", "qualifier": "updated", "schema": "dc"}, {"key": "yvv.contractresearch.funding", "value": "0", "language": "", "element": "contractresearch", "qualifier": "funding", "schema": "yvv"}, {"key": "dc.type.coar", "value": "http://purl.org/coar/resource_type/c_bdcc", "language": null, "element": "type", 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"value": "aineenvaihduntah\u00e4iri\u00f6t", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "rasva-arvot", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "kolesteroli", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "verensokeri", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.subject.yso", "value": "painoindeksi", "language": null, "element": "subject", "qualifier": "yso", "schema": "dc"}, {"key": "dc.format.content", "value": "fulltext", "language": null, "element": "format", "qualifier": "content", "schema": "dc"}, {"key": "dc.rights.url", "value": "https://rightsstatements.org/page/InC/1.0/", "language": null, "element": "rights", "qualifier": "url", "schema": "dc"}, {"key": "dc.type.okm", "value": "G2", "language": null, "element": "type", 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